Amabilidad, confort y espiritualidad en los cuidados paliativos oncológicos: Aporte para la humanización en salud

Introduction. For terminally ill cancer patients, it is essential to feel welcome, comfortable, and receive spiritual support during hospitalization. Objective. Describe the kindness, comfort measures and support provided spiritual care to the terminally ill cancer patients as perceived by nurses and family caregivers in a hospital in Chiclayo, Peru. Methods: Qualitative descriptive research, the convenience sample and the sample so formed 06 nurses and 06 family caregivers of cancer patients at terminal stage, obtained by the technique of saturation and redundancy. To collect data was used to guide semistructured interview validated by expert judgment and pilot, which was recorded prior informed consent. Data were processed manually by thematic content analysis. Results. a) The friendliness of the nurse-patient, b) Measures of comfort for satisfying basic needs, c) Spiritual support for the relief of suffering. Conclusions. Humanization in caring for cancer patients starts with the kindness that refers to the greeting, respect and therapeutic touch, even at a time when nurses perform comfort measures to relieve pain and satisfaction of basic needs the collaboration of the accompanying family; certainly the spiritual support, expressed in promoting faith rescues hope, prayer, respecting the religious beliefs and practices. Cancer is likely to generate higher sensitivity and compassion in health personnel.Introducción. Para los pacientes oncológicos en fase terminal, es fundamental sentirse acogidos, cómodos, y recibir apoyo espiritual durante su hospitalización. Objetivo: Describir la amabilidad, las medidas de confort y el apoyo espiritual que se brinda en el cuidado al paciente oncológico en fase terminal según la percepción de enfermeras y familiares cuidadores en un hospital de Chiclayo-Perú. Método. Investigación cualitativa descriptiva, el muestreo fue por conveniencia y la muestra lo conformó 06 enfermeras y 06 familiares cuidadores de pacientes oncológicos en fase terminal, obtenidos por la técnica de saturación y redundancia. Para recolectar los datos se usó guía de entrevista semiestructurada validado por juicio de expertos y prueba piloto, la cual fue grabada previo consentimiento informado. Los datos fueron procesados de manera manual mediante el análisis de contenido temático. Resultados. a) La amabilidad en la relación enfermera-paciente, b) Medidas de confort para satisfacción de necesidades básicas, c) Apoyo espiritual para el alivio del sufrimiento. Conclusiones. Existe humanización en el cuidado a pacientes oncológicos, se inicia con la amabilidad que se refiere al saludo, el respeto y el toque terapéutico, aun en momentos en que las enfermeras realizan las medidas de confort para aliviar el dolor y la satisfacción de las necesidades básicas con la colaboración del familiar acompañante; sin duda se rescata el apoyo espiritual, que se expresa en el fomento de la fe, la esperanza, la oración, respetando las creencias y prácticas religiosas. Es probable que el cáncer genere mayor sensibilidad y compasión en el personal de salud.Introdução. Para pacientes com câncer em estado terminal, é essencial para se sentir bem-vindo, confortável, e receber apoio espiritual durante a hospitalização. Objetivo. Descreva a bondade, medidas de conforto e apoio prestado assistência espiritual aos pacientes com câncer em estado terminal, como percebido pelos enfermeiros e cuidadores familiares em um hospital em Chiclayo, Peru. Método. Pesquisa qualitativa descritiva, a amostra de conveniência e a amostra assim formado 06 enfermeiras e 06 cuidadores familiares de doentes com cancro na fase terminal, obtidos pela técnica de saturação e redundância. Para coleta de dados foi usado para guiar entrevista semi-estruturada validada pelo julgamento e perito piloto, que foi gravado consentimento prévio. Os dados foram processados manualmente por meio de análise de conteúdo temática. Resultados. a) A simpatia das Medidas de enfermeiro-paciente, b) de conforto para satisfazer as necessidades básicas, c) apoio espiritual para o alívio do sofrimento. Conclusões. Humanização no atendimento de pacientes com câncer começa com a bondade que se refere ao cumprimento, respeito e toque terapêutico, mesmo num momento em que os enfermeiros executar medidas de conforto para aliviar a dor e satisfação das necessidades básicas a colaboração da família de acompanhamento; certamente o apoio espiritual, expressa na promoção resgata esperança fé, oração, respeitando as crenças e práticas religiosas. O câncer é susceptível de gerar maior sensibilidade e compaixão em pessoal de saúde

Guidelines for Innovation Platforms in Agricultural Research for Development : Decision support for research, development and funding agencies on how to design, budget and implement impactful Innovation Platforms

Innovation Platforms are fast becoming part of the mantra of agricultural research for development projects and programmes. Their basic tenet is that stakeholders depend on one another to achieve agricultural development outcomes, and hence need a space where they can learn, negotiate, and coordinate to overcome challenges and capture opportunities through a facilitated innovation process. This important publication provides a critical analysis of Innovation Platforms, their defining features, key functions, and what they can and – as importantly – cannot do.It will be invaluable reading both for those who fund development projects andprogrammes and would like to understand when Innovation Platforms are the approach of choice, and for those practitioners who implement and facilitate Innovation Platforms and would like to understand better their design principles and practical implementation issues.Because Innovation Platforms have been successful in addressing agricultural challenges, there is a risk that they will be promoted as a panacea for all problems in the agricultural sector. As the authors make clear, however, not all constraints will require Innovation Platforms and, if there is a simpler and cheaper alternative, that should be the first choice. It is essential to think more critically about when, how, and in what form Innovation Platforms can contribute meaningfully to Agricultural development impacts.The document was developed through a learning collaboration between CGIARresearch centres and other academic and more applied research centres. Elevenof the 15 CGIAR centres participated and contributed their expertise and experiences across multiple agricultural systems, geographies, and types of complex constraint. The booklet provides information grounded in a rich practical experience of key design and implementation principles, and the financial and human resources that need to be made available, and it makes suggestions for more effective monitoring, evaluation, and learning. It also lists reference materials, answers frequently asked questions, and provides a decision support tool for research, development, and funding agencies.All in all, this publication offers a lot for those who aspire to make sensible use ofInnovation Platforms in pursuing agricultural development

The upgrade of the ALICE TPC with GEMs and continuous readout

The upgrade of the ALICE TPC will allow the experiment to cope with the high interaction rates foreseen for the forthcoming Run 3 and Run 4 at the CERN LHC. In this article, we describe the design of new readout chambers and front-end electronics, which are driven by the goals of the experiment. Gas Electron Multiplier (GEM) detectors arranged in stacks containing four GEMs each, and continuous readout electronics based on the SAMPA chip, an ALICE development, are replacing the previous elements. The construction of these new elements, together with their associated quality control procedures, is explained in detail. Finally, the readout chamber and front-end electronics cards replacement, together with the commissioning of the detector prior to installation in the experimental cavern, are presented. After a nine-year period of R&D, construction, and assembly, the upgrade of the TPC was completed in 2020.publishedVersio

The present and future of QCD

This White Paper presents an overview of the current status and future perspective of QCD research, based on the community inputs and scientific conclusions from the 2022 Hot and Cold QCD Town Meeting. We present the progress made in the last decade toward a deep understanding of both the fundamental structure of the sub-atomic matter of nucleon and nucleus in cold QCD, and the hot QCD matter in heavy ion collisions. We identify key questions of QCD research and plausible paths to obtaining answers to those questions in the near future, hence defining priorities of our research over the coming decades

The genetic architecture of the human cerebral cortex

INTRODUCTION The cerebral cortex underlies our complex cognitive capabilities. Variations in human cortical surface area and thickness are associated with neurological, psychological, and behavioral traits and can be measured in vivo by magnetic resonance imaging (MRI). Studies in model organisms have identified genes that influence cortical structure, but little is known about common genetic variants that affect human cortical structure. RATIONALE To identify genetic variants associated with human cortical structure at both global and regional levels, we conducted a genome-wide association meta-analysis of brain MRI data from 51,665 individuals across 60 cohorts. We analyzed the surface area and average thickness of the whole cortex and 34 cortical regions with known functional specializations. RESULTS We identified 306 nominally genome-wide significant loci (P < 5 × 10−8) associated with cortical structure in a discovery sample of 33,992 participants of European ancestry. Of the 299 loci for which replication data were available, 241 loci influencing surface area and 14 influencing thickness remained significant after replication, with 199 loci passing multiple testing correction (P < 8.3 × 10−10; 187 influencing surface area and 12 influencing thickness). Common genetic variants explained 34% (SE = 3%) of the variation in total surface area and 26% (SE = 2%) in average thickness; surface area and thickness showed a negative genetic correlation (rG = −0.32, SE = 0.05, P = 6.5 × 10−12), which suggests that genetic influences have opposing effects on surface area and thickness. Bioinformatic analyses showed that total surface area is influenced by genetic variants that alter gene regulatory activity in neural progenitor cells during fetal development. By contrast, average thickness is influenced by active regulatory elements in adult brain samples, which may reflect processes that occur after mid-fetal development, such as myelination, branching, or pruning. When considered together, these results support the radial unit hypothesis that different developmental mechanisms promote surface area expansion and increases in thickness. To identify specific genetic influences on individual cortical regions, we controlled for global measures (total surface area or average thickness) in the regional analyses. After multiple testing correction, we identified 175 loci that influence regional surface area and 10 that influence regional thickness. Loci that affect regional surface area cluster near genes involved in the Wnt signaling pathway, which is known to influence areal identity. We observed significant positive genetic correlations and evidence of bidirectional causation of total surface area with both general cognitive functioning and educational attainment. We found additional positive genetic correlations between total surface area and Parkinson’s disease but did not find evidence of causation. Negative genetic correlations were evident between total surface area and insomnia, attention deficit hyperactivity disorder, depressive symptoms, major depressive disorder, and neuroticism. CONCLUSION This large-scale collaborative work enhances our understanding of the genetic architecture of the human cerebral cortex and its regional patterning. The highly polygenic architecture of the cortex suggests that distinct genes are involved in the development of specific cortical areas. Moreover, we find evidence that brain structure is a key phenotype along the causal pathway that leads from genetic variation to differences in general cognitive function

ϒ production in p–Pb collisions at √sNN=8.16 TeV

ϒ production in p–Pb interactions is studied at the centre-of-mass energy per nucleon–nucleon collision √sNN = 8.16 TeV with the ALICE detector at the CERN LHC. The measurement is performed reconstructing bottomonium resonances via their dimuon decay channel, in the centre-of-mass rapidity intervals 2.03 < ycms < 3.53 and −4.46 < ycms < −2.96, down to zero transverse momentum. In this work, results on the ϒ(1S) production cross section as a function of rapidity and transverse momentum are presented. The corresponding nuclear modification factor shows a suppression of the ϒ(1S) yields with respect to pp collisions, both at forward and backward rapidity. This suppression is stronger in the low transverse momentum region and shows no significant dependence on the centrality of the interactions. Furthermore, the ϒ(2S) nuclear modification factor is evaluated, suggesting a suppression similar to that of the ϒ(1S). A first measurement of the ϒ(3S) has also been performed. Finally, results are compared with previous ALICE measurements in p–Pb collisions at √sNN = 5.02 TeV and with theoretical calculations.publishedVersio

(Anti-)deuteron production in pp collisions at 1as=13TeV

The study of (anti-)deuteron production in pp collisions has proven to be a powerful tool to investigate the formation mechanism of loosely bound states in high-energy hadronic collisions. In this paper the production of (anti-)deuterons is studied as a function of the charged particle multiplicity in inelastic pp collisions at s=13 TeV using the ALICE experiment. Thanks to the large number of accumulated minimum bias events, it has been possible to measure (anti-)deuteron production in pp collisions up to the same charged particle multiplicity (d Nch/ d \u3b7 3c 26) as measured in p\u2013Pb collisions at similar centre-of-mass energies. Within the uncertainties, the deuteron yield in pp collisions resembles the one in p\u2013Pb interactions, suggesting a common formation mechanism behind the production of light nuclei in hadronic interactions. In this context the measurements are compared with the expectations of coalescence and statistical hadronisation models (SHM)

Multiplicity dependence of inclusive J/psi production at midrapidity in pp collisions at root s=13 TeV

Measurements of the inclusive J/psi yield as a function of charged-particle pseudorapidity density dN(ch)/d eta in pp collisions at root s = 13 TeV with ALICE at the LHC are reported. The J/psi meson yield is measured at midrapidity (vertical bar y vertical bar <0.9) in the dielectron channel, for events selected based on the charged-particle multiplicity at midrapidity (vertical bar eta vertical bar <1) and at forward rapidity (-3.7 <eta <-1.7 and 2.8 <eta <5.1); both observables are normalized to their corresponding averages in minimum bias events. The increase of the normalized J/psi yield with normalized dN(ch)/d eta is significantly stronger than linear and dependent on the transverse momentum. The data are compared to theoretical predictions, which describe the observed trends well, albeit not always quantitatively. (C) 2020 European Organization for Nuclear Research. Published by Elsevier B.V.Peer reviewe