Conceptual design of a functional electrical stimulation cycling platform as a rehabilitation therapy for spinal cord injury or stroke

Stroke and spinal cord injuries (SCI) are leading causes of disability worldwide, involving problems in mobility, balance and coordination, among others. While aerobic exercise is associated with a greater plasticity in the motor cortex of healthy individuals, its effect on neuroplasticity after suffer- ing a stroke or a SCI is still unknown. Besides, there is no methodology to promote both cardiovascular and neuroplastic recovery in patients suffering from neurological injuries. Up to now, it has been demonstrated that physical exercise is a therapeutic intervention in many rehabilitation programs that, apart from providing clear benefits related to the phys- ical conditioning, functionality, mood and cardiovascular health, it could also promote neuroplasticity. The literature suggests that stronger neuroplastic responses are elicited in mid-to-high intensity training programs, but the lack of homogeneity in the dose-response and the non-uniform eval- uations of the neuroplasticity seem to be a limitation to gen- eralise the obtained results. The combination of functional electrical stimulation (FES) with the benefits of cardiovas- cular exercise makes cycling assisted by FES a promising approach to target both the aerobic capacity and the neu- romotor function. The objective of this project is to prove that aerobic exercise during personalized FES-cycling could contribute to enhance the process of neuroplasticity, and to maintain locomotor and cardiovascular function in patients with stroke or spinal cord injury.This work is partially developed within the Research Network FUSION “Red Tem´atica Sobre Fusi´on de Tec- nolog´ıas Rob´oticas y Estimulaci´on El´ectrica Neuro- muscular para Neurorrehabilitaci´on de Trastornos del Movimiento”, grant by Agencia Estatal de Investigaci´on (RED2022-134319-T)

Carbon Stocks of Tropical Coastal Wetlands within the Karstic Landscape of the Mexican Caribbean

Coastal wetlands can have exceptionally large carbon (C) stocks and their protection and restoration would constitute an effective mitigation strategy to climate change. Inclusion of coastal ecosystems in mitigation strategies requires quantification of carbon stocks in order to calculate emissions or sequestration through time. In this study, we quantified the ecosystem C stocks of coastal wetlands of the Sian Ka'an Biosphere Reserve (SKBR) in the Yucatan Peninsula, Mexico. We stratified the SKBR into different vegetation types (tall, medium and dwarf mangroves, and marshes), and examined relationships of environmental variables with C stocks. At nine sites within SKBR, we quantified ecosystem C stocks through measurement of above and belowground biomass, downed wood, and soil C. Additionally, we measured nitrogen (N) and phosphorus (P) from the soil and interstitial salinity. Tall mangroves had the highest C stocks (987 ± 338 Mg ha⁻¹) followed by medium mangroves (623 ± 41 Mg ha⁻¹), dwarf mangroves (381 ± 52 Mg ha⁻¹) and marshes (177 ±73 Mg ha⁻¹). At all sites, soil C comprised the majority of the ecosystem C stocks (78-99%). Highest C stocks were measured in soils that were relatively low in salinity, high in P and low in N: P, suggesting that P limits C sequestration and accumulation potential. In this karstic area, coastal wetlands, especially mangroves, are important C stocks. At the landscape scale, the coastal wetlands of Sian Ka'an covering approximate to ≈172,176 ha may store 43.2 to 58.0 million Mg of C.Keywords: Ignition, Sea level, Mangrove forests, Enrichment, Organic matter, Florida, Biomass, Sediments, Nutrient dynamics, Brazilian AmazonKeywords: Ignition, Sea level, Mangrove forests, Enrichment, Organic matter, Florida, Biomass, Sediments, Nutrient dynamics, Brazilian Amazo

How Much Nubia‐Eurasia Convergence Is Accommodated by the NE End of the Eastern Betic Shear Zone (SE Spain)? Constraints From GPS Velocities

We present the first GPS‐derived geodetic observations from the NE end of the Eastern Betic Shear Zone obtained from the Bajo Segura GPS network (SE Spain). The network has 11 GPS sites and was sampled four times between 1999 and 2013. Despite the low signal‐to‐noise ratio of the residual velocities obtained, the velocities are nonzero at 95% confidence level. We postulate that the GPS data point to the partitioning of deformation into the NNW–SSE shortening and a N70E left‐lateral component. The maximum deformation rates are located along the two main active faults in the study area. The maximum shortening rates (north component) in the southern region of the Bajo Segura Basin vary from west to east, ranging from 0.2 to 0.7 mm/year along the Bajo Segura Fault Zone. On the northern border of the basin, along the Crevillente Fault Zone, left‐lateral displacement varies between 0.4 and 0.7 mm/year in the E‐W direction. The GPS‐based regional geodynamic models of the Western Mediterranean indicate that the residual shortening of the Eurasia‐Nubia plate convergence is accommodated in the eastern part of the Iberian Peninsula and the Algero‐Balearic Basin. Our results indicate that part of this residual deformation occurs at the NE end of the Eastern Betic Shear Zone, but significant deformation must be accommodated also to the north (External Betics) and to the south (Cartagena Basin and offshore area). We postulate that Eurasia‐Nubia plate convergence is transferred to the Eastern Betics because of the thin and rigid (potentially oceanic) crust of the Algero‐Balearic Basin, which acts as an indenter.This research was funded by the Spanish Ministry of Economy and Competitiveness (research project CGL2011‐30153‐C02‐02), University of Alicante (research project VIGROB053), University of Jaén (PAIUJA 2019/2020, CEACTierra), and RNM282 Research Group of Junta de Andalucía

Revista de Vertebrados de la Estación Biológica de Doñaña

Alimentación de la boga del Guadiana (Chondrostoma polylepis wi/lkommi, Stein. 1866) en la interfase río-embalse de Sierra Boyera (Córdoba. España)Predación del búho real (Bubo bubo) sobre la perdiz roja (Alectoris rufa): selección de edad y sexoAlimentación de la nutria (Lutra lufra L, 1758)en el Nordeste de la Península IbéricaDatos sobre la distribución espacialde micromamíferos en el Parque Nacionalde DoñanaGuía para el reconocimiento microscópico de los pelos de los mamíferos de la Patagonia.Sobre la distribución geográfica de Anaecypris hispanica (STEINDACHNER, 1866) (OSTEICHTHYES, CYPRINIDAE)Cronología del periodo reproductor de Rana temporaria L. en La Coruña (NW de España).Un nuevo caso de melanismo en Natrix natrix (LINNAEUS 1758) procedente de Fuente Dé (Santander)Nuevas citas de anfibios y reptiles para el SE de la Península Ibérica.Datos sobre la dieta invernal del Búho chico (Asia atus) en la provinvia de LeónLa Distribucióndel Mara (Dolichotis patagonum) según criterios ecológicos e históricosSolapamiento entre la dieta de la cabra montés (Capra pyrenaica) y la del muflón (Ovis musimon)Nota sobre dietas de carnívoros e índices de abundancia en una Reserva de caza del norte de España.Discriminación osteométrica en el géneroTalpa (LINNEO, 1758), en el norte IbéricoObservaciones sobre el comportamiento depredativo de algunos colúbridos Ibéricos en estado salvajePeer reviewe

La recerca infermera en cures de la salut a Catalunya

Recerca infermera; cures de la salut; pràctica professionalInvestigación enfermera; curas de salud; práctica profesionalResearch nurse; Health cures; Professional practiceDocument fruit del treball i la discussió d’un grup d’infermeres de Catalunya que es dediquen a la recerca en diferents àmbits (assistencial, docent i gestor) que intenta recollir la realitat en què es troba el col·lectiu d'infermers i infermeres en relació amb la recerca. Després de descriure els diferents rols que es poden desenvolupar, s’han descrit el context, les estratègies necessàries per desenvolupar la recerca i els recursos necessaris i recomanats per poder-ho assolir. L’objectiu últim d’aquest document ha estat establir el posicionament del Departament de Salut envers el plantejament de la recerca infermera en cures de la salut.Documento fruto del trabajo y la discusión de un grupo de enfermeras de Cataluña que se dedican a la investigación en distintos ámbitos (asistencial, docente y gestor) que intenta recoger la realidad en la que se encuentra el colectivo de enfermeros y enfermeras en relación con la investigación. Una vez descritos los distintos roles que se pueden desarrollar, se han descrito el contexto, las estrategias necesarias para desarrollar la investigación y los recursos necesarios y recomendados para poder conseguirlo. El objetivo final de este documento ha sido establecer el posicionamiento del Departament de Salut ante el planteamiento de la investigación enfermera en curas de la salud

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial

Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials. Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure. Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen. Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049

Search for new particles in events with energetic jets and large missing transverse momentum in proton-proton collisions at root s=13 TeV

A search is presented for new particles produced at the LHC in proton-proton collisions at root s = 13 TeV, using events with energetic jets and large missing transverse momentum. The analysis is based on a data sample corresponding to an integrated luminosity of 101 fb(-1), collected in 2017-2018 with the CMS detector. Machine learning techniques are used to define separate categories for events with narrow jets from initial-state radiation and events with large-radius jets consistent with a hadronic decay of a W or Z boson. A statistical combination is made with an earlier search based on a data sample of 36 fb(-1), collected in 2016. No significant excess of events is observed with respect to the standard model background expectation determined from control samples in data. The results are interpreted in terms of limits on the branching fraction of an invisible decay of the Higgs boson, as well as constraints on simplified models of dark matter, on first-generation scalar leptoquarks decaying to quarks and neutrinos, and on models with large extra dimensions. Several of the new limits, specifically for spin-1 dark matter mediators, pseudoscalar mediators, colored mediators, and leptoquarks, are the most restrictive to date.Peer reviewe

Combined searches for the production of supersymmetric top quark partners in proton-proton collisions at root s=13 TeV

A combination of searches for top squark pair production using proton-proton collision data at a center-of-mass energy of 13 TeV at the CERN LHC, corresponding to an integrated luminosity of 137 fb(-1) collected by the CMS experiment, is presented. Signatures with at least 2 jets and large missing transverse momentum are categorized into events with 0, 1, or 2 leptons. New results for regions of parameter space where the kinematical properties of top squark pair production and top quark pair production are very similar are presented. Depending on themodel, the combined result excludes a top squarkmass up to 1325 GeV for amassless neutralino, and a neutralinomass up to 700 GeV for a top squarkmass of 1150 GeV. Top squarks with masses from 145 to 295 GeV, for neutralino masses from 0 to 100 GeV, with a mass difference between the top squark and the neutralino in a window of 30 GeV around the mass of the top quark, are excluded for the first time with CMS data. The results of theses searches are also interpreted in an alternative signal model of dark matter production via a spin-0 mediator in association with a top quark pair. Upper limits are set on the cross section for mediator particle masses of up to 420 GeV

Development and validation of HERWIG 7 tunes from CMS underlying-event measurements

This paper presents new sets of parameters (“tunes”) for the underlying-event model of the HERWIG7 event generator. These parameters control the description of multiple-parton interactions (MPI) and colour reconnection in HERWIG7, and are obtained from a fit to minimum-bias data collected by the CMS experiment at s=0.9, 7, and 13Te. The tunes are based on the NNPDF 3.1 next-to-next-to-leading-order parton distribution function (PDF) set for the parton shower, and either a leading-order or next-to-next-to-leading-order PDF set for the simulation of MPI and the beam remnants. Predictions utilizing the tunes are produced for event shape observables in electron-positron collisions, and for minimum-bias, inclusive jet, top quark pair, and Z and W boson events in proton-proton collisions, and are compared with data. Each of the new tunes describes the data at a reasonable level, and the tunes using a leading-order PDF for the simulation of MPI provide the best description of the dat