Managing international branch campuses: what do we know? [forthcoming]

peer-reviewedOver the last decade, the growth of the international branch campus (IBC) has been one of the most striking developments in the internationalisation of higher education. There are now over 200 IBCs across the world, mostly in the Middle East and East and South‐east Asia. Despite the growing numbers of IBCs and the considerable financial and reputational risk they pose to their home universities, relatively little is known about the challenges of managing these foreign outposts. This paper reviews the growing, but still fragmented, literature in this increasingly important sector of higher education. It finds that managers of IBCs are faced with a range of challenges, which primarily stem from dealing with key stakeholder groups: students, staff, home and host country quality regulators, the home university and the host government, as well as the IBC's local joint venture partners. It concludes that further work is required to better understand the factors which influence and constrain IBC managers in balancing the competing interests of stakeholders.ACCEPTEDpeer-reviewe

Loss of gastrokine-2 drives premalignant gastric inflammation and tumor progression

Chronic mucosal inflammation is associated with a greater risk of gastric cancer (GC) and, therefore, requires tight control by suppressive counter mechanisms. Gastrokine-2 (GKN2) belongs to a family of secreted proteins expressed within normal gastric mucosal cells. GKN2 expression is frequently lost during GC progression, suggesting an inhibitory role; however, a causal link remains unsubstantiated. Here, we developed Gkn2 knockout and transgenic overexpressing mice to investigate the functional impact of GKN2 loss in GC pathogenesis. In mouse models of GC, decreased GKN2 expression correlated with gastric pathology that paralleled human GC progression. At baseline, Gkn2 knockout mice exhibited defective gastric epithelial differentiation but not malignant progression. Conversely, Gkn2 knockout in the IL-11/STAT3-dependent gp130[superscript F/F] GC model caused tumorigenesis of the proximal stomach. Additionally, gastric immunopathology was accelerated in Helicobacter pylori–infected Gkn2 knockout mice and was associated with augmented T helper cell type 1 (Th1) but not Th17 immunity. Heightened Th1 responses in Gkn2 knockout mice were linked to deregulated mucosal innate immunity and impaired myeloid-derived suppressor cell activation. Finally, transgenic overexpression of human gastrokines (GKNs) attenuated gastric tumor growth in gp130[superscript F/F] mice. Together, these results reveal an antiinflammatory role for GKN2, provide in vivo evidence that links GKN2 loss to GC pathogenesis, and suggest GKN restoration as a strategy to restrain GC progression

The preliminary urban missionary outreach of the apostle Paul as referred to in Acts 13�14

The objective of this article is to deal precisely and systematically with the preliminary urban missionary outreach of the apostle Paul as referred to the book of Acts, chapters 13�14. This article covers an ample spectrum of Paul�s mission work together with his companions. The book of Acts gives us a full exposition of the Holy Spirit as the primary agent of mission. The Holy Spirit led the church in Antioch of Syria in the dedication of Paul and Barnabas for their mission work which was specifically to the Gentiles as the Jews who were given the first preference rejected the Gospel (Ac 13:46). Christ in Acts 9:15 indicated his intention of choosing Paul as his chosen vessel to bear his name before the Gentiles, and kings, and the children of Israel, and this commission of Paul to the Gentiles was also referred to in Acts 22:21. The result of the apostles� propagation of the Word of God was that many Gentile people from different cities repented and became Christians. Although the apostles encountered many challenges and opposition, their initial campaign ended in a good mode, as they experienced the wonderful works of God to the Gentiles as God had opened a door of faith (salvation) among the Gentiles.Intradisciplinary and/or interdisciplinary implications: This article deals with missiological issues as it refers to Paul, who together with his crew encountered many challenges in their mission work like an opposition, expulsion, exaltation, stoning and so on. Even though they faced those challenges, they did not evacuate their responsibility of propagating the Word of God in different metropolitan areas. Thus where the element of �perseverance of the saints� of the Reformed Dogmatics comes in.</p

Silencing Glypican-1 enhances the antitumor effects of Pictilisib via downregulating PI3K/Akt/ERK signaling in chemo-resistant esophageal adenocarcinoma

Poorly differentiated esophageal adenocarcinoma (PDEAC) has a dismal prognosis. Glypican-1(GPC-1) is known to be upregulated in several cancer types in contrast to healthy tissues, rendering it as a biomarker. Nevertheless, the potential therapeutic targeting of GPC-1 has not been explored in PDEAC. There is accumulating evidence that GPC-1, via upregulation of PI3K/Akt/ERK signaling, plays a crucial role in the progression and chemoresistance in cancer. Pictilisib, a class I pan PI3K inhibitor, has shown promising antitumor results in clinical trials, however, has not gained widespread success due to acquired drug resistance. This study investigated the role of GPC-1 in chemo-resistant PDEAC and appraises the impact of targeted silencing of GPC-1 on the antitumor effects of Pictilisib in PDEAC cell lines. Immunohistochemistry assays in PDEAC tissue specimens demonstrated a pronounced intensity of staining with GPC-1. Upregulation of GPC-1 was found to be correlated with advanced stage and poor prognosis. In-vitro studies examined the influence of GPC-1 knockdown and Pictilisib, both as individual agents and in combination, on cytotoxicity, cell cycle distribution, apoptosis, and gene expression profiles. Silencing GPC-1 alone showed significantly reduced cell viability, migration, colony formation, epithelial-mesenchymal transition, and stemness in PDEAC cells. Significantly, knockdown of GPC-1 combined with low-dose Pictilisib led to enhancement of cytotoxicity, cell cycle arrest, and apoptosis in ESO-26 and OE-33 cells. In the xenograft mouse model, the combination of Pictilisib and GPC-1 knockdown exhibited synergy. These findings suggest that GPC-1 represents a promising target to augment chemosensitivity in esophageal adenocarcinoma

Language has a home: how case officers make use of language analysis in asylum decisions

This article explores the ways in which the results of language analyses were taken into account when Swedish Migration Agency (SMA) case officers built arguments concerning unaccompanied children's countries of origin. The research literature on LADO has primarily commented on risks of unreliability. Data was drawn from one calendar year of asylum decisions concerning unaccompanied children, and the sample where LADO had been conducted was analysed by qualitative thematic analysis. The main finding indicates that LADO is primarily used as an enhancer of other circumstances present in the asylum case, which means that it has the potential to 'tip the scales' into approval or rejection. The findings also suggest that case officers use the results of LADO in different ways to regulate the issue of credibility depending on the political and geographical dynamics in the children's reported countries of origin. The practical implications are that migration authorities should regularly examine to what extent the results of LADO are given weight in asylum case processing and that the influence of LADO results on individual decisions should be comprehensively explained in child consequence analyses.</p