33 research outputs found
Ethical issues in the export, storage and reuse of human biological samples in biomedical research: perspectives of key stakeholders in Ghana and Kenya
- Author
- A Abou-Zeid
- A Cambon-Thomsen
- A Muula
- C Molyneux
- C Molyneux
- C Staunton
- C Weijer
- Catherine S Molyneux
- D Wendler
- D Wendler
- DM Kamuya
- DM Kamuya
- DM Secko
- EJ Emanuel
- G Sirugo
- G Van Schalkwyk
- J De Vries
- J Fairhead
- J Fereday
- J Kaye
- J Kaye
- J Ritchie
- K Moodley
- M Parker
- MA Igbe
- MalariaGEN
- MG Hansson
- Michael Parker
- MP Adoga
- N Mays
- NK Denzin
- P Tindana
- PA Andanda
- Paulina Tindana
- PO Tindana
- PS Butterfield
- PW Geissler
- R Charo
- RE Boyatzis
- S Dalal
- S Langat
- S Molyneux
- SM Gibbons
- Susan Bull
- THA Consortium
- TL Beauchamp
- V Marsh
- V Marsh
- Y-Y Teo
- ᅟ
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Cancer patient perceptions on the ethical and legal issues related to biobanking
- Author
- A Abbott
- A Abou-Zeid
- A Boggio
- AA Lemke
- AL McGuire
- B Elger
- B Godard
- B Godard
- B McMurter
- C Rachul
- C Ye
- Christen Rachul
- CME Halverson
- DM Secko
- E Vermuelen
- E Vermuelen
- EJ Emanuel
- G Helgesson
- J Murphy
- J Murphy
- Jaime O Claudio
- Jean CY Wang
- K Hoeyer
- K Hug
- KA Kaphingst
- KC Doherty
- L Ring
- LM Beskow
- M Fong
- Mark D Minden
- MM Mello
- R Gertz
- R Skloot
- RA Charo
- RD Pentz
- RJ Bryant
- SB Trinidad
- SM Wolf
- T Caulfield
- Timothy Caulfield
- TM Meulenkamp
- Z Master
- Zubin Master
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Multivariable regression analysis in Schistosoma mansoni-infected individuals in the Sudan reveals unique immunoepidemiological profiles in uninfected, egg+ and non-egg+ infected individuals
- Author
- A Abou-Zeid
- A Kimura
- AC La Flamme
- Achim Hoerauf
- Anna Wiszniewsky
- CM Fitzsimmons
- CW Naus
- D Negrao-Correa
- DG Colley
- DM Karanja
- DW Dunne
- E Hams
- E Speziali
- E van Liempt
- EJ Pearce
- EJ Pearce
- G Katawa
- H Ismail
- Ibtisam A. Goreish
- IR Caldas
- JD Turner
- K Walter
- Kathrin Arndts
- Kenneth Pfarr
- KF Hoffmann
- KM Mitchell
- L Meurs
- Laura E. Layland
- LE Layland
- LE Layland
- LE van der Vlugt
- M Mbow
- M Ritter
- M Webster
- Manuel Ritter
- Maria Yazdanbakhsh
- ME Woolhouse
- Mike Doenhoff
- Misk El Yemen A. Atti El Mekki
- N Katz
- NB Kabatereine
- NJ Wilson
- NM Eltayeb
- P Hagan
- P Steinmann
- PG Fallon
- PJ Hotez
- PL Falcao
- R Correa-Oliveira
- R Tweyongyere
- Rolf Fimmers
- S Metenou
- S Rutz
- S Scheer
- S Wilson
- Sandra Arriens
- SJ Jenkins
- T Adjobimey
- T Milner
- Tayseer Elamin Mohamed Elfaki
- Y Ye
- YH Lee
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/05/2016
- Field of study
Background: In the Sudan, Schistosoma mansoni infections are a major cause of morbidity in schoolaged children and infection rates are associated with available clean water sources. During infection, immune responses pass through a Th1 followed by Th2 and Treg phases and patterns can relate to different stages of infection or immunity.
Methodology: This retrospective study evaluated immunoepidemiological aspects in 234 individuals(range 4–85 years old) from Kassala and Khartoum states in 2011. Systemic immune profiles(cytokines and immunoglobulins) and epidemiological parameters were surveyed in n = 110 persons presenting patent S. mansoni infections (egg+), n = 63 individuals positive for S. mansoni via PCR in sera but egg negative (SmPCR+) and n = 61 people who were infection-free (Sm uninf). Immunoepidemiological findings were further investigated using two binary multivariable regression analysis.
Principal Findings: Nearly all egg+ individuals had no access to latrines and over 90% obtained water via the canal stemming from the Atbara River. With regards to age, infection and an egg+ status was linked to young and adolescent groups. In terms of immunology, S. mansoni infection per se was strongly associated with increased SEA-specific IgG4 but not IgE levels. IL-6, IL-13 and IL-10 were significantly elevated in patently-infected individuals and positively correlated with egg load. In contrast, IL-2 and IL-1β were significantly lower in SmPCR+ individuals when compared to Sm uninf and egg+ groups which was further confirmed during multivariate regression analysis.
Conclusions/Significance: Schistosomiasis remains an important public health problem in the Sudan with a high number of patent individuals. In addition, SmPCR diagnostics revealed another cohort of infected individuals with a unique immunological profile and provides an avenue for future studies on non-patent infection states. Future studies should investigate the downstream signalling pathways/mechanisms of IL-2 and IL-1β as potential diagnostic markers in order to distinguish patent from non-patent individuals
Paxillin: a crossroad in pathological cell migration
- Author
- A Bhatt
- A Burdyga
- A Efimov
- A Esquela-Kerscher
- A Gozin
- A Ihermann-Hella
- A Nayal
- AA Birukova
- AE German
- AF Palazzo
- AJ Ridley
- AM Pasapera
- AM Sanchez
- Ana María López-Colomé
- AS Menko
- B Marengo
- B Wehrle-Haller
- C Huang
- C Raimondi
- C Veith
- CE Turner
- CE Turner
- CK Wood
- CL Cortesio
- CM Laukaitis
- CM Souza
- CT Hu
- D Leopoldt
- D Li
- D Moik
- D Wormer
- DA Hsia
- DA Tumbarello
- DB Speert
- DJ Webb
- DJ Webb
- DM Rose
- DP LaLonde
- DW Wu
- E Png
- Edith López
- ER Horton
- GC Chen
- GS Wu
- H Ku
- H Zhang
- Irene Lee-Rivera
- J Chen
- J Pribic
- J Qin
- J Qin
- J St-Pierre
- JE Sero
- JE Shortrede
- JJ Toutounchian
- JL Bos
- JM Dong
- L Herreros
- LH Sun
- LK Robertson
- LL Zhang
- LY Geer
- LY Romanova
- M Gitik
- M Hagel
- M Hirakawa
- M Li
- M Raftopoulou
- M Sattler
- MA Woodrow
- MC Brown
- MC Brown
- MC Brown
- MC Subauste
- MD Schaller
- MH Lee
- N Abou Zeid
- NO Deakin
- NO Deakin
- NO Deakin
- NO Deakin
- P Devreotes
- P Fu
- P Fu
- PP Eleniste
- PS Leventhal
- PS Leventhal
- PW Chen
- R Jagadeeswaran
- R Kanteti
- R Salgia
- R Wade
- R Wade
- R Zaidel-Bar
- R Zaidel-Bar
- Regina Benavides-Hidalgo
- RG Hodge
- RS Pillai
- S Ishibe
- S Ishibe
- S Kaushik
- S Sachdev
- S Teranishi
- SA Parsons
- SE Winograd-Katz
- SH Nam
- SL Bellis
- SL Bellis
- SM Short
- SN Nikolopoulos
- T Du
- T Ishitani
- T Kuboyama
- T Torii
- TB Deramaudt
- W Zhang
- X Cai
- X Tong
- Y Bi
- Y Mazaki
- Y Mazaki
- Y Miyamoto
- Y Miyamoto
- YL Hu
- Z Huang
- ZL Chen
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period
- Author
- Aad G
- Abbott B
- Abdallah J
- Abdinov O
- Abeloos B
- Aben R
- Abolins M
- Abou Zeid OS
- Abraham NL
- Abramowicz H
- Abreu H
- Abreu R
- Abulaiti Y
- Acharya BS
- Adamczyk L
- Adams DL
- Adelman J
- Adomeit S
- Adye T
- Affolder AA
- Agatonovic-Jovin T
- Agricola J
- Aguilar-Saavedra A
- Ahlen SP
- Ahmadov F
- Aielli G
- Akerstedt H
- Akesson TP
- Akimov AV
- Alberghi GL
- Alberich LC
- Albert J
- Albrand S
- Alconada Verzini MJ
- Aleksa M
- Aleksandrov IN
- Alexa C
- Alexander G
- Alexopoulos T
- Alhroob M
- Aliev M
- Alimonti G
- Alison J
- Alkire SP
- Allbrooke BMM
- Allen BW
- Allport PP
- Aloisio A
- Alonso A
- Alonso F
- Alpigiani C
- Alvarez Piqueras D
- Alviggi MG
- Amadio BT
- Amako K
- Amaral Coutinhoa Y
- Amelung C
- Amidei D
- Amor Dos Santos SP
- Amorim A
- Amoroso S
- Amram N
- Amundsen G
- Anastopoulos C
- Ancu LS
- Andari N
- Andeen T
- Anders G
- Anders JK
- Andersb CF
- Anderson KJ
- Andreazza A
- Andrei V
- Angelidakis S
- Angelozzi I
- Anger P
- Angerami A
- Anghinolfi F
- Anisenkov AV
- Anjos N
- Annovi A
- Antonelli M
- Antonov A
- Antos J
- Anulli F
- Aoki M
- Arabidze G
- Arai Y
- Araque JP
- Arce ATH
- Arduh FA
- Arduini G
- Arguin J-F
- Argyropoulos S
- Arik M
- Armadans RC
- Armbruster AJ
- Armitage LJ
- Arnaez O
- Arnold H
- Arratia M
- Arslan O
- Artamonov A
- Artoni G
- Artz S
- Asai S
- Asbah N
- Ashkenazi A
- Asman B
- Asquith L
- Assamagan K
- Astalos R
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- Atlay NB
- Augsten K
- Avolio G
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- Ayoub MK
- Azuelos G
- Baak MA
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- Bachacou H
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- Zhemchugov A
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- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- 'IOP Publishing'
- Publication date
- 01/01/2016
- Field of study
This paper discusses various observations on beam-induced and cosmic-ray backgrounds
in the ATLAS detector during the LHC 2012 proton-proton run. Building on published
results based on 2011 data, the correlations between background and residual pressure of the beam
vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated.
New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC
abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and
from ghost charge are analysed with improved methods, showing that ghost charge in individual
radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated
cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates
are compared to Monte Carlo simulations and to the fake jet rates from beam background. A
thorough analysis of a particular LHC fill, where abnormally high background was observed, is
presented. Correlations between backgrounds and beam intensity losses in special fills with very
high β∗ are studied
Beam-induced and cosmic-ray backgrounds observed in the ATLAS detector during the LHC 2012 proton-proton running period
- Author
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- Zeman M
- Zemla A
- Zeng JC
- Zeng Q
- Zengel K
- Zenin O
- Zenis T
- Zerwas D
- Zhang D
- Zhang F
- Zhang G
- Zhang H
- Zhang J
- Zhang L
- Zhang R
- Zhang R
- Zhang X
- Zhang Z
- Zhao X
- Zhao Y
- Zhao Z
- Zhemchugov A
- Zhong J
- Zhou B
- Zhou C
- Zhou L
- Zhou L
- Zhou M
- Zhou N
- Zhu CG
- Zhu H
- Zhu J
- Zhu Y
- Zhuang X
- Zhukov K
- Zibell A
- Zieminska D
- Zimine NI
- Zimmermann C
- Zimmermann S
- Zinonos Z
- Zinser M
- Ziolkowski M
- Zivkovic L
- Zobernig G
- Zoccoli A
- zur Nedden M
- Zurzolo G
- Zwalinski L
- Publication venue
- IOP PUBLISHING LTD
- Publication date
- 01/05/2016
- Field of study
This paper discusses various observations on beam-induced and cosmic-ray backgrounds in the ATLAS detector during the LHC 2012 proton-proton run. Building on published results based on 2011 data, the correlations between background and residual pressure of the beam vacuum are revisited. Ghost charge evolution over 2012 and its role for backgrounds are evaluated. New methods to monitor ghost charge with beam-gas rates are presented and observations of LHC abort gap population by ghost charge are discussed in detail. Fake jets from colliding bunches and from ghost charge are analysed with improved methods, showing that ghost charge in individual radio-frequency buckets of the LHC can be resolved. Some results of two short periods of dedicated cosmic-ray background data-taking are shown; in particular cosmic-ray muon induced fake jet rates are compared to Monte Carlo simulations and to the fake jet rates from beam background. A thorough analysis of a particular LHC fill, where abnormally high background was observed, is presented. Correlations between backgrounds and beam intensity losses in special fills with very high β* are studied
Sinus Excision, Release of Coccycutaneous Attachments and Dermal-Subcuticular Closure (XRD Procedure): A Novel Technique in Flattening the Natal Cleft in Pilonidal Sinus Treatment
- Author
- Publication venue
- The Royal College of Surgeons of England
- Publication date
- Field of study
"It's for a good cause, isn't it?" - Exploring views of South African TB research participants on sample storage and re-use
- Author
- Publication venue
- BMC
- Publication date
- 01/01/2012
- Field of study
<p>Abstract</p> <p>Background</p> <p>The banking of biological samples raises a number of ethical issues in relation to the storage, export and re-use of samples. Whilst there is a growing body of literature exploring participant perspectives in North America and Europe, hardly any studies have been reported in Africa. This is problematic in particular in light of the growing amount of research taking place in Africa, and with the rise of biobanking practices also on the African continent. In order to investigate the perspectives of African research participants, we conducted a study with research participants in a TB study in the Western Cape, South Africa.</p> <p>Methods</p> <p>Semi-structured interviews were conducted using an interview guide which drew on the most prominent themes expressed in current literature on sample storage, re-use and exportation. Interviews were conducted in Afrikaans and subsequently translated into English by the same interviewer. Interviews were transcribed verbatim and analysed qualitatively.</p> <p>Results</p> <p>The results of our study indicate that the majority of participants were supportive of giving one-time consent to the storage and re-use of their samples. The concept of research being for a “good cause” was a central prerequisite. Additionally, a significant minority requested that they be re-contacted if a future use was not stipulated on the original consent. There was also considerable variation in how participants understood the concept of a ‘good cause’, with participants describing three distinct categories of research, of which two were generally thought to constitute ‘good cause’ research. Research that was for-profit was considered to fall outside the spectrum of ‘good cause’ research. Participants displayed confidence in the abilities of the researchers to make future decisions regarding sample use, but seemed unaware of the role of ethics committees in either this process or more generally.</p> <p>Conclusions</p> <p>Participants expressed a wide and complex range of views about issues of sample storage and re-use, and they showed a great deal of trust in researchers. Participants’ willingness to have their samples stored and re-used is consistent with findings from existing studies. However, in contrast to existing literature, participants were generally not in favour of for-profit research. Further research needs to be done to explore these ideas in other communities, both in South Africa and other countries.</p
Social interactions in transportation: analyzing groups and spatial networks
- Author
- A Páez
- A Páez
- Antonio Páez
- C Ho
- CR Bhat
- CR Bhat
- CR Bhat
- D Fukuda
- DM Scott
- DM Scott
- Elenna Dugundji
- ER Dugundji
- ER Dugundji
- ER Dugundji
- F Goetzke
- F Goetzke
- F Goetzke
- F Goetzke
- Frank Goetzke
- HJ Timmermans
- IN Sener
- IN Sener
- JA Carrasco
- JA Carrasco
- JA Carrasco
- JA Carrasco
- JL Walker
- JP Gliebe
- JP Gliebe
- K Train
- KA Small
- KE Whalen
- M Abou-Zeid
- M Abou-Zeid
- M Ben-Akiva
- M Bradley
- M Kamargianni
- M Kowald
- M Kowald
- M Kroesen
- M Kuwano
- MK Adjemian
- N Ronald
- R Sidharthan
- R Sidharthan
- Regine Gerike
- S Srinivasan
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Impact of Bio- and Organic Fertilizers on Potato Yield, Quality and Tuber Weight Loss After Harvest
- Author
- A Maggio
- A Makaraviciute
- A Moschella
- AL Wszelaki
- AMM Hammad
- AV Peterburgski
- B Venkateswarlu
- D Bojinova
- D Lairon
- DD Douds
- DM Amber
- E Boligłowa
- E Erhart
- E Rembialkowska
- E Rembialkowska
- EE Abou El-Khair
- EM Awad
- F Camin
- G Atimanav
- H Kolbe
- Hassan A. Hassan
- J Hajšlová
- K Delate
- K Gottschalk
- K Muller
- K Woese
- KJ Vessey
- LE Drinkwater
- LJ Kampshake
- LP Canellas
- LR Bulluck
- M Järvan
- M Volterrani
- MA Malboobi
- ML Jackson
- MM Arafa
- Mohamed M. El-Mogy
- MR Carter
- MR Finckh
- MY Abou-Zeid
- PR Hesse
- PR Warman
- QA Norman
- S Heaton
- S Stamatoados
- Sayed F. El-Sayed
- SD Abou-Hussein
- WH Eppendorfer
- XF Sheng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study