The added value of the multi-system spread information for ocean heat content and steric sea level investigations in the CMEMS GREP ensemble reanalysis product

Since 2016, the Copernicus Marine Environment Monitoring Service (CMEMS) has produced and disseminated an ensemble of four global ocean reanalyses produced at eddy-permitting resolution for the period from 1993 to present, called GREP (Global ocean Reanalysis Ensemble Product). This dataset offers the possibility to investigate the potential benefits of a multi-system approach for ocean reanalyses, since the four reanalyses span by construction the same spatial and temporal scales. In particular, our investigations focus on the added value of the information on the ensemble spread, implicitly contained in the GREP ensemble, for temperature, salinity, and steric sea level studies. It is shown that in spite of the small ensemble size, the spread is capable of estimating the flow-dependent uncertainty in the ensemble mean, although proper re-scaling is needed to achieve reliability. The GREP members also exhibit larger consistency (smaller spread) than their predecessors, suggesting advancement with time of the reanalysis vintage. The uncertainty information is crucial for monitoring the climate of the ocean, even at regional level, as GREP shows consistency with CMEMS high-resolution regional products and complement the regional estimates with uncertainty estimates. Further applications of the spread include the monitoring of the impact of changes in ocean observing networks; the use of multi-model ensemble anomalies in hybrid ensemble-variational retrospective analysis systems, which outperform static covariances and represent a promising application of GREP. Overall, the spread information of the GREP product is found to significantly contribute to the crucial requirement of uncertainty estimates for climatic datasets.Data from the reanalyses presented in this work are available from the Copernicus Marine Environment Monitoring Service (CMEMS, http://marine.copernicus.eu/). Part of this work was supported by the EOS COST Action (“Evaluation of Ocean Synthesis”, http://eos-cost.eu/) through its Short Term Scientific Missions program. The full C-GLORS dataset is available at http://c-glors.cmcc.it. This work has received funding from the Copernicus Marine Environment Monitoring Service (CMEMS).Published287-3124A. Oceanografia e climaJCR Journa

Lenalidomide in combination with dexamethasone at first relapse in comparison with its use as later salvage therapy in relapsed or refractory multiple myeloma

This subset analysis of data from two phase III studies in patients with relapsed or refractory multiple myeloma (MM) evaluated the benefit of initiating lenalidomide plus dexamethasone at first relapse. Multivariate analysis showed that fewer prior therapies, along with β2-microglobulin (≤2.5 mg/L), predicted a better time to progression (TTP; study end-point) with lenalidomide plus dexamethasone treatment. Patients with one prior therapy showed a significant improvement in benefit after first relapse compared with those who received two or more therapies. Patients with one prior therapy had significantly prolonged median TTP (17.1 vs. 10.6 months; P=0.026) and progression-free survival (14.1 vs. 9.5 months, P=0.047) compared with patients treated in later lines. Overall response rates were higher (66.9% vs. 56.8%, P=0.06), and the complete response plus very good partial response rate was significantly higher in first relapse (39.8% vs. 27.7%, P=0.025). Importantly, overall survival was significantly prolonged for patients treated with lenalidomide plus dexamethasone with one prior therapy, compared with patients treated later in salvage (median of 42.0 vs. 35.8 months, P=0.041), with no differences in toxicity, dose reductions, or discontinuations despite longer treatment. Therefore, lenalidomide plus dexamethasone is both effective and tolerable for second-line MM therapy and the data suggest that the greatest benefit occurs with earlier use

The Copernicus Marine Environment Monitoring Service Ocean State Report

The Copernicus Marine Environment Monitoring Service (CMEMS) Ocean State Report (OSR) provides an annual report of the state of the global ocean and European regional seas for policy and decision-makers with the additional aim of increasing general public awareness about the status of, and changes in, the marine environment. The CMEMS OSR draws on expert analysis and provides a 3-D view (through reanalysis systems), a view from above (through remote-sensing data) and a direct view of the interior (through in situ measurements) of the global ocean and the European regional seas. The report is based on the unique CMEMS monitoring capabilities of the blue (hydrography, currents), white (sea ice) and green (e.g. Chlorophyll) marine environment. This first issue of the CMEMS OSR provides guidance on Essential Variables, large-scale changes and specific events related to the physical ocean state over the period 1993–2015. Principal findings of this first CMEMS OSR show a significant increase in global and regional sea levels, thermosteric expansion, ocean heat content, sea surface temperature and Antarctic sea ice extent and conversely a decrease in Arctic sea ice extent during the 1993–2015 period. During the year 2015 exceptionally strong large-scale changes were monitored such as, for example, a strong El Niño Southern Oscillation, a high frequency of extreme storms and sea level events in specific regions in addition to areas of high sea level and harmful algae blooms. At the same time, some areas in the Arctic Ocean experienced exceptionally low sea ice extent and temperatures below average were observed in the North Atlantic Ocean

A História da Alimentação: balizas historiográficas

Os M. pretenderam traçar um quadro da História da Alimentação, não como um novo ramo epistemológico da disciplina, mas como um campo em desenvolvimento de práticas e atividades especializadas, incluindo pesquisa, formação, publicações, associações, encontros acadêmicos, etc. Um breve relato das condições em que tal campo se assentou faz-se preceder de um panorama dos estudos de alimentação e temas correia tos, em geral, segundo cinco abardagens Ia biológica, a econômica, a social, a cultural e a filosófica!, assim como da identificação das contribuições mais relevantes da Antropologia, Arqueologia, Sociologia e Geografia. A fim de comentar a multiforme e volumosa bibliografia histórica, foi ela organizada segundo critérios morfológicos. A seguir, alguns tópicos importantes mereceram tratamento à parte: a fome, o alimento e o domínio religioso, as descobertas européias e a difusão mundial de alimentos, gosto e gastronomia. O artigo se encerra com um rápido balanço crítico da historiografia brasileira sobre o tema

Quelle correction troposphérique humide pour l'altimétrie côtière et continentale ?

TOULOUSE3-BU Sciences (315552104) / SudocTOULOUSE-Observ. Midi Pyréné (315552299) / SudocSudocFranceF

One-Dimensional Variational Retrieval of the Wet Tropospheric Correction for Altimetry in Coastal Regions

International audienceNot Availabl

Etude expérimentale sur un nouveau procédé de cuti-réaction à la tuberculine (Procédé Lautier)

Thèse : Médecine : Université de Bordeaux : 1908N° d'ordre : 10

On the Wet Tropospheric Correction for Altimetry in Coastal Regions

International audienceNot Availabl

Large scale surveys for cetaceans : line transect assumptions, reliability of abundance estimates and improving survey efficiency – A response to MacLeod

PostprintPeer reviewe