SYNTHESIS AND IDENTIFICATION OF 6 ,7-MEMBERD CYCLES OF EPANE AND EPINE FROM (DIAZ ,DIOX, DITHI ,DISELEN)

This research involve , synthesis of six and seven-memberd saturated and unsaturated compounds[1-12] of (diazepane , dithiepane , dioxepane , diselenepane) ,which contain two or more hetroatoms (N, S ,O and Se) by several steps via condensation  reactions. All synthesized compounds have been investigated using melting points and different chemical techniques (elemental analysis (C.H.N), H.NMR–spectra , FT.IR–spectra)

Synthesis of (5,6,7,8)-Membered Rings of (Sulfur ,Nitrogen) via Cyclization of Imine Compounds

In this paper , synthesis of a series of compounds from  hetero (Atoms, cycles) like  (5,6,7,8-membered )ring via cyclo addition reaction of anil compound to produce compound [1-13], this reactions involved addition of  carbonyl compounds like (( succinic acid , malonic acid , any compounds have  two terminal  from  amine  and  thiol or  carboxyl group)) to anil compounds  to  produce  various  membered  rings. The structure of the newly synthesized compounds [1-13] were confirmed with (C.H.N)- analysis & substantiated with (FT.IR ,H.NMR) data  & melting points. Keywords : eight membered , sulphur ,macrocycle , Imine ,heterocycle, five membered

Synthesis & Study of Anesthesia Organic Compounds

In the  present work , mono & bicyclic compounds [1-8] were synthesized as  derivatives of analagisic by alkalytion of 2-aminothiozoline with carbonyl compounds (succinic acid ., chloro aceticacid .,2,5-hexan-dione ., 3-chloro propoyl chloride ), where as the compounds [9-12] were synthesized by condensation between diketone compounds with (2-amino benzothiazole ,guanine) . The synthesized compounds structures were characarterized by several methods :{(C.H.N)-analysis , FT.IR-spectra , 1H.NMR-spectra } & melting points . Keyword: Anesthesia , pharmaceiutical compounds ., diketone Introduction : Asystematic investigation of this class of compounds lead revealed  that thiazol containing pharmacoactive agents play important role in medicinal chemistry and has a long history of application in agrochemicals and pharmaceiuticals industry as a analgesic and anti-inflammatory drugs are prescribed simultaneously in normal practice. The target compounds constitute an essential pharmacophore in many naturally occurring and biologically active agents.Thiazoles fused with different compounds that are known to contribut as antitumor and antimicrobial(1,2). The mono & bicyclic compounds are class of compounds well known for along time as anesthetic drugsin surgery such as diazepine compounds(3-5)which were first introduced for the treatment of anxiety (4-6) . In this study , the synthesized compounds (thiazolo diazepine , benzoimidazol, thiazolo pyrimidone ,benzothiazolo pyrimidine , guano pyrimidine ) are cyclic compounds in which one or more of nitrogen atoms which contain five , six & seven membered unsaturated rings of mono or bicyclic compounds (3,5) . In this work , the cyclic nitrogen compounds were synthesized by cyclocondensation of amino compounds with carbonyl compounds led to formation of mono & bicyclic compounds   [1-12] , which used as analgesic , relaxative , hypnotic(7,8)& other uses(9-20)

Survey in Substitution Reactions and Elimination Reactions

The reactions of alkyl halides typically involve either substitution or elimination pathways. Depending on a variety of factors, the reaction mechanism can be either SN1, SN2, E1, E2, or some combination of these.  By understanding the influences different factors have on each of these mechanisms, it is usually possible to predict which mechanism will predominate. Keywords: SN1, SN2, E1, E2 ,elimination , substitution ,conditions

Synthesis & Characterization of Saccharine Derivatives

The formation of saccharine derivatives [1-15] is obtained by reaction of saccharine with carbonyl –containing compounds (ketone, aldehyde , ester , di ester ) or with amide compounds (alkyl di amine  , Aryl di amine ), some of steps involved mannich reaction and aldol reaction to synthesis of new open chain compounds which represented (  amides , alkene , sulphone derivatives , amines derivatives, esters , ethers ) . All newly synthesized compounds [1-16] were characterized by (elemental analysis , FT.IR , H.NMR)-spectroscopic analysis & melting points . Keyword: saccharine , sulphone, aldol reaction , alkylation , mannich reaction

Synthesis & Characterization of Saccharine Derivatives

The formation of saccharine derivatives [1-15] is obtained by reaction of saccharine with carbonyl –containing compounds (ketone, aldehyde , ester , di ester ) or with amide compounds (alkyl di amine  , Aryl di amine ), some of steps involved mannich reaction and aldol reaction to synthesis of new open chain compounds which represented (  amides , alkene , sulphone derivatives , amines derivatives, esters , ethers ) . All newly synthesized compounds [1-16] were characterized by (elemental analysis , FT.IR , H.NMR)-spectroscopic analysis & melting points . Keyword: saccharine , sulphone, aldol reaction , alkylation , mannich reaction

STUDYING OF (THERMAL ,CHROMATOGRAPHIC ,CHEMICAL ,MICROBIAL)-BEHAVIOR OF (SULFUR AND NITROGEN)–ORGANIC COMPOUNDS

AbstractSeries  sulfur and  nitrogen organic  compounds  were   prepared in our  previously paper(1), which act various  compounds ( thia, sulfur, aze, sulfide ) from halogenation reaction ,condensation reaction, cyclization reaction . The synthesized  compounds have been studied  ((chromatography  behavior ,  DSC- thermal  measurements))  for stability of  compounds , studying  of  physical   and  other  analytical  studies  like  solubility  in  various  solvents )) , then  tested  in  microbial  studying. Keywords :solve , impo, vari

SYNTHESIS AND INVISTIGATION OF NEW CYCLICMANNICH BASES

The aim of this paper , cyclic compounds of  mannich bases were synthesized through condensation of diketone compounds with ammonia or amine derivatives to give enamino  ketone as intermediate , which reacts with aldehyde compounds to yield compounds [1-4] . All structures of formated compounds were characterized by (C.H.N)elementary analysis , 1HNMRspectra and FT-IRspectra.The data obtained gave good support for synthesized compounds [1-4] .  Keyword :CyclicMannich Bases ,intermediate

Synthesis with Investigation of New Bio- Chemical Compounds and Studying of (Bio-Chemical ,Chromatography ,Spectral , Analytical) - Behavior

Series bio - compounds prepared in this work which bearing bio – nuclei like thiazole ring via cyclization by acid or azotation reaction in cold medium or condensation by refluxing process , some these compounds included two process at same compound like formazan compound [9 and 10].All formatted compounds [1-10] were identified by using (TLC) and techniques((FT.IR ,1H.NMR ,13C.NMR ,Chromatography Analysis)) ,then studying((biological activity studying , chromatography behavior , studying of physical characterization and other analytical studies like solubility in various solvents )) . Keywords: formazan , thiazole , bio , active,azo, imine

Survey in Nuclear Magnetic Resonance Spectroscopy

Over the past fifty years nuclear magnetic resonance spectroscopy, commonly referred to as NMR, has become the preeminent technique for determining the structure of organic compounds. Of all the spectroscopic methods, it is the only one for which a complete analysis and interpretation of the entire spectrum is normally expected. Although larger amounts of sample are needed than for mass spectroscopy, NMR is non-destructive, and with modern instruments good data may be obtained from samples weighing less than a milligram. To be successful in using NMR as an analytical tool, it is necessary to understand the physical principles on which the methods are based. Keywords : NMR , spectra , spin , nuclear , magnetic , data.