Lepton Portal Limit of Inert Higgs Doublet Dark Matter with Radiative Neutrino Mass

We study an extension of the Inert Higgs Doublet Model (IHDM) by three copies of right handed neutrinos and heavy charged leptons such that both the inert Higgs doublet and the heavy fermions are odd under the $Z_2$ symmetry of the model. The neutrino masses are generated at one loop in the scotogenic fashion. Assuming the neutral scalar of the inert Higgs to be the dark matter candidate, we particularly look into the region of parameter space where dark matter relic abundance is primarily governed by the inert Higgs coupling with the leptons. This corresponds to tiny Higgs portal coupling of dark matter as well as large mass splitting within different components of the inert Higgs doublet suppressing the coannihilations. Such lepton portal couplings can still produce the correct relic abundance even if the Higgs portal couplings are arbitrarily small. Such tiny Higgs portal couplings may be responsible for suppressed dark matter nucleon cross section as well as tiny invisible branching ratio of the standard model Higgs, to be probed at ongoing and future experiments. We also briefly discuss the collider implications of such a scenario.Comment: 10 pages, 7 figure

Memory chip design using cadence

In this paper an effort is made to design 16 bit SRAM memory array on 180nm technology. For high-speed memory applications such as cache, a SRAM is often used. Access time, speed, and power consumption are the three key parameters for an SRAM memory design (SRAM). The integrated SRAM is operated with analog input voltage of 0 to 1.8v. The 16 bit SRAM memory has been designed, implemented &analysed in standard UMC180nm technology library using Cadence tool.We alsoanalyse the read and write operation of the designed memory cell

Resolving blood group discrepancy in patients of tertiary care centre in Odisha, India

Background: Blood grouping consists of both forward grouping; reverse grouping and both procedures should agree with each other.A blood group discrepancy exists when results of red cell testing do not agree with serum testing, usually due to unexpected negative or positive results in either forward or reverse typing. ABO and Rh blood group discrepancy is associated with incompatible transfusion reaction.Blood group discrepancy should be resolved before transfusion and blood group to be properly labeled to prevent transfusion reaction.Methods: A prospective study was carried in SCB blood bank which is under the Department of Transfusion Medicine, SCB Medical College and Hospital, Cuttack, Odisha from January 2015 to October-2016. Total 25,559 blood samples of patients were included in the study and hemolysed samples excluded. The ABO and Rh D typing was done by tube technique using monoclonal IgM (Tulip Diagnostic P Ltd.) Anti-A, Anti-B, Anti-D and pooled A, B and O cell.Results: A total of 25,559 blood group testing were done where we found 57 blood group discrepancies with overall frequency was 0.22%. Out of 57 discrepancies we were found 20 (35.09%) cases of technical error and 37 (64.91%) cases of sample related error. Among these sample related problems, we found weak/missing antibody, weak antigen expression, rouleaux, cold autoantibodies, cold alloantibodies, Bombay phenotype with the frequency of 13.51%, 2.70%, 2.70%, 54.06%, 8.11%, 18.92% respectively.Conclusions: Mistyping either a donor or a recipient can lead to transfusion with ABO-incompatible blood, which can result in severe hemolysis and may even result in the death of the recipient. Any discrepancy between forward and reverse blood grouping methods should be resolved before transfusion of blood components

Length–weight relationship for three estuarine fish species from the Chilika Lagoon, India

501-502We investigated the length–weight relationships (LWRs) for Sillago vincenti McKay, 1980, Triacanthus nieuhofii Bleeker, 1852 and Terapon puta Cuvier, 1829 from the Chilika lagoon in India. Sampling was conducted in central sector of the Chilika from April to November of 2017. Specimens were caught in mono-filament gill nets of mesh size 28-36 mm and fixed set nets of mesh size 16-24 mm. From LWR estimation, the determined intercept (a value) and slope (b value) were found to be 0.007 and 3.039 for Sillago vincenti, 0.010 and 2.997 for Triacanthus nieuhofii and 0.008 and 3.156 for Terapon puta. The relationships between length and weight in all three species were highly correlated (p <0.05)

Platelet audit: To weigh the rationality between requirement and uses in blood transfusion

Background: Blood transfusion especially the transfusion of blood component is an important part for better patient management than whole blood transfusion. Despite various approved guidelines, non-compliance regarding rational use prevails in transfusion services.Methods: In the present study; retrospective audit was conducted for a period of six months in the department of Transfusion Medicine, SCB Medical College and Hospital revealed on 3871 number of platelets prepared.Results: Out of 3757 units of platelet issued, there was 10.9% group nonspecific platelet transfusion, 31% inappropriate platelet transfusion and 1.99% wastage.Conclusions: The goal of transfusion service is to provide adequate number of safe blood components to the patient requiring this transfusion as per clinical guideline. This can be achieved by platelet audit which plays an important tool to reduce the inappropriate transfusion in patients, by improving the practice, in adherence to guidelines and focusing the areas of pitfall

Preparation and Evaluation of Sodium Alginate Microparticles using Pepsin

Aim: The main aim of this article is to prepare and evaluate sodium alginate microparticles and evaluate on the basis of their characterization. The drug is dissolved, encapsulated or attached to a microparticles matrix. Depending upon method of preparation microparticles were obtained. Microparticles were developed as a carrier for vaccines and other disease like rheumatoid arthritis, cancer etc. Microparticles were developed to increase the efficacy of active pharmaceutical ingredient to a specific targeted site. Material and Method: Microparticles of Sodium Alginate, Pepsin and Calcium Chloride were prepared in six batches (A-F) with different ratio of sodium alginate and calcium chloride respectively i.e. (0.25:2.5), (0.25:5), (0.25:7.5), (0.5:2.5), (0.5:5), (0.5:7.5) by using a homogenizing method. Microparticles were evaluated for particle size distribution, zeta potential and morphology. Result and Discussion:&nbsp; The normal particle size of each of the six batches were analyzed by Zeta Sizer (Delsa C Particle Analyzer) and it was found that the Batch B (0.25:5) delivered the best microparticles with size distribution of 1.2731 (µm). All batches were seen under Motic magnifying microscope by using the Sulforhodamine B (M.W. 479.02) color as staining dye. Microparticles was found to be semi spherical in shape. Conclusion: Results of all the six batches was contrasted based on particle size investigation, zeta potential and morphology. Batch B (0.25:5) was considered as the best formulation. Key words:&nbsp; Micro Particle, Pepsin, Sodium Alginate and Calcium Chloride, Sulforhodamine B, Zeta Sizer

Production of He-4 and (4) in Pb-Pb collisions at root(NN)-N-S=2.76 TeV at the LHC

Results on the production of He-4 and (4) nuclei in Pb-Pb collisions at root(NN)-N-S = 2.76 TeV in the rapidity range vertical bar y vertical bar <1, using the ALICE detector, are presented in this paper. The rapidity densities corresponding to 0-10% central events are found to be dN/dy4(He) = (0.8 +/- 0.4 (stat) +/- 0.3 (syst)) x 10(-6) and dN/dy4 = (1.1 +/- 0.4 (stat) +/- 0.2 (syst)) x 10(-6), respectively. This is in agreement with the statistical thermal model expectation assuming the same chemical freeze-out temperature (T-chem = 156 MeV) as for light hadrons. The measured ratio of (4)/He-4 is 1.4 +/- 0.8 (stat) +/- 0.5 (syst). (C) 2018 Published by Elsevier B.V.Peer reviewe

Azimuthal anisotropy of charged jet production in root s(NN)=2.76 TeV Pb-Pb collisions

We present measurements of the azimuthal dependence of charged jet production in central and semi-central root s(NN) = 2.76 TeV Pb-Pb collisions with respect to the second harmonic event plane, quantified as nu(ch)(2) (jet). Jet finding is performed employing the anti-k(T) algorithm with a resolution parameter R = 0.2 using charged tracks from the ALICE tracking system. The contribution of the azimuthal anisotropy of the underlying event is taken into account event-by-event. The remaining (statistical) region-to-region fluctuations are removed on an ensemble basis by unfolding the jet spectra for different event plane orientations independently. Significant non-zero nu(ch)(2) (jet) is observed in semi-central collisions (30-50% centrality) for 20 <p(T)(ch) (jet) <90 GeV/c. The azimuthal dependence of the charged jet production is similar to the dependence observed for jets comprising both charged and neutral fragments, and compatible with measurements of the nu(2) of single charged particles at high p(T). Good agreement between the data and predictions from JEWEL, an event generator simulating parton shower evolution in the presence of a dense QCD medium, is found in semi-central collisions. (C) 2015 CERN for the benefit of the ALICE Collaboration. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).Peer reviewe