Apoptosis and autoimmune thyroid disease: following a TRAIL to thyroid destruction?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72844/1/j.1365-2265.2001.01345.x.pd

Crosstalk between cAMP and MAP Kinase Signaling in the Regulation of Cell Proliferation

Hormonal stimulation of cyclic adenosine monophosphate (cAMP) and the cAMP-dependent protein kinase PKA regulates cell growth by multiple mechanisms. A hallmark of cAMP is its ability to stimulate cell growth in many cell types while inhibiting cell growth in others. In this review, the cell type-specific effects of cAMP on the mitogen-activated protein (MAP) kinase (also called extracellular signal-regulated kinase, or ERK) cascade and cell proliferation are examined. Two basic themes are discussed. First, the capacity of cAMP for either positive or negative regulation of the ERK cascade accounts for many of the cell type-specific actions of cAMP on cell proliferation. Second, there are several specific mechanisms involved in the inhibition or activation of ERKs by cAMP. Emerging new data suggest that one of these mechanisms might involve the activation of the GTPase Rap1, which can activate or inhibit ERK signaling in a cell-specific manner

SRM・CRMの観点から考察する商社営業のコンピテンシー

Stem cells have captured the imagination of the general public by their potential as new therapeutic tools in the fight against degenerative diseases. This potential is based on their capability for self-renewal and at the same time for producing progenitor cells that will eventually provide the building blocks for tissue and organ regeneration. These processes are carefully orchestrated in the organism by means of a series of molecular cues. An emerging molecule which is responsible for some of these physiological responses is adrenomedullin, a 52-amino acid regulatory peptide which increases proliferation and regulates cell fate of stem cells of different origins. Adrenomedullin binds to specific membrane receptors in stem cells and induces several intracellular pathways such as those involving cAMP, Akt, or MAPK. Regulation of adrenomedullin levels may help in directing the growth and differentiation of stem cells for applications (e.g., cell therapy) both in vitro and in vivo. © 2012 Elsevier Inc.Peer Reviewe

Contrôle de la prolifération cellulaire de la thyrode :rôle de l'apoptose, de "l'Hepatocyte Growth Factor" et de la cascade de l'AMP cyclique

Doctorat en Sciencesinfo:eu-repo/semantics/nonPublishe

Protein phosphorylation, kinases, and phosphates: 20th European Symposium on Hormones and Cell Regulation Strasbourg, France, September 22-25, 1995

Journal Articleinfo:eu-repo/semantics/publishe

TTF-1 gene expression in resting or cyclic AMP stimulated primary dog thyrocyte cultures

info:eu-repo/semantics/publishe

Eosinophils affect functions of in vitro-activated human CD3-CD4+ T cells.

info:eu-repo/semantics/publishe