499 research outputs found

    Peripleo: a tool for exploring heterogenous data through the dimensions of space and time

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    This is the author accepted manuscript. The final version is available from Code4Lib via the URL in this record.This article introduces Peripleo, a prototype spatiotemporal search and visualization tool. Peripleo enables users to explore the geographic, temporal and thematic composition of distributed digital collections in their entirety, and then to progressively filter and drill down to explore individual records. We provide an overview of Peripleo's features, and present the underlying technical architecture. Furthermore, we discuss how datasets that differ vastly in terms of size, content type and theme can be made uniformly accessible through a set of lightweight metadata conventions we term “connectivity through common references”. Our current demo installation links approximately half a million records from 25 datasets. These datasets originate from a spectrum of sources, ranging from the small personal photo collection with 35 records, to the large institutional database with 134.000 objects. The product of research in the Andrew W. Mellon-funded Pelagios 3 project, Peripleo is Open Source software.The authors wish to thank the Andrew W. Mellon Foundation for funding this work

    Pelagios and the emerging graph of ancient world data

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    This paper discusses an emerging cloud of Linked Open Data in the humanities sometimes referred to as the Graph of Ancient World Data (GAWD). It provides historical back- ground to the domain, before gong on to describe the open and decentralised characteristics which have partially characterised its development. This is done principally through the lens of Pelagios, a collaborative initiative led by the authors which connects online historical resources based on common references to places. The benefits and limitations of the approach are evaluated, in particular its low barrier to entry, open architecture and restricted scope. The paper concludes with a number of suggestion for encouraging the adoption of Linked Open Data within other humanities communities and beyond

    Site-directed mutagenesis reveals a unique requirement for tyrosine residues in IL-7Rα and TSLPR cytoplasmic domains in TSLP-dependent cell proliferation

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    <p>Abstract</p> <p>Background</p> <p>Thymic stromal lymphopoietin (TSLP) is an interleukin-7 (IL-7) like cytokine, which plays an important role in the regulation of immune responses to allergens. TSLP binds to a heterodimeric receptor complex composed of the IL-7 receptor α chain (IL-7Rα) and the TSLP receptor (TSLPR, also known as CRLF2). It has previously been suggested that the lone tyrosine residue in the mouse TSLPR cytoplasmic domain is required for cell proliferation using chimeric receptor systems. Also the role of tyrosine residues in the IL-7Rα cytoplasmic domain in TSLP signaling has not yet been investigated. We undertook a systematic analysis to test the role of tyrosine residues of both the IL-7Rα and the TSLPR in inducing cell proliferation in a growth factor dependent cell line, Ba/F3.</p> <p>Results</p> <p>A multiple sequence alignment of the IL-7Rα and TSLPR cytoplasmic domains revealed conservation of most, but not all, cytoplasmic tyrosine residues across several species. Our site-directed mutagenesis experiments revealed that the single tyrosine residue in human TSLPR was not required for TSLP-dependent cell proliferation. It has previously been reported that Y449 of human IL-7Rα is required for IL-7 dependent proliferation. Interestingly, in contrast to IL-7 signaling, none of tyrosine residues in the human IL-7Rα cytoplasmic domain were required for TSLP-dependent cell proliferation in the presence of a wild type TSLPR. However, the mutation of all cytoplasmic four tyrosine residues of human IL-7Rα and human TSLPR to phenylalanine residues abolished the proliferative ability of the TSLP receptor complex in response to TSLP.</p> <p>Conclusion</p> <p>These results suggest that TSLP requires at least one cytoplasmic tyrosine residue to transmit proliferative signals. Unlike other members of IL-2 cytokine family, tyrosine residues in IL-7Rα and TSLPR cytoplasmic domains play a redundant role in TSLP-mediated cell growth.</p

    Radiative forcing in the 21st century due to ozone changes in the troposphere and the lower stratosphere

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    Radiative forcing due to changes in ozone is expected for the 21st century. An assessment on changes in the tropospheric oxidative state through a model intercomparison ("OxComp'') was conducted for the IPCC Third Assessment Report (IPCC-TAR). OxComp estimated tropospheric changes in ozone and other oxidants during the 21st century based on the "SRES'' A2p emission scenario. In this study we analyze the results of 11 chemical transport models (CTMs) that participated in OxComp and use them as input for detailed radiative forcing calculations. We also address future ozone recovery in the lower stratosphere and its impact on radiative forcing by applying two models that calculate both tropospheric and stratospheric changes. The results of OxComp suggest an increase in global-mean tropospheric ozone between 11.4 and 20.5 DU for the 21st century, representing the model uncertainty range for the A2p scenario. As the A2p scenario constitutes the worst case proposed in IPCC-TAR we consider these results as an upper estimate. The radiative transfer model yields a positive radiative forcing ranging from 0.40 to 0.78 W m(-2) on a global and annual average. The lower stratosphere contributes an additional 7.5-9.3 DU to the calculated increase in the ozone column, increasing radiative forcing by 0.15-0.17 W m(-2). The modeled radiative forcing depends on the height distribution and geographical pattern of predicted ozone changes and shows a distinct seasonal variation. Despite the large variations between the 11 participating models, the calculated range for normalized radiative forcing is within 25%, indicating the ability to scale radiative forcing to global-mean ozone column change

    The impact of Aeolus wind retrievals on ECMWF global weather forecasts

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    Abstract Aeolus is the world's first spaceborne Doppler Wind Lidar, providing profiles of horizontal line-of-sight (HLOS) wind retrievals. Numerical weather prediction (NWP) impact and error statistics of Aeolus Level-2B (L2B) wind statistics have been assessed using the European Centre for Medium-range Weather Forecasts (ECMWF) global data assimilation system. Random and systematic error estimates were derived from observation minus background departure statistics. The HLOS wind random error standard deviation is estimated to be in the range 4.0-7.0 m/s for the Rayleigh-clear and 2.8-3.6 m/s for the Mie-cloudy, depending on atmospheric signal levels which in turn depend on instrument performance, atmospheric backscatter properties and the processing algorithms. Complex systematic HLOS wind error variations on time-scales less than one orbit were identified, most strongly affecting the Rayleigh-clear winds. NWP departures and instrument housekeeping data confirmed that it is caused by temperature gradients across the primary mirror. A successful bias correction scheme was implemented in the operational processing chain in April 2020. In Observing System Experiments (OSEs), Aeolus provides statistically significant improvement in short-range forecasts as verified by observations sensitive to temperature, wind and humidity. Longer forecast range verification shows positive impact that is strongest at the day two to three forecast range: 2% improvement in root-mean-square error for vector wind and temperature in the tropical upper troposphere and lower stratosphere, and polar troposphere. Positive impact up to 9 days is found in the tropical lower stratosphere. Both Rayleigh-clear and Mie-cloudy winds provide positive impact, but the Rayleigh accounts for most tropical impact. The Forecast Sensitivity Observation Impact (FSOI) metric is available since 9 January 2020, when Aeolus was operationally assimilated, which confirms Aeolus is a useful contribution to the global observing system, with the Rayleigh-clear and Mie-cloudy winds providing similar overall short-range impact in 2020

    Successful new product development by optimizing development process effectiveness in highly regulated sectors: the case of the Spanish medical devices sector

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    Rapid development and commercialization of new products is of vital importance for small and medium sized enterprises (SME) in regulated sectors. Due to strict regulations, competitive advantage can hardly be achieved through the effectiveness of product concepts only. If an SME in a highly regulated sector wants to excell in new product development (NPD) performance, the company should focus on the flexibility, speed, and productivity of its NPD function: i.e. the development process effectiveness. Our main research goals are first to explore if SMEs should focus on their their development process effectiveness rather than on their product concept effectiveness to achieve high NPD performance; and second, to explore whether a shared pattern in the organization of the NPD function can be recognized to affect NPD performance positively. The medical devices sector in Spain is used as an example of a\ud highly regulated sector. A structured survey among 11 SMEs, of which 2 were studied also as in in-depth case studies, led to the following results. First of all, indeed the companies in the dataset which focused on the effectiveness of their development process, stood out in NPD performance. Further, the higher performing companies did have a number of commonalities in the organisation of their NPD function: 1) The majority of the higher performing firms had an NPD strategy characterized by a predominantly incremental project portfolio.\ud 2) a) Successful firms with an incremental project portfolio combined this with a functional team structure b) Successful firms with a radical project portfolio combined this with a heavyweight or autonomous team structure.\ud 3) A negative reciprocal relationship exists between formalization of the NPD processes and the climate of the NPD function, in that a formalized NPD process and an innovative climate do not seem to reinforce each other. Innovative climate combined with an informal NPD process does however contribute positively to NPD performance. This effect was stronger in combination with a radical project portfolio. The highest NPD performance was measured for companies focusing mainly on incremental innovation. It is argued that in highly regulated sectors, companies with an incremental product portfolio would benefit from employing a functional structure. Those companies who choose for a more radical project portfolio in highly regulated sectors should be aware\ud that they are likely to excell only in the longer term by focusing on strategic flexibility. In their NPD organization, they might be well advised to combine informal innovation processes with an innovative climate

    Correction of wind bias for the lidar on-board Aeolus using telescope temperatures

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    The European Space Agency satellite Aeolus provides continuous profiles of the horizontal line-of-sight wind component at a global scale. It was successfully launched into space in August 2018 with the goal to improve numerical weather prediction (NWP). Aeolus data has already been successfully assimilated into several NWP models and has already helped to significantly improve the quality of weather forecasts. To achieve this major milestone the identification and correction of several systematic error sources was necessary. One of them is related to small temperatures fluctuations across the 1.5 m diameter primary mirror of the telescope which cause varying wind biases along the orbit of up to 8 m/s. This paper presents a detailed overview of the influence of the telescope temperature variations on the Aeolus wind products and describes the approach to correct for this systematic error source in the operational near-real-time (NRT) processing. It was shown that the telescope temperature variations along the orbit are due to changes of the top-of-atmosphere short- and long-wave radiation of the Earth and the response of the telescope’s thermal control system to that. To correct for this effect ECMWF model-equivalent winds are used as bias reference to describe the wind bias in a multiple linear regression model as a function of various temperature sensors located on the primary telescope mirror. This correction scheme has been in operational use at ECMWF since April 2020 and is capable of reducing a large part of the telescope-induced wind bias. In cases where the influence of the temperature variations is particularly strong it was shown that the bias correction can improve the orbital bias variation by up to 53 %. Moreover, it was demonstrated that the approach of using ECMWF model-equivalent winds is justified by the fact that the global bias of models u-component winds w.r.t to radiosondes is smaller than 0.3 m/s. However, this paper also presents the alternative of using Aeolus ground return winds which serve as zero wind reference in the multiple linear regression model. The results show that the approach based on ground return winds only performs 10.8 % worse than the ECMWF model-based approach and thus has good potential for future applications for upcoming reprocessing campaigns or even in the NRT processing of Aeolus wind products

    Climate setting in sourcing teams: Developing a measurement scale for team creativity climate

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    Creative sourcing strategies, designed to extract more value from the supply base, have become a competitive, strategic differentiator. To fuel creativity, companies install sourcing teams that can capitalize on the specialized knowledge and expertise of their employees across the company. This article introduces the concept of a team creativity climate (TCC) - team members' shared perceptions of their joint policies, procedures, and practices with respect to developing creative sourcing strategies – as a means to address the unique challenges associated with a collective, cross-functional approach to develop value-enhancing sourcing strategies. Using a systematic scale development process that validates the proposed concept, the authors confirm its ability to predict sourcing team performance, and suggest some research avenues extending from this concept
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