6 research outputs found

    The Stuttering Poet: A Deleuzian Reading of a Laforguian Poetics

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    This article explores the complex relationship between the yankee, the Impressionist and the minoritarian in Laforgue's work and suggests that Deleuze's notions of the minor and of stuttering, and his analysis of the characteristics of Anglo-American writing, are particularly pertinent to our understanding of Laforgue's poetics. There is a nineteenth-century context for the minor, but there is a danger that we capitulate to a ‘majoritarian’ criticism if we too quickly espouse lines of filiation. The article constructs an account of Laforgue's developing perception of, and relationship with, verse prosody by examining how he scumbles the outlines and activity of syllables, how he pushes line-structure into a terrain vague, how he re-orientates accent towards the qualitative and tunes the acoustic to Hartmann's Unconscious. His uses of the imperative and infinitive, and their associated punctuations, are related to his responses to Impressionism. The argument ends with reflections on Deleuzian becoming in Laforgue

    New genetic loci link adipose and insulin biology to body fat distribution.

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    Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

    Utilisation et acceptabilité des moustiquaires imprégnées au niveau familial en milieu rural - Mbébé-Kikot-Cameroun

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    En Afrique sub-saharienne, le paludisme demeure un des probRmcs essentiels de Santé Publique. Y faire face passe actuellement par une chimio thérapie adaptée des acch fébriles (OMS-1986) et par IC renforcemen

    Genetic studies of body mass index yield new insights for obesity biology

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    Note: A full list of authors and affiliations appears at the end of the article. Obesity is heritable and predisposes to many diseases. To understand the genetic basis of obesity better, here we conduct a genome-wide association study and Metabochip meta-analysis of body mass index (BMI), a measure commonly used to define obesity and assess adiposity, in up to 339,224 individuals. This analysis identifies 97 BMI-associated loci (P 20% of BMI variation. Pathway analyses provide strong support for a role of the central nervous system in obesity susceptibility and implicate new genes and pathways, including those related to synaptic function, glutamate signalling, insulin secretion/action, energy metabolism, lipid biology and adipogenesis.</p
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