Environmental Influences on Young Adult Male Height. A Comparison of Town and Countryside in the Netherlands, 1815-1900

The first phase of industrialization has often been associated with decreasing standards of living for workers, and early industrial towns and cities gained bad reputations. One of the best indicators for living conditions in early life is young adult height, and the literature has often pointed at urban-rural differences in heights to illustrate the initial decrease of living standards due to urbanization and industrialization. But how was urban residence connected to height? Causal mechanisms can include disease environment related to crowdedness, food availability or the nature of urban versus rural work. But perhaps urban-rural differences can simply be attributed to compositional effects, e.g. in cities relatively more poor, illiterate or incomplete families were to be found. Another question is whether urban-rural differences are limited to large cities compared to the rest, or whether we also find differences between towns and villages. In this brief, exploratory paper, we combine two detailed local datasets to provide answers to these questions. We contrast an early industrializing town, with a typical proletarian sub-culture of tile bakers and a significant middle class (Woerden in the province of South-Holland) to an agrarian community (the village of Akersloot and surrounding area in the province of North-Holland). Our dataset allows us to disentangle effects of the family composition, the family’s socio-economic status, food prices, and the environment on bodily growth of 1,738 young men. Our results suggest that the specific conditions of urban workers were more important for the physical development of their children than the urban or rural setting itself

Evaluating functional brain organization in individuals and identifying contributions to network overlap

Individual differences in the spatial organization of resting-state networks have received increased attention in recent years. Measures of individual-specific spatial organization of brain networks and overlapping network organization have been linked to important behavioral and clinical traits and are therefore potential biomarker targets for personalized psychiatry approaches. To better understand individual-specific spatial brain organization, this paper addressed three key goals. First, we determined whether it is possible to reliably estimate weighted (non-binarized) resting-state network maps using data from only a single individual, while also maintaining maximum spatial correspondence across individuals. Second, we determined the degree of spatial overlap between distinct networks, using test-retest and twin data. Third, we systematically tested multiple hypotheses (spatial mixing, temporal switching, and coupling) as candidate explanations for why networks overlap spatially. To estimate weighted network organization, we adopt the Probabilistic Functional Modes (PROFUMO) algorithm, which implements a Bayesian framework with hemodynamic and connectivity priors to supplement optimization for spatial sparsity/independence. Our findings showed that replicable individual-specific estimates of weighted resting-state networks can be derived using high-quality fMRI data within individual subjects. Network organization estimates using only data from each individual subject closely resembled group-informed network estimates (which was not explicitly modeled in our individual-specific analyses), suggesting that cross-subject correspondence was largely maintained. Furthermore, our results confirmed the presence of spatial overlap in network organization, which was replicable across sessions within individuals and in monozygotic twin pairs. Intriguingly, our findings provide evidence that overlap between 2-network pairs is indicative of coupling. These results suggest that regions of network overlap concurrently process information from both contributing networks, potentially pointing to the role of overlapping network organization in the integration of information across multiple brain systems

Enhancing the cellular uptake of Py–Im polyamides through next-generation aryl turns

Pyrrole–imidazole (Py–Im) hairpin polyamides are a class of programmable, sequence-specific DNA binding oligomers capable of disrupting protein–DNA interactions and modulating gene expression in living cells. Methods to control the cellular uptake and nuclear localization of these compounds are essential to their application as molecular probes or therapeutic agents. Here, we explore modifications of the hairpin γ-aminobutyric acid turn unit as a means to enhance cellular uptake and biological activity. Remarkably, introduction of a simple aryl group at the turn potentiates the biological effects of a polyamide targeting the sequence 5′-WGWWCW-3′ (W = A/T) by up to two orders of magnitude. Confocal microscopy and quantitative flow cytometry analysis suggest this enhanced potency is due to increased nuclear uptake. Finally, we explore the generality of this approach and find that aryl-turn modifications enhance the uptake of all polyamides tested, while having a variable effect on the upper limit of polyamide nuclear accumulation. Overall this provides a step forward for controlling the intracellular concentration of Py–Im polyamides that will prove valuable for future applications in which biological potency is essential

Neutral and Charged Polymers at Interfaces

Chain-like macromolecules (polymers) show characteristic adsorption properties due to their flexibility and internal degrees of freedom, when attracted to surfaces and interfaces. In this review we discuss concepts and features that are relevant to the adsorption of neutral and charged polymers at equilibrium, including the type of polymer/surface interaction, the solvent quality, the characteristics of the surface, and the polymer structure. We pay special attention to the case of charged polymers (polyelectrolytes) that have a special importance due to their water solubility. We present a summary of recent progress in this rapidly evolving field. Because many experimental studies are performed with rather stiff biopolymers, we discuss in detail the case of semi-flexible polymers in addition to flexible ones. We first review the behavior of neutral and charged chains in solution. Then, the adsorption of a single polymer chain is considered. Next, the adsorption and depletion processes in the many-chain case are reviewed. Profiles, changes in the surface tension and polymer surface excess are presented. Mean-field and corrections due to fluctuations and lateral correlations are discussed. The force of interaction between two adsorbed layers, which is important in understanding colloidal stability, is characterized. The behavior of grafted polymers is also reviewed, both for neutral and charged polymer brushes.Comment: a review: 130 pages, 30 ps figures; final form, added reference

Auditory-motor entrainment and phonological skills: precise auditory timing hypothesis (PATH)

Phonological skills are enhanced by music training, but the mechanisms enabling this cross-domain enhancement remain unknown. To explain this cross-domain transfer, we propose a precise auditory timing hypothesis (PATH) whereby entrainment practice is the core mechanism underlying enhanced phonological abilities in musicians. Both rhythmic synchronization and language skills such as consonant discrimination, detection of word and phrase boundaries, and conversational turn-taking rely on the perception of extremely fine-grained timing details in sound. Auditory-motor timing is an acoustic feature which meets all five of the pre-conditions necessary for cross-domain enhancement to occur (Patel, 2011, 2012, 2014). There is overlap between the neural networks that process timing in the context of both music and language. Entrainment to music demands more precise timing sensitivity than does language processing. Moreover, auditory-motor timing integration captures the emotion of the trainee, is repeatedly practiced, and demands focused attention. The PATH predicts that musical training emphasizing entrainment will be particularly effective in enhancing phonological skills

Evidence for multiple rhythmic skills

Rhythms, or patterns in time, play a vital role in both speech and music. Proficiency in a number of rhythm skills has been linked to language ability, suggesting that certain rhythmic processes in music and language rely on overlapping resources. However, a lack of understanding about how rhythm skills relate to each other has impeded progress in understanding how language relies on rhythm processing. In particular, it is unknown whether all rhythm skills are linked together, forming a single broad rhythmic competence, or whether there are multiple dissociable rhythm skills. We hypothesized that beat tapping and rhythm memory/sequencing form two separate clusters of rhythm skills. This hypothesis was tested with a battery of two beat tapping and two rhythm memory tests. Here we show that tapping to a metronome and the ability to adjust to a changing tempo while tapping to a metronome are related skills. The ability to remember rhythms and to drum along to repeating rhythmic sequences are also related. However, we found no relationship between beat tapping skills and rhythm memory skills. Thus, beat tapping and rhythm memory are dissociable rhythmic aptitudes. This discovery may inform future research disambiguating how distinct rhythm competencies track with specific language functions

The relationship between spatial configuration and functional connectivity of brain regions

Brain connectivity is often considered in terms of the communication between functionally distinct brain regions. Many studies have investigated the extent to which patterns of coupling strength between multiple neural populations relates to behaviour. For example, studies have used ‘functional connectivity fingerprints’ to characterise individuals’ brain activity. Here, we investigate the extent to which the exact spatial arrangement of cortical regions interacts with measures of brain connectivity. We find that the shape and exact location of brain regions interact strongly with the modelling of brain connectivity, and present evidence that the spatial arrangement of functional regions is strongly predictive of non-imaging measures of behaviour and lifestyle. We believe that, in many cases, cross-subject variations in the spatial configuration of functional brain regions are being interpreted as changes in functional connectivity. Therefore, a better understanding of these effects is important when interpreting the relationship between functional imaging data and cognitive traits

Classification of temporal ICA components for separating global noise from fMRI data: Reply to Power

We respond to a critique of our temporal Independent Components Analysis (ICA) method for separating global noise from global signal in fMRI data that focuses on the signal versus noise classification of several components. While we agree with several of Power's comments, we provide evidence and analysis to rebut his major criticisms and to reassure readers that temporal ICA remains a powerful and promising denoising approach

The between-match variability of peak power output and Creatine Kinase responses to soccer match-play

Post-match assessments of peak power output (PPO) during countermovement jumps and Creatine Kinase (CK) concentrations are common markers of recovery status in soccer players. Yet, the impact of soccer match-play on recovery in the 48 h after competition is unclear and the between-match variability of these responses has not been examined. Fourteen reserve team players from an English Premier League club were examined over 1-4 matches per player. CK and PPO were measured before, 24 h and 48 h after each match. Data were analyzed with within-subjects linear mixed models. Compared with the pre-match baseline, PPO was 237±170 W and 98±168 W lower at 24 h and 48 h, respectively (P≤0.005) and CK was elevated (+24 h: +334.8±107.2 μ·L, +48 h: +156.9±121.0 μ·L; both P≤0.001) after match-play. These responses were consistent across the different matches and playing positions (P>0.05). Within-subjects correlations between PPO and CK were significant (r=-0.558; P≤0.005). The between-match variability of PPO was 10.9%, 11.0% and 9.9% respectively at baseline, +24 h and +48 h whereas for CK the variability was 41.7%, 30.0% and 34.3%, respectively. These findings highlight that greater than 48 h is needed to restore metabolic and performance perturbations following soccer match-play and that CK demonstrates greater between-match variability than PPO. Such information is likely to be of interest to those responsible for the design of training schedules in the days following a match and sports scientists whose responsibilities include the monitoring of recovery status in soccer players