1,921 research outputs found
Investigating Homology between Proteins using Energetic Profiles
- Author
- A Pascual-Garcia
- AG Murzin
- AJ Oakley
- AL Lee
- AL Lehninger
- AR Fersht
- C Sander
- CB Anfinsen
- CC Huang
- CD Mol
- CM Wood
- CR Babu
- D Kern
- DM Ford
- DR Bickel
- DW Li
- F Poy
- G Hernandez
- G Spraggon
- H Pan
- J Vertrees
- J Vertrees
- J Vertrees
- J Vertrees
- JA D'Aquino
- James O. Wrabl
- JB Thoden
- JB Thoden
- JD Dunitz
- JF Andersen
- JM Chandonia
- JO Wrabl
- JO Wrabl
- JO Wrabl
- JS Milne
- K Lim
- K Natarajan
- K Sharp
- KA Henzler-Wildman
- KY Hwang
- L Holm
- L Liu
- L Swint-Kruse
- LN Kinch
- M Morra
- N Tokuriki
- NV Grishin
- O Jardetzky
- PA Alexander
- PA Alexander
- PA Alexander
- R Kolodny
- R Li
- R Lumry
- R Thom
- RI Sadreyev
- RR Krug
- SA Larson
- SJ Benkovic
- SK Katti
- SS Taylor
- ST Whitten
- SW Englander
- T Hamma
- T Liu
- TL Creighton
- TP Schrank
- V Alva
- V Guillet
- Vijay S. Pande
- Vincent J. Hilser
- VJ Hilser
- VJ Hilser
- VJ Hilser
- VJ Hilser
- W Kabsch
- W Kabsch
- WH Press
- X Tao
- Y Bai
- Y Papanikolau
- Publication venue
- Public Library of Science
- Publication date
- 01/03/2010
- Field of study
Accumulated experimental observations demonstrate that protein stability is often preserved upon conservative point mutation. In contrast, less is known about the effects of large sequence or structure changes on the stability of a particular fold. Almost completely unknown is the degree to which stability of different regions of a protein is generally preserved throughout evolution. In this work, these questions are addressed through thermodynamic analysis of a large representative sample of protein fold space based on remote, yet accepted, homology. More than 3,000 proteins were computationally analyzed using the structural-thermodynamic algorithm COREX/BEST. Estimated position-specific stability (i.e., local Gibbs free energy of folding) and its component enthalpy and entropy were quantitatively compared between all proteins in the sample according to all-vs.-all pairwise structural alignment. It was discovered that the local stabilities of homologous pairs were significantly more correlated than those of non-homologous pairs, indicating that local stability was indeed generally conserved throughout evolution. However, the position-specific enthalpy and entropy underlying stability were less correlated, suggesting that the overall regional stability of a protein was more important than the thermodynamic mechanism utilized to achieve that stability. Finally, two different types of statistically exceptional evolutionary structure-thermodynamic relationships were noted. First, many homologous proteins contained regions of similar thermodynamics despite localized structure change, suggesting a thermodynamic mechanism enabling evolutionary fold change. Second, some homologous proteins with extremely similar structures nonetheless exhibited different local stabilities, a phenomenon previously observed experimentally in this laboratory. These two observations, in conjunction with the principal conclusion that homologous proteins generally conserved local stability, may provide guidance for a future thermodynamically informed classification of protein homology
Genome-Wide Analysis of Structural Variants in Parkinson Disease
- Author
- Beach TG
- Billingsley KJ
- Blauwendraat C
- Brand H
- Bubb VJ
- Casey B
- Chia R
- Collins RL
- Cookson MR
- Dalgard CL
- Ding J
- Ehrlich DJ
- Ferrucci L
- Gibbs JR
- Grenn FP
- Hardy J
- Hernandez D
- Illarionova A
- Jerez PA
- Levine K
- Mahmoud M
- Makarious MB
- Markham A
- Moore A
- Nalls MA
- Pierce-Hoffman E
- Quinn JP
- Reed X
- Ryten M
- Scholz SW
- Sedlazeck FJ
- Serrano GE
- Singleton AB
- Talkowski ME
- Tanaka T
- Torkamani A
- Traynor BJ
- Vitale D
- Walker M
- Zhao X
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 25/01/2023
- Field of study
OBJECTIVE:
Identification of genetic risk factors for Parkinson disease (PD) has to date been primarily limited to the study of single nucleotide variants, which only represent a small fraction of the genetic variation in the human genome. Consequently, causal variants for most PD risk are not known. Here we focused on structural variants (SVs), which represent a major source of genetic variation in the human genome. We aimed to discover SVs associated with PD risk by performing the first large-scale characterization of SVs in PD.
METHODS:
We leveraged a recently developed computational pipeline to detect and genotype SVs from 7,772 Illumina short-read whole genome sequencing samples. Using this set of SV variants, we performed a genome-wide association study using 2,585 cases and 2,779 controls and identified SVs associated with PD risk. Furthermore, to validate the presence of these variants, we generated a subset of matched whole-genome long-read sequencing data.
RESULTS:
We genotyped and tested 3,154 common SVs, representing over 412 million nucleotides of previously uncatalogued genetic variation. Using long-read sequencing data, we validated the presence of three novel deletion SVs that are associated with risk of PD from our initial association analysis, including a 2 kb intronic deletion within the gene LRRN4.
INTERPRETATION:
We identified three SVs associated with genetic risk of PD. This study represents the most comprehensive assessment of the contribution of SVs to the genetic risk of PD to date. ANN NEUROL 202
Conducting High-Value Secondary Dataset Analysis: An Introductory Guide and Resources
- Author
- A Mehrotra
- AA Ginde
- AF Hernandez
- AG Mainous 3rd
- Alexander K. Smith
- AM Shea
- AN Trivedi
- BA Williams
- BD Sommers
- Bruce E. Landon
- Christina C. Wee
- DM Doolan
- EC Lindenberger
- Ellen P. McCarthy
- J Tjia
- JA Linder
- JM Madden
- John Z. Ayanian
- JS Harman
- JS Ross
- KE Hoffman
- Kenneth E. Covinsky
- LR Hausmann
- M Shlipak
- MA Steinman
- Michael A. Steinman
- MS Goel
- NT Nguyen
- P Carcaise-Edinboro
- PB Bach
- SA Byfield
- SA Ibrahim
- SA Mohanty
- SJ Lee
- SJ Lee
- VJ Gilchrist
- WS Browner
- Publication venue
- Springer-Verlag
- Publication date
- 01/01/2011
- Field of study
Secondary analyses of large datasets provide a mechanism for researchers to address high impact questions that would otherwise be prohibitively expensive and time-consuming to study. This paper presents a guide to assist investigators interested in conducting secondary data analysis, including advice on the process of successful secondary data analysis as well as a brief summary of high-value datasets and online resources for researchers, including the SGIM dataset compendium (www.sgim.org/go/datasets). The same basic research principles that apply to primary data analysis apply to secondary data analysis, including the development of a clear and clinically relevant research question, study sample, appropriate measures, and a thoughtful analytic approach. A real-world case description illustrates key steps: (1) define your research topic and question; (2) select a dataset; (3) get to know your dataset; and (4) structure your analysis and presentation of findings in a way that is clinically meaningful. Secondary dataset analysis is a well-established methodology. Secondary analysis is particularly valuable for junior investigators, who have limited time and resources to demonstrate expertise and productivity
Genomic Risk Profiling of Ischemic Stroke: Results of an International Genome-Wide Association Meta-Analysis
- Author
- Andrew Singleton
- BB Worrall
- Bradford B. Worrall
- CD Anderson
- CJ Johnson
- CJ Willer
- D Harold
- Dena G. Hernandez
- DF Gudbjartsson
- HP Adams Jr
- J Bamford
- J Rosand
- James F. Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- JF Meschia
- John Hardy
- Kerra Pearce
- Luigi Ferrucci
- M Matarin
- MA Ikram
- Mar Matarin
- Michael A. Nalls
- Pankaj Sharma
- R Lemmens
- Ralf Krahe
- RM Durbin
- Robert D. Brown
- S Purcell
- S Seshadri
- S Yadav
- SE Vermeer
- Stephen S. Rich
- SW Scholz
- Thomas G. Brott
- UG Schulz
- VJ Howard
- Y Li
- Publication venue
- PUBLIC LIBRARY SCIENCE
- Publication date
- 21/09/2011
- Field of study
Introduction: Familial aggregation of ischemic stroke derives from shared genetic and environmental factors. We present a meta-analysis of genome-wide association scans (GWAS) from 3 cohorts to identify the contribution of common variants to ischemic stroke risk.Methods: This study involved 1464 ischemic stroke cases and 1932 controls. Cases were genotyped using the Illumina 610 or 660 genotyping arrays; controls, with Illumina HumanHap 550Kv1 or 550Kv3 genotyping arrays. Imputation was performed with the 1000 Genomes European ancestry haplotypes (August 2010 release) as a reference. A total of 5,156,597 single-nucleotide polymorphisms (SNPs) were incorporated into the fixed effects meta-analysis. All SNPs associated with ischemic stroke (P < 1 x 10(-5)) were incorporated into a multivariate risk profile model.Results: No SNP reached genome-wide significance for ischemic stroke (P < 5 x 10(-8)). Secondary analysis identified a significant cumulative effect for age at onset of stroke (first versus fifth quintile of cumulative profiles based on SNPs associated with late onset, beta = 14.77 [10.85, 18.68], P = 5.5 x 10(-12)), as well as a strong effect showing increased risk across samples with a high propensity for stroke among samples with enriched counts of suggestive risk alleles (P < 5 x 10(-6)). Risk profile scores based only on genomic information offered little incremental prediction.Discussion: There is little evidence of a common genetic variant contributing to moderate risk of ischemic stroke. Quintiles based on genetic loading of alleles associated with a younger age at onset of ischemic stroke revealed a significant difference in age at onset between those in the upper and lower quintiles. Using common variants from GWAS and imputation, genomic profiling remains inferior to family history of stroke for defining risk. Inclusion of genomic (rare variant) information may be required to improve clinical risk profiling
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alda Junior WL
- Alexander J
- Aliev T
- Almeida N
- Alver B
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunes JR
- Antunovic Z
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Aranyi A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arisaka K
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Atac M
- Atramentov O
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
- Bacchetta N
- Bachtis M
- Baden A
- Baeni L
- Baesso P
- Baffioni S
- Bagliesi G
- Bai Y
- Baillon P
- Bainbridge R
- Bakhshiansohi H
- Bakirci MN
- Bakken JA
- Balazs M
- Ball AH
- Ball G
- Ban Y
- Banerjee S
- Banerjee S
- Bansal S
- Banzuzi K
- Barbagli G
- Barberis E
- Barbone L
- Bardak C
- Barfuss AF
- Bargassa P
- Barge D
- Baringer P
- Barker A
- Barnes VE
- Barnett BA
- Barney D
- Barone L
- Barrett M
- Bartalini P
- Barth C
- Basegmez S
- Basso L
- Battilana C
- Baty C
- Bauer G
- Bauerdick LAT
- Baumgartel D
- Baur U
- Bayshev I
- Bazterra VE
- Bean A
- Beauceron S
- Beaudette F
- Beaupere N
- Bedjidian M
- Beernaert K
- Behrenhoff W
- Behrens U
- Belforte S
- Beliy N
- Belknap D
- Bell AJ
- Bell KW
- Bellan P
- Bellan R
- Bellato M
- Bellinger JN
- Belotelov I
- Belyaev A
- Belyaev A
- Benaglia A
- Bencze G
- Bendavid J
- Benedetti D
- Benelli G
- Benhabib L
- Beni N
- Benucci L
- Benussi L
- Benvenuti AC
- Beranek S
- Beretvas A
- Bergauer T
- Berger J
- Bergholz M
- Beri SB
- Bernardes CA
- Bernardini J
- Bernet C
- Berry D
- Berry E
- Berryhill J
- Bertl W
- Berzano U
- Besancon M
- Betchart B
- Bethani A
- Betts RR
- Beuselinck R
- Bhat PC
- Bhatnagar V
- Bhattacharya S
- Bhattacharya S
- Bhatti A
- Bialas W
- Bialkowska H
- Bian JG
- Bianchi G
- Bianchini L
- Bianco S
- Biasini M
- Biino C
- Bilei GM
- Bilin B
- Bilinskas MJ
- Bilki B
- Bilmis S
- Biselli A
- Bisello D
- Bitioukov S
- Blekman F
- Blobel V
- Bloch D
- Bloch I
- Bloch P
- Bloom K
- Bluj M
- Blumenfeld B
- Blyweert S
- Bobrovskyi S
- Boccali T
- Bocci A
- Bochenek J
- Bodek A
- Bodin D
- Boimska B
- Boldizsar L
- Bolla G
- Bolognesi S
- Bolton T
- Bonacorsi D
- Bonato A
- Bondu O
- Bontenackels M
- Boos E
- Bornheim A
- Borras K
- Borrello L
- Bortignon P
- Bortoletto D
- Bose S
- Bose T
- Bostock F
- Botta C
- Boudoul G
- Boulahouache C
- Boumediene D
- Bourilkov D
- Boutemeur M
- Boutle S
- Braibant-Giacomelli S
- Branca A
- Branson JG
- Breedon R
- Breto G
- Breuker H
- Brew C
- Brigliadori L
- Brigljevic V
- Brinkerhoff A
- Broccolo G
- Brochero Cifuentes JA
- Brom JM
- Brona G
- Brooke JJ
- Broutin C
- Brown RM
- Brownson E
- Brun H
- Bruno G
- Bryer AG
- Buchmann MA
- Buchmuller O
- Bunkowski K
- Bunn J
- Buontempo S
- Burgmeier A
- Burkett K
- Busson P
- Busza W
- Butler JN
- Butler PH
- Butt J
- Butz E
- Bylsma B
- Cabrera A
- Cabrillo IJ
- Caebergs T
- Cakir A
- Calabria C
- Calderon De La Barca Sanchez M
- Calderon A
- Cali IA
- Calligaris L
- Callner J
- Calvert B
- Calvo E
- Campagnari C
- Campbell A
- Camporesi T
- Capiluppi P
- Caponeri B
- Cappello G
- Cardaci M
- Carlin R
- Carlsmith D
- Carrillo Moreno S
- Carroll R
- Cartiglia N
- Carvalho W
- Casal B
- Casimiro Linares E
- Castaldi R
- Castello R
- Castilla-Valdez H
- Castro A
- Castro E
- Caudron J
- Caulfield M
- Cavallari F
- Cavallo FR
- Cavallo N
- Cavanaugh R
- Ceard L
- Ceballos GG
- Cepeda M
- Cerati GB
- Cerci DS
- Cerci S
- Cerizza G
- Cerminara G
- Cerrada M
- Chabert EC
- Chadwick M
- Chakaberia I
- Chamizo Llatas M
- Chan M
- Chang P
- Chang S
- Chang YH
- Chang YH
- Chang YW
- Chanon N
- Chao Y
- Charaf O
- Charlot C
- Chasco M
- Chasserat J
- Chatrchyan S
- Chatterjee A
- Chauhan S
- Checchia P
- Chen GM
- Chen HS
- Chen J
- Chen KF
- Chen KH
- Chen M
- Chen Y
- Chen Z
- Cherepanov V
- Chertok M
- Chetluru V
- Cheung HWK
- Chhibra SS
- Chierici R
- Chiochia V
- Chiorboli M
- Chlebana F
- Cho Y
- Choi M
- Choi S
- Choi Y
- Choi YK
- Chou JP
- Choudhary BC
- Choudhury RK
- Choudhury S
- Christiansen T
- Chuang SH
- Chung J
- Chung YS
- Chwalek T
- Ciesielski R
- Cihangir S
- Cimmino A
- Cipriano PMR
- Cirino G
- Cittolin S
- Ciulli V
- Civinini C
- Claes DR
- Clare R
- Clarida W
- Clement E
- Clerbaux B
- Cline D
- CMS Collaboration
- Cockerill DJA
- Codispoti G
- Colafranceschi S
- Colaleo A
- Cole JE
- Colino N
- Collard C
- Colling D
- Conetti S
- Contardo D
- Conte E
- Contreras-Campana C
- Contreras-Campana E
- Conway J
- Conway R
- Cooper SI
- Cooper W
- Cornelis T
- Correa Martins Junior M
- Cortezon EP
- Cossutti F
- Costa M
- Costa S
- Costantini S
- Coughlan JA
- Cousins R
- Covarelli R
- Cox B
- Cox PT
- Creanza D
- Cremaldi LM
- Cripps N
- Cuevas J
- Cuffiani M
- Cumalat JP
- Cuplov V
- Cure B
- Cushman P
- Cussans D
- Custodio A
- Cutajar M
- Cutts D
- Cwiok M
- Czellar S
- D'Agnolo RT
- D'Alessandro R
- D'Alfonso M
- D'Enterria D
- D'Hondt J
- Da Costa EM
- Daci N
- Dahmes B
- Dahms T
- Dallavalle GM
- Damgov J
- Damiao DD
- Dammann D
- Danielson T
- Das S
- Daskalakis G
- Dasu S
- Daubie E
- Dauncey P
- David A
- Davids M
- Davies G
- de Barbaro P
- De Benedetti A
- De Boer W
- de Cassagnac RG
- De Cosa A
- de Fatis TT
- De Filippis N
- De Gruttola M
- De Guio F
- De Jeneret JD
- De La Cruz B
- De La Cruz-Burelo E
- De Lentdecker G
- De Mattia M
- de Monchenault GH
- De Oliveira Martins C
- De Palma M
- De Roeck A
- de Troconiz JF
- De Visscher S
- De Wolf EA
- Deisher A
- Deiters K
- Dejardin M
- del Arbol PMR
- Del Re D
- Delaere C
- Delgado Peris A
- Deliomeroglu M
- Dell'Orso R
- Della Negra M
- Della Ricca G
- Demaria N
- Demina R
- Demortier L
- Denegri D
- Deniz M
- Depasse P
- Dermenev A
- Dero V
- Dhingra N
- Di Giovanni GP
- Di Guida S
- Di Marco E
- Di Matteo L
- Diamond B
- Dias FA
- Diemoz M
- Dierlamm A
- Dietz C
- Dietz-Laursonn E
- Diez Pardos C
- Dimitrov A
- Dinardo ME
- Dirkes G
- Dissertori G
- Dittmar M
- Djordjevic M
- Dobrzynski L
- Dobson M
- Dobur D
- Doesburg R
- Dogangun O
- Dolen J
- Dominguez Vazquez D
- Dominguez A
- Dominik W
- Don CKK
- Dorigo T
- Dorney B
- Doroba K
- Dozen C
- Draeger J
- Dragicevic M
- Dragoiu C
- Drell BR
- Dremin I
- Drouhin F
- Drozdetskiy A
- du Pree T
- Duarte Campderros J
- Duarte J
- Dubinin M
- Dudero PR
- Dudko L
- Duenser M
- Dugad S
- Duggan D
- Dumanoglu I
- Dupont-Sagorin N
- Duric S
- Duris J
- Durkin LS
- Duru F
- Dutta D
- Dutta S
- Dutta V
- Dzelalija M
- Eads M
- Eartly DP
- Eckerlin G
- Ecklund KM
- Eckstein D
- Edelhoff M
- Edelmaier CJ
- Eerola P
- Efron J
- Eggert N
- Ekmedzic M
- El Mamouni H
- Elgammal S
- Elliott-Peisert A
- Ellison J
- Elmer P
- Elvira VD
- Enderle H
- Engh D
- Eno SC
- Epshteyn V
- Erbacher R
- Erdmann M
- Erdmann W
- Erfle J
- Erhan S
- Ero J
- Erofeeva M
- Ershov A
- Esen S
- Eshaq Y
- Eskut E
- Etesami SM
- Eugster J
- Eusebi R
- Evangelou I
- Evans D
- Everaerts P
- Everett A
- Evstyukhin S
- Fabbri F
- Fabbri F
- Fabbricatore P
- Fabbro B
- Fabjan C
- Fabozzi F
- Faccioli P
- Fahim A
- Falkiewicz A
- Fanelli C
- Fanfani A
- Fano L
- Fantasia C
- Farrell C
- Fasanella D
- Fassi F
- Faure JL
- Favaro C
- Favart D
- Fay J
- Fedi G
- Fehling D
- Feindt M
- Felcini M
- Feld L
- Ferapontov A
- Ferencek D
- Ferguson T
- Ferguson W
- Fernandez Bedoya C
- Fernandez Menendez J
- Fernandez Perez Tomei TR
- Fernandez Ramos JP
- Fernandez M
- Ferrando A
- Ferri F
- Ferro C
- Field RD
- Finger M
- Finger M
- Fiore L
- Fiorendi S
- Fiori F
- Fisher M
- Fisk I
- Flacher H
- Flanagan W
- Flix J
- Florez C
- Flossdorf A
- Flowers K
- Flucke G
- Flugge G
- Foa L
- Focardi E
- Folgueras S
- Fonseca De Souza S
- Fontaine J-C
- Ford WT
- Forthomme L
- Foudas C
- Fouz MC
- Franci D
- Francis B
- Franzoni G
- Frazier R
- Freeman J
- Freudenreich K
- Friedl M
- Friis E
- Frisch B
- Frosali S
- Frueboes T
- Fruhwirth R
- Fu Y
- Fulcher J
- Funk W
- Furic IK
- Futyan D
- Gabathuler K
- Gabella W
- Gabusi M
- Gaddi A
- Galanti M
- Gallinaro M
- Gallo E
- Gamsizkan H
- Ganguly S
- Ganjour S
- Gao Y
- Garcia G
- Garcia-Abia P
- Garcia-Bellido A
- Gardner M
- Garrido RGR
- Gartner J
- Gary JW
- Gascon S
- Gasparini F
- Gataullin M
- Gaultney V
- Gauthier L
- Gavrilov V
- Gay APR
- Gaz A
- Gebbert U
- Geenen H
- Geffert P
- Geiser A
- Geisler M
- Gele D
- Genchev V
- Gennai S
- Georgiou G
- Geralis T
- Gerbaudo D
- Gerber CE
- Gershtein Y
- Gerwig H
- Geurts FJM
- Ghete VM
- Ghezzi A
- Giacomelli P
- Giammanco A
- Giassi A
- Gibbons LK
- Giffels M
- Gigi D
- Gilbert A
- Gill K
- Gilmore J
- Giordano D
- Giordano F
- Girgis S
- Giunta M
- Giurgiu G
- Givernaud A
- Glege F
- Gleyzer SV
- Gninenko S
- Goadhouse S
- Gobbo B
- Godang R
- Godinovic N
- Godshalk A
- Goerlach U
- Goerner M
- Goh J
- Gokbulut G
- Gokieli R
- Goldberg S
- Goldenzweig P
- Goldstein J
- Golf F
- Gollapinni S
- Golovtsov V
- Golubev N
- Golunov A
- Golutvin I
- Gomber B
- Gomez Moreno B
- Gomez G
- Gomez JA
- Goncharov M
- Gonzalez Caballero I
- Gonzalez Lopez O
- Gonzalez Sanchez J
- Gonzalez JS
- Gonzi S
- Goodell J
- Gorbounov N
- Gorski M
- Gotra Y
- Gottschalk E
- Goulianos K
- Gouskos L
- Gouzevitch M
- Govoni P
- Gowdy S
- Goy Lopez S
- Gozzelino A
- Grab C
- Grachov O
- Gramenitski I
- Grandi C
- Gras P
- Grassi M
- Gray L
- Gray R
- Graziano A
- Green D
- Gregoire G
- Gregores EM
- Gribushin A
- Griffiths S
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- Yildirim E
- Yilmaz Y
- Yohay R
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- Yoo J
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- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
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- Zatserklyaniy A
- Zeinali M
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- Zeyrek M
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- Zoeller MH
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Jet energy measurement with the ATLAS detector in proton-proton collisions at root s=7 TeV
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdelalim AA
- Abdesselam A
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- Abramowicz H
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- Acharya BS
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- Adomeit S
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- Aleksandrov IN
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- Zarzhitsky P
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- Zhemchugov A
- Zheng S
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- Zieminska D
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- Zitoun R
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- Zwalinski L
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/03/2013
- Field of study
The jet energy scale and its systematic uncertainty are determined for jets measured with the ATLAS detector at the LHC in proton-proton collision data at a centre-of-mass energy of âs = 7TeV corresponding to an integrated luminosity of 38 pb-1. Jets are reconstructed with the anti-kt algorithm with distance parameters R=0. 4 or R=0. 6. Jet energy and angle corrections are determined from Monte Carlo simulations to calibrate jets with transverse momenta pTâĽ20 GeV and pseudorapidities {pipe}Ρ{pipe}<4. 5. The jet energy systematic uncertainty is estimated using the single isolated hadron response measured in situ and in test-beams, exploiting the transverse momentum balance between central and forward jets in events with dijet topologies and studying systematic variations in Monte Carlo simulations. The jet energy uncertainty is less than 2. 5 % in the central calorimeter region ({pipe}Ρ{pipe}<0. 8) for jets with 60â¤pT<800 GeV, and is maximally 14 % for pT<30 GeV in the most forward region 3. 2â¤{pipe}Ρ{pipe}<4. 5. The jet energy is validated for jet transverse momenta up to 1 TeV to the level of a few percent using several in situ techniques by comparing a well-known reference such as the recoiling photon pT, the sum of the transverse momenta of tracks associated to the jet, or a system of low-pT jets recoiling against a high-pT jet. More sophisticated jet calibration schemes are presented based on calorimeter cell energy density weighting or hadronic properties of jets, aiming for an improved jet energy resolution and a reduced flavour dependence of the jet response. The systematic uncertainty of the jet energy determined from a combination of in situ techniques is consistent with the one derived from single hadron response measurements over a wide kinematic range. The nominal corrections and uncertainties are derived for isolated jets in an inclusive sample of high-pT jets. Special cases such as event topologies with close-by jets, or selections of samples with an enhanced content of jets originating from light quarks, heavy quarks or gluons are also discussed and the corresponding uncertainties are determined. Š 2013 CERN for the benefit of the ATLAS collaboration
Performance of CMS muon reconstruction in pp collision events at sqrt(s) = 7 TeV
- Author
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- Yildirim E
- Yilmaz Y
- Yohay R
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- Yumiceva F
- Yun JC
- Zabel J
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- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zang SL
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- Zeinali M
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- Zoeller MH
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- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2012
- Field of study
The performance of muon reconstruction, identification, and triggering in CMS
has been studied using 40 inverse picobarns of data collected in pp collisions
at sqrt(s) = 7 TeV at the LHC in 2010. A few benchmark sets of selection
criteria covering a wide range of physics analysis needs have been examined.
For all considered selections, the efficiency to reconstruct and identify a
muon with a transverse momentum pT larger than a few GeV is above 95% over the
whole region of pseudorapidity covered by the CMS muon system, abs(eta) < 2.4,
while the probability to misidentify a hadron as a muon is well below 1%. The
efficiency to trigger on single muons with pT above a few GeV is higher than
90% over the full eta range, and typically substantially better. The overall
momentum scale is measured to a precision of 0.2% with muons from Z decays. The
transverse momentum resolution varies from 1% to 6% depending on pseudorapidity
for muons with pT below 100 GeV and, using cosmic rays, it is shown to be
better than 10% in the central region up to pT = 1 TeV. Observed distributions
of all quantities are well reproduced by the Monte Carlo simulation.Comment: Replaced with published version. Added journal reference and DO
Search for the neutral Higgs bosons of the minimal supersymmetric standard model in pp collisions at root s=7 TeV with the ATLAS detector
- Author
- Aad G
- Abajyan T
- Abbott B
- Abdallah J
- Abdelalim AA
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- Abolins M
- AbouZeid OS
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- Acharya BS
- Adam ER
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- Adelman J
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- Aleksa M
- Aleksandrov IN
- Alessandria F
- Alexa C
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- Alison J
- Allbrooke BMM
- Allison LJ
- Allport PP
- Allwood-Spiers SE
- Almenar CC
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- Aloisio A
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- Zobernig G
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- zur Nedden M
- Zutshi V
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- Publication venue
- Publication date
- 01/02/2013
- Field of study
A search for neutral Higgs bosons of the Minimal Supersymmetric Standard Model (MSSM) is reported. The analysis is based on a sample of proton-proton collisions at a centre-of-mass energy of 7TeV recorded with the ATLAS detector at the Large Hadron Collider. The data were recorded in 2011 and correspond to an integrated luminosity of 4.7 fb-1 to 4.8 fb-1. Higgs boson decays into oppositely-charged muon or Ď lepton pairs are considered for final states requiring either the presence or absence of b-jets. No statistically significant excess over the expected background is observed and exclusion limits at the 95% confidence level are derived. The exclusion limits are for the production cross-section of a generic neutral Higgs boson, Ď, as a function of the Higgs boson mass and for h/A/H production in the MSSM as a function of the parameters mA and tan β in the mhmax scenario for mA in the range of 90GeV to 500 GeV. Copyright CERN
X-ray emission from the Sombrero galaxy: discrete sources
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- Wyslouch B
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- Yilmaz Y
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- Zanetti M
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- Ziebarth EB
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- Zoeller MH
- Zorbilmez C
- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2010
- Field of study
We present a study of discrete X-ray sources in and around the
bulge-dominated, massive Sa galaxy, Sombrero (M104), based on new and archival
Chandra observations with a total exposure of ~200 ks. With a detection limit
of L_X = 1E37 erg/s and a field of view covering a galactocentric radius of ~30
kpc (11.5 arcminute), 383 sources are detected. Cross-correlation with Spitler
et al.'s catalogue of Sombrero globular clusters (GCs) identified from HST/ACS
observations reveals 41 X-rays sources in GCs, presumably low-mass X-ray
binaries (LMXBs). We quantify the differential luminosity functions (LFs) for
both the detected GC and field LMXBs, whose power-low indices (~1.1 for the
GC-LF and ~1.6 for field-LF) are consistent with previous studies for
elliptical galaxies. With precise sky positions of the GCs without a detected
X-ray source, we further quantify, through a fluctuation analysis, the GC LF at
fainter luminosities down to 1E35 erg/s. The derived index rules out a
faint-end slope flatter than 1.1 at a 2 sigma significance, contrary to recent
findings in several elliptical galaxies and the bulge of M31. On the other
hand, the 2-6 keV unresolved emission places a tight constraint on the field
LF, implying a flattened index of ~1.0 below 1E37 erg/s. We also detect 101
sources in the halo of Sombrero. The presence of these sources cannot be
interpreted as galactic LMXBs whose spatial distribution empirically follows
the starlight. Their number is also higher than the expected number of cosmic
AGNs (52+/-11 [1 sigma]) whose surface density is constrained by deep X-ray
surveys. We suggest that either the cosmic X-ray background is unusually high
in the direction of Sombrero, or a distinct population of X-ray sources is
present in the halo of Sombrero.Comment: 11 figures, 5 tables, ApJ in pres
Azimuthal anisotropy of charged particles at high transverse momenta in PbPb collisions at sqrt(s[NN]) = 2.76 TeV
- Author
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullin S
- Abdulsalam A
- Acosta D
- Acosta JG
- Acosta MV
- Adair A
- Adam N
- Adam W
- Adams MR
- Adams T
- Adiguzel A
- Adler V
- Adzic P
- Afanasiev S
- Agostino L
- Agram JL
- Aguilar-Benitez M
- Aguilo E
- Ahmad M
- Ahmad WH
- Ahuja S
- Akchurin N
- Akgun B
- Akgun U
- Akin IV
- Alagoz E
- Albajar C
- Albayrak EA
- Albergo S
- Albrow M
- Alcaraz Maestre J
- Alda Junior WL
- Alexander J
- Aliev T
- Alimena J
- Almeida N
- Alverson G
- Alves GA
- Amapane N
- Amsler C
- Anagnostou G
- Anastassov A
- Anderson J
- Anderson M
- Andrea J
- Andreev V
- Andreev V
- Andreev Y
- Andrews W
- Anghel IM
- Anjos TS
- Antonelli L
- Antunovic Z
- Apanasevich L
- Appelt E
- Apresyan A
- Arce P
- Arcidiacono R
- Arenton MW
- Arfaei H
- Argiro S
- Arneodo M
- Arora S
- Asawatangtrakuldee C
- Asghar MI
- Askew A
- Assran Y
- Ata M
- Attikis A
- Auffray E
- Autermann C
- Auzinger G
- Avdeeva E
- Avery P
- Avetisyan A
- Avila C
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzolini V
- Azzurri P
- Baarmand MM
- Babb J
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- Winn D
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- Wissing C
- Wittich P
- Wittmer B
- Woehri HK
- Wolf M
- Wolf R
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- Won S
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- Wood J
- Wood JS
- Worm SD
- Wright D
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- Wuerthwein F
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- Wyslouch B
- Xiao H
- Xie S
- Xu M
- Yagil A
- Yalvac M
- Yang F
- Yang M
- Yang Y
- Yang ZC
- Yazgan E
- Yelton J
- Yetkin T
- Yi K
- Yildirim E
- Yilmaz Y
- Yohay R
- Yoo HD
- Yoo J
- Yoon AS
- York A
- Yu I
- Yu SS
- Yumiceva F
- Yun JC
- Zabel J
- Zabi A
- Zablocki J
- Zaganidis N
- Zakaria M
- Zalewski P
- Zanetti M
- Zang J
- Zarubin A
- Zatserklyaniy A
- Zeinali M
- Zeise M
- Zeuner WD
- Zeyrek M
- Zhang J
- Zhang Z
- Zheng Y
- Zhokin A
- Zhu B
- Zhu RY
- Zhukov V
- Zhukova V
- Ziebarth EB
- Ziegler J
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- Zotto P
- Zou W
- Zumerle G
- Zuranski A
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2012
- Field of study
The azimuthal anisotropy of charged particles in PbPb collisions at
nucleon-nucleon center-of-mass energy of 2.76 TeV is measured with the CMS
detector at the LHC over an extended transverse momentum (pt) range up to
approximately 60 GeV. The data cover both the low-pt region associated with
hydrodynamic flow phenomena and the high-pt region where the anisotropies may
reflect the path-length dependence of parton energy loss in the created medium.
The anisotropy parameter (v2) of the particles is extracted by correlating
charged tracks with respect to the event-plane reconstructed by using the
energy deposited in forward-angle calorimeters. For the six bins of collision
centrality studied, spanning the range of 0-60% most-central events, the
observed v2 values are found to first increase with pt, reaching a maximum
around pt = 3 GeV, and then to gradually decrease to almost zero, with the
decline persisting up to at least pt = 40 GeV over the full centrality range
measured.Comment: Replaced with published version. Added journal reference and DO
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