Mid-infrared optical properties of non-magnetic-metal/CoFeB/MgO heterostructures

We report on the optical characterization of non-magnetic metal/ferromagnetic (Co$_{20}$Fe$_{60}$B$_{20}$)/MgO heterostructures and interfaces by using mid infrared spectroscopic ellipsometry at room temperature. We extracted for the mid-infrared range the dielectric function of Co$_{20}$Fe$_{60}$B$_{20}$, that is lacking in literature, from a multisample analysis. From the optical modelling of the heterostructures we detected and determined the dielectric tensor properties of a two-dimensional gas (2DEG) forming at the non-magnetic metal and the CoFeB interface. These properties comprise independent Drude parameters for the in-plane and out-of plane tensor components, with the latter having an epsilon-near-zero frequency within our working spectral range. A feature assigned to spin-orbit coupling (SOC) is identified. Furthermore, it is found that both, the interfacial properties, 2DEG Drude parameters and SOC strength, and the apparent dielectric function of the MgO layer depend on the type of the underlying nonmagnetic metal, namely, Pt, W, or Cu. The results reported here should be useful in tailoring novel phenomena in such types of heterostructures by assessing their optical response noninvasively, complementing existing characterization tools such as angle-resolved photoemission spectroscopy, and those related to electron/spin transport.Comment: 11 pages, 7 figures. See supplemental material in 10.1088/1361-6463/acd00f/met

Determinants of Survival in Malignant Pleural Mesothelioma: A Surveillance, Epidemiology, and End Results (SEER) Study of 14,228 Patients

INTRODUCTION: Left untreated, malignant pleural mesothelioma (MPM) is associated with uniformly poor prognosis. Better survival has been reported with surgery-based multimodality therapy, but to date, no trial has demonstrated survival benefit of surgery over other therapies. We evaluated whether cancer-directed surgery influenced survival independently from other predictors in a large population-based dataset. METHODS: The SEER database was explored from 1973 to 2009 to identify all cases of pathologically-proven MPM. Age, sex, race, year of diagnosis, histology stage, cancer-directed surgery, radiation, and vital status were analyzed. The association between prognostic factors and survival was estimated using Cox regression and propensity matched analysis. RESULTS: There were 14,228 patients with pathologic diagnosis of MPM. On multivariable analysis, female gender, younger age, early stage, and treatment with surgery were independent predictors of longer survival. In comparison to no treatment, surgery alone was associated with significant improvement in survival [adjusted hazard ratio (adj HR) 0.64 (0.61-0.67)], but not radiation [adj HR 1.15 (1.08-1.23)]. Surgery and radiation combined had similar survival as surgery alone [adj HR 0.69 (0.64-0.76)]. Results were similar when cases diagnosed between 1973 and 1999 were compared to cases diagnosed between 2000 and 2009. CONCLUSIONS: Despite developments in surgical and radiation techniques, the prognosis for MPM patients has not improved over the past 4 decades. Cancer-directed surgery is independently associated with better survival, suggesting that multimodal surgery-based therapy can benefit these patients. Further research in adjuvant treatment is necessary to improve prognosis in this challenging disease

Experimental and quantum chemical studies of a novel synthetic prenylated chalcone

BACKGROUND: Chalcones are ubiquitous natural compounds with a wide variety of reported biological activities, including antitumoral, antiviral and antimicrobial effects. Furthermore, chalcones are being studied for its potential use in organic electroluminescent devices; therefore the description of their spectroscopic properties is important to elucidate the structure of these molecules. One of the main techniques available for structure elucidation is the use of Nuclear Magnetic Resonance Spectroscopy (NMR). Accordingly, the prediction of the NMR spectra in this kind of molecules is necessary to gather information about the influence of substituents on their spectra. RESULTS: A novel substituted chalcone has been synthetized. In order to identify the functional groups present in the new synthesized compound and confirm its chemical structure, experimental and theoretical (1)H-NMR and (13)C-NMR spectra were analyzed. The theoretical molecular structure and NMR spectra were calculated at both the Hartree-Fock and Density Functional (meta: TPSS; hybrid: B3LYP and PBE1PBE; hybrid meta GGA: M05-2X and M06-2X) levels of theory in combination with a 6-311++G(d,p) basis set. The structural parameters showed that the best method for geometry optimization was DFT:M06-2X/6-311++G(d,p), whereas the calculated bond angles and bond distances match experimental values of similar chalcone derivatives. The NMR calculations were carried out using the Gauge-Independent Atomic Orbital (GIAO) formalism in a DFT:M06-2X/6-311++G(d,p) optimized geometry. CONCLUSION: Considering all HF and DFT methods with GIAO calculations, TPSS and PBE1PBE were the most accurate methods used for calculation of (1)H-NMR and (13)C-NMR chemical shifts, which was almost similar to the B3LYP functional, followed in order by HF, M05-2X and M06-2X methods. All calculations were done using the Gaussian 09 software package. Theoretical calculations can be used to predict and confirm the structure of substituted chalcones with good correlation with the experimental data

Copper: Synthesis Techniques in Nanoscale and Powerful Application as an Antimicrobial Agent

Nanosized metal particles show specific physical and chemical properties that allow the creation of new composites materials, which are important for multiple applications in biology and medicine such as infections control. Metal nanoparticles, mainly copper, exhibit excellent inhibitory effect on Gram-positive and Gram-negative bacteria; therefore the exploration about the efficient, economical, and friendly environmental technics to synthesize inorganic nanoparticles is imperative. In this work a brief overview of the several methods is made including the comparison of the methods, mainly between sonochemical, microwave, and chemical routes. It allows determining the optimal parameters and technical conditions to synthesize copper nanoparticles with physical and chemical properties suitable for the oral bacterial inhibition

Invasive pulmonary aspergillosis in heart transplant recipients: Is mortality decreasing

Introduction: Infection remains a major complication among heart transplant (HT) recipients, causing approximately 20% of deaths in the first year after transplantation. In this population, Aspergillus spp. can have various clinical presentations including invasive pulmonary aspergillosis (IPA), with high mortality (53-78%). Objectives: To establish the characteristics of IPA infection in HT recipients and their outcomes in our center. Methods: Among 328 HTs performed in our center between 1998 and 2016, we identified five cases of IPA. Patient medical records were examined and clinical variables were extracted. Results: All cases were male, and mean age was 62 years. The most common indication for HT was non-ischemic dilated cardiomyopathy. Productive cough was reported as the main symptom. The radiological assessment was based on chest X-ray and chest computed tomography. The most commonly reported radiographic abnormality was multiple nodular opacities in both techniques. Bronchoscopy was performed in all patients and Aspergillus fumigatus was isolated in four cases on bronchoalveolar lavage culture. Treatment included amphotericin in four patients, subsequently changed to voriconazole in three, and posaconazole in one patient, with total treatment lasting an average of 12 months. Neutropenia was found in only one patient, renal failure was observed in two patients, and concurrent cytomegalovirus infection in three patients. All patients were alive after a mean follow-up of 18 months. Conclusions: IPA is a potentially lethal complication after HT. Early diagnosis and prompt initiation of aggressive treatment are the cornerstone of better survival

Rare Variants in 48 Genes Account for 42% of Cases of Epilepsy With or Without Neurodevelopmental Delay in 246 Pediatric Patients

In order to characterize the genetic architecture of epilepsy in a pediatric population from the Iberian Peninsula (including the Canary Islands), we conducted targeted exome sequencing of 246 patients with infantile-onset seizures with or without neurodevelopmental delay. We detected 107 variants in 48 different genes, which were implicated in neuronal excitability, neurodevelopment, synaptic transmission, and metabolic pathways. In 104 cases (42%) we detected variant(s) that we classified as pathogenic or likely pathogenic. Of the 48 mutated genes, 32 were dominant, 8 recessive and 8 X-linked. Of the patients for whom family studies could be performed and in whom pathogenic variants were identified in dominant or X-linked genes, 82% carried de novo mutations. The involvement of small copy number variations (CNVs) is 9%. The use of progressively updated custom panels with high mean vertical coverage enabled establishment of a definitive diagnosis in a large proportion of cases (42%) and detection of CNVs (even duplications) with high fidelity. In 10.5% of patients we detected associations that are pending confirmation via functional and/or familial studies. Our findings had important consequences for the clinical management of the probands, since a large proportion of the cohort had been clinically misdiagnosed, and their families were subsequently able to avail of genetic counseling. In some cases, a more appropriate treatment was selected for the patient in question, or an inappropriate treatment discontinued. Our findings suggest the existence of modifier genes that may explain the incomplete penetrance of some epilepsy-related genes. We discuss possible reasons for non-diagnosis and future research directions. Further studies will be required to uncover the roles of structural variants, epimutations, and oligogenic inheritance in epilepsy, thereby providing a more complete molecular picture of this disease. In summary, given the broad phenotypic spectrum of most epilepsy-related genes, efficient genomic tools like the targeted exome sequencing panel described here are essential for early diagnosis and treatment, and should be implemented as first-tier diagnostic tools for children with epilepsy without a clear etiologic basis

Infrared Ellipsometry Analysis of Heritage Photographic Prints

[EN] Focusing on the photographic archive of Julian Carrillo (Mexico), we study and characterize the photographic processes of a set of 13 photographs dated between 1884 and 1925. By using infrared spectroscopic ellipsometry, we classified a selected set of photographs according to its kind of binder. Thus, we recognized for each photograph, the presence of proteins, and therefore, the particular photographic process. Furthermore, we have identified the presence of baryta layer, the use of plasticizer, and the eventual coating utilized to protect the photograph, whose composition was based in natural organic components, mainly shellac, beeswax, or camphorNieto-Villena, A.; Martinez, JR.; Flores-Camacho, JM.; Lastras-Martinez, A.; De La Cruz-Mendoza, JA.; Ortega-Zarzosa, G.; Valcarcel Andrés, JC.... (2018). Infrared Ellipsometry Analysis of Heritage Photographic Prints. Studies in Conservation. 63(8):466-476. https://doi.org/10.1080/00393630.2018.1476962S466476638Brambilla, L., Riedo, C., Baraldi, C., Nevin, A., Gamberini, M. C., D’Andrea, C., … Toniolo, L. (2011). Characterization of fresh and aged natural ingredients used in historical ointments by molecular spectroscopic techniques: IR, Raman and fluorescence. Analytical and Bioanalytical Chemistry, 401(6), 1827-1837. doi:10.1007/s00216-011-5168-zCasoli, A., & Fornaciari, S. (2014). An analytical study on an early twentieth-century Italian photographs collection by means of microscopic and spectroscopic techniques. Microchemical Journal, 116, 24-30. doi:10.1016/j.microc.2014.04.003Cattaneo, B., Chelazzi, D., Giorgi, R., Serena, T., Merlo, C., & Baglioni, P. (2008). Physico-chemical characterization and conservation issues of photographs dated between 1890 and 1910. Journal of Cultural Heritage, 9(3), 277-284. doi:10.1016/j.culher.2008.01.004Daher, C., Paris, C., Le Hô, A.-S., Bellot-Gurlet, L., & Échard, J.-P. (2010). A joint use of Raman and infrared spectroscopies for the identification of natural organic media used in ancient varnishes. Journal of Raman Spectroscopy, 41(11), 1494-1499. doi:10.1002/jrs.2693Edwards, H. G. M., Farwell, D. W., & Daffner, L. (1996). Fourier-transform Raman spectroscopic study of natural waxes and resins. I. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 52(12), 1639-1648. doi:10.1016/0584-8539(96)01730-8Fujiwara, H. (2007). Spectroscopic Ellipsometry. doi:10.1002/9780470060193Hendriks, K., & Ross, L. (1988). Chemical Treatments of Discoloured Photographic Prints: Image Manipulation or Legitimate Restoration? The Journal of Photographic Science, 36(3), 132-132. doi:10.1080/00223638.1988.11736990Mallégol, J., Gardette, J.-L., & Lemaire, J. (2000). Long-term behavior of oil-based varnishes and paints. Photo- and thermooxidation of cured linseed oil. Journal of the American Oil Chemists’ Society, 77(3), 257-263. doi:10.1007/s11746-000-0042-4Nieto-Villena, A., Martínez, J. R., de la Cruz-Mendoza, J. A., Valcárcel-Andrés, J. C., Ortega-Zarzosa, G., Solbes-García, Á., & Vázquez-Martínez, E. (2018). Atomic force microscopy as a tool for binder identification in ancient photographic processes. Surface and Interface Analysis, 50(4), 496-505. doi:10.1002/sia.6408Ostroff, Eugene. 1966. “Restoration of Photographs by Neutron Activation.” Science 154 (3745): 119–123. http://science.sciencemag.org/content/154/3745/119.Othmer, Kirk, ed. 2005. Encyclopedia of Chemical Technology. Vol. 17, 5th ed. New York: Wiley.Ricci, C., Bloxham, S., & Kazarian, S. G. (2007). ATR-FTIR imaging of albumen photographic prints. Journal of Cultural Heritage, 8(4), 387-395. doi:10.1016/j.culher.2007.07.002Sifontes, Á. B., Cañizales, E., Toro-Mendoza, J., Ávila, E., Hernández, P., Delgado, B. A., … Cruz-Barrios, E. (2015). Obtaining Highly Crystalline Barium Sulphate Nanoparticles via Chemical Precipitation and Quenching in Absence of Polymer Stabilizers. Journal of Nanomaterials, 2015, 1-8. doi:10.1155/2015/510376Stulik, Dusan, Herant Khanjian, Alberto de Tagle, and Alexandra M. Botelho. 2002. “Investigation of Jean-Louis-Marie-Eugene Durieu’s Toning and Varnishing Experiments: A Non-Destructive Approach.” ICOM Committee for Conservation 13th Triennial Meeting, Río de Janeiro, 658–663.Price, Beth A., and Boris Pretzel, eds. 2009. Infrared and Raman Users Group Spectral Database. 2007 ed. Vol. 1 & 2. Philadelphia: IRUG. Accessed June 20, 2014. http://www.irug.org/.Vila, A., & Centeno, S. A. (2013). FTIR, Raman and XRF identification of the image materials in turn of the 20th century pigment-based photographs. Microchemical Journal, 106, 255-262. doi:10.1016/j.microc.2012.07.01

Near barrier scattering of 8He on 208Pb

The exotic nucleus 8He is investigated by means of the measurement of the angular distributions of the elastic channel and the 6He and 4He fragment yields produced in the collision with a 208Pb target at two energies around the Coulomb barrier, 16 and 22 MeV. The experiment was performed at the GANIL-SPIRAL facility, with the aim of extracting information about the structure of 8He and the relevant reaction mechanisms. In this contribution, details of the experimental setup and preliminary data on elastic cross sections are reporte

Near barrier scattering of 8He on 208Pb

The exotic nucleus 8He is investigated by means of the measurement of the angular distributions of the elastic channel and the 6He and 4He fragment yields produced in the collision with a 208Pb target at two energies around the Coulomb barrier, 16 and 22 MeV. The experiment was performed at the GANIL-SPIRAL facility, with the aim of extracting information about the structure of 8He and the relevant reaction mechanisms. In this contribution, details of the experimental setup and preliminary data on elastic cross sections are reported

Measurement of the cross-section and charge asymmetry of WW bosons produced in proton-proton collisions at s=8\sqrt{s}=8 TeV with the ATLAS detector

This paper presents measurements of the $W^+ \rightarrow \mu^+\nu$ and $W^- \rightarrow \mu^-\nu$ cross-sections and the associated charge asymmetry as a function of the absolute pseudorapidity of the decay muon. The data were collected in proton--proton collisions at a centre-of-mass energy of 8 TeV with the ATLAS experiment at the LHC and correspond to a total integrated luminosity of 20.2~\mbox{fb^{-1}}. The precision of the cross-section measurements varies between 0.8% to 1.5% as a function of the pseudorapidity, excluding the 1.9% uncertainty on the integrated luminosity. The charge asymmetry is measured with an uncertainty between 0.002 and 0.003. The results are compared with predictions based on next-to-next-to-leading-order calculations with various parton distribution functions and have the sensitivity to discriminate between them.Comment: 38 pages in total, author list starting page 22, 5 figures, 4 tables, submitted to EPJC. All figures including auxiliary figures are available at https://atlas.web.cern.ch/Atlas/GROUPS/PHYSICS/PAPERS/STDM-2017-13