Annual to seasonal glacier mass balance in High Mountain Asia derived from Pl\ue9iades stereo images: examples from the Pamir and the Tibetan Plateau

\ua9 Copyright: Glaciers are crucial sources of freshwater in particular for the arid lowlands surrounding High Mountain Asia. To better constrain glacio-hydrological models, annual, or even better, seasonal information about glacier mass changes is highly beneficial. In this study, we evaluate the suitability of very-high-resolution Pl\ue9iades digital elevation models (DEMs) to measure glacier mass balance at annual and seasonal scales in two regions of High Mountain Asia (Muztagh Ata in Eastern Pamirs and parts of western Nyainq\ueantanglha, south-central Tibetan Plateau), where recent estimates have shown contrasting glacier behaviour. The average annual mass balance in Muztagh Ata between 2019 and 2022 was -0.07ĝ€\uaf\ub1ĝ€\uaf0.20ĝ€\uafmĝ€\uafw.e.ĝ€\uafa-1, suggesting the continuation of a recent phase of slight mass loss following a prolonged period of balanced mass budgets previously observed. The mean annual mass balance in western Nyainq\ueantanglha was highly negative for the same period (-0.60ĝ€\uaf\ub1ĝ€\uaf0.15ĝ€\uafmĝ€\uafw.e.ĝ€\uafa-1), suggesting increased mass loss rates compared to the approximately previous 5 decades. The 2022 winter (+0.13ĝ€\uaf\ub1ĝ€\uaf0.24ĝ€\uafmĝ€\uafw.e.) and summer (-0.35ĝ€\uaf\ub1ĝ€\uaf0.15ĝ€\uafmĝ€\uafw.e.) mass budgets in Muztagh Ata and western Nyainq\ueantanglha (-0.03ĝ€\uaf\ub1ĝ€\uaf0.27ĝ€\uafmĝ€\uafw.e. in winter; -0.63ĝ€\uaf\ub1ĝ€\uaf0.07ĝ€\uafmĝ€\uafw.e. in summer) suggest winter- and summer-accumulation-type regimes, respectively. We support our findings by implementing the Sentinel-1-based Glacier Index to identify the firn and wet-snow areas on glaciers and characterize the accumulation type. The good match between the geodetic and Glacier Index results supports the potential of very-high-resolution Pl\ue9iades data to monitor mass balance at short timescales and improves our understanding of glacier accumulation regimes across High Mountain Asia

Estrategias de reparación para sitios web incompletos

El desarrollo y mantenimiento de sitios Web no es un tarea fácil. Garantizar que la información de un sitio Web es consistente resulta cada vez más difícil, por ello los administradores Web necesitan de mecanismos que ayuden a reparar estas inconsistencias. En este trabajo, completamos la metodología de reparación semiautomática de sitios Web erróneos presentada en un trabajo anterior con el tratamiento de los errores de completitud. Comenzamos con la categorización de dichos errores mediante dos nuevos órdenes que definimos sobre el conjunto de errores de completitud obtenidos en el proceso de verificación. Utilizando estos ordenes, definimos sendas estrategias capaces de minimizar la cantidad de acciones de reparación a realizarse para generar un sitio Web completo con respecto a su especificación.IV Workshop de Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Estrategias de reparación para sitios web incompletos

El desarrollo y mantenimiento de sitios Web no es un tarea fácil. Garantizar que la información de un sitio Web es consistente resulta cada vez más difícil, por ello los administradores Web necesitan de mecanismos que ayuden a reparar estas inconsistencias. En este trabajo, completamos la metodología de reparación semiautomática de sitios Web erróneos presentada en un trabajo anterior con el tratamiento de los errores de completitud. Comenzamos con la categorización de dichos errores mediante dos nuevos órdenes que definimos sobre el conjunto de errores de completitud obtenidos en el proceso de verificación. Utilizando estos ordenes, definimos sendas estrategias capaces de minimizar la cantidad de acciones de reparación a realizarse para generar un sitio Web completo con respecto a su especificación.IV Workshop de Ingeniería de Software y Base de DatosRed de Universidades con Carreras en Informática (RedUNCI

Spotlight on Geminin

In the previous issue of Breast Cancer Research, Gardner and co-workers describe a novel interaction between Geminin, a protein that prevents reinitiation of DNA replication, and Topoisomerase IIα (TopoIIα), an enzyme essential for removing catenated intertwines between sister chromatids. Geminin facilitates the action of TopoIIα, thereby promoting termination of DNA replication at the same time it inhibits initiation. In this manner, Geminin ensures that cells duplicate their genome once, but only once, each time they divide. Remarkably, either depletion of Geminin or over-expression of Geminin inhibits the action of TopoIIα, thereby making Geminin an excellent target for cancer chemotherapy

Timeless standards for species delimitation

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Antimicrobial resistance among migrants in Europe: a systematic review and meta-analysis

BACKGROUND: Rates of antimicrobial resistance (AMR) are rising globally and there is concern that increased migration is contributing to the burden of antibiotic resistance in Europe. However, the effect of migration on the burden of AMR in Europe has not yet been comprehensively examined. Therefore, we did a systematic review and meta-analysis to identify and synthesise data for AMR carriage or infection in migrants to Europe to examine differences in patterns of AMR across migrant groups and in different settings. METHODS: For this systematic review and meta-analysis, we searched MEDLINE, Embase, PubMed, and Scopus with no language restrictions from Jan 1, 2000, to Jan 18, 2017, for primary data from observational studies reporting antibacterial resistance in common bacterial pathogens among migrants to 21 European Union-15 and European Economic Area countries. To be eligible for inclusion, studies had to report data on carriage or infection with laboratory-confirmed antibiotic-resistant organisms in migrant populations. We extracted data from eligible studies and assessed quality using piloted, standardised forms. We did not examine drug resistance in tuberculosis and excluded articles solely reporting on this parameter. We also excluded articles in which migrant status was determined by ethnicity, country of birth of participants' parents, or was not defined, and articles in which data were not disaggregated by migrant status. Outcomes were carriage of or infection with antibiotic-resistant organisms. We used random-effects models to calculate the pooled prevalence of each outcome. The study protocol is registered with PROSPERO, number CRD42016043681. FINDINGS: We identified 2274 articles, of which 23 observational studies reporting on antibiotic resistance in 2319 migrants were included. The pooled prevalence of any AMR carriage or AMR infection in migrants was 25·4% (95% CI 19·1-31·8; I2 =98%), including meticillin-resistant Staphylococcus aureus (7·8%, 4·8-10·7; I2 =92%) and antibiotic-resistant Gram-negative bacteria (27·2%, 17·6-36·8; I2 =94%). The pooled prevalence of any AMR carriage or infection was higher in refugees and asylum seekers (33·0%, 18·3-47·6; I2 =98%) than in other migrant groups (6·6%, 1·8-11·3; I2 =92%). The pooled prevalence of antibiotic-resistant organisms was slightly higher in high-migrant community settings (33·1%, 11·1-55·1; I2 =96%) than in migrants in hospitals (24·3%, 16·1-32·6; I2 =98%). We did not find evidence of high rates of transmission of AMR from migrant to host populations. INTERPRETATION: Migrants are exposed to conditions favouring the emergence of drug resistance during transit and in host countries in Europe. Increased antibiotic resistance among refugees and asylum seekers and in high-migrant community settings (such as refugee camps and detention facilities) highlights the need for improved living conditions, access to health care, and initiatives to facilitate detection of and appropriate high-quality treatment for antibiotic-resistant infections during transit and in host countries. Protocols for the prevention and control of infection and for antibiotic surveillance need to be integrated in all aspects of health care, which should be accessible for all migrant groups, and should target determinants of AMR before, during, and after migration. FUNDING: UK National Institute for Health Research Imperial Biomedical Research Centre, Imperial College Healthcare Charity, the Wellcome Trust, and UK National Institute for Health Research Health Protection Research Unit in Healthcare-associated Infections and Antimictobial Resistance at Imperial College London

Strategic directions in constraint programming

An abstract is not available

Landslide susceptibility mapping at VAZ watershed (Iran) using an artificial neural network model: a comparison between multilayer perceptron (MLP) and radial basic function (RBF) algorithms

Landslide susceptibility and hazard assessments are the most important steps in landslide risk mapping. The main objective of this study was to investigate and compare the results of two artificial neural network (ANN) algorithms, i.e., multilayer perceptron (MLP) and radial basic function (RBF) for spatial prediction of landslide susceptibility in Vaz Watershed, Iran. At first, landslide locations were identified by aerial photographs and field surveys, and a total of 136 landside locations were constructed from various sources. Then the landslide inventory map was randomly split into a training dataset 70 % (95 landslide locations) for training the ANN model and the remaining 30 % (41 landslides locations) was used for validation purpose. Nine landslide conditioning factors such as slope, slope aspect, altitude, land use, lithology, distance from rivers, distance from roads, distance from faults, and rainfall were constructed in geographical information system. In this study, both MLP and RBF algorithms were used in artificial neural network model. The results showed that MLP with Broyden–Fletcher–Goldfarb–Shanno learning algorithm is more efficient than RBF in landslide susceptibility mapping for the study area. Finally the landslide susceptibility maps were validated using the validation data (i.e., 30 % landslide location data that was not used during the model construction) using area under the curve (AUC) method. The success rate curve showed that the area under the curve for RBF and MLP was 0.9085 (90.85 %) and 0.9193 (91.93 %) accuracy, respectively. Similarly, the validation result showed that the area under the curve for MLP and RBF models were 0.881 (88.1 %) and 0.8724 (87.24 %), respectively. The results of this study showed that landslide susceptibility mapping in the Vaz Watershed of Iran using the ANN approach is viable and can be used for land use planning