A third wave of selective exposure research? The challenges posed by hyperpartisan news on social media

Hyperpartisan news on social media presents new challenges for selective exposure theory. These challenges are substantial enough to usher in a new era -a third wave- of selective exposure research. In this essay, we trace the history of the first two waves of research in order to better understand the current situation. We then assess the implications of recent developments for selective exposure research

TERT promoter mutations are highly recurrent in SHH subgroup medulloblastoma

Telomerase reverse transcriptase (TERT) promoter mutations were recently shown to drive telomerase activity in various cancer types, including medulloblastoma. However, the clinical and biological implications of TERT mutations in medulloblastoma have not been described. Hence, we sought to describe these mutations and their impact in a subgroup-specific manner. We analyzed the TERT promoter by direct sequencing and genotyping in 466 medulloblastomas. The mutational distributions were determined according to subgroup affiliation, demographics, and clinical, prognostic, and molecular features. Integrated genomics approaches were used to identify specific somatic copy number alterations in TERT promoter-mutated and wild-type tumors. Overall, TERT promoter mutations were identified in 21 % of medulloblastomas. Strikingly, the highest frequencies of TERT mutations were observed in SHH (83 %; 55/66) and WNT (31 %; 4/13) medulloblastomas derived from adult patients. Group 3 and Group 4 harbored this alteration in <5 % of cases and showed no association wit

City of Hitchcock Comprehensive Plan 2020-2040

Hitchcock is a small town located in Galveston County (Figure 1.1), nestled up on the Texas Gulf Coast. It lies about 40 miles south-east of Houston. The boundaries of the city encloses an area of land of 60.46 sq. miles, an area of water of 31.64 sq. miles at an elevation just 16 feet above sea level. Hitchcock has more undeveloped land (~90% of total area) than the county combined. Its strategic location gives it a driving force of opportunities in the Houston-Galveston Region.The guiding principles for this planning process were Hitchcock’s vision statement and its corresponding goals, which were crafted by the task force. The goals focus on factors of growth and development including public participation, development considerations, transportation, community facilities, economic development, parks, and housing and social vulnerabilityTexas Target Communitie

Cytogenetic Prognostication Within Medulloblastoma Subgroups

PURPOSE: Medulloblastoma comprises four distinct molecular subgroups: WNT, SHH, Group 3, and Group 4. Current medulloblastoma protocols stratify patients based on clinical features: patient age, metastatic stage, extent of resection, and histologic variant. Stark prognostic and genetic differences among the four subgroups suggest that subgroup-specific molecular biomarkers could improve patient prognostication. PATIENTS AND METHODS: Molecular biomarkers were identified from a discovery set of 673 medulloblastomas from 43 cities around the world. Combined risk stratification models were designed based on clinical and cytogenetic biomarkers identified by multivariable Cox proportional hazards analyses. Identified biomarkers were tested using fluorescent in situ hybridization (FISH) on a nonoverlapping medulloblastoma tissue microarray (n = 453), with subsequent validation of the risk stratification models. RESULTS: Subgroup information improves the predictive accuracy of a multivariable survival model compared with clinical biomarkers alone. Most previously published cytogenetic biomarkers are only prognostic within a single medulloblastoma subgroup. Profiling six FISH biomarkers (GLI2, MYC, chromosome 11 [chr11], chr14, 17p, and 17q) on formalin-fixed paraffin-embedded tissues, we can reliably and reproducibly identify very low-risk and very high-risk patients within SHH, Group 3, and Group 4 medulloblastomas. CONCLUSION: Combining subgroup and cytogenetic biomarkers with established clinical biomarkers substantially improves patient prognostication, even in the context of heterogeneous clinical therapies. The prognostic significance of most molecular biomarkers is restricted to a specific subgroup. We have identified a small panel of cytogenetic biomarkers that reliably identifies very high-risk and very low-risk groups of patients, making it an excellent tool for selecting patients for therapy intensification and therapy de-escalation in future clinical trials

Large meta-analysis of genome-wide association studies identifies five loci for lean body mass

Lean body mass, consisting mostly of skeletal muscle, is important for healthy aging. We performed a genome-wide association study for whole body (20 cohorts of European ancestry with n = 38,292) and appendicular (arms and legs) lean body mass (n = 28,330) measured using dual energy X-ray absorptiometry or bioelectrical impedance analysis, adjusted for sex, age, height, and fat mass. Twenty-one single-nucleotide polymorphisms were significantly associated with lean body mass either genome wide (p < 5 x 10(-8)) or suggestively genome wide (p < 2.3 x 10(-6)). Replication in 63,475 (47,227 of European ancestry) individuals from 33 cohorts for whole body lean body mass and in 45,090 (42,360 of European ancestry) subjects from 25 cohorts for appendicular lean body mass was successful for five single-nucleotide polymorphisms in/ near HSD17B11, VCAN, ADAMTSL3, IRS1, and FTO for total lean body mass and for three single-nucleotide polymorphisms in/ near VCAN, ADAMTSL3, and IRS1 for appendicular lean body mass. Our findings provide new insight into the genetics of lean body mass

Evaluation of appendicitis risk prediction models in adults with suspected appendicitis

Background Appendicitis is the most common general surgical emergency worldwide, but its diagnosis remains challenging. The aim of this study was to determine whether existing risk prediction models can reliably identify patients presenting to hospital in the UK with acute right iliac fossa (RIF) pain who are at low risk of appendicitis. Methods A systematic search was completed to identify all existing appendicitis risk prediction models. Models were validated using UK data from an international prospective cohort study that captured consecutive patients aged 16–45 years presenting to hospital with acute RIF in March to June 2017. The main outcome was best achievable model specificity (proportion of patients who did not have appendicitis correctly classified as low risk) whilst maintaining a failure rate below 5 per cent (proportion of patients identified as low risk who actually had appendicitis). Results Some 5345 patients across 154 UK hospitals were identified, of which two‐thirds (3613 of 5345, 67·6 per cent) were women. Women were more than twice as likely to undergo surgery with removal of a histologically normal appendix (272 of 964, 28·2 per cent) than men (120 of 993, 12·1 per cent) (relative risk 2·33, 95 per cent c.i. 1·92 to 2·84; P < 0·001). Of 15 validated risk prediction models, the Adult Appendicitis Score performed best (cut‐off score 8 or less, specificity 63·1 per cent, failure rate 3·7 per cent). The Appendicitis Inflammatory Response Score performed best for men (cut‐off score 2 or less, specificity 24·7 per cent, failure rate 2·4 per cent). Conclusion Women in the UK had a disproportionate risk of admission without surgical intervention and had high rates of normal appendicectomy. Risk prediction models to support shared decision‐making by identifying adults in the UK at low risk of appendicitis were identified

Talking politics : political opinion expression and avoidance across conservative, liberal, and heterogeneous groups

Discussion among the public about politics and public affairs is a hallmark of deliberative democracy. Specifically, sharing information, expressing opinions, and learning about the perspectives of others defines a deliberative system. People oftentimes find expressing their political opinions difficult, unpleasant, and even threatening. Yet when people refrain from expressing their ideas and opinions, those points of view remain absent from the public sphere. The implications of avoiding the expression of political opinions are considered detrimental by those who think that society is better when people communicate their positions and understand the perspectives of others. This dissertation centers on the occurrence—and avoidance—of political opinion expression, or the act of openly stating one’s political opinion. I employed quantitative, thematic, and content analyses to investigate data from The Electronic Dialogue Project in Campaign 2000 (ED2K) and an original survey, to explore how often and in what contexts people avoid expressing their opinions during political conversations, the ways in which diverse opinions and opinion expression avoidance take place in conservative, liberal, and heterogeneous networks, the motivations for avoiding the expression of political opinions, and the strategies employed in avoidance. Among other findings, I provide evidence that challenges some commonly held assumptions about political talk. Results indicate that even within one conversation, people both expressed and avoided expressing their opinions about politics. Within political discussions overall, whether discussion members were in disagreement with one another did not influence their likelihood of directly expressing their opinions. Ideologically heterogeneous groups did not emerge as bastions of diverse opinions. Finally, I used a thematic analysis and drew from interpersonal communication, mass communication, political science, and social psychology, to uncover the motivations and strategies involved in people’s decisions to avoid expressing political opinions. Political talk is perhaps the most accessible form of political engagement and helps people to understand themselves, each other, and the world around us. This dissertation examined the occurrence of and contexts surrounding political opinion expression and avoidance, and the existence of disagreement and diversity in political discussions.Communication Studie

Engaging Young People: Deliberative Preferences in Discussions About News and Politics

The Internet affords users a unique and low-cost way to engage with news, politics, and one another. Although young people are the most likely age cohort to go online, it is questionable whether young people take advantage of the Internet as a deliberative space. We examine the way college students perceive the online world as a venue for political discussion by analyzing responses from six focus groups conducted with college students across the United States. Using deliberative theory as a guide, we examine focus group participants’ thoughts about political discussion both online and offline. Our findings indicate that young people’s preferences for online discussions about politics and the news consistently link to the ideals of deliberation. Young people prefer engaging with others who are knowledgeable and remain flexible and calm during discussions. Goals for engaging in conversations about politics primarily revolved around sharing information and opinions. Participants preferred civil discourse that focuses on commonalities rather than differences between people. This study provides greater insight into how the rising generation currently engages with politics and the news and reasons why many people hesitate to participate in online discussions about public affairs