Distance Learning in Higher Education

The Western Governors University (WGU) and the California Virtual University (CVU) are revealing examples of the complex issues involved in implementing distance learning on the public policy level. Although technology is certainly important, it has masked the fact that the WGU and CVU initiatives mark the rise of learner-centered higher education and the increased role of business in the academy. In comparing and contrasting WGU and CVU, it is clear that the WGU is a more radical proposition because of competency-based credit and the connection with private industry. Two important issues driving public policy are raised in these two efforts: First, are the California and Western Governors Association initiatives the product of the commercialization of education or the result of a reform of higher education that may lead to an increased learner-centered orientation? Second, what is the appropriate role of private industry in higher education

FASB and IASB Harmonization of Leases

In an effort to harmonize worldwide accounting standards, the two primary parties, the Financial Accounting Standards Board (FASB) and the International Accounting Standards Board (IASB), are taking a topic-by-topic approach in an attempt to develop accounting standards that are acceptable to both bodies. Upon completion of this project, the similar accounting standards will be used worldwide. However, the harmonization of accounting standards is made more difficult by the different approaches taken toward accounting standards setting. The FASB uses a rulesbased approach to standard setting while the IASB uses a principles-based approach. The current project under discussion by the two boards is one of the more difficult areas to harmonize - accounting for leases

Understanding disability glare: light scatter and retinal illuminance as predictors of sensitivity to contrast

The presence of a bright light in the visual field has two main effects on the retinal image: reduced contrast and increased retinal illuminance due to scattered light; the latter can, under some conditions, lead to an improvement in retinal sensitivity. The combined effect remains poorly understood, particularly at low light levels. A psychophysical flicker-cancellation test was used to measure the amount and angular distribution of scattered light in the eye for 40 observers. Contrast thresholds were measured using a functional contrast sensitivity test. Pupil-plane glare-source illuminances (i.e. 0, 1.35, 19.21 lm/m2), eccentricities (5°, 10°, 15°), and background luminances (1, 2.6, 26 cd/m2) were investigated. Visual performance was better than predicted, based on loss of retinal image contrast caused by scattered light, particularly in the mesopic range. Prediction accuracy improved significantly when the expected increase in retinal sensitivity in the presence of scattered light was also incorporated in the model

Relationship between interRAI HC and the ICF: opportunity for operationalizing the ICF

Background: The International Classification of Functioning, Disability and Health (ICF) is embraced as a framework to conceptualize human functioning and disability. Health professionals choose measures to represent the domains of the framework. The ICF coding classification is an administrative system but multiple studies have linked diverse clinical assessments to ICF codes. InterRAI-HC (home care) is an assessment designed to assist planning of care for patients receiving home care. Examining the relationship between the ICF and the interRAI HC is of particular interest because the interRAI assessments are widely used in clinical practice and research, are computerized, and uploaded to databases that serve multiple purposes including public reporting of quality in Canada and internationally. The objective of this study was to examine the relationship between the interRAI HC (home care) assessment and the ICF. Specifically, the goal was to determine the proportion of interRAI HC items that can be linked to each of the major domains of the ICF (Body Function, Body Structure, Activities and Participation, and the Environmental Factors), the chapters and the specific ICF codes

A modified bacterial one-hybrid system yields improved quantitative models of transcription factor specificity

We examine the use of high-throughput sequencing on binding sites recovered using a bacterial one-hybrid (B1H) system and find that improved models of transcription factor (TF) binding specificity can be obtained compared to standard methods of sequencing a small subset of the selected clones. We can obtain even more accurate binding models using a modified version of B1H selection method with constrained variation (CV-B1H). However, achieving these improved models using CV-B1H data required the development of a new method of analysis—GRaMS (Growth Rate Modeling of Specificity)—that estimates bacterial growth rates as a function of the quality of the recognition sequence. We benchmark these different methods of motif discovery using Zif268, a well-characterized C2H2 zinc-finger TF on both a 28 bp randomized library for the standard B1H method and on 6 bp randomized library for the CV-B1H method for which 45 different experimental conditions were tested: five time points and three different IPTG and 3-AT concentrations. We find that GRaMS analysis is robust to the different experimental parameters whereas other analysis methods give widely varying results depending on the conditions of the experiment. Finally, we demonstrate that the CV-B1H assay can be performed in liquid media, which produces recognition models that are similar in quality to sequences recovered from selection on solid media

Social Preferences and the Efficiency of Bilateral Exchange

Under what conditions do social preferences, such as altruism or a concern for fair outcomes, generate efficient trade? I analyze theoretically a simple bilateral exchange game: Each player sequentially takes an action that reduces his own material payoff but increases the other player’s. Each player’s preferences may depend on both his/her own material payoff and the other player’s. I identify necessary conditions and sufficient conditions on the players’ preferences for the outcome of their interaction to be Pareto efficient. The results have implications for interpreting the rotten kid theorem, gift exchange in the laboratory, and gift exchange in the field

Low lopinavir plasma or hair concentrations explain second-line protease inhibitor failures in a resource-limited setting.

In resource-limited settings, many patients, with no prior protease inhibitor (PI) treatment on a second-line, high genetic barrier, ritonavir-boosted PI-containing regimen have virologic failure

Consistent segment-wise matching with multi-layer graphs

Segment-wise matching is an important problem for higher-level understanding of shapes and geometry analysis. Many existing segment-wise matching techniques assume perfect segmentation, and would suffer from imperfect or over-segmentation inputs. To handle this shortcoming, we propose a multi-layer graph (MLG) to represent possible partially merged segments of input shape. We adapt the diffusion pruning technique on the MLGs to find high quality segment-wise matching. Experimental results on man-made shapes demonstrate the effectiveness of our method

Open String Wavefunctions in Warped Compactifications

We analyze the wavefunctions for open strings in warped compactifications, and compute the warped Kahler potential for the light modes of a probe D-brane. This analysis not only applies to the dynamics of D-branes in warped backgrounds, but also allows to deduce warping corrections to the closed string Kahler metrics via their couplings to open strings. We consider in particular the spectrum of D7-branes in warped Calabi-Yau orientifolds, which provide a string theory realizations of the Randall-Sundrum scenario. We find that certain background fluxes, necessary in the presence of warping, couple to the fermionic wavefunctions and qualitatively change their behavior. This modified dependence of the wavefunctions are needed for consistency with supersymmetry, though it is present in non-supersymmetric vacua as well. We discuss the deviations of our setup from the RS scenario and, as an application of our results, compute the warping corrections to Yukawa couplings in a simple model. Our analysis is performed both with and without the presence of D-brane world-volume flux, as well as for the case of backgrounds with varying dilaton.Comment: 52 pages, refs. added, minor correction

Model Building and Phenomenology of Flux-Induced Supersymmetry Breaking on D3-branes

We study supersymmetry breaking effects induced on D3-branes at singularities by the presence of NSNS and RR 3-form fluxes. First, we discuss some local constructions of chiral models from D3-branes at singularities, as well as their global embedding in flux compactifications. The low energy spectrum of these constructions contains features of the supersymmetric Standard Model. In these models, both the soft SUSY parameters and the mu-term are generated by turning on the 3-form NSNS and RR fluxes. We then explore some model-independent phenomenological features as, e.g., the fine-tuning problem of electroweak symmetry breaking in flux compactifications. We also comment on other phenomenological features of this scenario.Comment: 41 pages, 10 figure