Impacts of Cattle Grazing as a Tool to Control \u3ci\u3ePhragmites australis\u3c/i\u3e in Wetlands on Nitrogen, Phosphorus, and Carbon

Phragmites australis is a plant that is causing problems in wetlands by outcompeting native plants that provide food and shelter for millions of migratory birds. Currently, managers try to control Phragmites australis by spraying herbicide, burning, and mowing, but these methods are costly, time consuming, and have low levels of success. Adding grazing as a tool to control Phragmites australis provides a cheap and low labor alternative. However, there are many concerns regarding if grazing will cause nutrient loading in our wetlands that will decrease water quality and alter beneficial functions of wetlands. To better understand the effects of grazing in wetlands, we proposed a two-year study and received funding from many organizations including the Utah Department of Fire, Forestry, and State Lands, South Davis Sewer District, and the Utah Department of Environmental Quality and Water Quality. Also, the Utah Department of Natural Resources helped tremendously in allowing access to the sites, in the actual implementation of the project, coordinating with local ranchers who allowed for their cattle to be in the study, managed their cattle during the study, and assisted with fence installation, and many volunteers from Utah dedicated hunters helped with the fence installation. We collected water, manure, soil, and leaf samples over time to analyze nutrient changes and measured changes in the plants, water levels, soil cover, and litter cover over time. We then compiled and analyzed this information to better understand how grazing impacts our wetlands. As a result, we were able to make some recommendations for future research and how best to graze in wetlands with minimal impacts according to the information we found

Cattle grazing for invasive Phragmites australis (common reed) management in Northern Utah wetlands

This fact sheet provides suggestions for how cattle grazing can be integrated into Phragmites management programs in Northern Utah

AI is a viable alternative to high throughput screening: a 318-target study

: High throughput screening (HTS) is routinely used to identify bioactive small molecules. This requires physical compounds, which limits coverage of accessible chemical space. Computational approaches combined with vast on-demand chemical libraries can access far greater chemical space, provided that the predictive accuracy is sufficient to identify useful molecules. Through the largest and most diverse virtual HTS campaign reported to date, comprising 318 individual projects, we demonstrate that our AtomNet® convolutional neural network successfully finds novel hits across every major therapeutic area and protein class. We address historical limitations of computational screening by demonstrating success for target proteins without known binders, high-quality X-ray crystal structures, or manual cherry-picking of compounds. We show that the molecules selected by the AtomNet® model are novel drug-like scaffolds rather than minor modifications to known bioactive compounds. Our empirical results suggest that computational methods can substantially replace HTS as the first step of small-molecule drug discovery

Mortality and pulmonary complications in patients undergoing surgery with perioperative SARS-CoV-2 infection: an international cohort study

Background: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on postoperative recovery needs to be understood to inform clinical decision making during and after the COVID-19 pandemic. This study reports 30-day mortality and pulmonary complication rates in patients with perioperative SARS-CoV-2 infection. Methods: This international, multicentre, cohort study at 235 hospitals in 24 countries included all patients undergoing surgery who had SARS-CoV-2 infection confirmed within 7 days before or 30 days after surgery. The primary outcome measure was 30-day postoperative mortality and was assessed in all enrolled patients. The main secondary outcome measure was pulmonary complications, defined as pneumonia, acute respiratory distress syndrome, or unexpected postoperative ventilation. Findings: This analysis includes 1128 patients who had surgery between Jan 1 and March 31, 2020, of whom 835 (74·0%) had emergency surgery and 280 (24·8%) had elective surgery. SARS-CoV-2 infection was confirmed preoperatively in 294 (26·1%) patients. 30-day mortality was 23·8% (268 of 1128). Pulmonary complications occurred in 577 (51·2%) of 1128 patients; 30-day mortality in these patients was 38·0% (219 of 577), accounting for 81·7% (219 of 268) of all deaths. In adjusted analyses, 30-day mortality was associated with male sex (odds ratio 1·75 [95% CI 1·28–2·40], p\textless0·0001), age 70 years or older versus younger than 70 years (2·30 [1·65–3·22], p\textless0·0001), American Society of Anesthesiologists grades 3–5 versus grades 1–2 (2·35 [1·57–3·53], p\textless0·0001), malignant versus benign or obstetric diagnosis (1·55 [1·01–2·39], p=0·046), emergency versus elective surgery (1·67 [1·06–2·63], p=0·026), and major versus minor surgery (1·52 [1·01–2·31], p=0·047). Interpretation: Postoperative pulmonary complications occur in half of patients with perioperative SARS-CoV-2 infection and are associated with high mortality. Thresholds for surgery during the COVID-19 pandemic should be higher than during normal practice, particularly in men aged 70 years and older. Consideration should be given for postponing non-urgent procedures and promoting non-operative treatment to delay or avoid the need for surgery. Funding: National Institute for Health Research (NIHR), Association of Coloproctology of Great Britain and Ireland, Bowel and Cancer Research, Bowel Disease Research Foundation, Association of Upper Gastrointestinal Surgeons, British Association of Surgical Oncology, British Gynaecological Cancer Society, European Society of Coloproctology, NIHR Academy, Sarcoma UK, Vascular Society for Great Britain and Ireland, and Yorkshire Cancer Research

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

The Ages of Passive Galaxies in a z = 1.62 Protocluster

We present a study of the relation between galaxy stellar age and mass for 14 members of the $z=1.62$ protocluster IRC 0218, using multiband imaging and HST G102 and G141 grism spectroscopy. Using $UVJ$ colors to separate galaxies into star forming and quiescent populations, we find that at stellar masses $M_* \geq 10^{10.85} M_{\odot}$, the quiescent fraction in the protocluster is $f_Q=1.0^{+0.00}_{-0.37}$, consistent with a $\sim 2\times$ enhancement relative to the field value, $f_Q=0.45^{+0.03}_{-0.03}$. At masses $10^{10.2} M_{\odot} \leq M_* \leq 10^{10.85} M_{\odot}$, $f_Q$ in the cluster is $f_Q=0.40^{+0.20}_{-0.18}$, consistent with the field value of $f_Q=0.28^{+0.02}_{-0.02}$. Using galaxy $D_{n}(4000)$ values derived from the G102 spectroscopy, we find no relation between galaxy stellar age and mass. These results may reflect the impact of merger-driven mass redistribution, which is plausible as this cluster is known to host many dry mergers. Alternately, they may imply that the trend in $f_Q$ in IRC 0218 was imprinted over a short timescale in the protocluster's assembly history. Comparing our results with those of other high-redshift studies and studies of clusters at $z\sim 1$, we determine that our observed relation between $f_Q$ and stellar mass only mildly evolves between $z\sim 1.6$ and $z \sim 1$, and only at stellar masses $M_* \leq 10^{10.85} M_{\odot}$. Both the $z\sim 1$ and $z\sim 1.6$ results are in agreement that the red sequence in dense environments was already populated at high redshift, $z \ge 3$, placing constraints on the mechanism(s) responsible for quenching in dense environments at $z\ge 1.5$Comment: 17 pages, 8 figures, 3 tables. Accepted for publication in Ap

Publisher Correction: Genetic tool development in marine protists: emerging model organisms for experimental cell biology.

An amendment to this paper has been published and can be accessed via a link at the top of the paper

Genetic tool development in marine protists: emerging model organisms for experimental cell biology

Abstract: Diverse microbial ecosystems underpin life in the sea. Among these microbes are many unicellular eukaryotes that span the diversity of the eukaryotic tree of life. However, genetic tractability has been limited to a few species, which do not represent eukaryotic diversity or environmentally relevant taxa. Here, we report on the development of genetic tools in a range of protists primarily from marine environments. We present evidence for foreign DNA delivery and expression in 13 species never before transformed and for advancement of tools for eight other species, as well as potential reasons for why transformation of yet another 17 species tested was not achieved. Our resource in genetic manipulation will provide insights into the ancestral eukaryotic lifeforms, general eukaryote cell biology, protein diversification and the evolution of cellular pathways