Improving Navy recruiting with data farming

Proceedings of the 2016 Winter Simulation Conference T. M. K. Roeder, P. I. Frazier, R. Szechtman, E. Zhou, T. Huschka, and S. E. Chick, eds.Secretary of the Navy Ray Mabus states that people provide “the Navy and Marine Corps’ greatest edge” (Mabus, 2015). To help recruit and manage this dynamic workforce of more than 300,000 active duty Sailors, the Navy uses mathematical models and simulation to assess the potential impacts and risks of changes to force structure, budgets, policies, and the economy. One important model is the Planned Re-source Optimization (PRO) model. PRO is currently being used to inform recruiting resourcing decisions. The decisions may involve, for example, advertising, enlistment bonuses, number of production recruiters, etc. A limitation of PRO is the lack of an interface to facilitate extensive experimentation. This paper summarizes an effort underway to enhance the analytic utility of the PRO model by embedding it in a data farming environment. This enhanced tool is called the “Planned Resource Optimization Model with Ex-perimental Design” (PROM-WED)

Improving Navy MPTE Studies with Model-Driven Big Data

The goal of this research was to improve upon the ability of OPNAV N1 analysts to quickly and efficiently obtain experiment-based information from their computational models. The enhanced information will enable N1’s analysts to better support Navy leadership in resource and policy decisions that shape the future Navy and help it retain and develop its most talented Sailors. This project built on previous collaborations with N1 using data farming to enhance the information gleaned from their Navy talent management models, such as the Officer Strategic Analysis Model (OSAM) model, the Production Resource Optimization (PRO) model, and the Navy Total Force Strength Model (NTFSM). During this research period, (1) Ensign William Desousa (2015) investigated the behavior of economic inputs in NTFSM; (2) Lieutenant Peter Bazalaki (2016) used the new data farming capabilities we developed in OSAM to investigate Surface Warfare Officer (SWO) inventory across a breadth of possibilities; and (3) Lieutenant Allison Hogarth (2016) built, tested, and demonstrated a user interface in Excel that enables users of the PRO model to automatically execute a sophisticated design of experiments—the tool that enables this new capability is known as Production Resource Optimization Model With Experimental Design (PROMWED). In addition to working with the student-officers, the faculty supporting this project performed an empirical study of statistical software packages that may provide better understanding of the high-dimensional behavior of manpower models in the future (Erickson, Ankenman, & Sanchez 2016).Naval Research ProgramPrepared for Topic Sponsor: OPNAV N1; Research POC Name: Mr. Ian AndersoNPS-N16-N154-

4 '-Phosphopantetheine corrects CoA, iron, and dopamine metabolic defects in mammalian models of PKAN

Pantothenate kinase-associated neurodegeneration (PKAN) is an inborn error of CoA metabolism causing dystonia, parkinsonism, and brain iron accumulation. Lack of a good mammalian model has impeded studies of pathogenesis and development of rational therapeutics. We took a new approach to investigating an existing mouse mutant of Pank2 and found that isolating the disease-vulnerable brain revealed regional perturbations in CoA metabolism, iron homeostasis, and dopamine metabolism and functional defects in complex I and pyruvate dehydrogenase. Feeding mice a CoA pathway intermediate, 4 '-phosphopantetheine, normalized levels of the CoA-, iron-, and dopamine-related biomarkers as well as activities of mitochondrial enzymes. Human cell changes also were recovered by 4 '-phosphopantetheine. We can mechanistically link a defect in CoA metabolism to these secondary effects via the activation of mitochondrial acyl carrier protein, which is essential to oxidative phosphorylation, iron-sulfur cluster biogenesis, and mitochondrial fatty acid synthesis. We demonstrate the fidelity of our model in recapitulating features of the human disease. Moreover, we identify pharmacodynamic biomarkers, provide insights into disease pathogenesis, and offer evidence for 4 '-phosphopantetheine as a candidate therapeutic for PKAN

Limits and barriers to adaptation to climate variability and change in Bangladeshi coastal fishing communities

Limits and barriers to adaptation restrict people’s ability to address the negative impacts of climate change or manage risks in a way that maximises their wellbeing. There is a lack of evidence of this on small-scale fishing communities in developing countries. This study identifies and characterises limits and barriers to adaptation of fishing activities to cyclones and examines interactions between them in two fishing communities in Bangladesh, using household questionnaires, oral history interviews, vulnerability matrices and focus group discussions. The limits include physical characteristics of climate and sea like higher frequency and duration of cyclones, and hidden sandbars. Barriers include technologically poor boats, inaccurate weather forecast, poor radio signal, lack of access to credit, low incomes, underestimation of cyclone occurrence, coercion of fishermen by the boat owners and captains, lack of education, skills and livelihood alternatives, unfavourable credit schemes, lack of enforcement of fishing regulations and maritime laws, and lack of access to fish markets. These local and wider scale factors interact in complex ways and constrain completion of fishing trips, coping with cyclones at sea, safe return of boats from sea, timely responses to cyclones and livelihood diversification. The findings indicate a need for further detailed research into the determinants and implications of such limits and barriers, in order to move towards an improved characterisation of adaptation and to identify most suitable means to overcome the limits and barriers

The genetic architecture of the human cerebral cortex

The cerebral cortex underlies our complex cognitive capabilities, yet little is known about the specific genetic loci that influence human cortical structure. To identify genetic variants that affect cortical structure, we conducted a genome-wide association meta-analysis of brain magnetic resonance imaging data from 51,665 individuals. We analyzed the surface area and average thickness of the whole cortex and 34 regions with known functional specializations. We identified 199 significant loci and found significant enrichment for loci influencing total surface area within regulatory elements that are active during prenatal cortical development, supporting the radial unit hypothesis. Loci that affect regional surface area cluster near genes in Wnt signaling pathways, which influence progenitor expansion and areal identity. Variation in cortical structure is genetically correlated with cognitive function, Parkinson's disease, insomnia, depression, neuroticism, and attention deficit hyperactivity disorder

Improving Navy recruiting with the new Planned Resource Optimization Model with Experimental Design (PROM-WED)

The Navy spends over $300 million per year to recruit approximately 35,000 new active duty enlisted Sailors. The Navy has historically used a non-linear optimization model, the Planned Resource Optimization (PRO) model, to help inform decisions on the allocation of those recruiting resources. Input variables to the PRO model include economic influences and policy factors. The result is a recommended allocation of resources for advertisements, recruiters, enlistment bonuses, and education incentives. The PRO model's primary limitations are (1) potential deviations of input variables are not taken into consideration, and (2) extensive experimentation is not feasible. Realistically, input variables to the PRO model fluctuate, are unpredictable, and can interact with other variables to influence the recruiting environment and affect the optimal allocation of recruiting resources. This paper describes the Planned Resource Optimization Model with Experimental Design (PROM-WED), a tool that alleviates the limitations and enhances the analytic utility of the legacy PRO model. PROM-WED embeds the legacy PRO model within a data farming environment. PROM-WED's graphical user interface and decision support capability provide decision makers with robust insights into variable interactions and uncertainties to better inform their recruiting resourcing decisions.http://archive.org/details/improvingnavyrec1094552992Outstanding ThesisLieutenant, United States NavyApproved for public release; distribution is unlimited

Femur Fractures in 5 Individuals With Pantothenate Kinase-associated Neurodegeneration: The Role of Dystonia and Suggested Management

BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, neurodegenerative disorder that manifests with progressive loss of ambulation and refractory dystonia, especially in the early-onset classic form. This leads to osteopenia and stress on long bones, which pose an increased risk of atraumatic femur fractures. The purpose of this study is to describe the unique challenges in managing femur fractures in PKAN and the effect of disease manifestations on surgical outcomes. METHODS: A retrospective case review was conducted on 5 patients (ages 10 to 20 y) with PKAN with a femur fracture requiring surgical intervention. Data regarding initial presentation, surgical treatment, complications, and outcomes were obtained. RESULTS: All patients were non-ambulatory, with 4 of 5 patients sustaining an atraumatic femur fracture in the setting of dystonia episode. One patient had an additional contralateral acetabular fracture. Postoperatively, 4 of the 5 patients sustained orthopaedic complications requiring surgical revision, with 3 of these secondary to dystonia. Overall, 4 required prolonged hospitalization in the setting of refractory dystonia. CONCLUSION: Femur fractures in PKAN present distinct challenges for successful outcomes. A rigid intramedullary rod with proximal and distal interlocking screws is most protective against surgical complications associated with refractory dystonia occurring during the postoperative period. Multidisciplinary planning for postoperative care is essential and may include aggressive sedation and pain management to decrease the risk of subsequent injuries or complications. LEVEL OF EVIDENCE: Level IV

Femur Fractures in 5 Individuals With Pantothenate Kinase-associated Neurodegeneration:The Role of Dystonia and Suggested Management

BACKGROUND: Pantothenate kinase-associated neurodegeneration (PKAN) is a rare, neurodegenerative disorder that manifests with progressive loss of ambulation and refractory dystonia, especially in the early-onset classic form. This leads to osteopenia and stress on long bones, which pose an increased risk of atraumatic femur fractures. The purpose of this study is to describe the unique challenges in managing femur fractures in PKAN and the effect of disease manifestations on surgical outcomes.METHODS: A retrospective case review was conducted on 5 patients (ages 10 to 20 y) with PKAN with a femur fracture requiring surgical intervention. Data regarding initial presentation, surgical treatment, complications, and outcomes were obtained.RESULTS: All patients were non-ambulatory, with 4 of 5 patients sustaining an atraumatic femur fracture in the setting of dystonia episode. One patient had an additional contralateral acetabular fracture. Postoperatively, 4 of the 5 patients sustained orthopaedic complications requiring surgical revision, with 3 of these secondary to dystonia. Overall, 4 required prolonged hospitalization in the setting of refractory dystonia.CONCLUSION: Femur fractures in PKAN present distinct challenges for successful outcomes. A rigid intramedullary rod with proximal and distal interlocking screws is most protective against surgical complications associated with refractory dystonia occurring during the postoperative period. Multidisciplinary planning for postoperative care is essential and may include aggressive sedation and pain management to decrease the risk of subsequent injuries or complications.LEVEL OF EVIDENCE: Level IV.</p