Antidiabetic principle from Eclipta prostrata

The methanol extract of the whole plant of Eclipta prostrata and one of its isolated compounds, eclalbasaponin II were administered to alloxan-induced diabetic rats for 28 and 7 consecutive days, respectively. During the study, a potent antidiabetic activity was observed. Blood sugar was significantly (p < 0.001) reduced by E. prostrata extract (300 mg/kg) and eclalbasaponin II (10 mg/kg), as compared to untreated diabetic rats. Analyses of alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) showed no significant (p < 0.001) hepatotoxicity by E. prostrata extractive in alloxan-induced diabetic rats when compared to the diabetic control rats.Colegio de Farmacéuticos de la Provincia de Buenos Aire

Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: a systematic analysis for the Global Burden of Disease Study 2017.

BACKGROUND: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. METHODS: The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries-Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODEm), to generate cause fractions and cause-specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised

Dhaka Food Agenda 2041 Foresight and Scenario development : Workshop Report Dhaka Food Systems project

This report is a compilation of a workshop sessions held with stakeholders engaged in a foresight and scenario develop process to develop a Dhaka Food Agenda 2041. The report describes the rationale and the different steps undertaken in the process as well as its outputs. Stakeholders have interacted and explored the Dhaka Metropolitan food system and discussed the linkages between issues in the domain of food and nutrition security, food safety, food loss and waste, fresh markets and value chains. In terms of output they have deliberated that one of the major uncertainties is the shift in diets of citizens related to the uncertainty of having thriving small and sustainable businesses versus big- companies (supermarketisation). The participants developed different scenarios and their narratives that are varying from least to most desirable situation. The workshops have led to evidence and dialogue on the needs and opportunities to aim for a sustainable and inclusive food system in Dhaka in 2041. In conclusion, the report presents the steps that will follow the scoping, mapping, analysis of drivers and trends and the scenario development feeding into the further development of the Dhaka Food Agenda 2041