The astrometric data reduction software (ADRS) and error budget for PRIMA

The Astrometric Data-Reduction Software (ADRS) processes fringe, delay, environmental, and calibration data for PRIMA narrow-angle astrometry. It is automated software designed to provide fully-calibrated differential delays and separation angles. The ADRS is divided into on-line and off-line processing. The former deals with calibration and data compression, while the latter applies corrections and calculates science quantities. PRIMA is the first VLTI instrument that may require removal of long-term environmental trends. The trend identification and fitting routines are not part of the distributed on-line and off-line processing software. Instead, files containing fit parameters will be updated regularly. Coding is presently underway. The PRIMA error budget summarizes the principal sources of error in PRIMA astrometric observation

Cardiovascular disease in a cohort exposed to the 1940-45 Channel Islands occupation

BACKGROUND To clarify the nature of the relationship between food deprivation/undernutrition during pre- and postnatal development and cardiovascular disease (CVD) in later life, this study examined the relationship between birth weight (as a marker of prenatal nutrition) and the incidence of hospital admissions for CVD from 1997–2005 amongst 873 Guernsey islanders (born in 1923–1937), 225 of whom had been exposed to food deprivation as children, adolescents or young adults (i.e. postnatal undernutrition) during the 1940–45 German occupation of the Channel Islands, and 648 of whom had left or been evacuated from the islands before the occupation began. METHODS Three sets of Cox regression models were used to investigate (A) the relationship between birth weight and CVD, (B) the relationship between postnatal exposure to the occupation and CVD and (C) any interaction between birth weight, postnatal exposure to the occupation and CVD. These models also tested for any interactions between birth weight and sex, and postnatal exposure to the occupation and parish of residence at birth (as a marker of parish residence during the occupation and related variation in the severity of food deprivation). RESULTS The first set of models (A) found no relationship between birth weight and CVD even after adjustment for potential confounders (hazard ratio (HR) per kg increase in birth weight: 1.12; 95% confidence intervals (CI): 0.70 – 1.78), and there was no significant interaction between birth weight and sex (p = 0.60). The second set of models (B) found a significant relationship between postnatal exposure to the occupation and CVD after adjustment for potential confounders (HR for exposed vs. unexposed group: 2.52; 95% CI: 1.54 – 4.13), as well as a significant interaction between postnatal exposure to the occupation and parish of residence at birth (p = 0.01), such that those born in urban parishes (where food deprivation was worst) had a greater HR for CVD than those born in rural parishes. The third model (C) found no interaction between birth weight and exposure to the occupation (p = 0.43). CONCLUSION These findings suggest that the levels of postnatal undernutrition experienced by children, adolescents and young adults exposed to food deprivation during the 1940–45 occupation of the Channel Islands were a more important determinant of CVD in later life than the levels of prenatal undernutrition experienced in utero prior to the occupatio

Large dust particles in disks around T Tauri stars

We present 7-mm continuum observations of 14 low-mass pre-main-sequence stars in the Taurus-Auriga star-forming region obtained with the Very Large Array with ~1.5" resolution and ~0.3 mJy rms sensitivity. For 10 objects, the circumstellar emission has been spatially resolved. The large outer disk radii derived suggest that the emission at this wavelength is mostly optically thin. The millimetre spectral energy distributions are characterised by spectral indices alpha = 2.3 to 3.2. After accounting for contribution from free-free emission and corrections for optical depth, we determine dust opacity indices beta in the range 0.5 to 1.6, which suggest that millimetre-sized dust aggregates are present in the circumstellar disks. Four of the sources with beta > 1 may be consistent with submicron-sized dust as found in the interstellar medium. Our findings indicate that dust grain growth to millimetre-sized particles is completed within less than 1 Myr for the majority of circumstellar disks.Comment: 11 pages, 4 figure

Interstellar polarization and grain alignment: the role of iron and silicon

We compiled the polarimetric data for a sample of lines of sight with known abundances of Mg, Si, and Fe. We correlated the degree of interstellar polarization $P$ and polarization efficiency (the ratio of $P$ to the colour excess $E(B-V)$ or extinction $A_V$) with dust phase abundances. We detect an anticorrelation between $P$ and the dust phase abundance of iron in non silicate - containing grains ]_\rm d, a correlation between $P$ and the abundance of Si, and no correlation between $P/E(B-V)$ or $P/A_V$ and dust phase abundances. These findings can be explained if mainly the silicate grains aligned by the radiative mechanism are responsible for the observed interstellar linear polarization.Comment: Accepted for publication in Astronomy and Astrophysic

Circumstellar masers in the Magellanic Clouds

We have searched for 22 GHz H2O and 43/86/129 GHz SiO masers in bright IRAS point sources in the SMC and LMC, to test whether the kinematics of the mass loss from these stars depends on metallicity. H2O masers were detected in the red supergiants IRAS04553-6825 and IRAS05280-6910, and tentatively in the luminous IR object IRAS05216-6753 and the AGB star IRAS05329-6708. SiO masers were detected in IRAS04553-6825. The outflow velocity increases between the H2O masing zone near the dust-formation region and the more distant OH masing zone from 18 to 26 km/s for IRAS04553-6825 and from 6 to 17 km/s for IRAS05280-6910. The total sample of LMC targets is analysed in comparison with circumstellar masers in the Galactic Centre. The photon fluxes of circumstellar masers in the LMC are very similar to those in the Galactic Centre. The expansion velocities in the LMC appear to be 20% lower than for similarly bright OH masers in the Galactic Centre, but the data are consistent with no difference in expansion velocity. OH/IR stars in the LMC appear to have slower accelerating envelopes than OH/IR stars in the Galactic Centre. Masers in the LMC have blue-asymmetric emission profiles. This may be due to the amplification of stellar and/or free-free radiation, rather than the amplification of dust emission, and may be more pronounced in low metallicity envelopes. SiO maser strength increases with the photometric amplitude at 2.2 micron but is independent of the photometric amplitude at 10 micron. This suggests a strong connection between shocks in the dust-free SiO masing zone and the dust formation process. Appendices describe H2O maser emission from R Dor in the Milky Way, optical echelle spectroscopy of IRAS04553-6825, and the properties of masers in the Galactic Centre (Abridged).Comment: 19 pages, 17 figures. Accepted for publication in Astronomy & Astrophysics Main Journa

Three-micron spectra of AGB stars and supergiants in nearby galaxies

The dependence of stellar molecular bands on the metallicity is studied using infrared L-band spectra of AGB stars (both carbon-rich and oxygen-rich) and M-type supergiants in the Large and Small Magellanic Clouds (LMC and SMC) and in the Sagittarius Dwarf Spheroidal Galaxy. The spectra cover SiO bands for oxygen-rich stars, and acetylene (C2H2), CH and HCN bands for carbon-rich AGB stars. The equivalent width of acetylene is found to be high even at low metallicity. The high C2H2 abundance can be explained with a high carbon-to-oxygen (C/O) ratio for lower metallicity carbon stars. In contrast, the HCN equivalent width is low: fewer than half of the extra-galactic carbon stars show the 3.5micron HCN band, and only a few LMC stars show high HCN equivalent width. HCN abundances are limited by both nitrogen and carbon elemental abundances. The amount of synthesized nitrogen depends on the initial mass, and stars with high luminosity (i.e. high initial mass) could have a high HCN abundance. CH bands are found in both the extra-galactic and Galactic carbon stars. None of the oxygen-rich LMC stars show SiO bands, except one possible detection in a low quality spectrum. The limits on the equivalent widths of the SiO bands are below the expectation of up to 30angstrom for LMC metallicity. Several possible explanations are discussed. The observations imply that LMC and SMC carbon stars could reach mass-loss rates as high as their Galactic counterparts, because there are more carbon atoms available and more carbonaceous dust can be formed. On the other hand, the lack of SiO suggests less dust and lower mass-loss rates in low-metallicity oxygen-rich stars. The effect on the ISM dust enrichment is discussed.Comment: accepted for A&

The T Tauri star RY Tau as a case study of the inner regions of circumstellar dust disks

We study the inner region of the circumstellar disk around the TTauri star RY Tau. Our aim is to find a physical description satisfying the available interferometric data, obtained with the mid-infrared interferometric instrument at the Very Large Telescope Interferometer, as well as the spectral energy distribution. We also compare the findings with the results of similar studies, including those of intermediate-mass stars. Our analysis is done within the framework of a passive circumstellar disk, which is optionally supplemented by the effects of accretion and an added envelope. To achieve a more consistent and realistic model, we used our continuum transfer code MC3D. In addition, we studied the shape of the 10um silicate emission feature in terms of the underlying dust population, both for single-dish and for interferometric measurements. We show that a modestly flaring disk model with accretion can explain both the observed spectral energy distribution and the mid-infrared visibilities obtained with the mid-infrared infrared instrument. We found an interesting ambiguity: a circumstellar active disk model with an added envelope, and a lower accretion rate than in the active disk model without envelope, could represent the observations equally as well. This type of model with the envelope should be considered a viable alternative in future models of other TTauri stars. The approach of a disk with a puffed-up inner rim wall and the influence of a stellar companion is also discussed. From the study of the silicate emission feature we see evidence for dust evolution in a TTauri star, with a decreasing fraction of small amorphous and an increasing fraction of crystalline particles closer to the star.Comment: 19 pages, 23 figures; accepted by Astronomy & Astrophysic

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.Peer reviewedPublisher PD