Tool Modeling with Fujaba

AbstractThis paper is a small tutorial on tool building with Fujaba. With the help of a small case study, we exemplify how the different requirements of an environment for a visual language may be addressed using Fujaba graph transformations. This covers abstract and concrete syntax, static and operational semantics, and model transformations. This case study shows, how the more sophisticated language elements of Fujaba may be exploited in modeling complex aspects of the desired CASE tool. In addition, we address some not graph grammar related aspects in building such an environment, e.g. the graphical user interface and multi-user support

eDOBS - Graphical Debugging for Eclipse

This paper presents the eDOBS tool. eDOBS is the little brother of the Fujaba environment. While Fujaba is used to create graph grammar based specifications and programs, eDOBS is used to browse graphs, to edit graphs, and to execute graph transformations

Local Citizen Participation in the European Context

Europe is undergoing change, it is changing ever more rapidly, and the relationships are becoming increasingly complex. In Germany, we will lose nearly 17 million inhabitants in the next 30 years, according to the latest forecasts. Every third person in this country will be 65 or older by then. The number of students will be halved in the next 30 years. The energy transition must be achieved. For a European city, it is more than ever important to find answers to the crucial questions of the f..

An Exploratory Investigation on the Challenges to the New Brazilian Automotive Suppliers

This paper analyzes the B2B (business-to-business) relationships between big and small or medium-sized enterprises in the automotive sector in Brazil to tentatively identify the challenges that hinder the insertion of SMEs (small and medium-sized nterprises) in this supply chain. This multiple case study analyzed the largest car part manufacturers and the largest car assembly plants located in the state of Rio Grande do Sul, Brazil. This was followed by studies of small and medium-sized businesses that had been indicated by the executives of the large companies studied. The objective was to answer the question: why are very few SMEs successful in their attempts at inserting themselves in the automotive supply chain. As identified, the main challenges faced by SMEs that do not operate in the auto chain are: the differences in the organizational objectives and the little know-how about the reality of B2B transactions in this sector

Hydrogen bond network topology in liquid water and methanol: a graph theory approach

Networks are increasingly recognized as important building blocks of various systems in nature and society. Water is known to possess an extended hydrogen bond network, in which the individual bonds are broken in the sub-picosecond range and still the network structure remains intact. We investigated and compared the topological properties of liquid water and methanol at various temperatures using concepts derived within the framework of graph and network theory (neighbour number and cycle size distribution, the distribution of local cyclic and local bonding coefficients, Laplacian spectra of the network, inverse participation ratio distribution of the eigenvalues and average localization distribution of a node) and compared them to small world and Erdős–Rényi random networks. Various characteristic properties (e.g. the local cyclic and bonding coefficients) of the network in liquid water could be reproduced by small world and/or Erdős–Rényi networks, but the ring size distribution of water is unique and none of the studied graph models could describe it. Using the inverse participation ratio of the Laplacian eigenvectors we characterized the network inhomogeneities found in water and showed that similar phenomena can be observed in Erdős–Rényi and small world graphs. We demonstrated that the topological properties of the hydrogen bond network found in liquid water systematically change with the temperature and that increasing temperature leads to a broader ring size distribution. We applied the studied topological indices to the network of water molecules with four hydrogen bonds, and showed that at low temperature (250 K) these molecules form a percolated or nearly-percolated network, while at ambient or high temperatures only small clusters of four-hydrogen bonded water molecules exist

Next-generation sequencing reveals substantial genetic contribution to dementia with Lewy bodies

Dementia with Lewy bodies (DLB) is the second most common neurodegenerative dementia after Alzheimer's disease. Although an increasing number of genetic factors have been connected to this debilitating condition, the proportion of cases that can be attributed to distinct genetic defects is unknown. To provide a comprehensive analysis of the frequency and spectrum of pathogenic missense mutations and coding risk variants in nine genes previously implicated in DLB, we performed exome sequencing in 111 pathologically confirmed DLB patients. All patients were Caucasian individuals from North America. Allele frequencies of identified missense mutations were compared to 222 control exomes. Remarkably, ~ 25% of cases were found to carry a pathogenic mutation or risk variant in APP, GBA or PSEN1, highlighting that genetic defects play a central role in the pathogenesis of this common neurodegenerative disorder. In total, 13% of our cohort carried a pathogenic mutation in GBA, 10% of cases carried a risk variant or mutation in PSEN1, and 2% were found to carry an APP mutation. The APOE ε4 risk allele was significantly overrepresented in DLB patients (p-value < 0.001). Our results conclusively show that mutations in GBA, PSEN1, and APP are common in DLB and consideration should be given to offer genetic testing to patients diagnosed with Lewy body dementia

Anion channel SLAH3 is a regulatory target of chitin receptor-associated kinase PBL27 in microbial stomatal closure

In plants, antimicrobial immune responses involve the cellular release of anions and are responsible for the closure of stomatal pores. Detection of microbe-associated molecular patterns (MAMPs) by pattern recognition receptors (PRRs) induces currents mediated via slow-type (S-type) anion channels by a yet not understood mechanism. Here, we show that stomatal closure to fungal chitin is conferred by the major PRRs for chitin recognition, LYK5 and CERK1, the receptor-like cytoplasmic kinase PBL27, and the SLAH3 anion channel. PBL27 has the capacity to phosphorylate SLAH3, of which S127 and S189 are required to activate SLAH3. Full activation of the channel entails CERK1, depending on PBL27. Importantly, both S127 and S189 residues of SLAH3 are required for chitin-induced stomatal closure and anti-fungal immunity at the whole leaf level. Our results demonstrate a short signal transduction module from MAMP recognition to anion channel activation, and independent of ABA-induced SLAH3 activation

A new method to analyse mosaics based on Symmetry Group theory applied to Islamic Geometric Patterns

[EN] This article presents a new method for analysing mosaics based on the mathematical principles of Symmetry Groups. This method has been developed to get the understanding present in patterns by extracting the objects that form them, their lattice, and the Wallpaper Group. The main novelty of this method resides in the creation of a higher level of knowledge based on objects, which makes it possible to classify the objects, to extract their main features (Point Group, principal axes, etc.), and the relationships between them. In order to validate the method, several tests were carried out on a set of Islamic Geometric Patterns from different sources, for which the Wallpaper Group has been successfully obtained in 85% of the cases. This method can be applied to any kind of pattern that presents a Wallpaper Group. Possible applications of this computational method include pattern classification, cataloguing of ceramic coatings, creating databases of decorative patterns, creating pattern designs, pattern comparison between different cultures, tile cataloguing, and so on.The authors wish to thank the Patronato de la Alhambra y Generalife (Granada, Spain) and the Patronato del Real Alcázar de Sevilla (Seville, Spain) for their valuable collaboration in this research work.Albert Gil, FE.; Gomis Martí, JM.; Blasco, J.; Valiente González, JM.; Aleixos Borrás, MN. (2015). A new method to analyse mosaics based on Symmetry Group theory applied to Islamic Geometric Patterns. Computer Vision and Image Understanding. 130:54-70. doi:10.1016/j.cviu.2014.09.002S547013