De la construcción entramada a la introducción de estructuras metálicas en Madrid

The study of buildings that have been preserved carried out by an analytical approach to original construction contracts, together with several damaged structures checked, has led to an overall timber frame house’s analysis. This approach could be divided into three main sections: first, traditional construction methods in Madrid from 1669 to nineteen hundred, within context. Next, a graphic analysis attending to information covered in construction contracts and the fact of being able to get information from buildings. Finally, it is shown an extended approach to case studies in buildings that have been preserved. This investigation is supported by a deep study of a particular corner of Madrid considered as a transition case study from timber frame systems to the introduction of iron columns and steel structures. Original construction method revealed could lead to focus on main pathologies of most of the houses built in Madrid before nineteen hundred.<br><br>El análisis de edificios construidos con entramado de madera que se han conservado y el estudio de los contratos de obra originales, ha permitido comparar estas construcciones. Se fundamenta en tres pilares básicos: la investigación y el análisis de contratos de obra originales desde 1669 hasta 1900; el análisis gráfico de este tipo de edificaciones, algunas desaparecidas y otras que han conservado; y la experiencia constructiva que ofrece la inspección de numerosos edificios con daños observables. Esta investigación se apoya en el recorrido detallado de una esquina singular con más de tres siglos de historia. Se puede considerar como edificio representativo de la transición de la construcción entramada y la introducción de los nuevos materiales: las columnas de fundición y las vigas metálicas. Su estudio permite recrear el proceso constructivo original y situar los daños más frecuentes en la mayor parte de los edificios anteriores a 1900

Recensiones [Revista de Historia Económica Año VII Invierno 1989 n. 1 pp. 219-253]

Linda Newson. The Cost Of Conquest. Indian decline in Honduras under the Spanish rule e Indian survival in colonial Nicaragua (Por Pedro Pérez Herrero).-- Pedro Rodríguez Campomanes. Reflexiones sobre el comercio español a Indias. (Por Luis Perdices Blas).-- Josep Fontana y otros. El comercio libre entre España y América Latina, 1765- 1824 (Por Andrés José Moreno Mengíbar).-- David-Sven Reher. Familia, población y sociedad en la provincia de Cuenca, 1700- 1970 (Por Concepción De Castro).-- Harvey J. Graff. The labyrinths of literacy. Reflections on literacy past and present (Por Clara E. Núñez).-- Bernard Elbaum y William Lazonick (Eds.) The decline of the Brittish Economy (Por Antonio F. Cubel Montesinos).-- Antonio Gómez Mendoza. Ferrocarril y mercado interior, Vol. 1: cereales, harinas y vinos, y Vol. 2: Manufacturas textiles, materias textiles, minerales, combustibles y metales (Por James Simpson).-- Carmen Sanchís Deusa. El transporte en el País Valenciano. Carreteras y ferrocarriles (Por Javier Vidal Olivares).-- José Manuel Naredo. La economía en evolución. Historia y perspectivas de las categorías básicas del pensamiento Eeconómico (Por Manuel Santos Redondo).-- Roger Backhouse. Historia del análisis económico moderno (Por Fernando Méndez Ibisate).-- William N. Parker (Ed.). Economic History and the modern economist (Por Gabriel Tortella)Publicad

Combined search for the standard model Higgs boson decaying to a bb pair using the full CDF data set

We combine the results of searches for the standard model Higgs boson based on the full CDF Run II data set obtained from sqrt(s) = 1.96 TeV p-pbar collisions at the Fermilab Tevatron corresponding to an integrated luminosity of 9.45/fb. The searches are conducted for Higgs bosons that are produced in association with a W or Z boson, have masses in the range 90-150 GeV/c^2, and decay into bb pairs. An excess of data is present that is inconsistent with the background prediction at the level of 2.5 standard deviations (the most significant local excess is 2.7 standard deviations).Comment: To be published in Phys. Rev. Lett (v2 contains minor updates based on comments from PRL

Evidence for t\bar{t}\gamma Production and Measurement of \sigma_t\bar{t}\gamma / \sigma_t\bar{t}

Using data corresponding to 6.0/fb of ppbar collisions at sqrt(s) = 1.96 TeV collected by the CDF II detector, we present a cross section measurement of top-quark pair production with an additional radiated photon. The events are selected by looking for a lepton, a photon, significant transverse momentum imbalance, large total transverse energy, and three or more jets, with at least one identified as containing a b quark. The ttbar+photon sample requires the photon to have 10 GeV or more of transverse energy, and to be in the central region. Using an event selection optimized for the ttbar+photon candidate sample we measure the production cross section of, and the ratio of cross sections of the two samples. Control samples in the dilepton+photon and lepton+photon+\met, channels are constructed to aid in decay product identification and background measurements. We observe 30 ttbar+photon candidate events compared to the standard model expectation of 26.9 +/- 3.4 events. We measure the ttbar+photon cross section to be 0.18+0.08 pb, and the ratio of the cross section of ttbar+photon to ttbar to be 0.024 +/- 0.009. Assuming no ttbar+photon production, we observe a probability of 0.0015 of the background events alone producing 30 events or more, corresponding to 3.0 standard deviations.Comment: 9 pages, 3 figure

Precision Top-Quark Mass Measurements at CDF

We present a precision measurement of the top-quark mass using the full sample of Tevatron $\sqrt{s}=1.96$ TeV proton-antiproton collisions collected by the CDF II detector, corresponding to an integrated luminosity of 8.7 $fb^{-1}$. Using a sample of $t\bar{t}$ candidate events decaying into the lepton+jets channel, we obtain distributions of the top-quark masses and the invariant mass of two jets from the $W$ boson decays from data. We then compare these distributions to templates derived from signal and background samples to extract the top-quark mass and the energy scale of the calorimeter jets with {\it in situ} calibration. The likelihood fit of the templates from signal and background events to the data yields the single most-precise measurement of the top-quark mass, \mtop = 172.85 \pm$0.71 (stat)$\pm$0.85 (syst) GeV/c^{2}.$Comment: submitted to Phys. Rev. Let

A search for resonant production of ttˉt\bar{t} pairs in $4.8\ \rm{fb}^{-1}ofintegratedluminosityof of integrated luminosity of p\bar{p}collisionsat collisions at \sqrt{s}=1.96\ \rm{TeV}$

We search for resonant production of tt pairs in 4.8 fb^{-1} integrated luminosity of ppbar collision data at sqrt{s}=1.96 TeV in the lepton+jets decay channel, where one top quark decays leptonically and the other hadronically. A matrix element reconstruction technique is used; for each event a probability density function (pdf) of the ttbar candidate invariant mass is sampled. These pdfs are used to construct a likelihood function, whereby the cross section for resonant ttbar production is estimated, given a hypothetical resonance mass and width. The data indicate no evidence of resonant production of ttbar pairs. A benchmark model of leptophobic Z \rightarrow ttbar is excluded with m_{Z'} < 900 GeV at 95% confidence level.Comment: accepted for publication in Physical Review D Sep 21, 201

Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV

We describe the measurement of the depth of maximum, Xmax, of the longitudinal development of air showers induced by cosmic rays. Almost four thousand events above 10^18 eV observed by the fluorescence detector of the Pierre Auger Observatory in coincidence with at least one surface detector station are selected for the analysis. The average shower maximum was found to evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/- 0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The interpretation of these results in terms of the cosmic ray mass composition is briefly discussed.Comment: Accepted for publication by PR

PDE 7 Inhibitors: New Potential Drugs for the Therapy of Spinal Cord Injury

BACKGROUND: Primary traumatic mechanical injury to the spinal cord (SCI) causes the death of a number of neurons that to date can neither be recovered nor regenerated. During the last years our group has been involved in the design, synthesis and evaluation of PDE7 inhibitors as new innovative drugs for several neurological disorders. Our working hypothesis is based on two different facts. Firstly, neuroinflammation is modulated by cAMP levels, thus the key role for phosphodiesterases (PDEs), which hydrolyze cAMP, is undoubtedly demonstrated. On the other hand, PDE7 is expressed simultaneously on leukocytes and on the brain, highlighting the potential crucial role of PDE7 as drug target for neuroinflammation. METHODOLOGY/PRINCIPAL FINDINGS: Here we present two chemically diverse families of PDE7 inhibitors, designed using computational techniques such as virtual screening and neuronal networks. We report their biological profile and their efficacy in an experimental SCI model induced by the application of vascular clips (force of 24 g) to the dura via a four-level T5-T8 laminectomy. We have selected two candidates, namely S14 and VP1.15, as PDE7 inhibitors. These compounds increase cAMP production both in macrophage and neuronal cell lines. Regarding drug-like properties, compounds were able to cross the blood brain barrier using parallel artificial membranes (PAMPA) methodology. SCI in mice resulted in severe trauma characterized by edema, neutrophil infiltration, and production of a range of inflammatory mediators, tissue damage, and apoptosis. Treatment of the mice with S14 and VP1.15, two PDE7 inhibitors, significantly reduced the degree of spinal cord inflammation, tissue injury (histological score), and TNF-α, IL-6, COX-2 and iNOS expression. CONCLUSIONS/SIGNIFICANCE: All these data together led us to propose PDE7 inhibitors, and specifically S14 and VP1.15, as potential drug candidates to be further studied for the treatment of SCI