Sociotechnical Imaginaries as a Lens to Analyze Advances in Biomedicine

Reorganizing Biomedical Research : Biobanks as Conditions of Possibility for Personalized Medicine / Heta Tarkkala. Helsinki : University of Helsinki, 2019

Making Sense of Science, University, and Industry : Sensemaking Narratives of Finnish and Israeli Scientists

Academic entrepreneurship and the commercialization of science have transformed higher education in recent decades. Although there is ample research on the topic, less is known about how individual scientists experience and perceive the transformation. Drawing on a narratological approach to sensemaking, this study examines how entrepreneurial scientists in Finland and Israel make sense of and narrate the perceived changes in the interface between science, university, and industry. An analysis of 53 semi-structured interviews reveals three sensemaking narratives demonstrating how scientists’ interactions with the industry have engendered perceived shifts in ‘regimes of value’ in universities. These narratives focus on: (1) bi-directional learning between academy and industry; (2) the use of new valuation devices and practices; and (3) changing relationships between scientists and universities. Our findings advance research on academic entrepreneurship by highlighting the coexisting regimes of value and the consequences they have for science, value, and power.publishedVersionPeer reviewe

Left ventricular dysfunction with reduced functional cardiac reserve in diabetic and non-diabetic LDL-receptor deficient apolipoprotein B100-only mice

BACKGROUND: Lack of suitable mouse models has hindered the studying of diabetic macrovascular complications. We examined the effects of type 2 diabetes on coronary artery disease and cardiac function in hypercholesterolemic low-density lipoprotein receptor-deficient apolipoprotein B100-only mice (LDLR(-/-)ApoB(100/100)). METHODS AND RESULTS: 18-month-old LDLR(-/-)ApoB(100/100 )(n = 12), diabetic LDLR(-/-)ApoB(100/100 )mice overexpressing insulin-like growth factor-II (IGF-II) in pancreatic beta cells (IGF-II/LDLR(-/-)ApoB(100/100), n = 14) and age-matched C57Bl/6 mice (n = 15) were studied after three months of high-fat Western diet. Compared to LDLR(-/-)ApoB(100/100 )mice, diabetic IGF-II/LDLR(-/-)ApoB(100/100 )mice demonstrated more calcified atherosclerotic lesions in aorta. However, compensatory vascular enlargement was similar in both diabetic and non-diabetic mice with equal atherosclerosis (cross-sectional lesion area ~60%) and consequently the lumen area was preserved. In coronary arteries, both hypercholesterolemic models showed significant stenosis (~80%) despite positive remodeling. Echocardiography revealed severe left ventricular systolic dysfunction and anteroapical akinesia in both LDLR(-/-)ApoB(100/100 )and IGF-II/LDLR(-/-)ApoB(100/100 )mice. Myocardial scarring was not detected, cardiac reserve after dobutamine challenge was preserved and ultrasructural changes revealed ischemic yet viable myocardium, which together with coronary artery stenosis and slightly impaired myocardial perfusion suggest myocardial hibernation resulting from chronic hypoperfusion. CONCLUSIONS: LDLR(-/-)ApoB(100/100 )mice develop significant coronary atherosclerosis, severe left ventricular dysfunction with preserved but diminished cardiac reserve and signs of chronic myocardial hibernation. However, the cardiac outcome is not worsened by type 2 diabetes, despite more advanced aortic atherosclerosis in diabetic animals

New genetic loci link adipose and insulin biology to body fat distribution.

Body fat distribution is a heritable trait and a well-established predictor of adverse metabolic outcomes, independent of overall adiposity. To increase our understanding of the genetic basis of body fat distribution and its molecular links to cardiometabolic traits, here we conduct genome-wide association meta-analyses of traits related to waist and hip circumferences in up to 224,459 individuals. We identify 49 loci (33 new) associated with waist-to-hip ratio adjusted for body mass index (BMI), and an additional 19 loci newly associated with related waist and hip circumference measures (P < 5 × 10(-8)). In total, 20 of the 49 waist-to-hip ratio adjusted for BMI loci show significant sexual dimorphism, 19 of which display a stronger effect in women. The identified loci were enriched for genes expressed in adipose tissue and for putative regulatory elements in adipocytes. Pathway analyses implicated adipogenesis, angiogenesis, transcriptional regulation and insulin resistance as processes affecting fat distribution, providing insight into potential pathophysiological mechanisms

Sociotechnical Imaginaries as a Lens to Analyze Advances in Biomedicine

Arvosteltu julkaisu on väitöskirja

Power and knowledge negotiations in a collectivity of practice : From peripheralization to epistemological suspicion

Knowledge co-creation at the boundaries of communities of practice (CoPs) can lead to heightened tensions and power struggles. This study examines how power struggles among CoPs can begin to structure knowledge creation processes. Drawing on a qualitative case study of a new medical research project, the study shows how power and knowledge negotiations became manifested through conflicting discursive positioning and coercive power affecting knowledge co-creation efforts. One CoP adopted an authoritative leader role, prioritized their own problem definition and knowledge creation process, and engaged in the peripheralization of other CoPs. The power and discursive moves prevented the development of shared problems and interconnected practices contributing to epistemological suspicion among the participating CoPs. The study offers new insights to research on power dynamics in situated learning and knowing by problematizing the relationship between localized practices and emerging interconnected practices, by shedding light on how discursive positioning and coercive power operate together, and by developing peripheralization and epistemological suspicion as potential explanations for how and why knowledge workers struggle to act on opportunities for knowledge co-creation.publishedVersionPeer reviewe

Nascent academic entrepreneurs and identity work at the boundaries of professional domains

Higher education institutions promote academic entrepreneurship through organizational arrangements such as innovation programs, incubators, and accelerators aimed at implementing the third mission of the university. While research has examined how these multi-professional arrangements support entrepreneurial efforts, less is known about their individual level implications which emerge as researchers are exposed to different professional values and practices. This article draws on a longitudinal qualitative study on an innovation program to investigate through what kinds of identity processes nascent academic entrepreneurs construct their professional identities and how as part of these processes they position themselves in relation to different professional domains. The analysis demonstrates three identity construction processes (hybridization, rejecting hybridization, and transitioning) and their associated identity work tactics (compartmentalizing, protecting, and reframing) at the boundaries of professional domains. Our contribution is in demonstrating how nascent academic entrepreneurs’ identity construction processes are influenced by internally and externally oriented identity work and their interactive dynamics. Moreover, the findings advance our understanding of how individuals can purposefully mould the fluidity of domain boundaries through identity work by making boundaries bridgeable, impermeable, or permeable. These findings have value for those developing organizational arrangements for the promotion of academic entrepreneurship and entrepreneurial identities.publishedVersionPeer reviewe

Torque teno virus primary infection kinetics in early childhood

Abstract Human torque teno viruses (TTVs) are a diverse group of small nonenveloped viruses with circular, single-stranded DNA genomes. These elusive anelloviruses are harbored in the blood stream of most humans and have thus been considered part of the normal flora. Whether the primary infection as a rule take(s) place before or after birth has been debated. The aim of our study was to determine the time of TTV primary infection and the viral load and strain variations during infancy and follow-up for up to 7 years. TTV DNAs were quantified in serial serum samples from 102 children by a pan-TTV quantitative PCR, and the amplicons from representative time points were cloned and sequenced to disclose the TTV strain diversity. We detected an unequivocal rise in TTV-DNA prevalence, from 39% at 4 months of age to 93% at 2 years; all children but one, 99%, became TTV-DNA positive before age 4 years. The TTV-DNA quantities ranged from 5 × 101 to 4 × 107 copies/mL, both within and between the children. In conclusion, TTV primary infections occur mainly after birth, and increase during the first two years with high intra- and interindividual variation in both DNA quantities and virus strains