Compression moulding of composites with hybrid fibre architectures

Advanced Sheet Moulding Compounds (ASMC) and unidirectional (UD) prepregs have been co-compression moulded to form a hybrid composite material. In-mould flow influences the UD fibre architecture in two ways. When UD fibres are aligned transversely to the ASMC flow direction, shearing occurs which causes local changes in fibre volume fraction and fibre waviness. When the UD fibres are aligned with the ASMC flow direction, ply migration takes place. In general, the composite stiffness follows a rule of mixtures relationship, with the stiffness proportional to the UD fibre content. A grid analysis method has been developed to quantify distortion in the UD plies. Staging the resin to 50% cure was shown to reduce ply distortion during moulding, whilst maintaining suitable inter-laminar shear strength. Adding an interfacial prepreg ply between the reinforcing UD fibres and the ASMC charge successfully prevented distortion in the UD fibres, avoiding shear thinning and fibre migration

Defect formation during preforming of a bi-axial non-crimp fabric with a pillar stitch pattern

To capture the asymmetrical shear behaviour of a bi-axial NCF with a pillar stitch, a non-orthogonal constitutive model was developed and implemented in finite element forming simulations. Preforming experiments indicate that the local distribution of defects is significantly different on both sides of each bi-axial ply, with two different defect mechanisms observed. Correlation with simulation results indicates that one defect type is caused by excessive shear, inducing out-of-plane wrinkling in regions of positive shear (macro-scale wrinkling). The other defect type is caused by fibre compression, inducing in-plane wrinkling in regions of negative shear (meso-scale wrinkling). Local distributions of shear angle and wrinkling strain were used to determine the wrinkling mode and to confirm the corresponding defect mechanism. Results indicate that simulations based on the advanced constitutive model can predict local shear angles within ±5°of experimental values and that predicted wrinkling positions and defect types correlate well with the experiments

Identification of common genetic risk variants for autism spectrum disorder

Autism spectrum disorder (ASD) is a highly heritable and heterogeneous group of neurodevelopmental phenotypes diagnosed in more than 1% of children. Common genetic variants contribute substantially to ASD susceptibility, but to date no individual variants have been robustly associated with ASD. With a marked sample-size increase from a unique Danish population resource, we report a genome-wide association meta-analysis of 18,381 individuals with ASD and 27,969 controls that identified five genome-wide-significant loci. Leveraging GWAS results from three phenotypes with significantly overlapping genetic architectures (schizophrenia, major depression, and educational attainment), we identified seven additional loci shared with other traits at equally strict significance levels. Dissecting the polygenic architecture, we found both quantitative and qualitative polygenic heterogeneity across ASD subtypes. These results highlight biological insights, particularly relating to neuronal function and corticogenesis, and establish that GWAS performed at scale will be much more productive in the near term in ASD.Peer reviewe

On the mechanisms governing gas penetration into a tokamak plasma during a massive gas injection

A new 1D radial fluid code, IMAGINE, is used to simulate the penetration of gas into a tokamak plasma during a massive gas injection (MGI). The main result is that the gas is in general strongly braked as it reaches the plasma, due to mechanisms related to charge exchange and (to a smaller extent) recombination. As a result, only a fraction of the gas penetrates into the plasma. Also, a shock wave is created in the gas which propagates away from the plasma, braking and compressing the incoming gas. Simulation results are quantitatively consistent, at least in terms of orders of magnitude, with experimental data for a D 2 MGI into a JET Ohmic plasma. Simulations of MGI into the background plasma surrounding a runaway electron beam show that if the background electron density is too high, the gas may not penetrate, suggesting a possible explanation for the recent results of Reux et al in JET (2015 Nucl. Fusion 55 093013)

High-order embedded WENO schemes

Embedded WENO schemes are a new family of weighted essentially nonoscillatory schemes that always utilise all adjacent smooth substencils. This results in increased control over the convex combination of lower-order interpolations. We show that more conventional WENO schemes, such as WENO-JS and WENO-Z (Borges et al., J. Comput. Phys., 2008; Jiang and Shu, J. Comput. Phys., 1996), do not exhibit this feature and as such do not always provide a desirable linear combination of smooth substencils. In a previous work, we have already developed the theory and machinery needed to construct embedded WENO methods and shown some five-point schemes (van Lith et al., J. Comput. Phys., 2016). Here, we construct a seven-point scheme and show that it too performs well using some numerical examples from the one-dimensional Euler equations