7 research outputs found
Mortality and pulmonary complications in patients undergoing surgery with perioperative sars-cov-2 infection: An international cohort study
- Author
- Aaraj M. A.
- Abate E.
- Abbott S. J.
- Abbott T. E. F.
- Abdalaziz H.
- Abdalla M. O.
- Abdelaal A. S.
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- Abdou H.
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- Velopulos C. G.
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- Vijay V.
- Vimalachandran D.
- Violante T.
- Viswanath Y. K. S.
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- Vulliamy P.
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- Wall J. J. S.
- Wall R.
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- Ward A.
- Warren O. J.
- Warwick D.
- Waseem S.
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- Whitehall E.
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- Worku D.
- Wormald J. C. R.
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- Yalamanchili S.
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- Yildiz A.
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- Zarate A.
- Zerbib P.
- Zmora O.
- Zonta S.
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (740%) had emergency surgery and 280 (248%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (261%) patients. 30-day mortality was 238% (268 of 1128). Pulmonary complications occurred in 577 (512%) of 1128 patients; 30-day mortality in these patients was 380% (219 of 577), accounting for 817% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 175 [95% CI 128-240], p<00001), age 70 years or older versus younger than 70 years (230 [165-322], p<00001), American Society of Anesthesiologists grades 3-5 versus grades 1-2 (235 [157-353], p<00001), malignant versus benign or obstetric diagnosis (155 [101-239], p=0046), emergency versus elective surgery (167 [106-263], p=0026), and major versus minor surgery (152 [101-231], p=0047). Interpretation Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
- Author
- Liza
- - AP-HP) Bertrand Dousset (H\uf4pital Cochin
- - APHP) Anne Thomin (H\uf4pital Trousseau
- - ASST Rhodense) Carlo Corbellin (Ospedale Di Rho
- - NYU Winthrop Hospital) Amir H Sohail (NYU Langone Health
- - Xarxa Assistencial Universit\ue0ria de Manresa) Pablo Collera Ormazabal (Fundaci\uf3 Althaia
- / Columbia University Medical Center) Miriam Callahan (NewYork-Presbyterian
- 3 University Hospital) Bridget Egan (Tallaght
- 4 Lapolla Pierfrancesco
- 5 Spain: Eduardo E Rubio Susana Henriques (Hospital Garcia de Orta).
- 6 G\uf3mez Marcos
- \u2013 IRCCS Francesca Gaino (Humanitas Clinical and Research Center
- \u2013 Italy) 20089 Rozzano (MI)
- \uc1ngel Hern\ue1ndez Bartolom\ue9 Miguel
- A Aaraj Mahmoud
- A Ayeni Funbi
- A Bass Gary
- A Benson Ruth
- A Bozkurt Mehmet
- A Breen Kerry
- A Breen Kerry
- A Breen Kerry
- A Callcut Rachael
- A Chung Eric
- A Coughlin Patrick
- A de Gheldere Charles
- A De Marchi Joshua
- A Elliott Jessie
- A Fahey Brian
- A Griffiths Ewen
- A Griffiths Ewen
- A Griffiths Ewen
- A Guariglia Claudio
- A Hirji Sameer
- A Khalefa Mohamed
- A Marra (Fondazione Policlinico Universitario Agostino Gemelli) Angelo
- A Nguyen (Frankfurt University Hospital Truong
- A Olson (Duke University Medical Center) Steven
- A Raptis Dimitri
- A Rollett Rebecca
- A Saeed Samerah
- A Salama Hiba
- A Salamah Abdulrauf
- A Schnitzbauer Andreas
- A Schnitzbauer Andreas
- A Singh Aminder
- A Stevens Kent
- A Stylianides Nicholas
- A Thaha Mohamed
- A Vega (12 de Octubre University Hospital) Viviana
- A Vivas Alfredo
- A Zappa Marco
- Abate Emmanuele
- Abdalaziz (Gloucestershire Royal Hospital) Hossam
- Abdelkarim Mostafa
- Abdou Hossam
- Aboelkassem-Ibrahim Ahmad
- Abuown Ala
- Acebes-Garcia Fernando
- Acharya Metesh
- Adamina Michel
- Addae-Boateng Emmanuel
- Adolfo Pisanu (Cagliari University Hospital) Mauro Podda
- Aftab Raiyyan
- AG Moir John
- Agarwal Arnav
- AH Ibrahim Mohamed
- Aitken (Queen Elizabeth University Hospital) Emma
- Al-Azzawi Marwa
- Al-Embideen Somya
- Al-Sukaini Ahmad
- Alakaloko Felix
- Alam (Heartlands Hospital) Ruhina
- Alameer Ehab
- Alderson Derek
- Ali Mohamed Ali (Queen Elizabeth Hospital King's Lynn) Inthekab
- Aliyeva (Acibadem Mehmet Ali Aydinlar University Zumrud
- Aljanadi Firas
- Almasri Murad
- Alonso Poza (Hospital Universitario del Sureste) Alfredo
- Alonso-Ortu\uf1o Paula
- Alser Osaid
- Alser Osaid
- Alser Osaid
- Altintoprak (Sakarya University Faculty of Medicine) Fatih
- Amalina Che Bakri Nur
- Amjad Rabbia
- Anania Gabriele
- and Westminster Hospital NHS FT and Imperial College London) Chelsea
- Andabaka Tatjana
- Andrea Pisani Ceretti (ASST Santi Paolo e Carlo) Nicol\uf2 M Mariani
- Angelou Dimitrios
- Anita Volpe (New York Presbyterian Queens) Stephen Merola
- Annamalai Seethalakshmi
- Annessi Valerio
- Anthoney James
- Anuradha R Bhama (Rush University Medical Center) Alfonso Torquati
- Anwar Sibtain
- Aragon-Chamizo Juan
- Ardito Antonella
- Arigoni Michele
- Armao Teodora
- Arminio (Ospedali Riuniti Azienda Ospedaliera Universitaria Foggia) Armando
- Armstrong Lara
- Asaad Peter
- Ashcroft James
- Ashmore Christopher
- Asqalan Ahmad
- Asti (IRCCS Policlinico San Donato Emanuele
- Aubry Emmanuelle
- Aytac Erman
- Ayuso-Herrera Esther
- Azerbaijan:Elgun Samadov Joana FF Simoes (Chair). 2 Collaborators: (denotes Local Principal Investigator) Algeria: Faraj S Almaadany (\uc9tablissement Hospitalier Sp\ue9cialis\ue9 en Canc\ue9rologie - Centre Pierre-et- Marie-Curie).
- B Avellana Rocio
- B Catton Andrew
- B Fonsi Giovanni
- B Hing Caroline
- B O'Meara Lindsay
- B Schaffer Kathryn
- B Yousuf (Tobruk Medical Center) Farhat
- B\ue0mbina (Fabrizio Spaziani Hospital Fabrizio
- Bailon-Cuadrado (Hospital Universitario R\uedo Hortega) Martin
- Baldi Caterina
- Baldini Edoardo
- Baldo (Ospedale Santa Corona Stefano
- Ballabio Michele
- Baloyiannis Ioannis
- Baltazar Gerard
- Bandiera Alessandro
- Barlow Emma
- Barmasse (Ospedale Regionale Umberto Parini) Roberto
- Barmpagianni Christina
- Baronio (Policlinico San Pietro) Gianluca
- Barra Fabio
- Bartholomew's Hospital) St
- Bartsch Anne-Marie
- Basgaran Amedra
- Basha Amr
- Bashkirova (North Middlesex University Hospital) Varvara
- Bastazza Marco
- BB Sullivan (The Royal London Hospital) Tom
- Beak Philip
- Belcher Elizabeth
- Belgium: Gabrielle H van Ramshorst Sevda Jafarova (Leyla Medical Center).
- Beltr\ue1n de Heredia Juan
- Belvedere Angela
- Ben\uedtez-Linero Inmaculada
- Benjamin Franklin) Campus
- Bergeat Damien
- Bernasconi Matteo
- Bhalla Ashish
- Bhangu Aneel
- Bianco Federica
- Bisagni Pietro
- BJ Borgstein Alexander
- Blake (Southport and Formby District General Hospital) Iain
- Blanco-Colino Ruth
- Blazquez-Martin (Hospital Principe De Asturias) Alma
- Boal Matthew
- Bologna) Ausl
- Bonavina Giulia
- Bonavina Luigi
- Bond-Smith Giles
- Booth (Freeman Hospital) Karen
- Borges Filipe
- Borghi Felice
- Borja De Lacy (Hospital Clinic Barcelona) F
- Bourke Grainne
- Boyle Emily
- Brachini Gioia
- Brain Jessie
- Brar Amanpreet
- Breckles Lisa
- Brendan L Skelly (Altnagelvin Area Hospital) Catherine Rossborough
- Brianza) Carate
- Brixton Genevieve
- Bruzzaniti Placido
- Bueser Teofila
- Burnside Nathan
- C Bosanquet David
- C Brown (Manchester University NHS Foundation Trust Benjamin
- C De Souza Anthony
- C Glasbey James
- C Glasbey James
- C Hopkins James
- C Lauscher Johannes
- C McIntyre Robert
- C Mckay Siobhan
- C Neary Paul
- C Nugent III William
- C Rodriguez-Sanjuan (Marqu\ue9s de Valdecilla University Hospital) Juan
- C Roslani April
- C Tucker Sarah
- C Velmahos (Massachusetts General Hospital) George
- C Winter Stuart
- Caballero Albert
- Cairo University) Mahmoud MA Elfiky (Kasr Alainy Faculty of Medicine
- Calcerrada-Alises Enrique
- Camacho Fern\ue1ndez-Pacheco (Complejo Hospitalario Universitario Insular-Materno Infantil) Borja
- Camarero Enrique
- Campagnaro Tommaso
- Campanelli Michela
- Candiani Massimo
- Cannoletta (Royal Brompton Hospital) Marina
- Cantalejo-Diaz (Hospital Universitario Miguel Servet) Miguel
- Cao Han
- Capizzi Vita
- Carcano (Ospedale di Circolo Giulio
- Carissimi Francesca
- Carlini Massimo
- Carlos Bernal-Sprekelsen Juan
- Carlos Catal\ue1 Bauset (Consorcio Hospital General Universitario) Juan
- Carlucci Michele
- Carmela Giuffrida Maria
- Carmichael Heather
- Carrasco Milagros
- Carrillo Mariana
- Carvello Michele
- Casati Massimiliano
- Castoro Carlo
- Castro Ruiz Carolina
- Catalan Vanesa
- Catriona R Luney (Nuffield Orthopaedic Centre) Benjamin JF Dean
- Cavaleiro Salom\ue9
- Cellerino Paola
- Center Amsterdam) Cancer
- Centinaio (Ospedale Maggiore di Lodi) Giovanna
- Cernei Cristina
- Cervellera Maurizio
- Chakrabortee Sohini
- Chamberlain Stephanie
- Chan Jeffrey
- Chang Grace
- Chaudhry Daoud
- Chebaro Alexandre
- Chen (Jamaica Hospital) David
- Chetty Govind
- Chia (Royal Derby Hospital) Zoe
- Chiappini Ambra
- Chiarugi (Azienda Ospedaliero Universitaria Pisana) Massimo
- Chidambaram Swathikan
- Chiozza Matteo
- Cholewa Hanna
- Chong (Evelina London Children's Hospital) Clara
- Choolani-Bhojwani Ekta
- Christian Cotsoglou (ASST Vimercate) Stefano Granieri
- Chui Karen
- Chung Choyin
- Cirillo Bruno
- Citterio Davide
- Clermidi Pauline
- Coccolini Federico
- Colletti Gaia
- Compagnoni Bruno
- Concepci\uf3n-Mart\uedn Vanesa
- Confalonieri Marco
- Connolly Hannah
- Conso Christel
- Conti Luigi
- Cooper Zara
- Corral Javier
- Costa Marta
- Costanzi Andrea
- Cox Daniel
- Cozza Valerio
- CR Wormald Justin
- Croatia: Jakov Mihanovic Nicolas Duchateau (Heilig Hart Ziekenhuis Lier).
- CS Clough Ethan
- Cuming Tamzin
- Cuneo)
- Curtis Miles
- Cuschieri Joseph
- D Baron Ryan
- D Bosch Karen
- D Brown Oliver
- D Bueno-Ca\uf1ones Alejandro
- D Cato Liam
- D Drake Thomas
- D Jenkinson Michael
- D Jenkinson Michael
- D Liyanage Aloka S
- D Pinkney Thomas
- D Rajgor Amarkumar
- D Stewart Grant
- D Tebala Giovanni
- D'Agruma Michele
- D'Andrea Giancarlo
- D\uedaz P\ue9rez David
- D\uedaz-Garc\ueda (Hospital Universitario Nuestra Se\uf1ora de Candelaria) Alberto
- Da Roit Anna
- da Saliceto\u201d Patrizio Capelli (Ospedale \u201cG.
- Dare Oliver
- Darko Ebenezer
- Data Monitoring and Ethics Committee: Deborah S Keller H. Hunt Batjer (University of Texas Southwestern).
- Day Andrew
- De Andr\ue9s-Asenjo Beatriz
- de Medicina Facultad
- De Miguel-Ardevines Maria-Carmen
- De Nardi Paola
- De Simone Veronica
- De Toma Giorgio
- Deepti Sinha (University College London Hospital) Nicholas Kalavrezos
- Dehal (Kaiser Permanente Panorama City Medical Center) Ahmed
- Dehart Dustin
- Del Giudice Roberto
- Delgado-Oliver Eduardo
- Denmark: Henry G Smith Bernarda Bakmaz (Zadar General Hospital).
- Denning Max
- Desai Anant
- Desender (Ghent University Hospital) Liesbeth
- Dester (ASST Valcamonica Ospedale di Esine) Sara
- Di Candido Francesca
- Di Chiara Francesco
- Di Franco Gregorio
- Di Giuseppe (Ente Ospedaliero Cantonale del Canton Ticino) Matteo
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Di Saverio Salomone
- Diaz-Pe\uf1a Patricia
- Dieguez Fernandez Beatriz
- Dissemination Committee: Michel Adamina Aneel Bhangu.
- Dolores Del Toro M
- Domodossola
- Doussot Alexandre
- Duff Sarah
- Dunning Joel
- Dunstan Matt
- Duque-Mallen Victoria
- Dziakova Jana
- E Canova Michaela
- e Carle Hospital Chiara Peluso (Santa Croce
- e Carlo ASST Santi Paolo
- E Dawson Brett
- E Dickson Kathryn
- E Hudson Victoria
- E Jenny (Johns Hopkins Hospital) Hillary
- E Lewis Sophia
- E Nita George
- e Oftalmico) Giulio Iacob (Ospedale Fatebenefratelli
- E P\ue9rez-S\ue1nchez Luis
- E Rice Henry
- E Ssentongo Anna
- e Universit\ue1rio de Coimbra) Ana C Almeida (Centro Hospitalar
- E Xyda Souzana
- Edward Fitzgerald J
- EF Abbott Tom
- EF Abbott Tom
- Egan Richard
- Egypt: Mohamed El Kassas University of Copenhagen).
- El Youzouri Hanan
- El-Ali (Queen's Hospital Abess
- Elaine YL Leung (The Pan Birmingham Gynaecological Cancer Centre) Sudha Sundar
- Elfeki Hossam
- Elhadi Muhammed
- Eljareh (Aljalaa Hospital) Mohammed
- Elkadi Hannah
- Elkady Ramy
- Elkhafeefi Fatimah
- Elmore Ugo
- Elmoslemany (The Walton Centre NHS Foundation Trust) Tarek
- EM Bouhuwaish Ahmad
- EM Brathwaite Collin
- Emmerson (North Manchester General Hospital) Oliver
- Enemosah Ibrahim
- English Camilla
- English William
- Ereidge Simon
- Escartin Jorge
- Estaire-Gomez Mercedes
- EuroSurg
- Evans (Queen Elizabeth the Queen Mother Hospital Margate) Jessica
- Exley Rebecca
- F Bath Michael
- F Cunha Miguel
- F Cunha Miguel
- F Davis Niall
- F Ridgway Paul
- Fabbri Nicol\uf3
- Falco Giuseppe
- Familiari Pietro
- Fancellu (Cliniche San Pietro Alessandro
- Fanjul G\uf3mez Mar\ueda
- Farik Shebani
- Farr\ue9 Font Roser
- Farrell Tony
- Fehervari Matyas
- Fell Adam
- Fern\ue1ndez- Mart\uednez Mar\ueda
- Fern\ue1ndez-Gomez Cruzado (Hospital Urduliz) Laura
- Fern\ue1ndez-Mar\uedn Reyes
- Fernandez-Camu\uf1as Angel
- Ferrara)
- Ferrara Francesco
- Ferrari Guglielmo
- Ferrero Simone
- FF Simoes Joana
- FF Simoes Joana
- Findlay Laura
- Fiore Marco
- Fiore Marco
- Fiori Enrico
- FJ Dunne Declan
- Flatman Michael
- Flindall Ian
- Fontana (Vittorio Emanuele Tommaso
- Ford (The Robert Jones and Agnes Hunt Orthopaedic Hospital) David
- Ford Samuel
- Forlani Stefano
- Fr\ue9d\ue9ric Bretagnol (H\uf4pital Louis-Mourier - GHU AP-HP. Nord - Universit\ue9 de Paris) David Moszkowicz
- France: Zaher Lakkis Mohamed Sherief (MISR Cancer Center/MISR International Hospital).
- Francisco de Vitoria Universidad
- Francone Elisa
- Frattaruolo Colomba
- Frio (Institute of Neurological Sciences of Bologna Federico
- Frosinone)
- G Aoun Salah
- G Barranquero Alberto
- G Blazer III Dan
- G Collins Chris
- G Edwards John
- G Edwards John
- G Morton Dion
- G Povey Meical
- G Velopulos Catherine
- G Wade Ryckie
- Gabriel Kinnaman (IU Health Methodist Hospital) Ashley D Meagher
- Gagliano Annalisa
- Gagliardi Filippo
- Gahunia Sukhpreet
- Gala Tanzeela
- Galfrascoli Elisa
- Galimberti Luca
- Galindo Jara (Hospital Universitario de Torrej\uf3n Pablo
- Gallagher Phoebe
- Galleano Raffaele
- Gallo Gaetano
- Gallo Gaetano
- Gallo Gaetano
- Galv\ue1n-P\ue9rez Armando
- Gamal Amira Ibrahim Sallam
- Gammeri Emanuele
- Ganau Mario
- Garc\ue9s-Garc\ueda Ra\ufal
- Garcia Fernandez Andres
- Garcia-Conde Delgado Maria
- Garulli (Ospedale Infermi di Rimini) Gianluca
- Gascon-Ferrer Isabel
- Gattolin (Regina Montis Regalis Hospital Andrea
- Gaujoux Sebastien
- Gentilli Sergio
- Georgiades Fanourios
- Germany: Carsten Kamphues Didier Ollat (Institut Mutualiste Montsouris).
- Gerogiannis (Kingston Hospital NHS Foundation Trust) Ioannis
- Ghanbari (Homerton University Hospital) Amir
- Ghosh Dhruv
- Giacometti Marco
- Giblin Anna-Victoria
- Gilbert (Surrey and Sussex Healthcare NHS Trust) Catherine
- Gim\ue9nez Clara
- Giorgakis Emmanouil
- Gipponi Manuel
- Glen Paul
- GlobalPaedSurg GlobalSurg
- Goatly Giles
- Gobatti (San Carlo Borromeo Hospital Davide
- Godbole Chintamani
- Gohil Kajal
- Gomez-Rosado Juan-Carlos
- Gonullu Emre
- Gonzalez-De Miguel Melania
- Gonzalez-Gonzalez Enrique
- Gordini Luca
- Gracia Isabel
- Gracia-Roche Carlos
- Greece: Konstantinos Bouchagier Markus W L\uf6ffler (University Hospital Tu\u308bingen).
- Green Susanna
- Grivon Manuela
- Grove (Department of Colorectal Surgery Thomas
- Guaglio Marcello
- Guaitoli (Perrino) Eleonora
- Guglielmi Alfredo
- Guha Soumya
- Gustavino (Unit of Obstetrics and Gynecology IRCCS Ospedale Policlinico San Martino Genoa) Claudio
- Guti\ue9rrez Samaniego Mar\ueda
- H Babu Bheemanakone
- H Chowdhury Abeed
- H Davidson Giana
- H Davidson Giana
- H Davidson Giana
- H Elfallal Ahmed
- H Emile Sameh
- H Kirmani Bilal
- H Liu Helen
- H Murphy Suzanne
- H van Ramshorst Gabrielle
- H\uf6lzle Frank
- Habeeb Amir
- Hagger Robert
- Hakmi Hazim
- Halkias Constantine
- Halkias Constantine
- Hampton (Rotherham District General Hospital) Matthew
- Handa Siddhartha
- Haq Iram
- Harky (Liverpool Heart and Chest Hospital) Amer
- Harries (Morriston Hospital Rhiannon
- Harrison Joseph
- Hasan Raashad
- Hawari Mohammad
- Hawkin Paul
- Hebblethwaite Bethany
- Helier University Hospitals NHS Trust) St
- Heritage Emily
- Hernandez Garcia Miguel
- Hernandez-Juara Pilar
- Herrero-Lopez Maria
- Hervieux Erik
- Heyd Bruno
- Higgs Simon
- Hitchman (Hull University Teaching Hospitals NHS Trust) Louise
- Ho Beatrice
- Hogan Aisling
- Hospital of Varese University
- Hospital Universitario del Henares) Miguel Angel Garcia-Ure\uf1a (Universidad Francisco de Vitoria
- Hospital) Atakent
- Hospital) Wythenshawe
- Hossain Tanvir
- Houston Roy
- Hurt Libor
- HV Byrne Matthew
- i Pujol) Alba Zarate (Hospital Germans Trias
- I Roxo (Brigham and Women's Hospital) Vanessa
- I van Berge Henegouwen (Amsterdam UMC Mark
- I Alessandro Di Bartolomeo (Policlinico Umberto
- Iannone Immacolata
- Ibrahim Sherif
- Iovino Domenico
- Ireland: Arnold DK Hill Paraskevi Tourountzi (Kavala General Hospital).
- Isik Arda
- Israel: Oded Zmora Thomas M Aherne (Galway University Hospital).
- Italy: Maurizio Zizzo Nadav Kugler (Shamir Medical Center).
- J Abbott Sarah
- J Baker Olivia
- J Baldwin Alexander
- J Beamish Andrew
- J Carlos William
- J Caruana Edward
- J Caruana Edward
- J Davies Emma
- J Diaz Jose
- J Doe Matthew
- J Eardley Nicola
- J Fern\ue1ndez Antonio
- J G\uf3mez D\uedaz Carlos
- J Hainsworth Alison
- J Hall Bria
- J Holme Thomas
- J Hutchinson Peter
- J Hutchinson Peter
- J Kalkwarf Kyle
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- Murcia)
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- N Mashbari Hassan
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- Novara)
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- O Ademuyiwa Adesoji
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- of Amsterdam University
- of Ferrara) University
- of Insubria University
- of Milan) University
- of Surgeons in Training (ASiT) Association
- of Surgery) Department
- of Washington) University
- Okafor Barbara U.
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- Padilla-Valverde (Hospital General Universitario De Ciudad Real) David
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- Pata Francesco
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- Pedram Panahi (University Hospitals Plymouth NHS Trust) Mariam Rela
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- Pereira Andr\ue9
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- Perra Teresa
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- Piacenza)
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- Portugal: Hugo Santos-Sousa Pakistan: Mariyah Anwer (Jinnah postgraduate medical center).
- Potter (Royal Bournemouth Hospital) Ryan
- Price Claire
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- Robertson (University of Arkansas for Medical Sciences) Ronald
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- Rolli Luigi
- Romano Silvio
- Rome)
- Romford)
- Ross Elizabeth
- Ross Howard
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- Royal Hospital) Princess
- Ruiz (Hospital General Universitario Reina Sof\ueda Miguel
- Ruiz- Grande Fernando
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- Sheffield)
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- Switzerland: Dimitri Christoforidis Ali A Ali karar (Al-rajhi).
- Syed Arooj
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- Thrush Jessica
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- Truant St\ue9phanie
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- Turkey: Volkan Ozben Georgios Peros (Kantonsspital Winterthur).
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- University Hospitals NHS Trust) Nottingham
- University of Rome) Sapienza
- University) Goethe
- University) Helwan
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- Vijay Vardhini
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- Vimalachandran Dale
- Violante Tommaso
- Vovola Fernanda
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- W Endorf (Hennepin Healthcare) Frederick
- W Etchill Eric
- W L\uf6ffler Markus
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- Winnand (University Hospital Aachen) Philipp
- Wong (Addenbrooke's Hospital) Ken
- Worku (Queen\u2019s Medical Centre Dawit
- Wright Naomi
- WS Ho (Leeds Teaching Hospitals NHS Trust Michael
- WT Ngu Albert
- y Cajal) Cristina Cerro (Hospital Universitario Ram\uf3n
- Y Oo (Department of Cardiothoracic Surgery Aung
- y Polit\ue9cnico La Fe) Blas Flor (Hospital Universitario
- Y van der Plas Willemijn
- Yalamanchili Seema
- Yershov (South Warwickshire NHS Foundation Trust) Danylo
- Young Richard
- Yousra Ahmed (Portsmouth Hospital NHS Trust) Simon Toh
- Yurttas Can
- Zadegan Frederic
- Zafar (Northwick Park Hospital) Noman
- Zakaria Rasheed
- Zambon Martina
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- ZE Durst Alexander
- Zerbib Philippe
- Zonta (Ospedale San Biagio Sandro
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2020
- Field of study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
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Machine learning risk prediction of mortality for patients undergoing surgery with perioperative SARS-CoV-2: the COVIDSurg mortality score
- Author
- Aigner F
- Ang E
- Ang Z
- Binder AD
- Boccalatte LA
- Boeckxstaens A
- Christiano A
- Clarke EM
- Cohnert TU
- Cope D
- Cordonnier A
- Cox DRA
- Dajti I
- Dawson AC
- De Coster J
- De Gheldere C
- De Praetere H
- De Robles S
- De Robles S
- De Smul G
- Desender L
- Drane A
- Duchateau N
- Dudi-Venkata NN
- Egoroff N
- Eibinger N
- Emmanuel K
- Fediuk M
- Flamey N
- Gemelli NA
- Grimm C
- Grimonprez A
- Guidi B
- Haenen L
- Holawe S
- Islam N
- Jaekers J
- Jamel W
- Janssen M
- Kahn J
- Karim S
- Komen N
- Kranawetter M
- Kroon HM
- Lah K
- Lerut P
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- Lumenta DB
- Martens T
- Messner D
- Michelitsch B
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- Nischwitz PS
- Nkenke E
- Oosterlinck W
- Pacilli M
- Papinutti A
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- Pau M
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- Pockney P
- Politis C
- Presl J
- Putnis S
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- Qin KR
- Quintens J
- Rahman Mitul A
- Richtig E
- Riddiough GE
- Roberts M
- Sammour T
- Schols G
- Seidel G
- Seitinger G
- Sermon A
- Sharpin C
- Smets C
- Smith DE
- Srekl-Filzmaier P
- Stiegler M
- Tollens T
- Uranitsch S
- Valenzuela JI
- Van Belle K
- Van de Putte D
- Van den Eynde J
- Van den Eynde R
- Van Ramshorst GH
- Varga M
- Wallaert P
- Weitzendorfer M
- Zimmermann M
- Öfner F
- Publication venue
- eScholarship, University of California
- Publication date
- 11/11/2021
- Field of study
To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide range of surgical services for selected patients
Outcomes after perioperative SARS-CoV-2 infection in patients with proximal femoral fractures: an international cohort study
- Author
- A'Court J
- Aawsaj Y
- Abbadessa F
- Abbas A
- Abbott S
- Abdalaziz H
- Abdalla M
- Abdeh L
- Abdelsaid K
- Abdou H
- Abdul-Jabar H
- Abood A
- Abou-Foul AK
- Abrate A
- Abu-Nayla I
- Abual-Rub Z
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- Ademuyiwa AO
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- Agilinko J
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- Al-Sukaini A
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- Aladeojebi A
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- Parente A
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- Parkins K
- Parmar C
- Parry J
- Parsons N
- Parsons N
- Pascoe J
- Pascua Gomez LA
- Pascual A
- Pasricha R
- Pata F
- Patel K
- Patel M
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- Pathanki AM
- Pathmanaban O
- Patience A
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- Pazionis T
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- Pereira A
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- Pesantez Peralta MA
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- Phillips JRA
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- Pinkney TD
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- Podolsky D
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- Politis C
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- Pompili C
- Ponniah Subbiah H
- Pop I
- Portinari M
- Pournaras D
- Powell S
- Powell-Smith E
- Prada Hervella GM
- Preece R
- Premakumar Y
- Price C
- Prieto Calvo M
- Pruiti Ciarello V
- Pruvot FR
- Pujol-Muncunill R
- Puppo A
- Pushpa-rajah J
- Quintana M
- Qureishi A
- Radenkovic D
- Radhakrishnan A
- Radica Koleva M
- Rae L
- Ragupathy K
- Rahman M
- Rai B
- Rajaretnam N
- Rajgor AD
- Rajput K
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- Ramallo-Solis I
- Ramos Bonilla A
- Ramos-De la Medina A
- Ramsay L
- Ramzi J
- Ranjit S
- Rapetto F
- Raptis DA
- Rashid MM
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- Razik A
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- Reghuram V
- Reguera-Rosal J
- Rehman S
- Rehman S
- Reid J
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- Rela M
- Renau-Cerrillo M
- Renovell Ferrer P
- Renza-Stingone E
- Revez T
- Revez T
- Reynolds J
- Ribeiro J
- Ribeiro R
- Ribeiro R
- Ribeiro VI
- Ribeiro VI
- Richards T
- Riches J
- Richmond M
- Richtig E
- Ridgway A
- Rio Rodrigues L
- Risk OBF
- Rivas F
- Rivas R
- Roberts K
- Robertson S
- Robertson-Smith B
- Robson A
- Rodrigues M
- Rodriguez Fraga A
- Rodriguez Gomez L
- Rodriguez Fernandez MI
- Rogers A
- Rogers LJ
- Rogers M
- Rogers S
- Rolls A
- Rooney J
- Rooney S
- Rosato F
- Rosello Anon A
- Ross E
- Ross H
- Ross L
- Ross S
- Roxo V
- Roy C
- Roy H
- Royle T
- Rozet F
- Rubio E
- Rudic M
- Ruivo A
- Ruiz G
- Rutherford D
- Ryska O
- Saadya A
- Saberi R
- Sachdeva A
- Saeed S
- Sagar J
- Sahnan K
- Sahni A
- Sait M
- Salas Sanchez R
- Saleh C
- Salerno G
- Salim A
- Salinas Hidalgo C
- Sanchez Aniceto G
- Sanchez Jimenez R
- Sanchez-Arteaga A
- Sanchez-Garcia S
- Sanchez-Pelaez D
- Sanchon L
- Sandblom G
- Sanderson L
- Sandkamp R
- Sanguesa MJ
- Sanserino K
- Santas M
- Santhirakumaran G
- Santini AJA
- Santos E
- Santos I
- Sarantitis I
- Sarjanoja E
- Sarma DR
- Sarni AL
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- Sarraf KM
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- Saxena S
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- Schroeppel TJ
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- Shankar S
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- Sohail AH
- Sohrabi C
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- Thiruchandran G
- Thiruvasagam VG
- Thomas M
- Thomas M
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- Toledo Martinez E
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- Townend P
- Townshend D
- Townshend D
- Tripathi SS
- Trompeter A
- Trout IM
- Truant S
- Tsinaslanidis P
- Tsoulfas G
- Tucker SC
- Turnbull A
- Turrado-Rodriguez V
- Tustin H
- Tzedakis S
- Tzerbinis H
- Uberai A
- Ubhi HK
- Unnithan A
- Urban S
- Urbani A
- Usman O
- Valdes-Hernandez J
- Valente da Costa A
- Valtzoglou V
- Van den Eynde J
- Van den Eynde R
- Van der Plas WY
- Van Heinsbergen M
- van Ramshorst G
- Vanker R
- Varcada M
- Vatish J
- Vatish M
- Vaughan P
- Vaz OP
- Vega V
- Vejsbjerg K
- Velmahos G
- Velopulos CG
- Venkatesan Sethuraman A
- Venn ML
- Ventura D
- Verberne C
- Vidya R
- Vidya R
- Vijay V
- Villalabeitia Ateca I
- Villamor Garcia I
- Vimalachandran D
- Vimalachandran D
- Viswanath Y
- Vitone L
- Vivas Lopez A
- Vives-Barquiel M
- Volpe A
- Von Oppell U
- Vovola F
- Wade RG
- Wadham B
- Wahed S
- Walker C
- Wall J
- Wallwork K
- Walters A
- Warburton H
- Ward A
- Ward AE
- Waseem S
- Watson LJ
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- Weerasinghe C
- Wells F
- Wensley F
- West R
- Wheatstone S
- Whelton C
- White T
- Whitehall E
- Wickramarachchi L
- Wilkin R
- Wilkin RJW
- Wilkins A
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- Williams G
- Williams J
- Williams K
- Williams MA
- Williams S
- Williams S
- Williams T
- Wilson MSJ
- Winter SC
- Winyard J
- Witek A
- Wong K
- Wood ML
- Woods R
- Woodward Z
- Wright FL
- Wright N
- Xicola Martinez M
- Xyda S
- Yalamanchili S
- Yanez C
- Yang H
- Yassin N
- Yener A
- Yershov D
- Young A
- Young R
- Yousef Y
- Youssef M
- Zadegan F
- Zafar N
- Zahid H
- Zakai D
- Zamvar V
- Zeiton M
- Zerbib P
- Zhang Y
- Zier L
- Zowgar A
- Publication venue
- 'BMJ'
- Publication date
- 01/01/2021
- Field of study
Objectives Studies have demonstrated high rates of mortality in people with proximal femoral fracture and SARS-CoV-2, but there is limited published data on the factors that influence mortality for clinicians to make informed treatment decisions. This study aims to report the 30-day mortality associated with perioperative infection of patients undergoing surgery for proximal femoral fractures and to examine the factors that influence mortality in a multivariate analysis. Setting Prospective, international, multicentre, observational cohort study. Participants Patients undergoing any operation for a proximal femoral fracture from 1 February to 30 April 2020 and with perioperative SARS-CoV-2 infection (either 7 days prior or 30-day postoperative). Primary outcome 30-day mortality. Multivariate modelling was performed to identify factors associated with 30-day mortality. Results This study reports included 1063 patients from 174 hospitals in 19 countries. Overall 30-day mortality was 29.4% (313/1063). In an adjusted model, 30-day mortality was associated with male gender (OR 2.29, 95% CI 1.68 to 3.13, p80 years (OR 1.60, 95% CI 1.1 to 2.31, p=0.013), preoperative diagnosis of dementia (OR 1.57, 95% CI 1.15 to 2.16, p=0.005), kidney disease (OR 1.73, 95% CI 1.18 to 2.55, p=0.005) and congestive heart failure (OR 1.62, 95% CI 1.06 to 2.48, p=0.025). Mortality at 30 days was lower in patients with a preoperative diagnosis of SARS-CoV-2 (OR 0.6, 95% CI 0.6 (0.42 to 0.85), p=0.004). There was no difference in mortality in patients with an increase to delay in surgery (p=0.220) or type of anaesthetic given (p=0.787). Conclusions Patients undergoing surgery for a proximal femoral fracture with a perioperative infection of SARS-CoV-2 have a high rate of mortality. This study would support the need for providing these patients with individualised medical and anaesthetic care, including medical optimisation before theatre. Careful preoperative counselling is needed for those with a proximal femoral fracture and SARS-CoV-2, especially those in the highest risk groups. Trial registration number NCT0432364
Strahlung und antagonistische Wirkungen
- Author
- A. Arnold
- A. C. Guillaume
- A. H. Roffo
- A. L. Shuck
- A. Ludwig
- A. Samsonow
- A. Ursprung
- A. Ursprung
- A. Ursprung
- A. W. Reinhard
- B. Polland
- C. Packard
- Ch. D. Snyder
- Ch. Gheldere de
- Ch. Sheard
- Ch. Sheard
- Ch. Sheard
- Ch. Sheard
- Ch. Sheard
- D. Quick
- D. T. Harris
- E. Bersa
- E. C. Teodoresco
- E. C. Teodoresco
- E. Hertel
- E. L. Johnson
- E. S. Castle
- E. Uhlmann
- F. Linke
- F. Ludwig
- F. Ludwig
- Fr. Weber
- G. D. Lieber
- G. E. Briggs
- G. Huber
- G. Klebs
- G. L. Funke
- G. Lockemann
- G. M. Darrow
- G. M. Higgins
- G. Politzer
- G. R. Burns
- G. Schaum
- G. Schorr
- G. Teichler
- G. W. Scarth
- G. Yamaha
- H. B. Glass
- H. Beikirch
- H. D. Griffith
- H. Döring
- H. F. Rosene
- H. G. Buy du
- H. Hellweger
- H. Holthusen
- H. Holthusen
- H. Holthusen
- H. L. Shirley
- H. L. Shirley
- H. Laurens
- H. Nothmann-Zuckerkandl
- H. P. Bottelier
- H. P. Cooper
- H. Schröder
- H. Schweickerdt
- H. W. Popp
- H. W. Popp
- J. Benoit
- J. Engster
- J. L. Pech
- J. M. Arthur
- J. M. Arthur
- J. Pekarek
- J. Plotnikow
- J. Plotnikow
- J. Plotnikow
- J. Schulze
- J. Stephan
- J. Stephan
- K. Förster
- K. Mori
- K. Steiner
- K. W. Paetz
- L. Buchta
- L. C. Chesley
- L. H. Flint
- L. Klein
- L. Pincussen
- L. Pincussen
- L. Pincussen
- L. Schall
- L. V. Heilbrunn
- L. V. Heilbrunn
- M. Bodenstein
- M. M. Brooks
- M. Ponzio
- M. R. Wurmser
- N. E. Pfeiffer
- O. Jírovec
- O. V. Hykeš
- O. Valentová
- P. Lazarus
- P. R. Burkholder
- P. S. Hudson
- P. Wels
- Ph. Keller
- R. Audubert
- R. Murakami
- R. Stahl
- R. Volk
- R. Řetovský
- Rubinstein
- S. V. Simon
- S. V. Simon
- T. H. Bissonnette
- T. Reiter
- Th. Schmucker
- V. Dolejšek
- V. Ducceschi
- V. Pospíšil
- V. Rivera
- V. V. Alpatov
- V. V. Alpatov
- W. Besnard
- W. E. Tottingham
- W. E. Tottingham
- W. E. Tottingham
- W. E. Tottingham
- W. Hausmann
- W. J. V. Osterhout
- W. Noethling
- W. Vahle
- W. W. Lepeschkin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Stoma-free Survival After Rectal Cancer Resection With Anastomotic Leakage: Development and Validation of a Prediction Model in a Large International Cohort.
- Author
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A N
- Abdulwahed Eman
- Abelevich Alexander
- Abu Elnga Ahmed Nagm Eldin
- Abujamra Saleh
- Acar Nihan Coşgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N
- Agostinelli Laura
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alcázar Montero José A
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M H
- Alshareea Entisar
- Altomare Donato F
- Altrabulsi Amani
- Alvarez-Bautista Francisco E
- Amano Takahiro
- Amelung Femke J
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Armao Francesca T
- Arroyo Antonio
- Ashmore Daniel
- Atak İbrahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula González
- Avanagh Dara O
- Avellaneda Nicolas
- Aversano Alessia
- Aydın Oguzhan
- Ayoub Kusay
- Azevedo Constança
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balık Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bassyouni Ashoush Fouad M
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan P
- Belvedere Angela
- Benkabbou Amine
- Benčurik Vladimir
- Bernal-Sprekelsen Juan C
- Berney Christophe
- Bethune Rob M
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
- Bişgin TAYFUN
- Bjørsum-Meyer Thomas
- Blas Juan L
- Bloemen Johanne G
- Boerma Evert-Jan G
- Bonito Alba Correa
- Borda Francisco Javier García
- Borda-Arrizabalaga Nerea
- Bottazzoli Elisa I
- Boutall Adam
- Bouvy Nicole D
- Božič Tajda Košir
- Brachini Gioia
- Bradley Nicholas
- Bremers Andreas J A
- Buchs Nicolas
- Buchwald Pamela
- Bulut Mehmet Türker
- Burger Jacobus W A
- Burghgraef Thijs A
- Busund Sondre
- Buzzi Gianluca
- Buğra Dursun
- Calabrò Marcello
- Calero-Lillo Aránzazu
- Calik Bulent
- Carbone Fabio
- Carreño-Villarreal Guillermo
- Carrie Augusto
- Carvello Michele
- Carvello Michele
- Catena Fausto
- Cengiz Fevzi
- Cerbo Daniele
- Ceretti Andrea P
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
- Chawla Tabish
- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- CiftciEngin Aybar Ahmet B
- Cifuentes-Ródenas José A
- Cirillo Bruno
- Ciubotaru Cezar
- Ciubotaru Cezar
- Clerici Federico
- Coco Claudio
- Coetzee Emile
- Colak Elif
- Collard Maxime K
- Colucci Nicola
- Colás-Ruiz Enrique
- Connelly Tara M
- Consten Esther C J
- Consten Esther C J
- Corbellini Carlo
- Cotte Eddy
- Creemers Davy M J
- Crescentini Giacomo
- D'Agostino Luca
- D'Alimonte Lucrezia
- D'Hoore André
- da Costa Devesa Helena M
- da Silva Nigel
- Daester Silvio
- Darias Iván Soto
- Darlin Lotten
- Darwich Haitham
- Dattani Mit
- de Andrés Beatriz
- de Gheldere Charles
- de Graaf Eelco J R
- de Groot-van Veen Irene
- de Haan Jael
- de La Cruz Cuadrado Cristina
- de Lacy Francisco B
- de Manzoni Giovanni
- de Nes Lindsey C F
- de Paola Gilda
- de Pasqual Carlo A
- de Simone Belinda D
- de Vriendt Stefanie
- de Wilt Johannes H W
- Deeknah Abdulqudus
- Defoort Barbara
- deGiuli Maurizio
- Dekker Jan-Willem T
- Del Hoyo Aretxabala Izaskun
- Delrio Paolo
- Demirkiran Ahmet
- den Boer Frank
- Denost Quentin
- Dewulf Maxime
- deÁngelis Nicola
- di Cosmo Maria A
- Di Saverio Salomone
- Dimofte Gabriel-Mihail
- Dinaux Anne M
- Dittrich Luca S
- Diéguez Beatriz
- Docampo Iria Losada
- Dogan Lütfi
- Doornebosch Pascal G
- Drozdov EvgeniyS
- Dudi-Venkata Nagendra N
- Dursun Ayberk
- Dziakova Jana
- Düzgün Özgül
- Echaniz Garazi Elorza
- Echiguer Sabrillah
- Eduard Galliamov
- Egea Jorge García
- El Muhtaseb Mohammad S
- El-Massoudi Youssef
- Elhadi Muhammed
- Elshennawy Eslam M
- Enriquez-Navascués José M
- Erdinc Kemal
- Eriksen Jacob D
- Ersryd Amanda L
- Escartín Jorge
- Espín-Basany Eloy
- Estaire-Gómez Mercedes
- Estefanía Diego
- Ewedah Moataz
- Fabbri Nicolò
- Fares Hala
- Farguell Jordi
- Faria Luis Queiroz
- Farnesi Francesca
- Fazzin Marta
- Feo Carlo V
- Ferenschild Floris T
- Fernández Cristina López
- Fernández-Hevia María
- Fernández-Hevia María
- Fernández-Hurtado Ignacio
- Fernández-Martínez Daniel
- Fernández-Martínez Daniel
- Ferreira Cátia
- Ferreira Rita Marques
- Ferrer Rocío
- Filimonov Victor B
- Filipov Emil
- Fioravanti Emanuela
- Flamey Nicolas
- Florea Sabrina
- Folkesson Joakim
- Foppa Caterina
- Foppa Caterina
- Forgan Tim
- Fowler George E
- Frasson Matteo
- Frivold Tone
- Frontali Alice
- Fujiwara Hajime
- Futaba Kaori
- Gaard Maria
- Gadan Soran
- Galleano Raffaele
- Gallo Gaetano
- García-Flórez Luis J
- García-Flórez Luis J
- Gareb Fahed
- Garmanova Tatiana
- Garulli Gianluca
- Gecim Ibrahim E
- Geitenbeek Ritch
- George Sarah
- Ghazouani Omar
- Ghignone Federico
- Ghmagh Reem
- Gialamas Eleftherios
- Gielis Manuel
- Gil Lopez Jose M
- Giuffrida Mario
- Golshani Parisa
- Gonzalez Ricardo
- Gonzálvez Paula
- Goutard Claire-Angéline
- Grass Julia-Kristin
- Graure Giorgiana M
- Gregussen Hilde
- Greijdanus Nynke G
- Gribnev Petar
- Grosek Jan
- Grossi Ugo
- Grotenhuis Brechtje A
- Grüter Alexander A J
- Guel-Klein Safak
- Guenin Marc-Olivier
- Gurjar Shashank
- Gómez Tania
- Gómez-Abril Segundo Á
- Gómez-Jurado María J
- Göbüt Hüseyin
- Günenç Erşan
- Gürtler Thomas
- Güzel Melek
- Haberal Elifcan
- Haddad Anis
- Hajjaj Baraa Nabil
- Hamdan Alaa
- Hamid Hytham K S
- Hammoodi Hayder
- Hani Mohammad Bani
- Hannink Gerjon
- Hasan Bassam
- Hassan Naya
- Hassan Soha Y
- Havenga Klaas
- Hazen Sanne J A
- Heemskerk Jeroen
- Heesink Vera
- Heidsma Charlotte M
- Heijnen Bob H M
- Herman Ayesiga
- Hernández Miguel
- Herrero Eduardo Ferrero
- Hess Gabriel F
- Ho Man-Fung
- Ho Yiu M
- Hoff Christiaan
- Hol Jeroen C
- Hollington Paul
- Holman Fabian A
- Hompes Roel
- Hoogteijling Tijs J
- Hulshof Lorenzo G W L
- Hussein Mohamed
- Iacomino Alessandro
- Ibrahim Aini F
- Ismail Razif
- Ivanov Tsvetomir
- Iversen Lene H
- Jadid Kaveh Dehlaghi
- Jakubauskas Matas
- Jakubauskiene Lina
- Jangmalm Staffan
- Janssen Paul T J
- Jou-Valencia Daniela
- Julaihi Rokayah
- Jutesten Henrik
- Kacem Montasser
- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
- Kara Yasin
- Karamanliev Martin
- Karavokyros Ioannis
- Karmi Fahed
- Karsten Tom
- Karydakis Lysandros
- Kaya Tayfun
- Kelly Michael E
- Keskin Metin
- Ketelaers Stijn H J
- Khader Ahmed A E
- Khedr Gehan Abd Elatti
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- Konishi Tsuyoshi
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- Luncă Sorinel
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- Martínek Lubomír
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- Matthiessen Peter
- Mattioni Laura A
- McCormick Paul H
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- Mehigan Brian J
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- Mendes Ana Filipa Dias
- Meroni Paola
- Mia Imraan
- Mikalauskas Saulius
- Mingoli Andrea
- Mishra Amitabh
- Mitteregger Martin
- Miu Victor
- Moctezuma-Velázquez Paulina
- Mohamed Abudi
- Mohsine Raouf
- Monib Fatma A
- Monson John
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- Morgan Matthew
- Msherghi Ahmed A
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- Muratore Andrea
- Muriel Jorge Sancho
- Musters Gijsbert D
- Muñoz-Collado Salvador
- Mușină Ana-Maria
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- Ng Simon Siu-Man
- Niazi Ammar
- Nichita Vladimir-Ion
- Niemer Quirine
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- Oldani Massimo
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- Picciariello Arcangelo
- Picone Emanuele
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- Semião Miguel
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- Siaw Oliver
- Sıbıç Osman
- Sica Giuseppe
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- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
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- Solomon Michael
- Soriero Domenico
- Souadka Amine
- Spinelli Antonino
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- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Arend G J Aalbers Ernst J
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- Stoica Bogdan
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- Suchkov Igor A
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- Suárez Marta Castro
- Suárez-Sánchez Aida
- Suárez-Sánchez Aida
- Syllaios Athanasios
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- Sánchez Teresa Rubio
- Sánchez-Guillén Luis
- Sökmen SELMAN
- Tababa Osama W E
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- Tuynmann Jurriaan B
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- van den Broek Nathalie E J
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- van Kessel Charlotte S
- van Praagh Jasper B
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- van Westreenen Hendrik L
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- Vanclooster Patrick
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- Vasile Mihai
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- Vuagniaux Aurélie
- Vázquez Andrea
- Waqar Usama
- Waqar Usama
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- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G
- Wildeboer Aurelia C L
- Wolthuis Albert
- Wong Michael P K
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkın Ömer
- Yanishev Alexey
- Yüksel Osman
- Zabala Jesús Gómez
- Zakaria Andee D
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- Zukanović Goran
- Zwakman Marije
- Çakır Murat
- Özata İbrahim H
- Özgür İlker
- Özkan Ömer Faruk
- Ülgür Hanife Şeyda
- Šantak Goran
- Šimleša Damir
- Šlenfuktas Vygintas
- Žilinskas Justas
- Publication venue
- Publication date
- 01/01/2023
- Field of study
Objective:To develop and validate a prediction model (STOMA score) for 1-year stoma-free survival in patients with rectal cancer (RC) with anastomotic leakage (AL).Background:AL after RC resection often results in a permanent stoma.Methods:This international retrospective cohort study (TENTACLE-Rectum) encompassed 216 participating centres and included patients who developed AL after RC surgery between 2014 and 2018. Clinically relevant predictors for 1-year stoma-free survival were included in uni and multivariable logistic regression models. The STOMA score was developed and internally validated in a cohort of patients operated between 2014 and 2017, with subsequent temporal validation in a 2018 cohort. The discriminative power and calibration of the models' performance were evaluated.Results:This study included 2499 patients with AL, 1954 in the development cohort and 545 in the validation cohort. Baseline characteristics were comparable. One-year stoma-free survival was 45.0% in the development cohort and 43.7% in the validation cohort. The following predictors were included in the STOMA score: sex, age, American Society of Anestesiologist classification, body mass index, clinical M-disease, neoadjuvant therapy, abdominal and transanal approach, primary defunctioning stoma, multivisceral resection, clinical setting in which AL was diagnosed, postoperative day of AL diagnosis, abdominal contamination, anastomotic defect circumference, bowel wall ischemia, anastomotic fistula, retraction, and reactivation leakage. The STOMA score showed good discrimination and calibration (c-index: 0.71, 95% CI: 0.66-0.76).Conclusions:The STOMA score consists of 18 clinically relevant factors and estimates the individual risk for 1-year stoma-free survival in patients with AL after RC surgery, which may improve patient counseling and give guidance when analyzing the efficacy of different treatment strategies in future studies
Stoma-free survival after anastomotic leak following rectal cancer resection: worldwide cohort of 2470 patients
- Author
- Aalbers Arend G.J.
- Abbas Ayman
- Abbood Ali Hashim
- Abdeen Basel
- Abdelaal Ahmed Samir
- Abdullah Nik A.N.
- Abdulwahed Eman
- Abelevich Alexander
- Abujamra Saleh
- Acar Nihan Coşgun
- Afzal Asma
- Agalianos Christos
- Agapov Mikhail N.
- Agostinelli Laura
- Ahmed Nagm Eldin Abu Elnga
- Ahmed Safia
- Aigner Felix
- Akyol Cihangir
- Al-Eryani Fatima
- Al-Juaifari Maytham A.
- Al-Najami Issam
- Alanez-Saavedra Javier
- Albakry Rudaina
- Alhardan Anas
- Alhisi Ahmed Jehad
- Ali Ahmed K.
- Alkady Eithar
- Allmer Caterina
- Alonso Alfredo
- Alrayes Bourhan M.H.
- Alshareea Entisar
- Altomare Donato F.
- Altrabulsi Amani
- Alvarez-Bautista Francisco E.
- Amano Takahiro
- Amelung Femke J.
- Anderin Kajsa
- Annicchiarico Alfredo
- Ansorena Yolanda Saralegui
- Antona Francisco Blanco
- Antonopoulou Maria-Ioanna
- Aprile Alessandra
- Aranda María J. Pizarro
- Aretxabala Izaskun del Hoyo
- Armao Francesca T.
- Arroyo Antonio
- Ashmore Daniel
- Ashoush Fouad M. Bassyouni
- Atak İbrahim
- Atanasov Boyko
- Atici Semra Demirli
- Atienza Paula González
- Avanagh Dara O.
- Avellaneda Nicolas
- Aversano Alessia
- Aybar Ahmet B. CiftciEngin
- Aydin Oguzhan
- Ayoub Kusay
- Azevedo Constanca
- Baatrup Gunnar
- Baban Bayar
- Badiani Sarit
- Bahadoer Renu R.
- Baili Efstratia
- Balalis Dimitrios
- Balci Bengi
- Balik Emre
- Ballabio Michele
- Baloyiannis Ioannis
- Barbero-Valenzuela Alejandro
- Bavikatte Akshay
- Bazaev Andrey
- Belev Nikolay
- Bellato Vittoria
- Beltrán de Heredia Juan P.
- Belvedere Angela
- Benkabbou Amine
- Benčurik Vladimir
- Bernal-Sprekelsen Juan C.
- Berney Christophe
- Bethune Rob M.
- Bhandari Santosh
- Bhat Sameer
- Binder Alf-Dorian
- Biondi Alberto
- Bisagni Pietro
- Bislenghi Gabriele
- Bissett Ian
- Bişgin Tayfun
- Bjorsum-Meyer Thomas
- Blas Juan L.
- Bloemen Johanne G.
- Boerma Evert-Jan G.
- Bonito Alba Correa
- Borda Francisco Javier García
- Borda-Arrizabalaga Nerea
- Bottazzoli Elisa I.
- Boutall Adam
- Bouvy Nicole D.
- Božič Tajda Košir
- Brachini Gioia
- Bradley Nicholas
- Bremers Andreas J.A.
- Buchs Nicolas
- Buchwald Pamela
- Bulut Mehmet Turker
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- Busund Sondre
- Buzzi Gianluca
- Buğra Dursun
- Calabro Marcello
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- Carbone Fabio
- Carreño-Villarreal Guillermo
- Carrie Augusto
- Carvello Michele
- Carvello Michele
- Catena Fausto
- Cengiz Fevzi
- Cerbo Daniele
- Ceretti Andrea P.
- Chandio Ashfaq
- Chaoui Ahmed
- Charalabopoulos Alexandros
- Chaudhri Sanjay
- Chautems Roland
- Chawla Tabish
- Chawla Tabish
- Cholewa Hannia
- Christodoulidis Grigorios
- Chrysos Emmanuel
- Cifuentes-Ródenas José A.
- Cirillo Bruno
- Ciubotaru Cezar
- Ciubotaru Cezar
- Clerici Federico
- Coco Claudio
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- Colucci Nicola
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- Consten Esther C.J.
- Consten Esther C.J.
- Corbellini Carlo
- Cotte Eddy
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- Crescentini Giacomo
- D'Agostino Luca
- D'Alimonte Lucrezia
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- da Costa Devesa Helena M.
- da Silva Nigel
- Daester Silvio
- Darias Iván Soto
- Darlin Lotten
- Darwich Haitham
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- de Gheldere Charles
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- de Groot-Van Veen Irene
- de Haan Jael
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- Ferreira Catia
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- Fioravanti Emanuela
- Flamey Nicolas
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- Folkesson Joakim
- Foppa Caterina
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- Forgan Tim
- Fowler George E.
- Frasson Matteo
- Frivold Tone
- Frontali Alice
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- George Sarah
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- Ghmagh Reem
- Gialamas Eleftherios
- Gielis Manuel
- Giuffrida Mario
- Gobut Huseyin
- Golshani Parisa
- Gonzalez Ricardo
- Gonzálvez Paula
- Goutard Claire-Angéline
- Grass Julia-Kristin
- Graure Giorgiana M.
- Gregussen Hilde
- Greijdanus Nynke G.
- Gribnev Petar
- Grosek Jan
- Grossi Ugo
- Grotenhuis Brechtje A.
- Gruter Alexander A.J.
- Guel-Klein Safak
- Guenin Marc-Olivier
- Gunenc Erşan
- Gurjar Shashank
- Gurtler Thomas
- Guzel Melek
- Gómez Tania
- Gómez-Abril Segundo Á.
- Gómez-Jurado María J.
- Haberal Elifcan
- Haddad Anis
- Hajjaj Baraa Nabil
- Hamdan Alaa
- Hamid Hytham K.S.
- Hammoodi Hayder
- Hani Mohammad Bani
- Hannink Gerjon
- Hasan Bassam
- Hassan Naya
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- Havenga Klaas
- Hazen Sanne J.A.
- Heemskerk Jeroen
- Heesink Vera
- Heidsma Charlotte M.
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- Hernández Miguel
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- Hess Gabriel F.
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- Hussein Mohamed
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- Ivanov Tsvetomir
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- Jou-Valencia Daniela
- Julaihi Rokayah
- Jutesten Henrik
- Kacem Montasser
- Kader Rawaz
- Kamer Erdinc
- Kapadia Raj
- Kara Yasin
- Karamanliev Martin
- Karavokyros Ioannis
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- Leijtens Jeroen W.A.
- Leung Edmund
- Leventoğlu Sezai
- Lindqvist Ebba
- Liu Jianliang
- Longhi Marco
- Lopez Jose M. Gil
- Lorenzon Laura
- Lorusso Leonardo
- Losada Manuel
- Lucchi Andrea
- Luncă Sorinel
- Lutfi Hamid
- Lydrup Marie-Louise
- López-Lara Manuel
- López-Rodríguez-Arias Francisco
- Macau Florin
- Machackova Maria
- Maghrebi Houcine
- Majbar Mohammed A.
- Mak Tony Wing-Chung
- Manatakis Dimitrios
- Mansour Ali
- Manzo Carlo A.
- Marchegiani Francesco
- Marcos Elena Bermejo
- Mariani Nicolò M.
- Marinelli Andreas
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- Maroli Annalisa
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- Picone Emanuele
- Pikuniene Ingrida
- Pinto Francisca Lima
- Pire-Abaitua Gerardo
- Pirozzolo Giovanni
- Piyadeoğlu Deniz
- Plastiras Aris
- Pletinckx Pieter
- Polat Fatih
- Polle Sebastiaan W.
- Polydorou Adreas
- Porta Andrea
- Poskus Tomas
- Pratschke Johann
- Pringle Heather C.M.
- Puca Lucia
- Pucciarelli Salvatore
- Qandeel Mahmoud W.M.
- Quintana Rita E. Medina
- Quiroga Ignacio Bodega
- Quiroga-Valcárcel Ana
- Rabadi Alexander
- Ramboiu Stefan Patrascu Sandu D.
- Ramsay George
- Rani Pallavi
- Rani Pallavi
- Rauf Hareem
- Rauf Hareem
- Recordare Alfonso
- Reddavid Rossella
- Rega Daniela
- Reudink Muriël
- Riedl Peter
- Riis Rolf
- Ripoli Maria Cristina
- Ris Frederic
- Rizzo Gianluca
- Roată Cristian-Ene
- Rodimov Sergey V.
- Rodríguez Carlos Sáez-Cazallas
- Rodríguez-Infante Antonio
- Romano Angela
- Rompou Aliki
- Roos Daphne
- Roscio Francesco
- Rosman Camiel
- Rotholtz Nicolas
- Rottoli Matteo
- Ruiz Hernan
- Runau Francois
- Rutegård Martin
- Rutten Harm J.T.
- Ruíz-García Pablo
- Ryan Jessica
- Rydbeck Daniel
- Saad Ahmad
- Sacchi Matteo M.
- Sacchi Matteo M.
- Sainz-Hernández Juan C.
- Salgado-Nesme Noel
- Salomon Mario
- Sambucci Daniele
- Sammarco Giuseppe
- Sammour Tarik
- Sampietro Gianluca M.
- Samsa Mehmet Veysi
- Santacruz Carlos Cerdán
- Santillan Mateo
- Santoro Giulio A.
- Sari Ahmet Can
- Sarmah Panchali
- Sarveswaran Janahan
- Sauvain Marc-Olivier
- Scabini Stefano
- Scheurink Lieke
- Schizas Dimitrios
- Schultz Johannes K.
- Sebai Amine
- Sebastian Boby
- Segelman Josefin
- Seitinger Gerald
- Semiao Miguel
- Septiem Javier García
- Serralta Daniel
- Shaban Mohamed
- Shaikh Shafaque
- Shapiro Joël
- Siaw Oliver
- Sibiç Osman
- Sica Giuseppe
- Sietses Colin
- Singh Baljit
- Singh Nirbhaibir
- Singh-Ranger Deepak
- Sinibaldi Giovanni
- Siragusa Leandro
- Sivrikoz Emre
- Sjo Ole H.
- Sjostrom Olle
- Skrovina Matej
- Sköldberg Filip
- Slavchev Mihail
- Slooter Gerrit D.
- Smeeing Diederik P.J.
- Sokmen Selman
- Sokolov Manol
- Soler-Silva Álvaro
- Solomon Michael
- Soriero Domenico
- Souadka Amine
- Spinelli Antonino
- Spinelli Antonino
- Spolverato Gaya
- Staffan Maria
- Stefanescu Victor
- Steller Ernst J.
- Stienstra Roxane M.
- Stoica Bogdan
- Stoica Bogdan
- Suchkov Igor A.
- Sultan Hytham
- Surlin Valeriu M.
- Suárez Marta Castro
- Suárez-Sánchez Aida
- Syllaios Athanasios
- Sánchez Teresa Rubio
- Sánchez-Guillén Luis
- Tababa Osama W.E.
- Taha-Mehlitz Stephanie
- Talboom Kevin
- Talsma Aaldert K.
- Tamelis Algimantas
- Tamini Nicolò
- Tanase Ioan
- Tanis Pieter J.
- Tantoura Mohammad
- Tanzanu Marta
- Tasende-Presedo Marta M.
- Tasis Nikolaos
- Taverne Sophie B.M.
- Tejedor Patricia
- Teras Juri
- Teras Roland M.
- Tiefenthal Marit
- Tomasicchio Giovanni
- Tomažič Aleš
- Tonchev Pencho
- Toorenvliet Boudewijn R.
- Torres María T.
- Toso Christian
- Tsimogiannis Konstantinos
- Tuynmann Jurriaan B.
- Tzovaras George
- Ubels Sander
- Ugolini Giampaolo
- Ulgur Hanife Şeyda
- Uluk Deniz
- Vailas Michail
- Vailati Bruna B.
- van Dalsen Annette D.
- van den Broek Nathalie E.J.
- van den Hengel Berber
- van der Burg Sjirk
- van der Zijden Charlène J.
- van Gerven Pieter
- van Kessel Charlotte S.
- van Praagh Jasper B.
- van Schaik Ted G.
- van Westreenen Hendrik L.
- van Workum Frans
- Vanclooster Patrick
- Vansteenbrugge Louis
- Vasile Mihai
- Venianaki Maria
- Verdaasdonk Emiel G.G.
- Vergara-Fernández Omar
- Vermaas Maarten
- Verstappen Sonja
- Vignotto Chiara
- Villar Óscar García
- Vittori Laura
- Vles Wouter J.
- von Flue Markus
- Voron Thibault
- Vosbeek Noortje
- Vuagniaux Aurelie
- Vázquez Andrea
- Waqar Usama
- Waqar Usama
- Ward Nicholas
- Warden Claire
- Westerterp Marinke
- Wienholts Kiedo
- Wiering Bastiaan
- Wijma Allard G.
- Wildeboer Aurelia C.L.
- Wolthuis Albert
- Wong Michael P.K.
- Woods Kayla
- Xenaki Sofia
- Xynos Evangelos
- Yalkin Omer
- Yanishev Alexey
- Yuksel Osman
- Zabala Jesús Gómez
- Zakaria Andee D.
- Zakaria Zaidi
- Zanini Nicola
- Zanus Giacomo
- Zazo Aya
- Zazo Rama
- Zucchella Martino
- Zukanović Goran
- Zwakman Marije
- Çakir Murat
- Ćosić Jurica
- Šantak Goran
- Šimleša Damir
- Šlenfuktas Vygintas
- Žilinskas Justas
- Publication venue
- Publication date
- 01/12/2023
- Field of study
Background: The optimal treatment of anastomotic leak after rectal cancer resection is unclear. This worldwide cohort study aimed to provide an overview of four treatment strategies applied. Methods: Patients from 216 centres and 45 countries with anastomotic leak after rectal cancer resection between 2014 and 2018 were included. Treatment was categorized as salvage surgery, faecal diversion with passive or active (vacuum) drainage, and no primary/secondary faecal diversion. The primary outcome was 1-year stoma-free survival. In addition, passive and active drainage were compared using propensity score matching (2: 1). Results: Of 2470 evaluable patients, 388 (16.0 per cent) underwent salvage surgery, 1524 (62.0 per cent) passive drainage, 278 (11.0 per cent) active drainage, and 280 (11.0 per cent) had no faecal diversion. One-year stoma-free survival rates were 13.7, 48.3, 48.2, and 65.4 per cent respectively. Propensity score matching resulted in 556 patients with passive and 278 with active drainage. There was no statistically significant difference between these groups in 1-year stoma-free survival (OR 0.95, 95 per cent c.i. 0.66 to 1.33), with a risk difference of -1.1 (95 per cent c.i. -9.0 to 7.0) per cent. After active drainage, more patients required secondary salvage surgery (OR 2.32, 1.49 to 3.59), prolonged hospital admission (an additional 6 (95 per cent c.i. 2 to 10) days), and ICU admission (OR 1.41, 1.02 to 1.94). Mean duration of leak healing did not differ significantly (an additional 12 (-28 to 52) days). Conclusion: Primary salvage surgery or omission of faecal diversion likely correspond to the most severe and least severe leaks respectively. In patients with diverted leaks, stoma-free survival did not differ statistically between passive and active drainage, although the increased risk of secondary salvage surgery and ICU admission suggests residual confounding