Abordagem Multidisciplinar Em Hormonioterapia Neoadjuvante No Câncer De Mama: Uma Revisão

Breast cancer is the most common type of cancer and the leading cause of cancerrelated death among women worldwide. Hormone receptor-positive (HR+) tumors represent the most common form of this disease, with more than 70% of breast cancers expressing these receptors. Response and benefit to neoadjuvant chemotherapy (NCT) varies according to HR expression, with lower responses in luminal tumors as compared with hormone receptor-negative (HR-) and human epidermal growth factor receptor 2-positive (HER2+) tumors. Neoadjuvant endocrine therapy (NET) is an option for selected patients with HR+ locally advanced breast cancer. Neoadjuvant endocrine therapy has a favorable toxicity profile, and is associated with benefits such as having low cost and being more easily available even for cancer care professionals outside major urban areas or tertiary centers. These factors are particularly relevant, as 70% of breast cancer deaths occur in women from lowincome and middle-income countries. Additionally, NET is being increasingly explored, not simply to allow for less extensive surgery, but also as a scientific tool, with the use of biomarkers to predict outcomes in adjuvant trials and for the individual patient. This review details the current and most relevant evidence about NET for breast cancer as well as the future directions of this field. © 2016 by Thieme-Revinter Publicações Ltda, Rio de Janeiro, Brazil.381261562

Forward jet production in deep inelastic ep scattering and low-x parton dynamics at HERA

Differential inclusive jet cross sections in neutral current deep inelastic ep scattering have been measured with the ZEUS detector. Three phase-space regions have been selected in order to study parton dynamics where the effects of BFKL evolution might be present. The measurements have been compared to the predictions of leading-logarithm parton shower Monte Carlo models and fixed-order perturbative QCD calculations. In the forward region, QCD calculations at order alpha_s^1 underestimate the data up to an order of magnitude at low x. An improved description of the data in this region is obtained by including QCD corrections at order alpha_s^2, which account for the lowest-order t-channel gluon-exchange diagrams, highlighting the importance of such terms in parton dynamics at low x.Comment: 25 pages, 4 figure

Search for Higgs bosons of the minimal supersymmetric standard model in p-pbar collisions at sqrt(s)=1.96 TeV

We report results from searches for neutral Higgs bosons produced in p-pbar collisions recorded by the Dzero experiment at the Fermilab Tevatron Collider. We study the production of inclusive neutral Higgs boson in the tautau final state and in association with a b quark in the btautau and bbb final states. These results are combined to improve the sensitivity to the production of neutral Higgs bosons in the context of the minimal supersymmetric standard model (MSSM). The data are found to be consistent with expectation from background processes. Upper limits on MSSM Higgs boson production are set for Higgs boson masses ranging from 90 to 300 GeV. We exclude tanBeta>20-30 for Higgs boson masses below 180 GeV. These are the most stringent constraints on MSSM Higgs boson production in p-pbar collisions.Comment: Submitted to Phys. Lett.

Development of a model of chronic rejection in rat renal allografts

SIGLEAvailable from British Library Document Supply Centre-DSC:D063304 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Measurement of subject multiplicities in neutral current deep inelastic scattering at HERA and determination of alpha(s)

The subjet multiplicity has been measured in neutral current e(+) p interactions at Q(2) > 125 GeV2 with the ZEUS detector at HERA using an integrated luminosity of 38.6 pb(-1). Jets were identified in the laboratory frame using the longitudinally invariant k(T) cluster algorithm. The number of jet-like substructures within jets, known as the subjet multiplicity, is defined as the number of clusters resolved in a jet by reapplying the jet algorithm at a smaller resolution scale y(cut). Measurements of the mean subjet multiplicity, , for jets with transverse energies E-T,E-jet > 15 GeV are presented. Next-to-leading-order perturbative QCD calculations describe the measurements well. The value of alpha(s) (M-Z), determined from at y(cut) = 10(-2) for jets with 25 < E-T,E-jet < 71 GeV, is alpha(s) (M-Z) = 0.1187 +/- 0.0017(stat.)(-0.0009)(+0.0024)(syst.)(-0.0076)(+0.0093)(th.). (C) 2003 Published by Elsevier Science B.V

Inclusive jet cross-sections in the Breit frame in neutral current deep inelastic scattering at HERA and determination of alpha(s)

Inclusive jet differential cross sections have been measured in neutral current deep inelastic e+p scattering for boson virtualities Q**2>125 GeV**2. The data were taken using the ZEUS detector at HERA and correspond to an integrated luminosity of 38.6 pb-1. Jets were identified in the Breit frame using the longitudinally invariant K_T cluster algorithm. Measurements of differential inclusive jet cross sections are presented as functions of jet transverse energy (E_T,jet), jet pseudorapidity and Q**2, for jets with E_T,jet>8 GeV. Next-to-leading-order QCD calculations agree well with the measurements both at high Q**2 and high E_T,jet. The value of alpha_s(M_Z), determined from an analysis of dsigma/dQ**2 for Q**2>500 GeV**2, is alpha_s(M_Z) = 0.1212 +/- 0.0017 (stat.) +0.0023 / -0.0031 (syst.) +0.0028 / -0.0027 (th.).Comment: 34 pages, 6 figures, 8 tables; submitted to Phys. Let