Design of Pumping Stations Using a Multicriteria Analysis and the Application of the AHP Method

[EN] The pumping station are very important hydraulic system in urban water supply be-cause the pumps raise the water head ensuring the minimum pressure required in drinking water systems. In the design of a pumping station, one of the most important criteria is the number of pumps. However, in the traditional design this criterion is de-fined arbitrarily. The other criteria are defined from the number of pumps and can be produce a design not optimal. In addition, the traditional design does not consider the environment importance to choose the pumps. The objective of this paper is defining a new design methodology for pumping sta-tions. It has been developed using a multicriteria analysis in which nine criteria are evaluated. The application of the analytic hierarchy process (AHP) allows finding an optimal solution. These design criteria have been associated in three cluster factors: technical factors, environmental factors, and economic factors. The results obtained allow not only to validate the methodology, but also to offer a solution to the problem of determining the most suitable model and the number of pumps of a pumping sta-tion.Sánchez-Ferrer, DS.; Briceño-León, CX.; Iglesias Rey, PL.; Martínez-Solano, FJ.; Fuertes-Miquel, VS. (2021). Design of Pumping Stations Using a Multicriteria Analysis and the Application of the AHP Method. Sustainability. 13(11):1-22. https://doi.org/10.3390/su13115876S122131

Department of Energy Solar Decathlon 2015

The goal of the Department of Energy (DOE) Solar Decathlon 2015 project is to design, build, and operate a zero-net energy solar-photovoltaic (solar-PV) powered residence. It is an international competition taking place in the fall of 2015 in Irvine, California. The design needs to be attractive, energy-efficient, innovative, and affordable. The Cal Poly team includes students from a variety of majors, including Architecture, Mechanical Engineering, Electrical Engineering, and many more. The different disciplines need to work together to create a functional and cohesive design. For our senior project, we have designed the electrical systems in the home, including the power, lighting, solar-PV systems, and energy monitoring. The design flow has four stages, Schematic Design (SD), Design Documents (DD), Construction Documents (CD), and Construction Administration (CA). Models were created using the AutoDesk software Revit, which is a building information modeling program with real-time 3D rendering. Our electrical design must comply with state and national building codes, such as the California Electrical Code (CEC) and National Electrical Code (NEC)

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Strongly scale-dependent polyspectra from curvaton self-interactions

We study the scale dependence of the non-linearity parameters f_NL and g_NL in curvaton models with self-interactions. We show that the spectral indices n_fNL=d ln|f_NL|/(d ln k) and n_gNL=d ln |g_NL|/(d ln k) can take values much greater than the slow--roll parameters and the spectral index of the power spectrum. This means that the scale--dependence of the bi and trispectrum could be easily observable in this scenario with Planck, which would lead to tight additional constraints on the model. Inspite of the highly non-trivial behaviour of f_NL and g_NL in the curvaton models with self-interactions, we find that the model can be falsified if g_NL(k) is also observed.Comment: 19 pages, many figures. v2: Figure 4 replaced with a corrected normalisation, conclusions unchanged. Matches version published in JCA

US Cosmic Visions: New Ideas in Dark Matter 2017: Community Report

This white paper summarizes the workshop "U.S. Cosmic Visions: New Ideas in Dark Matter" held at University of Maryland on March 23-25, 2017.Comment: 102 pages + reference

Structural and functional insight into human O-GlcNAcase.

O-GlcNAc hydrolase (OGA) removes O-linked N-acetylglucosamine (O-GlcNAc) from a myriad of nucleocytoplasmic proteins. Through co-expression and assembly of OGA fragments, we determined the three-dimensional structure of human OGA, revealing an unusual helix-exchanged dimer that lays a structural foundation for an improved understanding of substrate recognition and regulation of OGA. Structures of OGA in complex with a series of inhibitors define a precise blueprint for the design of inhibitors that have clinical value

Characterization of Novel Antimalarial Compound ACT-451840: Preclinical Assessment of Activity and Dose-Efficacy Modeling.

BACKGROUND: Artemisinin resistance observed in Southeast Asia threatens the continued use of artemisinin-based combination therapy in endemic countries. Additionally, the diversity of chemical mode of action in the global portfolio of marketed antimalarials is extremely limited. Addressing the urgent need for the development of new antimalarials, a chemical class of potent antimalarial compounds with a novel mode of action was recently identified. Herein, the preclinical characterization of one of these compounds, ACT-451840, conducted in partnership with academic and industrial groups is presented. METHOD AND FINDINGS: The properties of ACT-451840 are described, including its spectrum of activities against multiple life cycle stages of the human malaria parasite Plasmodium falciparum (asexual and sexual) and Plasmodium vivax (asexual) as well as oral in vivo efficacies in two murine malaria models that permit infection with the human and the rodent parasites P. falciparum and Plasmodium berghei, respectively. In vitro, ACT-451840 showed a 50% inhibition concentration of 0.4 nM (standard deviation [SD]: ± 0.0 nM) against the drug-sensitive P. falciparum NF54 strain. The 90% effective doses in the in vivo efficacy models were 3.7 mg/kg against P. falciparum (95% confidence interval: 3.3-4.9 mg/kg) and 13 mg/kg against P. berghei (95% confidence interval: 11-16 mg/kg). ACT-451840 potently prevented male gamete formation from the gametocyte stage with a 50% inhibition concentration of 5.89 nM (SD: ± 1.80 nM) and dose-dependently blocked oocyst development in the mosquito with a 50% inhibitory concentration of 30 nM (range: 23-39). The compound's preclinical safety profile is presented and is in line with the published results of the first-in-man study in healthy male participants, in whom ACT-451840 was well tolerated. Pharmacokinetic/pharmacodynamic (PK/PD) modeling was applied using efficacy in the murine models (defined either as antimalarial activity or as survival) in relation to area under the concentration versus time curve (AUC), maximum observed plasma concentration (Cmax), and time above a threshold concentration. The determination of the dose-efficacy relationship of ACT-451840 under curative conditions in rodent malaria models allowed prediction of the human efficacious exposure. CONCLUSION: The dual activity of ACT-451840 against asexual and sexual stages of P. falciparum and the activity on P. vivax have the potential to meet the specific profile of a target compound that could replace the fast-acting artemisinin component and harbor additional gametocytocidal activity and, thereby, transmission-blocking properties. The fast parasite reduction ratio (PRR) and gametocytocidal effect of ACT-451840 were recently also confirmed in a clinical proof-of-concept (POC) study