On-Surface Driven Formal Michael Addition Produces m-Polyaniline Oligomers on Pt(111)

On-surface synthesis is emerging as a highly rational bottom-up methodology for the synthesis of molecular structures that are unattainable or complex to obtain by wet chemistry. Here, oligomers of meta-polyaniline, a known ferromagnetic polymer, were synthesized from para-aminophenol building-blocks via an unexpected and highly specific on-surface formal 1, 4 Michael-type addition at the meta position, driven by the reduction of the aminophenol molecule. We rationalize this dehydrogenation and coupling reaction mechanism with a combination of in situ scanning tunneling and non-contact atomic force microscopies, high-resolution synchrotron-based X-ray photoemission spectroscopy and first-principles calculations. This study demonstrates the capability of surfaces to selectively modify local molecular conditions to redirect well-established synthetic routes, such as Michael coupling, towards the rational synthesis of new covalent nanostructures

Anisotropy studies around the galactic centre at EeV energies with the Auger Observatory

Data from the Pierre Auger Observatory are analyzed to search for anisotropies near the direction of the Galactic Centre at EeV energies. The exposure of the surface array in this part of the sky is already significantly larger than that of the fore-runner experiments. Our results do not support previous findings of localized excesses in the AGASA and SUGAR data. We set an upper bound on a point-like flux of cosmic rays arriving from the Galactic Centre which excludes several scenarios predicting sources of EeV neutrons from Sagittarius $A$. Also the events detected simultaneously by the surface and fluorescence detectors (the `hybrid' data set), which have better pointing accuracy but are less numerous than those of the surface array alone, do not show any significant localized excess from this direction.Comment: Matches published versio

New insights into the genetic etiology of Alzheimer's disease and related dementias

Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Construction status and prospects of the Hyper-Kamiokande project

The Hyper-Kamiokande project is a 258-kton Water Cherenkov together with a 1.3-MW high-intensity neutrino beam from the Japan Proton Accelerator Research Complex (J-PARC). The inner detector with 186-kton fiducial volume is viewed by 20-inch photomultiplier tubes (PMTs) and multi-PMT modules, and thereby provides state-of-the-art of Cherenkov ring reconstruction with thresholds in the range of few MeVs. The project is expected to lead to precision neutrino oscillation studies, especially neutrino CP violation, nucleon decay searches, and low energy neutrino astronomy. In 2020, the project was officially approved and construction of the far detector was started at Kamioka. In 2021, the excavation of the access tunnel and initial mass production of the newly developed 20-inch PMTs was also started. In this paper, we present a basic overview of the project and the latest updates on the construction status of the project, which is expected to commence operation in 2027

Prospects for neutrino astrophysics with Hyper-Kamiokande

Hyper-Kamiokande is a multi-purpose next generation neutrino experiment. The detector is a two-layered cylindrical shape ultra-pure water tank, with its height of 64 m and diameter of 71 m. The inner detector will be surrounded by tens of thousands of twenty-inch photosensors and multi-PMT modules to detect water Cherenkov radiation due to the charged particles and provide our fiducial volume of 188 kt. This detection technique is established by Kamiokande and Super-Kamiokande. As the successor of these experiments, Hyper-K will be located deep underground, 600 m below Mt. Tochibora at Kamioka in Japan to reduce cosmic-ray backgrounds. Besides our physics program with accelerator neutrino, atmospheric neutrino and proton decay, neutrino astrophysics is an important research topic for Hyper-K. With its fruitful physics research programs, Hyper-K will play a critical role in the next neutrino physics frontier. It will also provide important information via astrophysical neutrino measurements, i.e., solar neutrino, supernova burst neutrinos and supernova relic neutrino. Here, we will discuss the physics potential of Hyper-K neutrino astrophysics

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

X-shooting ULLYSES: massive stars at low metallicity

The spectral analysis of hot, massive stars is a fundamental astrophysical method of determining their intrinsic properties and feedback. With their inherent, radiation-driven winds, the quantitative spectroscopy for hot, massive stars requires detailed numerical modeling of the atmosphere and an iterative treatment in order to obtain the best solution within a given framework. Aims. We present an overview of different techniques for the quantitative spectroscopy of hot stars employed within the X-Shooting ULLYSES collaboration, ranging from grid-based approaches to tailored spectral fits. By performing a blind test for selected targets, we gain an overview of the similarities and differences between the resulting stellar and wind parameters. Our study is not a systematic benchmark between different codes or methods; our aim is to provide an overview of the parameter spread caused by different approaches. Methods. For three different stars from the XShooting ULLYSES sample (SMC O5 star AzV 377, LMC O7 star Sk -69° 50, and LMC O9 star Sk-66° 171), we employ different stellar atmosphere codes (CMFGEN, Fastwind, PoWR) and different strategies to determine their best-fitting model solutions. For our analyses, UV and optical spectroscopy are used to derive the stellar and wind properties with some methods relying purely on optical data for comparison. To determine the overall spectral energy distribution, we further employ additional photometry from the literature. Results. The effective temperatures found for each of the three different sample stars agree within 3 kK, while the differences in log g can be up to 0.2 dex. Luminosity differences of up to 0.1 dex result from different reddening assumptions, which seem to be systematically larger for the methods employing a genetic algorithm. All sample stars are found to be enriched in nitrogen. The terminal wind velocities are surprisingly similar and do not strictly follow the u∞−Teff relation. Conclusions. We find reasonable agreement in terms of the derived stellar and wind parameters between the different methods. Tailored fitting methods tend to be able to minimize or avoid discrepancies obtained with coarser or increasingly automatized treatments. The inclusion of UV spectral data is essential for the determination of realistic wind parameters. For one target (Sk -69° 50), we find clear indications of an evolved status

Solar energetic particle heavy ion properties in the widespread event of 2020 November 29

Context. Following a multi-year minimum of solar activity, a solar energetic particle event on 2020 Nov. 29 was observed by multiple spacecraft covering a wide range of solar longitudes including ACE, the Solar Terrestrial Relations Observatory-A, and the recently launched Parker Solar Probe and Solar Orbiter. Aims. Multi-point observations of a solar particle event, combined with remote-sensing imaging of flaring, shocks, and coronal mass ejections allows for a global picture of the event to be synthesized, and made available to the modeling community to test, constrain, and refine models of particle acceleration and transport according to such parameters as shock geometries and particle mass-to-charge ratios. Methods. Detailed measurements of heavy ion intensities, time dependence, fluences, and spectral slopes provided the required test data for this study. Results. The heavy ion abundances, timing, and spectral forms for this event fall well within the range found in prior surveys at 1 au. The spectra were well fitted by broken power law shapes; the Fe/O ratio was somewhat lower than the average of other events. In addition, 3He/4He was very low, with only the upper limits established here. © 2021 ESO.Immediate accessThis item from the UA Faculty Publications collection is made available by the University of Arizona with support from the University of Arizona Libraries. If you have questions, please contact us at [email protected]

The Characteristics of Solar X-Class Flares and CMEs: A Paradigm for Stellar Superflares and Eruptions?

This paper explores the characteristics of 42 solar X-class flares that were observed between February 2011 and November 2014, with data from the Solar Dynamics Observatory (SDO) and other sources. This flare list includes nine X-class flares that had no associated CMEs. In particular our aim was to determine whether a clear signature could be identified to differentiate powerful flares that have coronal mass ejections (CMEs) from those that do not. Part of the motivation for this study is the characterization of the solar paradigm for flare/CME occurrence as a possible guide to the stellar observations; hence we emphasize spectroscopic signatures. To do this we ask the following questions: Do all eruptive flares have long durations? Do CME-related flares stand out in terms of active-region size vs. flare duration? Do flare magnitudes correlate with sunspot areas, and, if so, are eruptive events distinguished? Is the occurrence of CMEs related to the fraction of the active-region area involved? Do X-class flares with no eruptions have weaker non-thermal signatures? Is the temperature dependence of evaporation different in eruptive and non-eruptive flares? Is EUV dimming only seen in eruptive flares? We find only one feature consistently associated with CME-related flares specifically: coronal dimming in lines characteristic of the quiet-Sun corona, i.e. 1 – 2 MK. We do not find a correlation between flare magnitude and sunspot areas. Although challenging, it will be of importance to model dimming for stellar cases and make suitable future plans for observations in the appropriate wavelength range in order to identify stellar CMEs consistently