The Academic Workplace: Perception versus Reality

Why are faculty becoming increasingly dissatisfied with the quality of the academic workplace? What accounts for burnout and low morale among so many college and university faculty? Is work life for professionals any more satisfying in the business world? What can academic leaders learn from business executives who work vigorously to reenergize their enterprises? Are corporate strategies aimed at enhancing the quality of work life applicable to improving satisfaction and productivity in our colleges and universities? These concerns were addressed by a number of education leaders at a conference on faculty work life jointly sponsored by the New England Resource Center for Higher Education and the New England Board of Higher Education in December 1988. This article sets forth contrasting viewpoints on a range of critical variables that affect the nature of the academic workplace and have a direct impact on the quality of faculty life. In an era of increasingly scarce resources and organizational uncertainty, it is anticipated that the crisis of faculty vitality will intensify. Strategies and options for enhancing the condition of faculty at this critical juncture in academe\u27s history warrant serious attention as higher education in New England charts its future development

The Status of Black and Hispanic Faculty in Massachusetts Colleges and Universities

To implement policies and programs that facilitate recruitment and retention of minority faculty, educators and policymakers must first determine the status of Blacks and Hispanics in the Commonwealth\u27s colleges and universities. The principal objective of this report is to provide that knowledge. The study has a dual purpose: to develop a data base on the availability of and demand for Black and Hispanic faculty in Massachusetts institutions of higher education, and to enhance our understanding of the strategies and programs required to foster recruitment and retention of underrepresented faculty. Furthermore, it seeks to identify hiring trends in different types of institutions in the state. In addition to ascertaining the number of Black and Hispanic faculty in colleges and universities, this study sought to determine the status of Black and Hispanic doctoral students in Massachusetts universities

The Academic Workplace: Perception versus Reality

Why are faculty becoming increasingly dissatisfied with the quality of the academic workplace? What accounts for burnout and low morale among so many college and university faculty? Is work life for professionals any more satisfying in the business world? What can academic leaders learn from business executives who work vigorously to reenergize their enterprises? Are corporate strategies aimed at enhancing the quality of work life applicable to improving satisfaction and productivity in our colleges and universities? These concerns were addressed by a number of education leaders at a conference on faculty work life jointly sponsored by the New England Resource Center for Higher Education and the New England Board of Higher Education in December 1988. This article setsforth contrasting viewpoints on a range of critical variables that affect the nature of the academic workplace and have a direct impact on the quality of faculty life. In an era of increasingly scarce resources and organizational uncertainty, it is anticipated that the crisis of faculty vitality will intensify. Strategies and options for enhancing the condition of faculty at this critical juncture in academe\u27s history warrant serious attention as higher education in New England charts its future development

The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.

Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization

A Guide for Social Science Journal Editors on Easing into Open Science

Journal editors have a large amount of power to advance open science in their respective fields by incentivising and mandating open policies and practices at their journals. The Data PASS Journal Editors Discussion Interface (JEDI, an online community for social science journal editors: www.dpjedi.org) has collated several resources on embedding open science in journal editing (www.dpjedi.org/resources). However, it can be overwhelming as an editor new to open science practices to know where to start. For this reason, we created a guide for journal editors on how to get started with open science. The guide outlines steps that editors can take to implement open policies and practices within their journal, and goes through the what, why, how, and worries of each policy and practice. This manuscript introduces and summarizes the guide (full guide: https://osf.io/hstcx).<br/

Analysis of shared common genetic risk between amyotrophic lateral sclerosis and epilepsy

Because hyper-excitability has been shown to be a shared pathophysiological mechanism, we used the latest and largest genome-wide studies in amyotrophic lateral sclerosis (n = 36,052) and epilepsy (n = 38,349) to determine genetic overlap between these conditions. First, we showed no significant genetic correlation, also when binned on minor allele frequency. Second, we confirmed the absence of polygenic overlap using genomic risk score analysis. Finally, we did not identify pleiotropic variants in meta-analyses of the 2 diseases. Our findings indicate that amyotrophic lateral sclerosis and epilepsy do not share common genetic risk, showing that hyper-excitability in both disorders has distinct origins

Genetic correlation between amyotrophic lateral sclerosis and schizophrenia

A. Palotie on työryhmän Schizophrenia Working Grp Psychiat jäsen.We have previously shown higher-than-expected rates of schizophrenia in relatives of patients with amyotrophic lateral sclerosis (ALS), suggesting an aetiological relationship between the diseases. Here, we investigate the genetic relationship between ALS and schizophrenia using genome-wide association study data from over 100,000 unique individuals. Using linkage disequilibrium score regression, we estimate the genetic correlation between ALS and schizophrenia to be 14.3% (7.05-21.6; P = 1 x 10(-4)) with schizophrenia polygenic risk scores explaining up to 0.12% of the variance in ALS (P = 8.4 x 10(-7)). A modest increase in comorbidity of ALS and schizophrenia is expected given these findings (odds ratio 1.08-1.26) but this would require very large studies to observe epidemiologically. We identify five potential novel ALS-associated loci using conditional false discovery rate analysis. It is likely that shared neurobiological mechanisms between these two disorders will engender novel hypotheses in future preclinical and clinical studies.Peer reviewe

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene

To identify novel genes associated with ALS, we undertook two lines of investigation. We carried out a genome-wide association study comparing 20,806 ALS cases and 59,804 controls. Independently, we performed a rare variant burden analysis comparing 1,138 index familial ALS cases and 19,494 controls. Through both approaches, we identified kinesin family member 5A (KIF5A) as a novel gene associated with ALS. Interestingly, mutations predominantly in the N-terminal motor domain of KIF5A are causative for two neurodegenerative diseases: hereditary spastic paraplegia (SPG10) and Charcot-Marie-Tooth type 2 (CMT2). In contrast, ALS-associated mutations are primarily located at the C-terminal cargo-binding tail domain and patients harboring loss-of-function mutations displayed an extended survival relative to typical ALS cases. Taken together, these results broaden the phenotype spectrum resulting from mutations in KIF5A and strengthen the role of cytoskeletal defects in the pathogenesis of ALS.Peer reviewe