55 research outputs found
Factores asociados al intento suicida e ideación suicida persistente en un Centro de Atención Primaria. Bogotá, 2004-2006
Objective: Characterising patients attempting suicide who were evaluated by psychiatry at the Primary Care Unit (PCU) 'La Estrella' from October/2004 to October/2005 and determining persistent suicidal ideation and associated factors. Methods: An initial description of attempted suicide patients (n=156). A subsequent case control study (n=77) determined persistent suicidal ideation cases (n=27). A multivariate model was used for determining the remaining factors associated with persistent suicide ideation. Results: Cases increased from 6 in October/2004 to 10 in October/2005, average 12 ± 3,6 cases monthly. 80 % were aged 30 or younger, 66,7 % were female, 24,4 % were students and 20,5 % were unemployed. 35,2 % suffered family dysfunction and 35.2% had conflicts between couples as precipitant factors. 49 % had consumed alcohol prior to the suicide attempt. Persistent suicidal ideation was associated with being 31 years old or older, being unemployed and having a higher number of previous suicide attempts, unresolved conflicts and family dysfunction. Logistical regression revealed unresolved conflicts (OR=106.7; 6,8; 1 668,4 95 % CI) and family dysfunction (OR=11.05; 1,7; 71,2 95 % CI) as predictor variables for persistent suicidal ideation. Conclusion Unresolved conflicts and family dysfunction were found to be predictor factors for persistent suicidal ideation in subjects who had attempted suicide. Consuming alcohol and other associated factors should be controlled by mental health prevention and promotion programmes
Plasma cytokines as potential biomarkers of kidney damage in patients with systemic lupus erythematosus
Background: Systemic lupus erythematosus is a heterogeneous chronic inflammatory autoimmune
disorder characterized by an exacerbated expression of cytokines and chemokines in
different tissues and organs. Renal involvement is a significant contributor to the morbidity
and mortality of systemic lupus erythematosus, and its diagnosis is based on renal biopsy,
an invasive procedure with a high risk of complications. Therefore, the development of
alternative, non-invasive diagnostic tests for kidney disease in patients with systemic lupus
erythematosus is a priority. Aim: To evaluate the plasma levels of a panel of cytokines and
chemokines using multiplex xMAP technology in a cohort of Colombian patients with active
and inactive systemic lupus erythematosus, and to evaluate their potential as biomarkers of
renal involvement. Results: Plasma from 40 systemic lupus erythematosus non-nephritis
patients and 80 lupus nephritis patients with different levels of renal involvement were analyzed
for 39 cytokines using Luminex xMAP technology. Lupus nephritis patients had significantly
increased plasma eotaxin, TNF-a, interleukin-17-a, interleukin-10, and interleukin-15
as compared to the systemic lupus erythematosus non-nephritis group. Macrophage-derived
chemokine, growth regulated oncogene alpha, and epidermal growth factor were significantly
elevated in systemic lupus erythematosus non-nephritis patients when compared to lupus
nephritis individuals. Plasma eotaxin levels allowed a discrimination between systemic lupus
erythematosus non-nephritis and lupus nephritis patients, for which we performed a receiver
operating characteristic curve to confirm. We observed a correlation of eotaxin levels with
active nephritis (Systemic Lupus Erythematosus Disease Activity Index). Our data indicate
that circulating cytokines and chemokines could be considered good predictors of renal
involvement in individuals with systemic lupus erythematosus
Reconstruction of inclined air showers detected with the Pierre Auger Observatory
We describe the method devised to reconstruct inclined cosmic-ray air showers
with zenith angles greater than detected with the surface array of
the Pierre Auger Observatory. The measured signals at the ground level are
fitted to muon density distributions predicted with atmospheric cascade models
to obtain the relative shower size as an overall normalization parameter. The
method is evaluated using simulated showers to test its performance. The energy
of the cosmic rays is calibrated using a sub-sample of events reconstructed
with both the fluorescence and surface array techniques. The reconstruction
method described here provides the basis of complementary analyses including an
independent measurement of the energy spectrum of ultra-high energy cosmic rays
using very inclined events collected by the Pierre Auger Observatory.Comment: 27 pages, 19 figures, accepted for publication in Journal of
Cosmology and Astroparticle Physics (JCAP
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
Measurement of the Depth of Maximum of Extensive Air Showers above 10^18 eV
We describe the measurement of the depth of maximum, Xmax, of the
longitudinal development of air showers induced by cosmic rays. Almost four
thousand events above 10^18 eV observed by the fluorescence detector of the
Pierre Auger Observatory in coincidence with at least one surface detector
station are selected for the analysis. The average shower maximum was found to
evolve with energy at a rate of (106 +35/-21) g/cm^2/decade below 10^(18.24 +/-
0.05) eV and (24 +/- 3) g/cm^2/decade above this energy. The measured
shower-to-shower fluctuations decrease from about 55 to 26 g/cm^2. The
interpretation of these results in terms of the cosmic ray mass composition is
briefly discussed.Comment: Accepted for publication by PR
The Pierre Auger Observatory III: Other Astrophysical Observations
Astrophysical observations of ultra-high-energy cosmic rays with the Pierre
Auger ObservatoryComment: Contributions to the 32nd International Cosmic Ray Conference,
Beijing, China, August 201
Marco activo de recursos de innovación docente: Madrid
Una guía de espacios e instituciones para actividades educativas complementarias en enseñanza secundaria y Formación Profesional
The Pierre Auger Observatory II: Studies of Cosmic Ray Composition and Hadronic Interaction models
Studies of the composition of the highest energy cosmic rays with the Pierre
Auger Observatory, including examination of hadronic physics effects on the
structure of extensive air showers.Comment: Contributions to the 32nd International Cosmic Ray Conference,
Beijing, China, August 201
The Pierre Auger Observatory IV: Operation and Monitoring
Technical reports on operations and monitoring of the Pierre Auger
ObservatoryComment: Constributions to 32nd International Cosmic Ray Conference, Beijing,
China, August 201
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