Plan de marketing Unidad de Deportes Sensuntepeque.

En este informe, relacionado con el plan de Marketing implementado en la Alcaldía Municipal de Sensuntepeque Cabañas, se presenta una descripción de forma general de las diversas actividades realizadas, desde el análisis general institucional, el entorno general, sectorial, competitivo, social, laboral, hasta el análisis deportivo, con el fin de ofrecer una propuesta de marketing acorde a las necesidades y proyecciones municipales. Para el logro exitoso del Plan se definieron estrategias, actividades, presupuesto y técnicas de marketing acordes al público objetivo. En la actualidad, con los avances tecnológicos, existen herramientas que facilitan el proceso de recolección y análisis de información de los clientes, lo cual permite medir la percepción de usuarios con relación al servicio deportivo que ofrece la municipalidad. En la gestión de la calidad del servicio, del funcionamiento de una organización deportiva, se utilizó el Modelo de Calidad EFQM, por medio de cuestionarios de autoevaluación adaptado a la realidad. Finalmente, se elaboró una propuesta de Plan de Marketing deportivo y mediante las páginas oficiales se publicitará las diversas actividades que se realizan, con el fin de lograr mayor cobertura y divulgación de actividades

“El píxel art como Técnica de Comunicación Gráfica a través de medios físicos para fiestas populares de Latacunga”

The case study is a project analysis of the popular festivals of the city of Latacunga, which are the faithful reflection of the culture and identity transmitting the tradition in a show worth seeing and being admired, according to (José Pereira Valarezo) based on the calendar of events in Ecuador from the book of popular festivals "there are approximately 172 festivities held throughout the year, of which 5% are held in the province of Cotopaxi" one of these festivities is the celebration of Mama Black is the Ecuadorian Andean festival of great popularity, relatively complex and in some unique way, the description of all of them in complex space and time, for which reason, with due investigation, it will be analyzed in depth. all the concepts of the main characters of the Mama Negra, either by its meaning within the festivity, its costume, its origin and its main characteristics, based on this information, Latacungueño folklore will be transmitted; the popular wisdom of manifestations that arise from the roots of the customs of both festivities, the one in September with greater religious nuances and the one in November with a projection of conservation of the characteristics of Cotopaxense folklore and of the city together with the commemoration of independence .El caso de estudio es un análisis proyectual de las fiestas populares de la ciudad de Latacunga, las cuales son el fiel reflejo de la cultura e identidad transmitiendo la tradición en un espectáculo digno de ver y ser admirado, según (José Pereira Valarezo) basado en el calendario de eventos del Ecuador del libro de las fiestas populares “existen un aproximado de 172 festividades realizadas en el transcurso de todo el año el cual el 5% son realizadas en la provincia de Cotopaxi” una de esas festividades es la celebración de la Mama Negra la fiesta andina ecuatoriana de gran popularidad relativamente compleja y de alguna forma única, la descripción de todas ellas en el espacio y tiempo complejas, por lo cual con la debida investigación se analizará a profundidad todos los conceptos de los personajes principales de la Mama Negra, ya sea por su significado dentro de la festividad, su trajería, su origen y sus características principales, en base a esta información se transmitirá el folclore latacungueño; la sabiduría popular de manifestaciones que surgen de las raíces de las costumbres de ambas festividades, la de septiembre con mayores matices religiosos y la de noviembre con una proyección de conservación de las características del folklore cotopaxense y de la ciudad junto a la conmemoración de la independencia

Preoperative cerebrospinal fluid β-Amyloid/Tau ratio and postoperative delirium

Objective: The neuropathogenesis of postoperative delirium remains unknown. Low cerebrospinal fluid (CSF) β-amyloid protein (Aβ) and high CSF Tau levels are associated with Alzheimer's disease. We, therefore, assessed whether lower preoperative CSF Aβ/Tau ratio was associated with higher incidence and greater severity of postoperative delirium. Methods: One hundred and fifty-three participants (71 ± 5 years, 53% men) who had total hip/knee replacement under spinal anesthesia were enrolled. CSF was obtained during initiation of spinal anesthesia. The incidence and severity of postoperative delirium were determined by Confusion Assessment Method (CAM) and Memorial Delirium Assessment Scale (MDAS) on postoperative day 1 and 2. Aβ40, Aβ42, and Tau levels in the CSF were measured by enzyme-linked immunosorbent assay. The relationships among these variables were determined, adjusting for age and gender. Results: Participants in the lowest quartile of preoperative CSF Aβ40/Tau and Aβ42/Tau ratio had higher incidence (32% vs. 17%, P = 0.0482) and greater symptom severity of postoperative delirium (Aβ40/Tau ratio: 4 vs. 3, P = 0.034; Aβ42/Tau ratio: 4 vs. 3, P = 0.062, the median of the highest MDAS score) as compared to the combination of the rest of the quartiles. The preoperative CSF Aβ40/Tau or Aβ42/Tau ratio was inversely associated with MDAS score (Aβ40/Tau ratio: −0.12 ± 0.05, P = 0.014, adj. −0.12 ± 0.05, P = 0.018; Aβ42/Tau ratio: −0.65 ± 0.26, P = 0.013, adj. −0.62 ± 0.27, P = 0.022). Interpretation Lower CSF Aβ/Tau ratio could be associated with postoperative delirium, pending confirmation of our preliminary results in further studies. These findings suggest potential roles of Aβ and/or Tau in postoperative delirium neuropathogenesis

SLC45A2 protein stability and regulation of melanosome pH determine melanocyte pigmentation.

SLC45A2 encodes a putative transporter expressed primarily in pigment cells. SLC45A2 mutations cause oculocutaneous albinism type 4 (OCA4) and polymorphisms are associated with pigmentation variation, but the localization, function, and regulation of SLC45A2 and its variants remain unknown. We show that SLC45A2 localizes to a cohort of mature melanosomes that only partially overlaps with the cohort expressing the chloride channel OCA2. SLC45A2 expressed ectopically in HeLa cells localizes to lysosomes and raises lysosomal pH, suggesting that in melanocytes SLC45A2 expression, like OCA2 expression, results in the deacidification of maturing melanosomes to support melanin synthesis. Interestingly, OCA2 overexpression compensates for loss of SLC45A2 expression in pigmentation. Analyses of SLC45A2- and OCA2-deficient mouse melanocytes show that SLC45A2 likely functions later during melanosome maturation than OCA2. Moreover, the light skin-associated SLC45A2 allelic F374 variant restores only moderate pigmentation to SLC45A2-deficient melanocytes due to rapid proteasome-dependent degradation resulting in lower protein expression levels in melanosomes than the dark skin-associated allelic L374 variant. Our data suggest that SLC45A2 maintains melanosome neutralization that is initially orchestrated by transient OCA2 activity to support melanization at late stages of melanosome maturation, and that a common allelic variant imparts reduced activity due to protein instability

Estrategias de innovación para la inserción del cacao salvadoreño en el mercado internacional, período 2007 - 2017.

Históricamente, el cacao formó parte de los principales cultivos que se producían en El Salvador; sin embargo, a partir de una serie de fenómenos naturales varias plantaciones se vieron destruidas lo que generó reducciones en sus niveles de producción y ante el surgimiento del modelo agroexportador esta situación continúo mermando la contribución del cultivo en términos económicos. Sin embargo, ante el agotamiento del modelo agroexportador en la década de los 70, y los efectos del cambio climático que permitió el surgimiento de nuevas enfermedades y plagas en determinados cultivos, la estructura productiva del sector agrícola en El Salvador experimento diversos cambios, en donde muchos productores decidieron trasladarse a otras actividades agrícolas. Ante el escenario anterior, en los últimos años se ha logrado identificar un incremento en los agentes que participan dentro del sector cacaotero por lo cual se inició un proceso de reactivación del mismo, a partir de esfuerzos públicos y privados que buscan fomentar la producción, así como desarrollar conocimientos y técnicas en los procesos de cultivo, post cosecha, transformación y comercialización del grano, interviniendo en los diferentes eslabones de la cadena y en las distintas actividades productivas que realizan los agentes a lo largo de esta. En ese sentido, la presente investigación realiza una caracterización y análisis de la cadena global del cacao utilizando el enfoque de cadenas globales de mercancías con el fin de definir y establecer una estrategia para el desarrollo del sector cacaotero salvadoreño. Dicha caracterización utiliza el enfoque antes mencionado ya que este permite identificar la red de procesos laborales y de producción que se requieren para la elaboración de un producto en específico, en otras palabras, este enfoque identifica de forma integrada, los procesos y actividades generadoras de valor que requiere la fabricación del cacao. A partir del análisis situacional se identifican que, en El Salvador, a pesar de contar con ciertas ventajas factoriales como la capacidad de producir cacao fino de aroma a partir del establecimiento de sistemas agroforestales, prevalecen diferentes limitantes que dificultan el establecimiento y desarrollo del sector a nivel nacional e internacional; los bajos niveles de productividad, así como la limitada capacidad de generación de valor a lo largo de los eslabones de la cadena, son limitantes que imposibilitan el desarrollo de ventajas competitivas que les permita a los agentes competir en mercados internacionales. Sin embargo, también se identifican casos atípicos de agentes que han sido capaces de ii participar en diversas actividades generadoras de valor dentro de la cadena, hasta el punto de producir derivados del cacao reconocidos internacionalmente por su calidad. Lo anterior, pone de manifiesto como ciertos agentes dentro del sector tienen las capacidades y condiciones necesarias para el desarrollo y posicionamiento del cultivo y derivados dentro del mercado, sin embargo al ser una minoría del total de agentes que participan, se vuelve una necesidad presentar diferentes estrategias y acciones de política que estén enfocadas en la generación de valor y aumento de competitividad del sector; para lograr lo anterior, se utiliza el planteamiento teórico de competitividad desarrollado por Michael Porter. Tomando como base el planteamiento teórico de Porter, la innovación es considerada como el desarrollo de nuevas tecnologías, así como mejorar los métodos o formas de hacer las cosas, dentro de las estrategias y alternativas de innovación propuestas en esta investigación se puede mencionar, la creación de un mapa de zonificación de la producción según capacidad de producción y la creación de una unidad especializada en la comercialización del cacao, entre otras. Estas alternativas están dirigidas a aumentar los niveles de productividad del sector que permita a los agentes percibir una mayor rentabilidad y con ello que estos logren ser competitivos en los mercados

Structural snapshot of a bacterial phytochrome in its functional intermediate state

Phytochromes are modular photoreceptors of plants, bacteria and fungi that use light as a source of information to regulate fundamental physiological processes. Interconversion between the active and inactive states is accomplished by a photoinduced reaction sequence which couples the sensor with the output module. However, the underlying molecular mechanism is yet not fully understood due to the lack of structural data of functionally relevant intermediate states. Here we report the crystal structure of a Meta-F intermediate state of an Agp2 variant from Agrobacterium fabrum. This intermediate, the identity of which was verified by resonance Raman spectroscopy, was formed by irradiation of the parent Pfr state and displays significant reorientations of almost all amino acids surrounding the chromophore. Structural comparisons allow identifying structural motifs that might serve as conformational switch for initiating the functional secondary structure change that is linked to the (de-)activation of these photoreceptors

Insertion of triangulated surfaces into a meccano tetrahedral discretization by means of mesh refinement and optimization procedures

This is the peer reviewed version of the following article: Ruiz Gironès , E., Oliver , A., Socorro, G., Cascón, J., Escobar, J.M., Montenegro, R., Sarrate, J. Insertion of triangulated surfaces into a meccano tetrahedral discretization by means of mesh refinement and optimization procedures. "International journal for numerical methods in engineering", 2018, which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/nme.5706/pdf. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.In this paper, we present a new method for inserting several triangulated surfaces into an existing tetrahedral mesh generated by the meccano method. The result is a conformal mesh where each inserted surface is approximated by a set of faces of the final tetrahedral mesh. First, the tetrahedral mesh is refined around the inserted surfaces to capture their geometric features. Second, each immersed surface is approximated by a set of faces from the tetrahedral mesh. Third, following a novel approach, the nodes of the approximated surfaces are mapped to the corresponding immersed surface. Fourth, we untangle and smooth the mesh by optimizing a regularized shape distortion measure for tetrahedral elements in which we move all the nodes of the mesh, restricting the movement of the edge and surface nodes along the corresponding entity they belong to. The refining process allows approximating the immersed surface for any initial meccano tetrahedral mesh. Moreover, the proposed projection method avoids computational expensive geometric projections. Finally, the applied simultaneous untangling and smoothing process delivers a high-quality mesh and ensures that the immersed surfaces are interpolated. Several examples are presented to assess the properties of the proposed method.Peer ReviewedPostprint (author's final draft

Insertion of triangulated surfaces into a meccano tetrahedral discretization by means of mesh refinement and optimization procedures

[EN]In this paper, we present a new method for inserting several triangulated surfaces into an existing tetrahedral mesh generated by the meccano method. The result is a conformal mesh where each inserted surface is approximated by a set of faces of the final tetrahedral mesh. First, the tetrahedral mesh is refined around the inserted surfaces to capture their geometric features. Second, each immersed surface is approximated by a set of faces from the tetrahedral mesh. Third, following a novel approach, the nodes of the approximated surfaces are mapped to the corresponding immersed surface. Fourth, we untangle and smooth the mesh by optimizing a regularized shape distortion measure for tetrahedral elements in which we move all the nodes of the mesh, restricting the movement of the edge and surface nodes along the corresponding entity they belong to. The refining process allows approximating the immersed surface for any initial meccano tetrahedral mesh. Moreover, the proposed projection method avoids computational expensive geometric projections. Finally, the applied simultaneous untangling and smoothing process delivers a high‐quality mesh and ensures that the immersed surfaces are interpolated. Several examples are presented to assess the properties of the proposed method.FEDER y Gobierno de España (Ministerio de Economía y Competitividad) y ondo Sectorial CONACYT SENER HIDROCARBURO

MFA09 (MFA 2009)

Catalogue of a culminating student exhibition held at the Mildred Lane Kemper Art Museum in 2009. Content includes A new paradigm / Carmon Colangelo -- Evolving practices / Patricia Olynyk -- Stephanie Barenz -- Carolyn Dawn Bendel -- Jacob Cruzen -- Rachel Ann Dennis -- Bryan Eaton -- Maya Escobar -- Meredith Foster -- Morgan Gehris -- Gina Grafos -- Stephen Hoskins -- Amelia Jones -- Hye Young Kim -- Anne Lindberg -- Goran Maric -- Kelda Martensen -- Erica L. Millspaugh -- Carianne Noga -- Joel Parker -- Rebecca C. Potts -- Shannon Randol -- Elaine Rickles -- Michael Kenneth Smith -- Dan Solberg -- Natalie Toney -- Glenn Tramantano -- Kathryn Trout -- J. Taylor Wallace.https://openscholarship.wustl.edu/books/1006/thumbnail.jp

Measurement of the inclusive and dijet cross-sections of b-jets in pp collisions at sqrt(s) = 7 TeV with the ATLAS detector

The inclusive and dijet production cross-sections have been measured for jets containing b-hadrons (b-jets) in proton-proton collisions at a centre-of-mass energy of sqrt(s) = 7 TeV, using the ATLAS detector at the LHC. The measurements use data corresponding to an integrated luminosity of 34 pb^-1. The b-jets are identified using either a lifetime-based method, where secondary decay vertices of b-hadrons in jets are reconstructed using information from the tracking detectors, or a muon-based method where the presence of a muon is used to identify semileptonic decays of b-hadrons inside jets. The inclusive b-jet cross-section is measured as a function of transverse momentum in the range 20 < pT < 400 GeV and rapidity in the range |y| < 2.1. The bbbar-dijet cross-section is measured as a function of the dijet invariant mass in the range 110 < m_jj < 760 GeV, the azimuthal angle difference between the two jets and the angular variable chi in two dijet mass regions. The results are compared with next-to-leading-order QCD predictions. Good agreement is observed between the measured cross-sections and the predictions obtained using POWHEG + Pythia. MC@NLO + Herwig shows good agreement with the measured bbbar-dijet cross-section. However, it does not reproduce the measured inclusive cross-section well, particularly for central b-jets with large transverse momenta.Comment: 10 pages plus author list (21 pages total), 8 figures, 1 table, final version published in European Physical Journal