Immunoexpression Of α2-integrin And Hsp47 In Hereditary Gingival Fibromatosis And Gingival Fibromatosis-associated Dental Abnormalities

Objective: The purpose of the present study was to investigate the expression of the α2-integrin subunit and heat shock protein 47 (Hsp47) in two families with isolated gingival fibromatosis (GF) form and one family with GF associated with dental abnormalities and normal gingiva (NG). Study Design: Immunohistochemistry was performed with antibodies against α2-integrin and Hsp47 in specimens from two unrelated families with hereditary gingival fibromatosis (Families 1 and 2) and from one family with a gingival fibromatosis-associated dental abnormality (Family 3); NG samples were used for comparison. The results were analysed statistically. Results: Immunoreactivity for α2-integrin and Hsp47 was observed in the nucleus of epithelial cells of both the basal and suprabasal layer and a more discreet signal was noted in connective tissue in all study samples. Hsp47 showed higher immunoreactivity in Family 2 compared with the other families (p≤0.05). Despite the markup α2-integrin was higher in Family 3 there was no statistically significant difference between the families studied (p≥0.05). Conclusions: Our results confirmed the heterogeneity of GF, such that similar patterns of expression of the condition may show differences in the expression of proteins such as Hsp47. Although no difference in α2-integrin expression was observed between GF and NG groups, future studies are necessary to determine the exact role of this protein in the various forms of GF and whether it contributes to GF pathogenesis. © Medicina Oral S. L. C.I.F. 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Who Believes in the Giant Skeleton Myth? An Examination of Individual Difference Correlates

This study examined individual difference correlates of belief in a narrative about the discovery of giant skeletal remains that contravenes mainstream scientific explanations. A total of 364 participants from Central Europe completed a survey that asked them to rate their agreement with a short excerpt describing the giant skeleton myth. Participants also completed measures of the Big Five personality factors, New Age orientation, anti-scientific attitudes, superstitious beliefs, and religiosity. Results showed that women, as compared with men, and respondents with lower educational qualifications were significantly more likely to believe in the giant skeleton myth, although effect sizes were small. Correlational analysis showed that stronger belief in the giant skeleton myth was significantly associated with greater anti-scientific attitudes, stronger New Age orientation, greater religiosity, stronger superstitious beliefs, lower Openness to Experience scores, and higher Neuroticism scores. However, a multiple regression showed that the only significant predictors of belief in myth were Openness, New Age orientation, and anti-scientific attitudes. These results are discussed in relation to the potential negative consequences of belief in myths

GRB970228 and a class of GRBs with an initial spikelike emission

(Shortened) The Swift and HETE-2 discovery of an afterglow associated possibly with short GRBs opened the new problematic of their nature and classification. This has been further enhanced by the GRB060614 observation and by a re-analysis of the BATSE catalog leading to the identification of a new GRB class with "an occasional softer extended emission lasting tenths of seconds after an initial spikelike emission". We plan: a) to fit this new class of "hybrid" sources within our "canonical GRB" scenario, where all GRBs are generated by a "common engine" (i.e. the gravitational collapse to a black hole); b) to propose GRB970228 as the prototype of the such a class. We analyze BeppoSAX data on GRB970228 in the 40-700 keV and 2-26 keV energy bands within the "fireshell" model. We find that GRB970228 is a "canonical GRB", like e.g. GRB050315, with the main peculiarity of a particularly low CircumBurst Medium (CBM) average density n_{cbm}~10^{-3} #/cm^3. We also simulate the light curve corresponding to a rescaled CBM density profile with n_{cbm}=1 #/cm^3. From such a comparison it follows that the total time-integrated luminosity is a faithful indicator of the GRB nature, contrary to the peak luminosity which is merely a function of the CBM density. We call attention on discriminating the short GRBs between the "genuine" and the "fake" ones. The "genuine" ones are intrinsically short, with baryon loading B \la 10^{-5}, as stated in our original classification. The "fake" ones, characterized by an initial spikelike emission followed by an extended emission lasting tenths of seconds, have a baryon loading 10^{-4} \la B \leq 10^{-2}. They are observed as such only due to an underdense CBM consistent with a galactic halo environment which deflates the afterglow intensity.Comment: 4 pages, 4 figures, to appear on A&A Letter

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bitstream/item/76018/1/ct57-2002.pd

ESO Imaging Survey: Optical follow-up of 12 selected XMM-Newton fields

(Abridged) This paper presents the data recently released for the XMM-Newton/WFI survey carried out as part of the ESO Imaging Survey (EIS) project. The aim of this survey is to provide optical imaging follow-up data in BVRI for identification of serendipitously detected X-ray sources in selected XMM-Newton fields. In this paper, fully calibrated individual and stacked images of 12 fields as well as science-grade catalogs for the 8 fields located at high-galactic latitude are presented. The data covers an area of \sim 3 square degrees for each of the four passbands. The median limiting magnitudes (AB system, 2" aperture, 5\sigma detection limit) are 25.20, 24.92, 24.66, and 24.39 mag for B-, V-, R-, and I-band, respectively. These survey products, together with their logs, are available to the community for science exploitation in conjunction with their X-ray counterparts. Preliminary results from the X-ray/optical cross-correlation analysis show that about 61% of the detected X-ray point sources in deep XMM-Newton exposures have at least one optical counterpart within 2" radius down to R \simeq 25 mag, 50% of which are so faint as to require VLT observations thereby meeting one of the top requirements of the survey, namely to produce large samples for spectroscopic follow-up with the VLT, whereas only 15% of the objects have counterparts down to the DSS limiting magnitude.Comment: 24 pages, 10 figures, accepted for publication in Astronomy and Astrophysics. Accompanying data releases available at http://archive.eso.org/archive/public_datasets.html (WFI images), http://www.eso.org/science/eis/surveys/release_65000025_XMM.html (optical catalogs), http://www.aip.de/groups/xray/XMM_EIS/ (X-ray data). Full resolution version available at http://www.astro.uni-bonn.de/~dietrich/publications/3785.ps.g

GRB060614: a "fake" short GRB from a merging binary system

(Shortened) CONTEXT: [...] GRB060614 is the first nearby long duration GRB clearly not associated to a bright Ib/c supernova. Moreover, its duration (T_{90} ~ 100s) makes it hardly classifiable as a short GRB. It presents strong similarities with GRB970228, the prototype of the new class of "fake" short GRBs that appear to originate from the coalescence of binary neutron stars or white dwarfs spiraled out into the galactic halo. AIMS: Within the "canonical" GRB scenario based on the "fireshell" model, we test if GRB060614 can be a "fake" or "disguised" short GRB. [...] METHODS: We fit GRB060614 light curves in Swift's BAT (15-150keV) and XRT (0.2-10keV) energy bands. Within the fireshell model, light curves are formed by two well defined and different components: the Proper-GRB (P-GRB), emitted at the fireshell transparency, and the extended afterglow, due to the interaction between the leftover accelerated baryonic and leptonic shell and the CBM. RESULTS: We determine the two free parameters describing the GRB source within the fireshell model. [...] A small average CBM density [...] is inferred, typical of galactic halos. The first spikelike emission is identified with the P-GRB and the following prolonged emission with the extended afterglow peak.[...] CONCLUSIONS: The anomalous GRB060614 finds a natural interpretation within our canonical GRB scenario: it is a "disguised" short GRB. [...] This result points to an old binary system, likely formed by a white dwarf and a neutron star, as the progenitor of GRB060614 and well justify the absence of an associated SN Ib/c. Particularly important for further studies of the final merging process are the temporal structures in the P-GRB down to 0.1s.Comment: 7 pages, 5 figures, to appear on Astronomy & Astrophysics. This new version fixes a typo in one label of Fig.

The optical afterglows and host galaxies of three short/hard gamma-ray bursts

Short GRBs are commonly thought to originate from the merging of double compact object binaries but direct evidence for this scenario is still missing. Optical observations of short GRBs allow us to measure redshifts, firmly identify host galaxies, characterize their properties, and accurately localize GRBs within them. Multiwavelength observations of GRB afterglows provide useful information on the emission mechanisms at work. These are all key issues that allow one to discriminate among different models of these elusive events. We carried out photometric observations of the short/hard GRB 051227, GRB 061006, and GRB 071227 with the ESO-VLT starting from several hours after the explosion down to the host galaxy level several days later. For GRB 061006 and GRB 071227 we also obtained spectroscopic observations of the host galaxy. We compared the results obtained from our optical observations with the available X-ray data of these bursts. For all the three above bursts, we discovered optical afterglows and firmly identified their host galaxies. About half a day after the burst, the optical afterglows of GRB 051227 and GRB 061006 present a decay significatly steeper than in the X-rays. In the case of GRB 051227, the optical decay is so steep that it likely indicates different emission mechanisms in the two wavelengths ranges. The three hosts are blue, star forming galaxies at moderate redshifts and with metallicities comparable to the Solar one. The projected offsets of the optical afterglows from their host galaxies centers span a wide range, but all afterglows lie within the light of their hosts and present evidence for local absorption in their X-ray spectra. We discuss our findings in light of the current models of short GRB progenitors.Comment: Accepted for publication by A&A. 11 pages, 9 figures; v2: minor changes and new version of Fig.

BVRI Light Curves for 29 Type Ia Supernovae

BVRI light curves are presented for 27 Type Ia supernovae discovered during the course of the Calan/Tololo Survey and for two other SNe Ia observed during the same period. Estimates of the maximum light magnitudes in the B, V, and I bands and the initial decline rate parameter m15(B) are also given.Comment: 17 pages, figures and tables are not included (contact first author if needed), to appear in the Astronomical Journa

Novel compounds targeting the RNA-binding protein HuR : Structure-based design, synthesis and interaction studies

The key role of RNA-binding proteins (RBPs) in regulating post-transcriptional processes and their involvement in several pathologies (i.e., cancer and neurodegeneration) have highlighted their potential as therapeutic targets. In this scenario, Embryonic Lethal Abnormal Vision (ELAV) or Hu proteins and their complexes with target mRNAs have been gaining growing attention. Compounds able to modulate the complex stability could constitute an innovative pharmacological strategy for the treatment of numerous diseases. Nevertheless, medicinal-chemistry efforts aimed at developing such compounds are still at an early stage. As part of our ongoing research in this field, we hereby present the rational design and synthesis of structurally novel HuR ligands, potentially acting as HuR-RNA interferers. The following assessment of the structural features of their interaction with HuR, combining saturation-transfer difference NMR and in silico studies, provides a guide for further research on the development of new effective interfering compounds of the HuR-RNA complex

Early-type galaxies with core collapse supernovae

It is widely accepted that the progenitors of core collapse SNe are young massive stars and therefore their host galaxies are mostly spiral or irregular galaxies dominated by a young stellar population. Surprisingly, among morphologically classified hosts of core collapse SNe, we find 22 cases where the host has been classified as an Elliptical or S0 galaxy. To clarify this apparent contradiction, we carry out a detailed morphological study and an extensive literature search for additional information on the sample objects. Our results are as follows: 1. Of 22 "early type" objects, 17 are in fact misclassified spiral galaxies, one is a misclassified irregular, and one is a misclassified ring galaxy. 2. Of the 3 objects maintaining the early type classification, one (NGC2768) is a suspected merger remnant, another (NGC4589) is definitely a merger, and the third (NGC2274) is in close interaction. The presence of some amount of young stellar population in these galaxies is therefore not unexpected. These results confirm the presence of a limited, but significant, number of core collapse SNe in galaxies generally classified of early type. In all cases, anyway, there are independent indicators of the presence in host galaxies of recent star formation due to merging or gravitational interaction.Comment: 12 pages, 1 figure, 1 table, accepted for publication in A&