Un modèle d'environnement pour la simulation multiniveau - Application à la simulation de foules

Cette thèse propose un modèle organisationnel et holonique de l'environnement pour la simulation des déplacements de piétons dans des bâtiments. Une foule de piétons peut être considérée comme un système composé d'un grand nombre d'entités en interaction, dont la dynamique globale ne peut se réduire à la somme des comportements de ses composants. La simulation multiniveau fondée sur les modèles multiagents holoniques constitue une approche permettant d'analyser la dynamique de tels systèmes. Elle autorise leur analyse en considérant plusieurs niveaux d'observation (microscopique, mésoscopique et macroscopique) et prend en compte les ressources de calcul disponibles. Dans ces systèmes, l'environnement est considéré comme l'une des parties essentielles. La dynamique des piétons composant la foule est alors clairement distinguée de celle de l'environnement dans lequel ils se déplacent. Un modèle organisationnel décrivant la structure et la dynamique de l'environnement est proposé. L'environnement est structurellement décomposé en zones, sous-zones, etc. Les organisations et les rôles de cet environnement sont projetés dans une société d'agents ayant en charge de simuler la dynamique de l'environnement et les différentes missions qui lui sont classiquement assignées dans les systèmes multiagents. Ce modèle précise également les règles de passage entre deux niveaux d'observation. Ainsi, chaque agent appartenant au modèle de l'environnement tente d'utiliser une approximation des comportements de ses sous-zones afin de limiter la consommation de ressources durant la simulation. La qualité de l'approximation entre ces deux niveaux d'observation est évaluée avec des indicateurs énergétiques. Ils permettent de déterminer si l'agent approxime correctement les comportements des agents associés aux sous-zones. En sus du modèle organisationnel et holonique proposé, nous présentons un modèle concret de la simulation de voyageurs dans un terminal d'aéroport. Ce modèle concret est implanté sur les plateformes JaSIM et Janus.This work presents a holonic organizational model of the environment for the simulation of pedestrians in buildings. A crowd of pedestrians is considered as a system composed of a large number of interacting entities. The global dynamics of this system cannot be reduced to the sum of the behaviors of its components, Multilevel simulation based on holonic multiagent models is one approach to analyze the dynamics of such systems. It allows their analysis by considering several levels of observation (microscopic, mesoscopic and macroscopic) and the available computing resources. In these systems, the environment is considered as an essential part. The behavior of the crowd is clearly distinguished from the behavior of the environment in which the pedestrians move. An organizational model is proposed to describe the structure and the dynamics of the indoor environment. This environment is structurally divided into areas, sub-areas, etc. Organizations and roles are mapped into a society of agents in charge of simulating the dynamics of the environment and their various missions in multiagent systems. This model also specifies the rules for changing the level of observation dynamically. Thus, each agent belonging to the model of the environment tries to use an approximation of behaviors of its sub-zones, and at the same time to minimize the resource consumption. The quality of the approximation between these two levels is evaluated with energy-based indicators. They help to determine if the agent approximates the behaviors of its sub-agents correctly. In addition to the organizational and holonic model proposed in this work, we present a concrete model of the simulation of passengers in an airport terminal. This concrete model is implemented on the platforms JaSIM and Janus.BELFORT-UTBM-SEVENANS (900942101) / SudocSudocFranceF

Use of small animal PET-CT imaging for in vivo assessment of tendon-to-bone healing: A pilot study.

BACKGROUND The availability of non-invasive means to evaluate and monitor tendon-bone healing processes in-vivo is limited. Micro Positron-Emission-Tomography (µPET) using 18F-Fluoride is a minimally invasive imaging modality, with which osteoblast activity and bone turnover can be assessed. The aim of this study was to investigate the use of serial in-vivo µPET/CT scans to evaluate bone turnover along the graft-tunnel interface in a rat ACL (anterior cruciate ligament) reconstruction model. METHODS Unilateral autograft ACL reconstruction was performed in six rats. µPET/CT-scans using 18F-Fluoride were performed 7, 14, 21, and 28 days postoperatively. Standard uptake values (SUV) were calculated for three tunnel regions (intraarticular aperture (IAA), mid-tunnel, and extraarticular aperture (EAA)) of the proximal tibia. Animals were sacrificed at 28 days and evaluated with µCT and histological analysis. RESULTS SUVs in both bone tunnels showed an increased 18F-Fluoride uptake at 7 days when compared to 14, 21, and 28 days. SUVs showed a gradient on the tibial side, with most bone turnover in the IAA and least in the EAA. At 7, 14, 21, and 28 days, there were significantly higher SUV values in the IAA compared to the EAA (p = .01, < .01, < .01, < .01). SUVs positively correlated with new bone volumetric density obtained with μCT (r = 0.449, p = .013). Volumetric density of newly formed bone detected on μCT correlated with osteoblast numbers observed along the tunnels in histological sections (r = 0.452, p < .016). CONCLUSIONS Serial in-vivo µPET/CT-scanning has the potential to provide insight into bone turnover and therefore osteoblastic activity during the healing process. As a result, it allows us to directly measure the effect of interventional strategies in tendon-bone healing

Identification of a BRCA2-Specific modifier locus at 6p24 related to breast cancer risk

Common genetic variants contribute to the observed variation in breast cancer risk for BRCA2 mutation carriers; those known to date have all been found through population-based genome-wide association studies (GWAS). To comprehensively identify breast cancer risk modifying loci for BRCA2 mutation carriers, we conducted a deep replication of an ongoing GWAS discovery study. Using the ranked P-values of the breast cancer associations with the imputed genotype of 1.4 M SNPs, 19,029 SNPs were selected and designed for inclusion on a custom Illumina array that included a total of 211,155 SNPs as part of a multi-consortial project. DNA samples from 3,881 breast cancer affected and 4,330 unaffected BRCA2 mutation carriers from 47 studies belonging to the Consortium of Investigators of Modifiers of BRCA1/2 were genotyped and available for analysis. We replicated previously reported breast cancer susceptibility alleles in these BRCA2 mutation carriers and for several regions (including FGFR2, MAP3K1, CDKN2A/B, and PTHLH) identified SNPs that have stronger evidence of association than those previously published. We also identified a novel susceptibility allele at 6p24 that was inversely associated with risk in BRCA2 mutation carriers (rs9348512; per allele HR = 0.85, 95% CI 0.80-0.90, P = 3.9×10−8). This SNP was not associated with breast cancer risk either in the general population or in BRCA1 mutation carriers. The locus lies within a region containing TFAP2A, which encodes a transcriptional activation protein that interacts with several tumor suppressor genes. This report identifies the first breast cancer risk locus specific to a BRCA2 mutation background. This comprehensive update of novel and previously reported breast cancer susceptibility loci contributes to the establishment of a panel of SNPs that modify breast cancer risk in BRCA2 mutation carriers. This panel may have clinical utility for women with BRCA2 mutations weighing options for medical prevention of breast cancer

An original phylogenetic approach identified mitochondrial haplogroup T1a1 as inversely associated with breast cancer risk in BRCA2 mutation carriers

Introduction: Individuals carrying pathogenic mutations in the BRCA1 and BRCA2 genes have a high lifetime risk of breast cancer. BRCA1 and BRCA2 are involved in DNA double-strand break repair, DNA alterations that can be caused by exposure to reactive oxygen species, a main source of which are mitochondria. Mitochondrial genome variations affect electron transport chain efficiency and reactive oxygen species production. Individuals with different mitochondrial haplogroups differ in their metabolism and sensitivity to oxidative stress. Variability in mitochondrial genetic background can alter reactive oxygen species production, leading to cancer risk. In the present study, we tested the hypothesis that mitochondrial haplogroups modify breast cancer risk in BRCA1/2 mutation carriers. Methods: We genotyped 22,214 (11,421 affected, 10,793 unaffected) mutation carriers belonging to the Consortium of Investigators of Modifiers of BRCA1/2 for 129 mitochondrial polymorphisms using the iCOGS array. Haplogroup inference and association detection were performed using a phylogenetic approach. ALTree was applied to explore the reference mitochondrial evolutionary tree and detect subclades enriched in affected or unaffected individuals. Results: We discovered that subclade T1a1 was depleted in affected BRCA2 mutation carriers compared with the rest of clade T (hazard ratio (HR) = 0.55; 95% confidence interval (CI), 0.34 to 0.88; P = 0.01). Compared with the most frequent haplogroup in the general population (that is, H and T clades), the T1a1 haplogroup has a HR of 0.62 (95% CI, 0.40 to 0.95; P = 0.03). We also identified three potential susceptibility loci, including G13708A/rs28359178, which has demonstrated an inverse association with familial breast cancer risk. Conclusions: This study illustrates how original approaches such as the phylogeny-based method we used can empower classical molecular epidemiological studies aimed at identifying association or risk modification effects.Peer reviewe

Genome-Wide Association Study in BRCA1 Mutation Carriers Identifies Novel Loci Associated with Breast and Ovarian Cancer Risk

BRCA1-associated breast and ovarian cancer risks can be modified by common genetic variants. To identify further cancer risk-modifying loci, we performed a multi-stage GWAS of 11,705 BRCA1 carriers (of whom 5,920 were diagnosed with breast and 1,839 were diagnosed with ovarian cancer), with a further replication in an additional sample of 2,646 BRCA1 carriers. We identified a novel breast cancer risk modifier locus at 1q32 for BRCA1 carriers (rs2290854, P = 2.7×10-8, HR = 1.14, 95% CI: 1.09-1.20). In addition, we identified two novel ovarian cancer risk modifier loci: 17q21.31 (rs17631303, P = 1.4×10-8, HR = 1.27, 95% CI: 1.17-1.38) and 4q32.3 (rs4691139, P = 3.4×10-8, HR = 1.20, 95% CI: 1.17-1.38). The 4q32.3 locus was not associated with ovarian cancer risk in the general population or BRCA2 carriers, suggesting a BRCA1-specific associat

A model of environment for the multilevel simulation : Application to the crowd simulation

Cette thèse propose un modèle organisationnel et holonique de l'environnement pour la simulation des déplacements de piétons dans des bâtiments. Une foule de piétons peut être considérée comme un système composé d'un grand nombre d'entités en interaction, dont la dynamique globale ne peut se réduire à la somme des comportements de ses composants. La simulation multiniveau fondée sur les modèles multiagents holoniques constitue une approche permettant d'analyser la dynamique de tels systèmes. Elle autorise leur analyse en considérant plusieurs niveaux d'observation (microscopique, mésoscopique et macroscopique) et prend en compte les ressources de calcul disponibles. Dans ces systèmes, l'environnement est considéré comme l'une des parties essentielles. La dynamique des piétons composant la foule est alors clairement distinguée de celle de l'environnement dans lequel ils se déplacent. Un modèle organisationnel décrivant la structure et la dynamique de l'environnement est proposé. L'environnement est structurellement décomposé en zones, sous-zones, etc. Les organisations et les rôles de cet environnement sont projetés dans une société d'agents ayant en charge de simuler la dynamique de l'environnement et les différentes missions qui lui sont classiquement assignées dans les systèmes multiagents. Ce modèle précise également les règles de passage entre deux niveaux d'observation. Ainsi, chaque agent appartenant au modèle de l'environnement tente d'utiliser une approximation des comportements de ses sous-zones afin de limiter la consommation de ressources durant la simulation. La qualité de l'approximation entre ces deux niveaux d'observation est évaluée avec des indicateurs énergétiques. Ils permettent de déterminer si l'agent approxime correctement les comportements des agents associés aux sous-zones. En sus du modèle organisationnel et holonique proposé, nous présentons un modèle concret de la simulation de voyageurs dans un terminal d'aéroport. Ce modèle concret est implanté sur les plateformes JaSIM et Janus.This work presents a holonic organizational model of the environment for the simulation of pedestrians in buildings. A crowd of pedestrians is considered as a system composed of a large number of interacting entities. The global dynamics of this system cannot be reduced to the sum of the behaviors of its components, Multilevel simulation based on holonic multiagent models is one approach to analyze the dynamics of such systems. It allows their analysis by considering several levels of observation (microscopic, mesoscopic and macroscopic) and the available computing resources. In these systems, the environment is considered as an essential part. The behavior of the crowd is clearly distinguished from the behavior of the environment in which the pedestrians move. An organizational model is proposed to describe the structure and the dynamics of the indoor environment. This environment is structurally divided into areas, sub-areas, etc. Organizations and roles are mapped into a society of agents in charge of simulating the dynamics of the environment and their various missions in multiagent systems. This model also specifies the rules for changing the level of observation dynamically. Thus, each agent belonging to the model of the environment tries to use an approximation of behaviors of its sub-zones, and at the same time to minimize the resource consumption. The quality of the approximation between these two levels is evaluated with energy-based indicators. They help to determine if the agent approximates the behaviors of its sub-agents correctly. In addition to the organizational and holonic model proposed in this work, we present a concrete model of the simulation of passengers in an airport terminal. This concrete model is implemented on the platforms JaSIM and Janus

Un modèle d'environnement pour la simulation multiniveau - Application à la simulation de foules

This work presents a holonic organizational model of the environment for the simulation of pedestrians in buildings. A crowd of pedestrians is considered as a system composed of a large number of interacting entities. The global dynamics of this system cannot be reduced to the sum of the behaviors of its components, Multilevel simulation based on holonic multiagent models is one approach to analyze the dynamics of such systems. It allows their analysis by considering several levels of observation (microscopic, mesoscopic and macroscopic) and the available computing resources. In these systems, the environment is considered as an essential part. The behavior of the crowd is clearly distinguished from the behavior of the environment in which the pedestrians move. An organizational model is proposed to describe the structure and the dynamics of the indoor environment. This environment is structurally divided into areas, sub-areas, etc. Organizations and roles are mapped into a society of agents in charge of simulating the dynamics of the environment and their various missions in multiagent systems. This model also specifies the rules for changing the level of observation dynamically. Thus, each agent belonging to the model of the environment tries to use an approximation of behaviors of its sub-zones, and at the same time to minimize the resource consumption. The quality of the approximation between these two levels is evaluated with energy-based indicators. They help to determine if the agent approximates the behaviors of its sub-agents correctly. In addition to the organizational and holonic model proposed in this work, we present a concrete model of the simulation of passengers in an airport terminal. This concrete model is implemented on the platforms JaSIM and Janus.Cette thèse propose un modèle organisationnel et holonique de l'environnement pour la simulation des déplacements de piétons dans des bâtiments. Une foule de piétons peut être considérée comme un système composé d'un grand nombre d'entités en interaction, dont la dynamique globale ne peut se réduire à la somme des comportements de ses composants. La simulation multiniveau fondée sur les modèles multiagents holoniques constitue une approche permettant d'analyser la dynamique de tels systèmes. Elle autorise leur analyse en considérant plusieurs niveaux d'observation (microscopique, mésoscopique et macroscopique) et prend en compte les ressources de calcul disponibles. Dans ces systèmes, l'environnement est considéré comme l'une des parties essentielles. La dynamique des piétons composant la foule est alors clairement distinguée de celle de l'environnement dans lequel ils se déplacent. Un modèle organisationnel décrivant la structure et la dynamique de l'environnement est proposé. L'environnement est structurellement décomposé en zones, sous-zones, etc. Les organisations et les rôles de cet environnement sont projetés dans une société d'agents ayant en charge de simuler la dynamique de l'environnement et les différentes missions qui lui sont classiquement assignées dans les systèmes multiagents. Ce modèle précise également les règles de passage entre deux niveaux d'observation. Ainsi, chaque agent appartenant au modèle de l'environnement tente d'utiliser une approximation des comportements de ses sous-zones afin de limiter la consommation de ressources durant la simulation. La qualité de l'approximation entre ces deux niveaux d'observation est évaluée avec des indicateurs énergétiques. Ils permettent de déterminer si l'agent approxime correctement les comportements des agents associés aux sous-zones. En sus du modèle organisationnel et holonique proposé, nous présentons un modèle concret de la simulation de voyageurs dans un terminal d'aéroport. Ce modèle concret est implanté sur les plateformes JaSIM et Janus

Multilevel Model of the 3D Virtual Environment for Crowd Simulation in Buildings

AbstractMultiagent-based simulations enable us to validate different use-case scenarios in a lot of application domains. The idea is to develop a realistic virtual environment to test particular domain-specific procedures. This paper presents a multilevel model of a physic environment for the simulation of crowd in a virtual 3D building. The major contributions of this paper is the agentification of the model to support multilevel simulation of the environment. Finally, the application of the model inside an airport terminal is presented

Oxidation of High-temperature Alloy Wires in Dry Oxygen and Water Vapor

Small diameter wires (150 to 250 microns) of the high temperature alloys Haynes 188, Haynes 230, Haynes 230, Haynes 214, Kanthal Al and PM2000 were oxidized at 1204 C in dry oxygen or 50% H2O /50% O2 for 70 Hours. The oxidation kinetics were monitored using a thermogravimetric technique. Oxide phase composition and morphology of the oxidized wires were determined by X-ray diffraction,field emission scanning electron microscopy, and energy dispersive spectroscopy. The alumina-forming alloys, Kanthal Al and PM2000, out-performed the chromia-forming alloys under this conditions. PM2000 was recommended as the most promising candidate for advanced hybrid seal applications for space reentry control surface seals or hypersonic propulsion system seals. This study also demonstrated that thermogravimetric analysis of small diameter wires is a powerful technique for the study of oxide volatility, oxide adherence, and breakaway oxidation