65 research outputs found
Overexpression of MicroRNAs from the miR-17-92 Paralog Clusters in AIDS-Related Non-Hodgkin's Lymphomas
- Author
- A Baraniskin
- A Cimmino
- A Martin
- A Ota
- A Tanzer
- A van den Berg
- A Ventura
- AI Saeed
- AJ O'Hara
- AJ O'Hara
- Alma Zernecke
- Beth D. Jamieson
- BP Lewis
- C Li
- C Xiao
- CH Lawrie
- Dharma R. Thapa
- DP Bartel
- E Gottwein
- E Gottwein
- G Gaidano
- GA Calin
- H-L Yan
- I Ivanovska
- J Jiang
- J Kluiver
- J Kluiver
- J Lin
- J Zhang
- JJ Goedert
- K Nie
- K Woods
- KA O'Donnell
- L He
- L Venturini
- LP Tan
- M Inomata
- M Raphael
- MJ Neat
- MT Pickering
- N Crum-Cianflone
- O Kirk
- O Monni
- Otoniel MartĂnez-Maza
- P Ballerini
- P Mu
- P Wong
- PH Rao
- PS Eis
- R Malumbres
- R Villuendas
- RL Skalsky
- RW Chen
- S Costinean
- S Griffiths-Jones
- S Mi
- T Kan
- T Xia
- U Klein
- V Olive
- V Pascual
- W Tam
- X Mao
- Xinmin Li
- Y-K Kim
- Z Yu
- Publication venue
- Public Library of Science
- Publication date
- 16/06/2011
- Field of study
Individuals infected by HIV are at an increased risk for developing non-Hodgkin's lymphomas (AIDS-NHL). In the highly active antiretroviral therapy (HAART) era, there has been a significant decline in the incidence of AIDS-associated primary central nervous system lymphoma (PCNSL). However, only a modest decrease in incidence has been reported for other AIDS-NHL subtypes. Thus, AIDS-NHLs remain a significant cause of morbidity and mortality in HIV infected individuals. Recently, much attention has been directed toward the role of miRNAs in cancer, including NHL. Several miRNAs, including those encoded by the miR-17-92 polycistron, have been shown to play significant roles in B cell tumorigenesis. However, the role of miRNAs in NHL in the setting of HIV infection has not been defined.We used quantitative realtime PCR to assess the expression of miRNAs from three different paralog clusters, miR-17-92, miR-106a-363, and miR-106b-25 in 24 cases of AIDS-NHLs representing four tumor types, Burkitt's lymphoma (BL, nâ=â6), diffuse large B-cell lymphoma (DLBCL, nâ=â8), primary central nervous system lymphoma (PCNSL, nâ=â5), and primary effusion lymphoma (PEL, nâ=â5). We also used microarray analysis to identify a differentiation specific miRNA signature of naĂŻve, germinal center, and memory B cell subsets from tonsils (nâ=â4). miRNAs from the miR-17-92 paralog clusters were upregulated by B cells, specifically during the GC differentiation stage. We also found overexpression of these miRNA clusters in all four AIDS-NHL subtypes. Finally, we also show that select miRNAs from these clusters (miR-17, miR-106a, and miR-106b) inhibited p21 in AIDS-BL and DLBCL cases, thus providing a mechanistic role for these miRNAs in AIDS-NHL pathogenesis.Dysregulation of miR-17-92 paralog clusters is a common feature of AIDS-associated NHLs
ZFP36 stabilizes RIP1 via degradation of XIAP and cIAP2 thereby promoting ripoptosome assembly
- Author
- Alexis Grande
- Andrea Martello
- BA Johnson
- Claudia Alecci
- CW Kim
- DP Harkin
- E Carballo
- E-W Lee
- Filippo Guizzetti
- G Kroemer
- G Stoecklin
- H Wang
- H Zhang
- I Sauer
- JY Lee
- Lucia Montorsi
- M Feoktistova
- Miriam dellâ Aquila
- MJM Bertrand
- N Al-Souhibani
- N Festjens
- N Goffart
- Nicola Volpi
- Paolo Salomoni
- RJ Rounbehler
- RJ Thapa
- RJ Thapa
- S Sanduja
- Sandra Parenti
- Sergio Ferrari
- SM Pollard
- T Selmi
- T Tenev
- Tommaso Selmi
- Tommaso Zanocco-Marani
- YM Schichl
- YM Schichl
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
A review of the effects of artemether-lumefantrine on gametocyte carriage and disease transmission
- Author
- A Assefa
- A Kakuru
- A Pareek
- A Sowunmi
- A Sowunmi
- A Sowunmi
- A Sowunmi
- A Sowunmi
- A Sowunmi
- A Yeka
- AB Tiono
- AC Eziefula
- AK Tshefu
- AM Ibrahium
- B Abuaku
- B Faye
- B Zani
- C Chen
- C Falade
- C Hatz
- CC John
- CH Roberts
- CJ Sutherland
- CT Happi
- D Joseph
- DP Mawili-Mboumba
- E Meltzer
- EA Juma
- EA Okiro
- F Smithuis
- G Githuka
- G LefĂšvre
- GH Stresman
- GO Gbotosho
- GO Gbotosho
- GO Gbotosho
- H Grueninger
- HU Okafor
- I Mikkelsen-Lopez
- I van den Broek
- IV van den Broek
- J Achan
- J Zwang
- J Zwang
- JP Guthmann
- JT Bousema
- K Banek
- KA Koram
- KB Beshir
- KI Barnes
- KI Barnes
- L von Seidlein
- LC Okell
- LC Okell
- LS Florey
- M Hommel
- M Makanga
- M Makanga
- M Makanga
- M van Vugt
- Michael Makanga
- MJ Hamel
- MJ Oesterholt
- MR Kamya
- MV Vugt
- NJ White
- NJ White
- Novartis
- P Chanda
- P Sawa
- P Schneider
- PF Mens
- Q Bassat
- R Shretta
- RD Gosling
- RJ Maude
- RJ Maude
- S Abdulla
- S Looareesuwan
- S Thapa
- SE Kern
- SJ Ceesay
- SJ Ceesay
- T Bousema
- T Bousema
- The Four Artemisinin-Based Combinations (4ABC) Study Group
- TK Mutabingwa
- World Health Organization
- World Health Organization
- Z Premji
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Effects of alpha-tocopherol on fracture resistance after endodontic treatment, bleaching and restoration
- Author
- Andrea Abi Rached DANTAS
- Araujo FO
- Attin T
- Basting RT
- Chng HK
- Dishman MV
- Freire A
- Goldberg M
- Gökçe B
- Kaya AD
- Keren Cristina Fagundes JORDĂO-BASSO
- Khoroushi M
- Khoroushi M
- Kimyai S
- Kimyai S
- Kuga MC
- Lai SC
- Lai SC
- Latta MA
- Leonardo RT
- Magro MG
- Mateus Rodrigues TONETTO
- Matheus CoĂȘlho BANDĂCA
- Milton Carlos KUGA
- Moosavi H
- Oliveira DP
- Piccioni MARV
- Plotino G
- Pobbe PO
- Pradeep P
- Roberto AR
- Sasaki RT
- Suellen Nogueira Linhares LIMA
- Thapa A
- Titley KC
- Turssi CP
- TĂŒrkĂŒn M
- TĂŒrkĂŒn M
- Whang HJ
- Woo JM
- Zhao H
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- 01/01/2016
- Field of study
Search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks in proton-proton collisions at root s=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- AdĂĄn DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aime' C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alonso AG
- Alvarez JDR
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amaral SMSD
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antchev G
- Antunovic Z
- Anuar AAB
- Apanasevich L
- Apollinari G
- Appelt E
- Apresyan A
- Apyan A
- Araujo M
- Arbelaez NV
- Arbol PMRD
- Arcaro D
- Arcidiacono R
- Arenton MW
- Argiro S
- Arneodo M
- Aruta C
- Asavapibhop B
- Asawatangtrakuldee C
- Asenov P
- Asghar MI
- Asilar E
- Askew A
- Asmuss P
- Atakisi IO
- Atanasov I
- Ather MW
- Attikis A
- Auffray E
- Aushev T
- Auzinger G
- Avati V
- Avery P
- Avila C
- Awan MIM
- Ayala E
- Ayala G
- Azarkin M
- Azhgirey I
- Aziz T
- Azzi P
- Azzurri P
- Baarmand MM
- Babaev A
- Babounikau I
- Bacchetta N
- Bachiller I
- Bachtis M
- Backhaus M
- Baden A
- Baechler J
- Bagliesi G
- Bahinipati S
- Baillon P
- Bainbridge R
- Bakas G
- Bakhshiansohi H
- Ball AH
- Ban Y
- Band R
- Bandyopadhyay H
- Banerjee S
- Banerjee S
- Banos LIE
- Bansal S
- Barbagli G
- Barberis E
- Bargassa P
- Baringer P
- Barnes VE
- Barney D
- Baron O
- Barrera CB
- Barrera CO
- Bartek R
- Bartosik N
- BartĂłk M
- Bastos D
- Battilana C
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- Bhowmik D
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- Bhyun JH
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- Bialkowska H
- Bianchini L
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- Biasini M
- Bihan A-CL
- Biino C
- Bilei GM
- Bilin B
- Bindhu VKMN
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- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2018
- Field of study
A search for dark matter produced in association with a Higgs boson decaying to a pair of bottom quarks is performed in proton-proton collisions at a center-of-mass energy of 13 TeV collected with the CMS detector at the LHC. The analyzed data sample corresponds to an integrated luminosity of 35.9 fb(-1). The signal is characterized by a large missing transverse momentum recoiling against a bottom quark-antiquark system that has a large Lorentz boost. The number of events observed in the data is consistent with the standard model background prediction. Results are interpreted in terms of limits both on parameters of the type-2 two-Higgs doublet model extended by an additional light pseudoscalar boson a (2HDM+a) and on parameters of a baryonic Z simplified model. The 2HDM+a model is tested experimentally for the first time. For the baryonic Z model, the presented results constitute the most stringent constraints to date.Peer reviewe
A Deep Neural Network for Simultaneous Estimation of b Jet Energy and Resolution
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- Zorbilmez C
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- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Ăzçelik Ă
- Publication venue
- Publication date
- 01/01/2020
- Field of study
We describe a method to obtain point and dispersion estimates for the energies of jets arising from b quarks produced in proton-proton collisions at an energy of s = 13 TeV at the CERN LHC. The algorithm is trained on a large sample of simulated b jets and validated on data recorded by the CMS detector in 2017 corresponding to an integrated luminosity of 41 fb - 1 . A multivariate regression algorithm based on a deep feed-forward neural network employs jet composition and shape information, and the properties of reconstructed secondary vertices associated with the jet. The results of the algorithm are used to improve the sensitivity of analyses that make use of b jets in the final state, such as the observation of Higgs boson decay to b b ÂŻ
Search for the production of W^{\pm} W^{\pm} W^{\mp} events at \sqrt{s} = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams MR
- Adams T
- Adan DP
- Adzic P
- Afanasiev S
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- Ahmad A
- Ahmad M
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- Ahmad WH
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- Alcaraz Maestre J
- Aleksandrov A
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- Alvarez Fernandez A
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- Zhang S
- Zhang Y
- Zhang Z
- Zhao J
- Zhokin A
- Zhu DH
- Zhu RY
- Zientek M
- Zlebcik R
- Zobec J
- Zoi I
- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
- Zotto P
- Zou D
- Zucchetta A
- Zumerle G
- Zuo X
- Zuolo D
- Publication venue
- AMER PHYSICAL SOC
- Publication date
- 01/07/2019
- Field of study
A search for the production of events containing three W bosons predicted by the standard model is reported. The search is based on a data sample of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the CMS experiment at the CERN LHC and corresponding to a total integrated luminosity of 35.9 fb^{-1}. The search is performed in final states with three leptons (electrons or muons), or with two same-charge leptons plus two jets. The observed (expected) significance of the signal for W^{\pm} W^{\pm} W^{\mp} production is 0.60 (1.78) standard deviations, and the ratio of the measured signal yield to that expected from the standard model is 0.34_{-0.34}^{+0.62}. Limits are placed on three anomalous quartic gauge couplings and on the production of massive axionlike particles
Search for dark matter produced in association with a leptonically decaying Z boson in protonâproton collisions at sâ=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
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- Zahid S
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- Zalewski P
- Zanetti M
- Zarubin A
- Zarucki M
- Zecchinelli AG
- Zenaiev O
- Zeuner WD
- Zghiche A
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- Zhu RY
- Ziemons T
- Zientek M
- Zlebcik R
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- Zolkapli Z
- Zorbakir IS
- Zorbilmez C
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- Zou D
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- Zuo X
- Zuolo D
- Zygala L
- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/12/2020
- Field of study
A search for dark matter particles is performed using events with a Z boson candidate and large missing transverse momentum. The analysis is based on protonâproton collision data at a center-of-mass energy of 13TeV, collected by the CMS experiment at the LHC in 2016â2018, corresponding to an integrated luminosity of 137fbâ1. The search uses the decay channels Zâee and ZâΌΌ. No significant excess of events is observed over the background expected from the standard model. Limits are set on dark matter particle production in the context of simplified models with vector, axial-vector, scalar, and pseudoscalar mediators, as well as on a two-Higgs-doublet model with an additional pseudoscalar mediator. In addition, limits are provided for spin-dependent and spin-independent scattering cross sections and are compared to those from direct-detection experiments. The results are also interpreted in the context of models of invisible Higgs boson decays, unparticles, and large extra dimensions.SCOAP
Recommended from our members
Search for low-mass dilepton resonances in Higgs boson decays to four-lepton final states in protonâproton collisions at âs=13TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
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- Ălvarez CR
- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Data Availability: This manuscript has no associated data or the data will not be deposited. [Authorsâ comment: For CMS Release and preservation of data used by the CMS Collaboration as the basis for publications is guided by the CMS policy as stated in âCMS data preservation, re-use and open access policyâ (https://cms-docdb.cern.ch/cgi-bin/PublicDocDB/RetrieveFile?docid=6032&filename=CMSDataPolicyV1.2.pdf&version=2).]Copyright © CERN for the benefit of the CMS collaboration 2022. A search for low-mass dilepton resonances in Higgs boson decays is conducted in the four-lepton final state. The decay is assumed to proceed via a pair of beyond the standard model particles, or one such particle and a Z boson. The search uses protonâproton collision data collected with the CMS detector at the CERN LHC, corresponding to an integrated luminosity of 137fbâ1, at a center-of-mass energy sâ=13TeV. No significant deviation from the standard model expectation is observed. Upper limits at 95% confidence level are set on model-independent Higgs boson decay branching fractions. Additionally, limits on dark photon and axion-like particle production, based on two specific models, are reported.SCOAP3
Measurements of pp â ZZ production cross sections and constraints on anomalous triple gauge couplings at â = 13 TeV
- Author
- Aarrestad TK
- Abbaneo D
- Abbiendi G
- Abbrescia M
- Abdalla H
- Abdullah WATW
- Abdullin S
- Abercrombie D
- Acharya H
- Acosta D
- Acosta JG
- Adam W
- Adams E
- Adams MR
- Adams T
- Adloff C
- Adzic P
- AdĂĄn DP
- Afanasiev S
- Agapitos A
- Agarwal G
- Aggleton R
- Agram J-L
- Aguilar-Benitez M
- Ahmad A
- Ahmad M
- Ahmad WH
- Ahmed A
- Ahuja S
- Aimeâ C
- Akchurin N
- Akgun B
- Akpinar A
- Albajar C
- Albergo S
- Albert A
- Albrow M
- Aleksandrov A
- Alexander J
- Alhusseini M
- Alimena J
- Alison J
- Allen B
- Almond J
- Alonso AG
- Alvarez JDR
- Alverson G
- Alves GA
- Aly R
- Alyari M
- Amapane N
- Amaral SMSD
- Ambrogi F
- Amendola C
- Amin N
- Amram O
- Amsler C
- Anagnostou G
- Anampa KH
- Anderson D
- Andrea J
- Andreev V
- Andreev Y
- Andrews MB
- Androsov K
- Angioni GLP
- Antchev G
- Antunovic Z
- Anuar AAB
- Apanasevich L
- Apollinari G
- Appelt E
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- Ăzçelik Ă
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 29/12/2020
- Field of study
© 2021 The CMS Collaboration. The production of Z boson pairs in protonâproton (pp) collisions, pp â (Z/â)(Z/â) â 2â2ââČ, where â,ââČ = e or ÎŒ, is studied at a center-of-mass energy of 13 TeV with the CMS detector at the CERN LHC. The data sample corresponds to an integrated luminosity of 137fbâ1, collected during 2016â2018. The ZZ production cross section, tot(pp â ZZ) = 17.4 ± 0.3 (stat) ± 0.5 (syst) ± 0.4 (Theo) ± 0.3 (lumi) pb, measured for events with two pairs of opposite-sign, same-flavor leptons produced in the mass region 60 < â+ââ < 120 GeV is consistent with standard model predictions. Differential cross sections are also measured and agree with theoretical predictions. The invariant mass distribution of the four-lepton system is used to set limits on anomalous ZZZ and ZZ couplings.SCOAP
- âŠ