98 research outputs found
Negative emotions in informal feedback: The benefits of disappointment and drawbacks of anger
Using the emotions as social information (EASI) model, this study investigated the emotional, attitudinal and behavioral reactions to failure feedback by manipulating negative emotional displays (angry, disappointed or none) and the position level and relational distance of the feedback source. Undergraduate students (N = 260) responded to an organizational failure feedback vignette and completed a subsequent performance task. Results demonstrated that guilt was the complementary emotional experience following displays of disappointment, while reciprocal anger followed displays of anger. These emotional reactions served as important mediators between the emotional displays paired with the feedback message and participant responses of social behaviors, creative task performance and perceptions of the feedback source. In addition, our findings indicated that negative emotions can have positive organizational and interpersonal outcomes. Guilt in response to disappointed displays resulted in beneficial behaviors and attitudes, while anger in response to angry displays was socially detrimental. The emotion displayed during feedback provision also served as a consistent contextual factor that did not interact with the position level or relational distance of the feedback source to impact behavioral and attitudinal reactions. Overall, this study indicates that discrete negative emotions have unique social-functional properties that require further investigation.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline
The Lack of Natural IgM Increases Susceptibility and Impairs Anti-Vi Polysaccharide IgG Responses in a Mouse Model of Typhoid
Circulating IgM present in the body prior to any apparent Ag exposure is referred to as natural IgM. Natural IgM provides protective immunity against a variety of pathogens. Salmonella enterica serovar Typhi (S. Typhi) is the causative agent of typhoid fever in humans. Because mice are not permissive to S. Typhi infection, we employed a murine model of typhoid using S. enterica serovar Typhimurium expressing the Vi polysaccharide (ViPS) of S. Typhi (S. Typhimurium strain RC60) to evaluate the role of natural IgM in pathogenesis. We found that natural mouse IgM binds to S. Typhi and S. Typhimurium. The severity of S. Typhimurium infection in mice is dependent on presence of the natural resistance-associated macrophage protein 1 (Nramp1) allele; therefore, we infected mice deficient in secreted form of IgM (sIgM) on either a Nramp1-resistant (129S) or -susceptible (C57BL/6J) background. We found that the lack of natural IgM results in a significantly increased susceptibility and an exaggerated liver pathology regardless of the route of infection or the Nramp1 allele. Reconstitution of sIgM-/- mice with normal mouse serum or purified polyclonal IgM restored the resistance to that of sIgM+/+ mice. Furthermore, immunization of sIgM-/- mice with heat-killed S. Typhi induced a significantly reduced anti-ViPS IgG and complement-dependent bactericidal activity against S. Typhi in vitro, compared with that of sIgM+/+ mice. These findings indicate that natural IgM is an important factor in reducing the typhoid severity and inducing an optimal anti-ViPS IgG response to vaccination
Joint associations of poor diet quality and prolonged television viewing time with abnormal glucose metabolism in Australian men and women
Objective. To examine the independent and joint associations of diet quality and television viewing time with abnormal glucose metabolism (AGM) in men and women
Novel diagnostic DNA methylation episignatures expand and refine the epigenetic landscapes of Mendelian disorders
Overlapping clinical phenotypes and an expanding breadth and complexity of genomic associations are a growing challenge in the diagnosis and clinical management of Mendelian disorders. The functional consequences and clinical impacts of genomic variation may involve unique, disorder-specific, genomic DNA methylation episignatures. In this study, we describe 19 novel episignature disorders and compare the findings alongside 38 previously established episignatures for a total of 57 episignatures associated with 65 genetic syndromes. We demonstrate increasing resolution and specificity ranging from protein complex, gene, sub-gene, protein domain, and even single nucleotide-level Mendelian episignatures. We show the power of multiclass modeling to develop highly accurate and disease-specific diagnostic classifiers. This study significantly expands the number and spectrum of disorders with detectable DNA methylation episignatures, improves the clinical diagnostic capabilities through the resolution of unsolved cases and the reclassification of variants of unknown clinical significance, and provides further insight into the molecular etiology of Mendelian conditions
Living Well with Diabetes: a randomized controlled trial of a telephone-delivered intervention for maintenance of weight loss, physical activity and glycaemic control in adults with type 2 diabetes
Background By 2025, it is estimated that approximately 1.8 million Australian adults (approximately 8.4% of the adult population) will have diabetes, with the majority having type 2 diabetes. Weight management via improved physical activity and diet is the cornerstone of type 2 diabetes management. However, the majority of weight loss trials in diabetes have evaluated short-term, intensive clinic-based interventions that, while producing short-term outcomes, have failed to address issues of maintenance and broad population reach. Telephone-delivered interventions have the potential to address these gaps. Methods/Design Using a two-arm randomised controlled design, this study will evaluate an 18-month, telephone-delivered, behavioural weight loss intervention focussing on physical activity, diet and behavioural therapy, versus usual care, with follow-up at 24 months. Three-hundred adult participants, aged 20-75 years, with type 2 diabetes, will be recruited from 10 general practices via electronic medical records search. The Social-Cognitive Theory driven intervention involves a six-month intensive phase (4 weekly calls and 11 fortnightly calls) and a 12-month maintenance phase (one call per month). Primary outcomes, assessed at 6, 18 and 24 months, are: weight loss, physical activity, and glycaemic control (HbA1c), with weight loss and physical activity also measured at 12 months. Incremental cost-effectiveness will also be examined. Study recruitment began in February 2009, with final data collection expected by February 2013. Discussion This is the first study to evaluate the telephone as the primary method of delivering a behavioural weight loss intervention in type 2 diabetes. The evaluation of maintenance outcomes (6 months following the end of intervention), the use of accelerometers to objectively measure physical activity, and the inclusion of a cost-effectiveness analysis will advance the science of broad reach approaches to weight control and health behaviour change, and will build the evidence base needed to advocate for the translation of this work into population health practice
A united statement of the global chiropractic research community against the pseudoscientific claim that chiropractic care boosts immunity.
BACKGROUND: In the midst of the coronavirus pandemic, the International Chiropractors Association (ICA) posted reports claiming that chiropractic care can impact the immune system. These claims clash with recommendations from the World Health Organization and World Federation of Chiropractic. We discuss the scientific validity of the claims made in these ICA reports. MAIN BODY: We reviewed the two reports posted by the ICA on their website on March 20 and March 28, 2020. We explored the method used to develop the claim that chiropractic adjustments impact the immune system and discuss the scientific merit of that claim. We provide a response to the ICA reports and explain why this claim lacks scientific credibility and is dangerous to the public. More than 150 researchers from 11 countries reviewed and endorsed our response. CONCLUSION: In their reports, the ICA provided no valid clinical scientific evidence that chiropractic care can impact the immune system. We call on regulatory authorities and professional leaders to take robust political and regulatory action against those claiming that chiropractic adjustments have a clinical impact on the immune system
ĐДжЎŃĐœĐ°ŃĐŸĐŽĐœŃĐč ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœŃĐč ĐșĐŸĐœĐșŃŃŃ ĐČ ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžĐž ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ ĐżŃĐŸĐČĐ”ĐŽĐ”ĐœĐžŃ (ĐœĐ° ĐżŃĐžĐŒĐ”ŃĐ” ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ 2017)
ĐĐœĐœĐŸŃĐ°ŃĐžŃ ĐČŃĐżŃŃĐșĐœĐŸĐč ĐșĐČалОŃĐžĐșĐ°ŃĐžĐŸĐœĐœĐŸĐč ŃĐ°Đ±ĐŸŃŃ ĐŃĐ»ĐŸĐČ ĐĐžĐșĐžŃĐ° ĐĄĐ”ŃгДДĐČĐžŃ Â«ĐĐĐĐĐŁĐĐĐ ĐĐĐĐ«Đ ĐĐŁĐĐ«ĐĐĐĐŹĐĐ«Đ ĐĐĐĐĐŁĐ ĐĄ РЀĐĐ ĐĐĐ ĐĐĐĐĐĐ ĐĐĐĐĐРХйРĐĐĐ« ĐĐ ĐĐĐĐĐĐĐĐŻ (ĐĐ ĐĐ ĐĐĐĐ Đ ĐĐĐ ĐĐĐĐĐĐĐĐŻ-2017)» Đ. ŃŃĐș. - ĐŃĐșĐŸĐČĐ° ĐĐ»Đ”ĐœĐ° ĐĐ»Đ°ĐŽĐžĐŒĐžŃĐŸĐČĐœĐ°, ĐŽĐŸĐșŃĐŸŃ ŃĐžĐ»ĐŸĐ»ĐŸĐłĐžŃĐ”ŃĐșĐžŃ
ĐœĐ°ŃĐș, ĐŽĐŸŃĐ”ĐœŃ ĐĐ°ŃДЎŃĐ° ŃĐČŃĐ·Đ”Đč Ń ĐŸĐ±ŃĐ”ŃŃĐČĐ”ĐœĐœĐŸŃŃŃŃ ĐŃĐœĐ°Ń ŃĐŸŃĐŒĐ° ĐŸĐ±ŃŃĐ”ĐœĐžŃ ĐĐșŃŃĐ°Đ»ŃĐœĐŸŃŃŃ: ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœŃĐč ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœŃĐč ĐșĐŸĐœĐșŃŃŃ ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžĐ” ĐșĐ°Đș ŃĐ°ĐŒĐŸĐ” ĐŒĐ°ŃŃŃĐ°Đ±ĐœĐŸĐ” ŃДгŃĐ»ŃŃĐœĐŸĐ” ĐČŃŃĐŸĐșĐŸŃĐ”Ń
ĐœĐŸĐ»ĐŸĐłĐžŃĐœĐŸĐ” ŃДлДĐČĐžĐ·ĐžĐŸĐœĐœĐŸĐ” Đž ĐŒĐ”ĐŽĐžĐ°-ŃĐŸĐ±ŃŃОД, ĐșĐŸŃĐŸŃĐŸĐ” . Đ Đ”Đ¶Đ”ĐłĐŸĐŽĐœĐŸ Đ°ĐșŃĐ”ĐœŃĐžŃŃĐ”Ń ĐČĐœĐžĐŒĐ°ĐœĐžĐ” Đ°ŃĐŽĐžŃĐŸŃОО ĐœĐ° ĐœĐ°ŃĐžĐŸĐœĐ°Đ»ŃĐœĐŸ-ĐșŃĐ»ŃŃŃŃĐœŃŃ
ĐŸŃĐŸĐ±Đ”ĐœĐœĐŸŃŃŃŃ
ŃŃŃĐ°ĐœŃ-ĐŸŃĐłĐ°ĐœĐžĐ·Đ°ŃĐŸŃĐ° ĐșĐŸĐœĐșŃŃŃĐ°, ŃĐŸŃĐŒĐžŃŃĐ”Ń Đ·ĐœĐ°ŃĐžŃДлŃĐœŃĐ” ŃŃŃĐžŃŃĐžŃĐ”ŃĐșОД ĐżĐŸŃĐŸĐșĐž Đž ŃĐ”ĐŒ ŃĐ°ĐŒŃĐŒ ŃĐżĐŸŃĐŸĐ±ŃŃĐČŃĐ”Ń ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃĐ”ŃŃĐžŃĐŸŃОО. ĐĐŸĐ»Đ”Đ” ŃĐŸĐłĐŸ, ĐżĐŸĐ±Đ”ĐŽĐ° ŃŃŃĐ°ĐœŃ-ŃŃĐ°ŃŃĐœĐžŃŃ ĐșĐŸĐœĐșŃŃŃĐ° ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ Đ·Đ°ŃĐ°ŃŃŃŃ ĐŸŃŃĐ°Đ¶Đ°Đ”Ń ĐžĐŽĐ”ĐŸĐ»ĐŸĐłĐŸ-ĐżĐŸĐ»ĐžŃĐžŃĐ”ŃĐșĐžĐč ĐČĐ”ĐșŃĐŸŃ ĐĐČŃĐŸĐżŃ Đž ĐżĐŸ ŃŃŃĐž ЎДла ĐČŃĐżĐŸĐ»ĐœŃĐ”Ń ŃŃĐœĐșŃĐžŃ ĐżĐŸĐ»ĐžŃĐžŃĐ”ŃĐșĐŸĐłĐŸ PR ŃŃŃĐ°ĐœŃ-ĐżĐŸĐ±Đ”ĐŽĐžŃĐ”Đ»Ń Đž ŃŃŃĐ°ĐœŃ-Ń
ĐŸĐ·ŃĐčĐșĐž ĐŒĐ”ŃĐŸĐżŃĐžŃŃĐžŃ. ĐĄĐ»Đ”ĐŽĐŸĐČĐ°ŃДлŃĐœĐŸ Đ°ĐœĐ°Đ»ĐžĐ· ĐžŃĐżĐŸĐ»ŃĐ·ŃĐ”ĐŒŃŃ
ĐœĐ° ĐŒĐ”ŃĐŸĐżŃĐžŃŃОО ĐșĐŸĐŒĐŒŃĐœĐžĐșĐ°ŃĐžĐČĐœŃŃ
ŃĐ”Ń
ĐœĐŸĐ»ĐŸĐłĐžĐč ŃĐČĐ»ŃĐ”ŃŃŃ Đ°ĐșŃŃĐ°Đ»ŃĐœŃĐŒ Đž ĐČĐŸŃŃŃĐ”Đ±ĐŸĐČĐ°ĐœĐœŃĐŒ ĐŽĐ»Ń ŃĐŸĐ±ŃŃĐžĐčĐœĐŸĐłĐŸ Đž ŃŃŃŃĐŸĐžŃДлŃĐœĐŸĐłĐŸ PR ĐбŃĐ”ĐșŃ ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ: ĐșĐŸĐŒĐŒŃĐœĐžĐșĐ°ŃĐžĐŸĐœĐœŃĐ” Đ°ĐșŃĐžĐČĐœĐŸŃŃĐž ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœĐŸĐłĐŸ ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœĐŸĐłĐŸ ĐșĐŸĐœĐșŃŃŃĐ° (ĐœĐ° ĐżŃĐžĐŒĐ”ŃĐ” ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ ĐČ ĐОДĐČĐ” ĐČ 2017 Đł.). ĐŃĐ”ĐŽĐŒĐ”Ń ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ: ŃŃĐœĐșŃĐžŃ ŃŃĐ°ŃŃŃĐœĐŸĐłĐŸ PR-ĐŒĐ”ŃĐŸĐżŃĐžŃŃĐžŃ ĐČ ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžĐž ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ. ĐŠĐ”Đ»Ń ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ: ĐŽĐŸĐșĐ°Đ·Đ°ŃŃ, ŃŃĐŸ ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœŃĐč ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœŃĐč ĐșĐŸĐœĐșŃŃŃ ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžĐ” ŃĐżĐŸŃĐŸĐ±ŃŃĐČŃĐ”Ń ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ ĐżŃĐŸĐČĐ”ĐŽĐ”ĐœĐžŃ. ĐĐ°ĐŽĐ°ŃĐž ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ: ŃĐ°Đ·ŃĐ°Đ±ĐŸŃĐ°ŃŃ ŃĐ”ŃĐŒĐžĐœĐŸĐ»ĐŸĐłĐžŃĐ”ŃĐșĐžĐč аппаŃĐ°Ń ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ ĐœĐ° ĐŸŃĐœĐŸĐČĐ” ĐœĐ°ŃŃĐœĐŸĐč лОŃĐ”ŃĐ°ŃŃŃŃ ĐżĐŸ ĐžĐŒĐžĐŽĐ¶ĐŒĐ”ĐčĐșĐžĐœĐłŃ, бŃĐ”ĐœĐŽĐžĐœĐłŃ Đž ĐžĐČĐ”ĐœŃ-ĐŒĐ”ĐœĐ”ĐŽĐ¶ĐŒĐ”ĐœŃŃ; ĐŸĐżŃДЎДлОŃŃ Đ°ĐșŃŃĐ°Đ»ŃĐœŃĐ” ĐșĐŸĐŒĐŒŃĐœĐžĐșĐ°ŃĐžĐŸĐœĐœŃĐ” ŃĐ”Ń
ĐœĐŸĐ»ĐŸĐłĐžĐž, ĐżŃĐžĐŒĐ”ĐœŃĐ”ĐŒŃĐ” ĐČ ŃĐ°ĐŒĐșĐ°Ń
ŃпДŃОалŃĐœŃŃ
ŃĐŸĐ±ŃŃĐžĐč ĐŽĐ»Ń ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ; ĐŸĐżĐžŃĐ°ŃŃ ŃĐŸĐ»Ń ĐĐČŃĐŸĐżĐ”ĐčŃĐșĐŸĐłĐŸ ĐĐ”ŃĐ°ŃДлŃĐœĐŸĐłĐŸ ĐĄĐŸŃĐ·Đ° ĐșĐ°Đș ĐŸŃĐłĐ°ĐœĐžĐ·Đ°ŃĐŸŃĐ° ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ ĐČ ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžĐž ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ ĐżŃĐŸĐČĐ”ĐŽĐ”ĐœĐžŃ ĐșĐŸĐœĐșŃŃŃĐ°; ĐŸŃĐ”ĐœĐžŃŃ ŃŃŃĐ”ĐșŃĐžĐČĐœĐŸŃŃŃ ŃĐ”Đ°Đ»ĐžĐ·ĐŸĐČĐ°ĐœĐœŃŃ
ĐșĐŸĐŒĐŒŃĐœĐžĐșĐ°ŃĐžĐČĐœŃŃ
ŃĐ”Ń
ĐœĐŸĐ»ĐŸĐłĐžĐč ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ ĐČ ŃĐ°ĐŒĐșĐ°Ń
ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ; ĐŽĐ°ŃŃ ŃĐ”ĐșĐŸĐŒĐ”ĐœĐŽĐ°ŃОО ĐżĐŸ ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ Ń ĐżĐŸĐŒĐŸŃŃŃ ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ. ĐąĐ”ĐŸŃĐ”ŃĐžŃĐ”ŃĐșĐ°Ń Đ±Đ°Đ·Đ°: ĐœĐ°ŃŃĐœŃĐ” ŃŃŃĐŽŃ Đ. ĐŃĐșĐŸĐČĐŸĐč, Đ. ĐĐ°ĐČŃŃ, Đ. ĐĐ°ĐœĐșŃŃŃ
ĐžĐœĐ°, Đ. ĐĐ¶Đ”ĐœĐ”ŃĐ°, Đ. ĐĐ°ĐČĐ”ŃĐžĐœĐŸĐč, ĐŁ. Đ„Đ°Đ»ŃŃбаŃŃĐ°, Đж. ĐĐŸĐ»ĐŽĐ±Đ»Đ°ŃŃĐ° Đ° ŃĐ°ĐșжД ŃŃŃĐŽŃ Đ. ĐĐ°ŃŃĐŒĐ°ĐœĐ° ĐŸ ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœĐŸĐŒ Đ±ĐžĐ·ĐœĐ”ŃĐ”, Đ. ĐĐ¶ĐŸŃĐŽĐ°ĐœĐ° ĐŸ ĐżŃĐŸĐŽĐČĐžĐ¶Đ”ĐœĐžĐž ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°Đœ Ń ĐżĐŸĐŒĐŸŃŃŃ ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ Đž ĐŽŃ. ĐĐŒĐżĐžŃĐžŃĐ”ŃĐșĐ°Ń Đ±Đ°Đ·Đ°: PR-ĐŽĐŸĐșŃĐŒĐ”ĐœŃŃ, ŃĐ°Đ·ĐŒĐ”ŃĐ”ĐœĐœŃĐ” ĐœĐ° ŃĐ°ĐčŃĐ” ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ Đž ĐĐČŃĐŸĐżĐ”ĐčŃĐșĐŸĐłĐŸ ĐĐ”ŃĐ°ŃДлŃĐœĐŸĐłĐŸ ĐĄĐŸŃĐ·Đ°; Đ±ĐŸĐ»Đ”Đ” ĐżĐŸĐ»ŃŃĐŸŃĐ° ĐŒĐžĐ»Đ»ĐžĐŸĐœĐ° ŃŃĐ°ŃĐ”Đč ĐŸĐ± ĐŁĐșŃĐ°ĐžĐœĐ” ĐČ Đ”ĐČŃĐŸĐżĐ”ĐčŃĐșĐžŃ
ĐĄĐĐ, ŃĐ°Đ·ĐŒĐ”ŃĐ”ĐœĐœŃĐ” ĐČ Đ±Đ°Đ·Đ” ĐżŃĐŸĐ”ĐșŃĐ° ĐŒĐŸĐœĐžŃĐŸŃĐžĐœĐłĐ° ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœĐŸĐłĐŸ ĐžĐŒĐžĐŽĐ¶Đ° ĐŁĐșŃĐ°ĐžĐœŃ Â«Oko»; ĐŽĐ°ĐœĐœŃĐ” Đ±Đ°Đ·Ń ĐŒĐ°ŃĐ”ŃĐžĐ°Đ»ĐŸĐČ ĐĄĐĐ Đž ŃĐŸŃОалŃĐœŃŃ
ĐŒĐ”ĐŽĐžĐ° Factiva; ĐŽĐ°ĐœĐœŃĐ” Google.Analytics. ĐŃĐ°ĐșŃĐžŃĐ”ŃĐșĐ°Ń Đ·ĐœĐ°ŃĐžĐŒĐŸŃŃŃ: ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžĐ” ĐŽĐŸĐșĐ°Đ·ŃĐČĐ°Đ”Ń, ŃŃĐŸ ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœŃĐč ĐŒŃĐ·ŃĐșĐ°Đ»ŃĐœŃĐč ĐșĐŸĐœĐșŃŃŃ ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžĐ” ŃĐŸŃĐŒĐžŃŃĐ”Ń ĐžĐŒĐžĐŽĐ¶ ŃŃŃĐ°ĐœŃ ĐżŃĐŸĐČĐ”ĐŽĐ”ĐœĐžŃ ĐœĐ”Đ·Đ°ĐČĐžŃĐžĐŒĐŸ ĐŸŃ ŃŃпДŃĐœĐŸŃŃĐž ĐžŃĐżĐŸĐ»ŃĐ·ĐŸĐČĐ°ĐœĐžŃ ĐșĐŸĐœĐșŃĐ”ŃĐœŃŃ
ŃĐ”Ń
ĐœĐŸĐ»ĐŸĐłĐžĐč ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ. йДзОŃŃ ĐžŃŃĐ»Đ”ĐŽĐŸĐČĐ°ĐœĐžŃ Đ±ŃлО Đ°ĐżŃĐŸĐ±ĐžŃĐŸĐČĐ°ĐœŃ ĐœĐ° ĐŒĐ”Đ¶ĐŽŃĐœĐ°ŃĐŸĐŽĐœĐŸĐŒ ĐœĐ°ŃŃĐœĐŸĐŒ ŃĐŸŃŃĐŒĐ” «ĐДЎОа ĐČ ŃĐŸĐČŃĐ”ĐŒĐ”ĐœĐœĐŸĐŒ ĐŒĐžŃĐ”. 57-Đ” ĐĐ”ŃĐ”ŃбŃŃĐłŃĐșОД ŃŃĐ”ĐœĐžŃ», ĐŸĐżŃблОĐșĐŸĐČĐ°ĐœŃ ĐČ ŃĐ±ĐŸŃĐœĐžĐșĐ” ĐŒĐ°ŃĐ”ŃĐžĐ°Đ»ĐŸĐČ ŃŃĐ°ŃĐ”Đč ŃĐŸŃŃĐŒĐ° Đž ĐžĐŒĐ”ŃŃ ŃŃĐ°ŃŃŃ ĐœĐ°ŃŃĐœĐŸĐč ŃŃĐ°ŃŃĐž, ŃĐ°Đ·ĐŒĐ”ŃĐ”ĐœĐœĐŸĐč ĐČ Đ±Đ°Đ·Đ” Đ ĐĐĐŠ. ĐĄŃŃŃĐșŃŃŃĐ° ŃĐ°Đ±ĐŸŃŃ: Đ Đ°Đ±ĐŸŃĐ° ŃĐŸŃŃĐŸĐžŃ ĐžĐ· ĐČĐČĐ”ĐŽĐ”ĐœĐžŃ, 3 глаĐČ: «ŃŃĐœĐșŃĐžŃ ŃпДŃОалŃĐœĐŸĐłĐŸ ŃĐŸĐ±ŃŃĐžŃ ĐČ ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžĐž ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ», «ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžĐ” ĐșĐ°Đș ŃпДŃОалŃĐœĐŸĐ” ŃĐŸĐ±ŃŃОД ĐĐČŃĐŸĐżĐ”ĐčŃĐșĐŸĐłĐŸ ĐĐ”ŃĐ°ŃДлŃĐœĐŸĐłĐŸ ĐĄĐŸŃза» Đž «ĐșĐŸĐŒĐŒŃĐœĐžĐșĐ°ŃĐžĐŸĐœĐœŃĐč ĐżĐŸŃĐ”ĐœŃОал ĐĐČŃĐŸĐČĐžĐŽĐ”ĐœĐžŃ ĐșĐ°Đș ĐżĐ»ĐŸŃĐ°ĐŽĐșĐž ĐŽĐ»Ń ŃĐŸŃĐŒĐžŃĐŸĐČĐ°ĐœĐžŃ ĐžĐŒĐžĐŽĐ¶Đ° ŃŃŃĐ°ĐœŃ», Đ·Đ°ĐșĐ»ŃŃĐ”ĐœĐžŃ, ŃпОŃĐșĐ° ĐžŃĐżĐŸĐ»ŃĐ·ĐŸĐČĐ°ĐœĐœĐŸĐč лОŃĐ”ŃĐ°ŃŃŃŃ ĐžĐ· 67 ĐżĐŸĐ·ĐžŃĐžĐč Đž 12 ĐżŃĐžĐ»ĐŸĐ¶Đ”ĐœĐžĐč. ĐбŃĐžĐč ĐŸĐ±ŃĐ”ĐŒ 76 ŃŃŃĐ°ĐœĐžŃ.Abstract of graduating qualification thesis Mikita Arlou INTERNATIONAL MUSIC CONTEST IN HOST COUNTRY IMAGE FORMATION (ON THE EXAMPLE OF EUROVISION 2017) Supervisor associate professor Elena Bykova, doctor of philology Department of PR in business full-time study Relevance: the international music contest Eurovision as the most wide scale regular high tech TV and Media event which annually emphasizes audience attention on national cultural features of the host country, forms tourist flows which have huge influence on territorial image formation. Besides the win of a participating in the Eurovision country often shows the ideological and political European vector and in fact serves as political PR of the winning or host country. Consequently the analysis of applied communication technologies is relevant and in-demand for event PR. Research object: communication activities of international music contest (on the example of Eurovision in Kyiv in 2017). Research subject: function of status PR event in country image formation. The aim of research: to prove that international music contest Eurovision contributes host country image formation. The tasks of research: to develop research terminology based on scientific literature on image making, branding and event management; to define actual communication technologies applied in special PR events on country image formation; to describe European Broadcasting Union role in host country image formation; to appreciate effectiveness of applied communication technologies on host country image formation in Eurovision; to give recommendations for host country image formation with the help of Eurovision. Theoretical base: scientific works written by E. Bykova, D. Gavra, A. Pankrukhin, B. Jenes, E. Kaverina, U. Halcbaur, J. Goldblatt and D. PassmanÂŽs works on music business and P. Jordan on county image building with the help of Eurovision, etc. The empirical base: PR documents from official Eurovision and European Broadcasting Union websites; more than 1.5 million articles on Ukraine in European media stored in the base of international Ukrainian image monitoring project Oko; content of the mass media and social media base Factiva; Google.Analytics data. Practical significance: the research proves that international music contest Eurovision is relevant for the host country image formation independently of the success level of applied country image formation communication technologies. Approbation: General positions of current thesis were aprobated on international scientific forum Media in modern world and were published at the collection of articles of the forum and have the status of a scientific article posted in the RINC database. Thesis structure: Research consists of introduction, 3 chapters: Special event function in country image formation, Eurovision as EBU special event and communication potential of Eurovision as a platform for image formation; conclusion, literature list from 67 positions and 12 attachments. The total volume is 76 pages
Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study
Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28â2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65â3·22], p\textless0·0001), American Society of Anesthesiologists grades 3â5 versus grades 1â2 (2·35 [1·57â3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01â2·39], p=0·046), emergency versus elective surgery (1·67 [1·06â2·63], p=0·026), and major versus minor surgery (1·52 [1·01â2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
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