delayed diagnosis of glioblastoma due to recent ruptured aneurysm a case report

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Analisi di interazione tra ambiente urbano e caratteristiche climatiche a scala locale tramite dati spaziali multisorgente e software open source

L’analisi dell’impatto dei cambiamenti climatici è attualmente uno degli argomenti principalmente discussi sia nell’ambito della ricerca scientifica sia all’interno della società civile. In questo contesto, l’ambiente urbano è considerato un elemento chiave per il monitoraggio e la comprensione dei cambiamenti climatici anche in rapporto alle attività antropiche che qui si concentrano. Il presente lavoro è stato sviluppato nell’ambito del concorso Data for Climate Action (D4CA), promosso da UN Global Pulse nell’estate del 2017. Esso presenta un approccio preliminare per l’analisi di particolari componenti dell’ambiente urbano - in relazione ai loro potenziali effetti di amplificazione dei cambiamenti climatici - sfruttando dati geospaziali multisorgente e software liberi e open source. Lo studio è proposto per la città di Milano e si compone di due principali esperimenti. Il primo riguarda l’analisi del contributo delle superfici urbane ai flussi di calore locali, tramite classificazione di immagini satellitari ad alta risoluzione - quali Sentinel-2 e PlanetScope - per la mappatura delle zone climatiche locali cittadine (Local Climate Zone) e la creazione di serie temporali di mappe di energia superficiale riflessa tramite l’utilizzo del modello LUMPS (Local Scale Urban Parameterization Scheme). Il secondo esperimento riguarda l'analisi del possibile contributo marginale ai flussi di calore - in termini di anomalie termiche locali - dovuti ad eventi di traffico significativi. In questo caso, i risultati non hanno evidenziato una diretta correlazione tra i due fenomeni. Analisi più dettagliate sono in corso tramite l’utilizzo di Big Traffic Data provenienti dalla piattaforma WAZE (e resi disponibili nell’ambito di D4CA), i quali permetteranno l’identificazione degli eventi di traffico significativi ad un più alto livello di dettaglio spaziale e temporale. Le analisi delle peculiarità del clima urbano a una scala di dettaglio vengono eseguite allo scopo di introdurre strumenti all’avanguardia da impiegare nel contesto della pianificazione urbana e nelle azioni di mitigazione dei cambiamenti climatici in aree densamente popolate. L’utilizzo esclusivo di software liberi e open source e di dataset spaziali a copertura globale garantisce all’analisi ampi margini di miglioramento nonché una potenziale applicabilità in contesti diversi da quello presentato nel caso di studio

Early season weed mapping in rice crops using multi-spectral UAV data

In this article, we propose an automatic procedure for classification of UAV imagery to map weed presence in rice paddies at early stages of the growing cycle. The objective was to produce a weed map (common weeds and cover crop remnants) to support variable rate technologies for site-specific weed management. A multi-spectral ortho-mosaic, derived from images acquired by a Parrot Sequoia sensor mounted on a quadcopter, was classified through an unsupervised clustering algorithm; cluster labelling into â weed/no weed classes was achieved using geo-referenced observations. We tested the best set of input features among spectral bands, spectral indices and textural metrics. Weed mapping performance was assessed by calculating overall accuracy (OA) and, for the weed class, omission (OE) and commission errors (CE). Classification results were assessed under an alarmist approach in order to minimise the chance of overestimating weed coverage. Under this condition, we found that best results are provided by a set of spectral indices (OA= 96.5%, weed CE = 2.0%). The output weed map was aggregated to a grid layer of 5 x 5 m to simulate variable rate management units; a weed threshold was applied to identify the portion of the field to be subject to treatment with herbicides. Ancillary information on weed and crop conditions were derived over the grid cells to support precision agronomic management of rice crops at the early stage of growth

Impact of Host Genes and Strand Selection on miRNA and miRNA* Expression

Dysregulation of miRNAs expression plays a critical role in the pathogenesis of genetic, multifactorial disorders and in human cancers. We exploited sequence, genomic and expression information to investigate two main aspects of post-transcriptional regulation in miRNA biogenesis, namely strand selection regulation and expression relationships between intragenic miRNAs and host genes. We considered miRNAs expression profiles, measured in five sizeable microarray datasets, including samples from different normal cell types and tissues, as well as different tumours and disease states. First, the study of expression profiles of “sister” miRNA pairs (miRNA/miRNA*, 5′ and 3′ strands of the same hairpin precursor) showed that the strand selection is highly regulated since it shows tissue-/cell-/condition-specific modulation. We used information about the direction and the strength of the strand selection bias to perform an unsupervised cluster analysis for the sample classification evidencing that is able to distinguish among different tissues, and sometimes between normal and malignant cells. Then, considering a minimum expression threshold, in few miRNA pairs only one mature miRNA is always present in all considered cell types, whereas the majority of pairs were concurrently expressed in some cell types and alternatively in others. In a significant fraction of concurrently expressed pairs, the major and the minor forms found at comparable levels may contribute to post-transcriptional gene silencing, possibly in a coordinate way. In the second part of the study, the behaved tendency to co-expression of intragenic miRNAs and their “host” mRNA genes was confuted by expression profiles examination, suggesting that the expression profile of a given host gene can hardly be a good estimator of co-transcribed miRNA(s) for post-transcriptional regulatory networks inference. Our results point out the regulatory importance of post-transcriptional phases of miRNAs biogenesis, reinforcing the role of such layer of miRNA biogenesis in miRNA-based regulation of cell activities

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Delayed diagnosis of glioblastoma due to recent ruptured aneurysm. A case report.

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Acute Supratentorial Ischemic Stroke: When Surgery Is Mandatory

Acute occlusion of middle cerebral artery (MCA) leads to severe brain swelling and to a malignant, often fatal syndrome. The authors summarize the current knowledge about such a condition and review the main surgical issues involved. Decompressive hemicraniectomy keeps being a valid option in accurately selected patients

Recovery after Delayed Surgery in a Case of Spinal Subdural Hematoma

Spinal chronic subdural hematoma (SCSH) is a rare pathology usually associated with trauma or hematological alterations or is due to iatrogenic causes; rarely SCSH can be spontaneous. We report a case of a 79-year-old female who underwent a surgical evacuation of a spontaneous SCSH one year after diagnosis. She presented with a severe paraparesis and showed a considerable improvement in sensory-motor performances after surgery. The treatment of spontaneous SCSH is not well defined and universally accepted. Early surgery is mandatory in cases presenting with severe deficits. To the best of our knowledge, this is the first case showing a good outcome in a case of SCSH following a delayed surgery. In our opinion, an aggressive approach should be considered as a viable option in cases of spontaneous SCSH even after a lasting spinal cord compression.Peer Reviewe

Recovery after Delayed Surgery in a Case of Spinal Subdural Hematoma

6nonenonePier Paolo Panciani;Claudio Cornali;Alessandro Agnoletti;Giacomo Esposito;Gabriele Ronchetti;Marco FontanellaPier Paolo Panciani, ; Cornali, Claudio; Alessandro, Agnoletti; Giacomo, Esposito; Gabriele, Ronchetti; Fontanella, Marco Mari