Indeterminacy and approximation in Mediterranean weight systems in the third and second millennia BC

Research on weight systems used during the Bronze Age, prior to the introduction of writing, generally assumes that the widespread use of metal as \u2018commodity currency\u2019 eventually resulted in the adoption of widely shared systems of measurement. Many studies aimed at the identification of recurrent weight values as multiples and/or submultiples of theoretical standard units. This approach faces two limitations: 1) the absence of written sources, or at least statistically sound samples, makes it difficult to either validate or reject any reconstruction of prehistoric systems; 2) in the literate Ancient World, different polities usually retained distinct systems. Here an alternative analytical framework is outlined, making use of elementary statistics and crosshistorical comparisons, and relying positively on \u2018indeterminacy\u2019 and \u2018approximation\u2019 rather than on \u2018exactness\u2019. Recurrent weight measures can correspond to \u2018Standard Average Quantities\u2019, rather than representing arrays of exact multiples/submultiples of given units. By departing from a \u2018fractional\u2019 theoretical logic, one can observe that constant exchange practice may have produced the normalisation of \u2018tradable quantities\u2019 and that this can happen without necessarily implying the unification of local systems.La recherche sur les unit\ue9s de poids employ\ue9es \ue0 l\u2019\uc2ge du Bronze pr\ue9suppose qu\u2019une utilisation courante du m\ue9tal, sous forme de mati\ue8re premi\ue8re, comme monnaie d\u2019\ue9change permit une g\ue9n\ue9ralisation d\u2019\ue9chelles de mesures communes. Plusieurs \ue9tudes ont \ue9t\ue9 men\ue9es afin d\u2019identifier les valeurs de poids r\ue9currentes repr\ue9sentant des multiples et/ou sous-multiples d\u2019unit\ue9s de mesure th\ue9oriques standardis\ue9es. Ces \ue9tudes ont deux limites : 1) l\u2019absence de sources \ue9crites ou au moins d\u2019un \ue9chantillonnage statistique fiable, rendant difficile de valider ou de rejeter toute tentative de reconstruction de syst\ue8mes pr\ue9historiques; 2) dans le monde ancien les diff\ue9rentes entit\ue9s politiques utilisent des unit\ue9s de mesures distinctes qui leur sont propres. Cet article pr\ue9sente une analyse alternative mettant en comparaison divers cas historiques connus avec des statistiques \ue9l\ue9mentaires, en s\u2019appuyant sur les concepts \u2018d\u2019ind\ue9termination\u2019 et \u2018d\u2019approximation\u2019, et non sur la notion \u2018d\u2019exactitude\u2019. Les mesures de poids r\ue9p\ue9t\ue9es peuvent davantage correspondre \ue0 des Standard Average Quantities (quantit\ue9s moyennes standardis\ue9es) qu\u2019\ue0 des s\ue9ries exactes des multiples ou des sous-multiples des unit\ue9s donn\ue9es. En s\u2019\ue9cartant d\u2019une logique \u2018fractionnelle\u2019 th\ue9orique, on peut observer que la pratique des \ue9changes constants peut avoir donn\ue9 lieu \ue0 une normalisation des \u2018quantit\ue9s \ue9changeables\u2019 sans la n\ue9cessit\ue9 d\u2019une unification des diff\ue9rents syst\ue8mes locaux

Breaking down the bullion : The compliance of bullion-currencies with official weight-systems in a case-study from the ancient Near East

In this paper we provide an analytical insight on a specific form of bullion-currency. Through the comparison of the statistical properties of different samples of hacksilver and balance weights from various contexts of the Near Eastern Bronze Age, the study attempts to assess whether the weight values of bullion-currencies can be expected to comply with existing weight-standards. The results of the statistical analyses on a silver hoard from Ebla (Syria) strongly suggest that hacksilver in the Bronze Age Near East was shaped and/or fragmented in order to comply with the weight-systems that were in use in the trade networks where it circulated. The results also show the possibility to quantify the level of affinity between different weight-systems. The study is intended to provide a starting point for future research, aimed at the identification of different forms of bullion-currencies in pre- and protohistoric economies

Role of a Novel Heparanase Inhibitor on the Balance between Apoptosis and Autophagy in U87 Human Glioblastoma Cells

Background: Heparanase (HPSE) is an endo-& beta;-glucuronidase that cleaves heparan sulfate side chains, leading to the disassembly of the extracellular matrix, facilitating cell invasion and metastasis dissemination. In this research, we investigated the role of a new HPSE inhibitor, RDS 3337, in the regulation of the autophagic process and the balance between apoptosis and autophagy in U87 glioblastoma cells. Methods: After treatment with RDS 3337, cell lysates were analyzed for autophagy and apoptosis-related proteins by Western blot. Results: We observed, firstly, that LC3II expression increased in U87 cells incubated with RDS 3337, together with a significant increase of p62/SQSTM1 levels, indicating that RDS 3337 could act through the inhibition of autophagic-lysosomal flux of LC3-II, thereby leading to accumulation of lipidated LC3-II form. Conversely, the suppression of autophagic flux could activate apoptosis mechanisms, as revealed by the activation of caspase 3, the increased level of cleaved Parp1, and DNA fragmentation. Conclusions: These findings support the notion that HPSE promotes autophagy, providing evidence that RDS 3337 blocks autophagic flux. It indicates a role for HPSE inhibitors in the balance between apoptosis and autophagy in U87 human glioblastoma cells, suggesting a potential role for this new class of compounds in the control of tumor growth progression

Satellite detection, long-range transport, and air quality impacts of volcanic sulfur dioxide from the 2014–2015 flood lava eruption at Bárðarbunga (Iceland)

The 2014–2015 Bárðarbunga-Veiðivötn fissure eruption at Holuhraun produced about 1.5 km3 of lava, making it the largest eruption in Iceland in more than 200 years. Over the course of the eruption, daily volcanic sulfur dioxide (SO2) emissions exceeded daily SO2 emissions from all anthropogenic sources in Europe in 2010 by at least a factor of 3. We present surface air quality observations from across Northern Europe together with satellite remote sensing data and model simulations of volcanic SO2 for September 2014. We show that volcanic SO2 was transported in the lowermost troposphere over long distances and detected by air quality monitoring stations up to 2750 km away from the source. Using retrievals from the Ozone Monitoring Instrument (OMI) and the Infrared Atmospheric Sounding Interferometer (IASI), we calculate an average daily SO2 mass burden of 99 ± 49 kilotons (kt) of SO2 from OMI and 61 ± 18 kt of SO2 from IASI for September 2014. This volcanic burden is at least a factor of 2 greater than the average SO2 mass burden between 2007 and 2009 due to anthropogenic emissions from the whole of Europe. Combining the observational data with model simulations using the United Kingdom Met Office's Numerical Atmospheric-dispersion Modelling Environment model, we are able to constrain SO2 emission rates to up to 120 kilotons per day (kt/d) during early September 2014, followed by a decrease to 20–60 kt/d between 6 and 22 September 2014, followed by a renewed increase to 60–120 kt/d until the end of September 2014. Based on these fluxes, we estimate that the eruption emitted a total of 2.0 ± 0.6 Tg of SO2 during September 2014, in good agreement with ground-based remote sensing and petrological estimates. Although satellite-derived and model-simulated vertical column densities of SO2 agree well, the model simulations are biased low by up to a factor of 8 when compared to surface observations of volcanic SO2 on 6–7 September 2014 in Ireland. These biases are mainly due to relatively small horizontal and vertical positional errors in the simulations of the volcanic plume occurring over transport distances of thousands of kilometers. Although the volcanic air pollution episodes were transient and lava-dominated volcanic eruptions are sporadic events, the observations suggest that (i) during an eruption, volcanic SO2 measurements should be assimilated for near real-time air quality forecasting and (ii) existing air quality monitoring networks should be retained or extended to monitor SO2 and other volcanic pollutants

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Shared cognition in childhood anxiety: interpretation bias in preschool children and their parents

Although interpretation bias has been associated with the development and/or maintenance of childhood anxiety, its origins remain unclear. The present study is the first to examine intergenerational transmission of this bias from parents to their preschool-aged children via the verbal information pathway. A community sample of fifty parent–child pairs was recruited. Parents completed measures of their own trait anxiety and interpretation bias, their child’s anxiety symptoms, and a written story-stem measure, to capture the way parents tell their children stories. Interpretation bias was assessed in preschool-aged children (aged between 2 years 7 months and 5 years 8 months) using an extended story-stem paradigm. Young children’s interpretation bias was not significantly associated with their own anxiety symptoms. Neither was there evidence for a significant association between parent and child interpretation bias. However, parents who reported they would tell their child one or more threatening story endings in the written story-stem task had significantly higher anxiety than those who did not include any threatening story endings. In turn, children whose parents did not include any threatening endings in their written stories had significantly lower threat interpretations on the child story-stem paradigm, compared to those with parents who included at least one threatening story ending. The results suggest that parental verbal information could play a role in the development of interpretation bias in young children

Child/Adolescent Anxiety Multimodal Study (CAMS): rationale, design, and methods

<p>Abstract</p> <p>Objective</p> <p>To present the design, methods, and rationale of the Child/Adolescent Anxiety Multimodal Study (CAMS), a recently completed federally-funded, multi-site, randomized placebo-controlled trial that examined the relative efficacy of cognitive-behavior therapy (CBT), sertraline (SRT), and their combination (COMB) against pill placebo (PBO) for the treatment of separation anxiety disorder (SAD), generalized anxiety disorder (GAD) and social phobia (SoP) in children and adolescents.</p> <p>Methods</p> <p>Following a brief review of the acute outcomes of the CAMS trial, as well as the psychosocial and pharmacologic treatment literature for pediatric anxiety disorders, the design and methods of the CAMS trial are described.</p> <p>Results</p> <p>CAMS was a six-year, six-site, randomized controlled trial. Four hundred eighty-eight (N = 488) children and adolescents (ages 7-17 years) with DSM-IV-TR diagnoses of SAD, GAD, or SoP were randomly assigned to one of four treatment conditions: CBT, SRT, COMB, or PBO. Assessments of anxiety symptoms, safety, and functional outcomes, as well as putative mediators and moderators of treatment response were completed in a multi-measure, multi-informant fashion. Manual-based therapies, trained clinicians and independent evaluators were used to ensure treatment and assessment fidelity. A multi-layered administrative structure with representation from all sites facilitated cross-site coordination of the entire trial, study protocols and quality assurance.</p> <p>Conclusions</p> <p>CAMS offers a model for clinical trials methods applicable to psychosocial and psychopharmacological comparative treatment trials by using state-of-the-art methods and rigorous cross-site quality controls. CAMS also provided a large-scale examination of the relative and combined efficacy and safety of the best evidenced-based psychosocial (CBT) and pharmacologic (SSRI) treatments to date for the most commonly occurring pediatric anxiety disorders. Primary and secondary results of CAMS will hold important implications for informing practice-relevant decisions regarding the initial treatment of youth with anxiety disorders.</p> <p>Trial registration</p> <p>ClinicalTrials.gov NCT00052078.</p

Associations of familial risk factors with social fears and social phobia: evidence for the continuum hypothesis in social anxiety disorder?

We examined parental psychopathology and family environment in subthreshold and DSM-IV threshold conditions of social anxiety disorder (SAD) in a representative cohort sample of 1,395 adolescents. Offspring and parental psychopathology was assessed using the DIA-X/M-CIDI; recalled parental rearing and family functioning via questionnaire. Diagnostic interviews in parents were supplemented by family history reports from offspring. The cumulative lifetime incidence was 23.07% for symptomatic SAD, and 18.38 and 7.41% for subthreshold and threshold SAD, respectively. The specific parent-to-offspring association for SAD occurred for threshold SAD only. For subthreshold and threshold SAD similar associations were found with other parental anxiety disorders, depression and substance use disorders. Parental rearing behaviour, but not family functioning, was associated with offspring threshold SAD, and although less strong and less consistent, also with subthreshold SAD. Results suggest a continued graded relationship between familial risk factors and offspring SAD. Parental psychopathology and negative parental styles may be used defining high-risk groups to assign individuals with already subthreshold conditions of SAD to early intervention programs