On the Continuous Formation of Field Spheroidal Galaxies in Hierarchical Models of Structure Formation

We re-examine the assembly history of field spheroidals as a potentially powerful discriminant of galaxy formation models. Whereas monolithic collapse and hierarchical, merger-driven, models suggest radically different histories for these galaxies, neither the theoretical predictions nor the observational data for field galaxies have been sufficiently reliable for precise conclusions to be drawn. A major difficulty in interpreting the observations, reviewed here, concerns the taxonomic definition of spheroidals in merger-based models. Using quantitative measures of recent star formation activity drawn from the internal properties of a sample of distant field galaxies in the Hubble Deep Fields, we undertake a new analysis to assess the continuous formation of spheroidal galaxies. Whereas abundances and redshift distributions of modelled spheroidals are fairly insensitive to their formation path, we demonstrate that the distribution and amount of blue light arising from recent mergers provides a more sensitive approach. With the limited resolved data currently available, the rate of mass assembly implied by the observed colour inhomogeneities is compared to that expected in popular Lambda-dominated cold dark matter models of structure formation. These models produce as many highly inhomogeneous spheroidals as observed, but underpredict the proportion of homogeneous, passive objects. We conclude that colour inhomogeneities, particularly when combined with spectroscopic diagnostics for large, representative samples of field spheroidals, will be a more valuable test of their physical assembly history than basic source counts and redshift distributions. Securing such data should be a high priority for the Advanced Camera for Surveys on Hubble Space Telescope.Comment: 14 pages, 7 figures, submitted to MNRA

Unveiling the oldest and most massive galaxies at very high redshift

(Abridged) This work explores the existence of high redshift massive galaxies unveiled with Spitzer+IRAC, but missed by conventional selection techniques based on optical and near-infrared observations. To this end, we use the multi-wavelength imaging data available for the GOODS-South field, and select a flux-limited sample from the IRAC 3.6um image to m(AB)<23.26. We confine our study to the galaxies undetected by the optical HST+ACS imaging and close to the detection limit of the K-band image (K>23.5 AB). Our selection unveiled 20 galaxies on which we performed a detailed photometric analysis. For each galaxy, we built an SED based on optical-to-8um photometry to estimate the photo-z and to derive the main galaxies physical properties. The majority of the sample sources show degenerate/bimodal solutions for the photometric redshifts (Abridged). These can either be heavily dust-enshrouded (Av~2-4) starbursts at 210^12 Lsun, or massive post-starburst galaxies in the redshift interval 4<z<9 with stellar masses of 10^11 Msun. One galaxy, the only source in our sample with both an X-ray and a 24um detection, might be an extremely massive object at z~8 detected during a post-starburst phase with concomitant QSO activity (although a lower-z solution is not excluded). Our investigation of Spitzer-selected galaxies with very red SEDs and completely undetected in the optical reveals a potential population of massive galaxies at z>4 which appear to include significant AGN emissions. These sources may be the oldest stellar systems at z~4. These, previously unrecognized, optically obscured objects might provide an important contribution to the massive-end (M>10^11 sun) of the high-z stellar mass function and they would almost double it (Abridged).Comment: Accepted for publication in Astronomy and Astrophysic

Cosmic Star Formation: Constraints on the Galaxy Formation Models

We study the evolution of the cosmic star formation by computing the luminosity density (LD) in the UV, B, J, and K bands, and the stellar mass density (MD) of galaxies in two reference models of galaxy evolution: the pure luminosity evolution (PLE) model developed by Calura & Matteucci (2003) and the semi-analytical model (SAM) of hierarchical galaxy formation by Menci et al. (2002). The former includes a detailed description of the chemical evolution of galaxies of different morphological types with no density evolution; the latter includes the merging histories of the galactic DM haloes, as predicted by the hierarchical clustering scenario, but it does not contain morphological classification nor chemical evolution. We find that at z< 1.5 both models are consistent with the available data on the LD of galaxies in all the considered bands. At high z, the LDs predicted in the PLE model show a peak due to the formation of ellipticals, whereas the SAM predicts a gradual decrease of the star formation and of the LD for z> 2.5. At such redshifts the PLE predictions tend to overestimate the present data in the B band whereas the SAM tends to underestimate the observed UV LD. As for the stellar MD, the PLE picture predicts that nearly 50% and 85% of the present stellar mass are in place at z=4 and z=1, respectively. According to the SAM, 50% and 60% of the present stellar mass are in place at z=1.2 and z=1, respectively. Both predictions fit the observed MD up to z=1. At z>1, the PLE model and the SAM tend to overestimate and underestimate the observed values, respectively. We discuss the origin of the above model results, and the role of observational uncertainties (such as dust extinction) in comparing models with observations.Comment: 14 pages, accepted for publication in MNRA

Hubble Space Telescope Imaging of the CFRS and LDSS Redshift Surveys---III. Field elliptical galaxies at 0.2 < z < 1.0

Surface photometry has been performed on a sample of 46 field elliptical galaxies. These galaxies are described well by a deVaucouleurs R^{1/4} profile. The sample was selected from the combined Canada-France and LDSS redshift surveys and spans the range 0.20 < z < 1.00. The relationship between galaxy half-light radius and luminosity evolves such that a galaxy of a given size is more luminous by Delta M_B=-0.97 \pm 0.14 mag at z=0.92 and the mean rest-frame color shifts blueward by Delta (U-V) =-0.68 \pm 0.11 at z=0.92 relative to the local cluster relations. Approximately 1/3 of these elliptical galaxies exhibit [OII] 3727 emission lines with equivalent widths > 15 angstroms indicating ongoing star formation. Estimated star-formation rates imply that \le 5% of the stellar mass in the elliptical galaxy population has been formed since z=1. We see no evidence for a decline in the space density of early-type galaxies with look-back time. The statistics and a comparison with local luminosity functions are both consistent with the view that the population of massive early-type galaxies was largely in place by z~1. This implies that merging is not required since that time to produce the present-day space density of elliptical galaxies.Comment: 21 pages plus 8 figures plus 5 tables. Accepted by Astrophysical Journa

Cosmic evolution of the galaxy mass and luminosity functions by morphological type from multi-wavelength data in the CDF-South

We constrain the evolution of the galaxy mass and luminosity functions from the analysis of (public) multi-wavelength data in the Chandra Deep Field South (CDFS) area, obtained from the GOODS and other projects, and including very deep high-resolution imaging by HST/ACS. Our reference catalogue of faint high-redshift galaxies, which we have thoroughly tested for completeness and reliability, comes from a deep (S(3.6micron)>1 microJy) image by IRAC on the Spitzer Observatory. These imaging data in the field are complemented with extensive optical spectroscopy by the ESO VLT/FORS2 and VIMOS spectrographs, while deep K-band VLT/ISAAC imaging is also used to derive further complementary statistical constraints and to assist the source identification and SED analysis. We have selected a highly reliable IRAC 3.6micron sub-sample of 1478 galaxies with S(3.6)>10microJy, 47% of which have spectroscopic redshift, while for the remaining objects both COMBO-17 and Hyperz are used to estimate the photometric redshift. This very extensive dataset is exploited to assess evolutionary effects in the galaxy luminosity and stellar mass functions, while luminosity/density evolution is further constrained with the number counts and redshift distributions. The deep ACS imaging allows us to differentiate these evolutionary paths by morphological type, which our simulations show to be reliable at least up to z=1.5 for the two main early- (E/S0) and late-type (Sp/Irr) classes. These data, as well as our direct estimate of the stellar mass function above M=10^(10)M_sun for the spheroidal subclass, consistently evidence a progressive dearth of such objects to occur starting at z=0.7, paralleled by an increase in luminosity. (abridged)Comment: paper accepted for publication in A&

Automated Morphological Classification of SDSS Red Sequence Galaxies

(abridged) In the last decade, the advent of enormous galaxy surveys has motivated the development of automated morphological classification schemes to deal with large data volumes. Existing automated schemes can successfully distinguish between early and late type galaxies and identify merger candidates, but are inadequate for studying detailed morphologies of red sequence galaxies. To fill this need, we present a new automated classification scheme that focuses on making finer distinctions between early types roughly corresponding to Hubble types E, S0, and Sa. We visually classify a sample of 984 non-starforming SDSS galaxies with apparent sizes >14". We then develop an automated method to closely reproduce the visual classifications, which both provides a check on the visual results and makes it possible to extend morphological analysis to much larger samples. We visually classify the galaxies into three bulge classes (BC) by the shape of the light profile in the outer regions: discs have sharp edges and bulges do not, while some galaxies are intermediate. We separately identify galaxies with features: spiral arms, bars, clumps, rings, and dust. We find general agreement between BC and the bulge fraction B/T measured by the galaxy modeling package GIM2D, but many visual discs have B/T>0.5. Three additional automated parameters -- smoothness, axis ratio, and concentration -- can identify many of these high-B/T discs to yield automated classifications that agree ~70% with the visual classifications (>90% within one BC). Both methods are used to study the bulge vs. disc frequency as a function of four measures of galaxy 'size': luminosity, stellar mass, velocity dispersion, and radius. All size indicators show a fall in disc fraction and a rise in bulge fraction among larger galaxies.Comment: 24 pages, 20 figures, MNRAS accepte

Caecal metastasis from breast cancer presenting as intestinal obstruction

<p>Abstract</p> <p>Background</p> <p>Gastrointestinal metastsasis from the breast cancer are rare. We report a patient who presented with intestinal obstruction due to solitary caecal metastasis from infiltrating ductal carcinoma of breast. We also review the available literature briefly.</p> <p>Case presentation</p> <p>A 72 year old lady with past history of breast cancer presented with intestinal obstruction due to a caecal mass. She underwent an emergency right hemicolectomy. The histological examination of the right hemicolectomy specimen revealed an adenocarcinoma in caecum staining positive for Cytokeratin 7 and Carcinoembryonic antigen and negative for Cytokeratin 20, CDX2 and Estrogen receptor. Eight out of 11 mesenteric nodes showed tumour deposits. A histological diagnosis of metastatic breast carcinoma was given.</p> <p>Conclusion</p> <p>To the best of our knowledge, this is the first case report of solitary metastasis to caecum from infiltrating ductal carcinoma of breast. Awareness of this possibility will aid in appropriate management of such patients.</p

On the buildup of massive early-type galaxies at z<~1. I- Reconciling their hierarchical assembly with mass-downsizing

Several studies have tried to ascertain whether or not the increase in abundance of the early-type galaxies (E-S0a's) with time is mainly due to major mergers, reaching opposite conclusions. We have tested it directly through semi-analytical modelling, by studying how the massive early-type galaxies with log(M_*/Msun)>11 at z~0 (mETGs) would have evolved backwards-in-time, under the hypothesis that each major merger gives place to an early-type galaxy. The study was carried out just considering the major mergers strictly reported by observations at each redshift, and assuming that gas-rich major mergers experience transitory phases of dust-reddened, star-forming galaxies (DSFs). The model is able to reproduce the observed evolution of the galaxy LFs at z<~1, simultaneously for different rest-frame bands (B, I, and K) and for different selection criteria on color and morphology. It also provides a framework in which apparently-contradictory results on the recent evolution of the luminosity function (LF) of massive, red galaxies can be reconciled, just considering that observational samples of red galaxies can be significantly contaminated by DSFs. The model proves that it is feasible to build up ~50-60% of the present-day mETG population at z<~1 and to reproduce the observational excess by a factor of ~4-5 of late-type galaxies at 0.8<z<1 through the coordinated action of wet, mixed, and dry major mergers, fulfilling global trends that are in general agreement with mass-downsizing. The bulk of this assembly takes place during ~1 Gyr elapsed at 0.8<z<1. The model suggests that major mergers have been the main driver for the observational migration of mass from the massive-end of the blue galaxy cloud to that of the red sequence in the last ~8 Gyr.(Abridged)Comment: Accepted for publication in Astronomy & Astrophysics; 21 pages, 8 figures. Minor corrections included, shortened title. Results and conclusions unchange

Increased CD8+ T cell responses to apoptotic T cell-associated antigens in multiple sclerosis.

BACKGROUND: Here, we evaluated the hypothesis that CD8(+) T cell responses to caspase-cleaved antigens derived from effector T cells undergoing apoptosis, may contribute to multiple sclerosis (MS) immunopathology. METHODS: The percentage of autoreactive CD8(+) T effector cells specific for various apoptotic T cell-associated self-epitopes (apoptotic epitopes) were detected in the peripheral blood and cerebrospinal fluid (CSF) by both enzyme-linked immunospot and dextramers of class I molecules complexed with relevant apoptotic epitopes. Moreover, the capacity of dextramer(+) CD8(+) T cells to produce interferon (IFN)-γ and/or interleukin (IL)-17 in response to the relevant apoptotic epitopes was evaluated by the intracellular cytokine staining. Cross-presentation assay of apoptotic T cells by dendritic cells was also evaluated ex vivo. RESULTS: We found that polyfunctional (IFN-γ and/or IL-17 producing) autoreactive CD8(+) T cells specific for apoptotic epitopes were represented in MS patients with frequencies significantly higher than in healthy donors. These autoreactive CD8(+) T cells with a strong potential to produce IFN-γ or IL-17 in response to the relevant apoptotic epitopes were significantly accumulated in the CSF from the same patients. In addition, the frequencies of these autoreactive CD8(+) T cells correlated with the disease disability. Cross-presentation assay revealed that caspase-cleaved cellular proteins are required to activate apoptotic epitope-specific CD8(+) T cells ex vivo. CONCLUSION: Taken together, these data indicate that apoptotic epitope-specific CD8(+) T cells with strong inflammatory potential are recruited at the level of the inflammatory site, where they may be involved in MS immunopathology through the production of high levels of inflammatory cytokines