Importancia de la contextualización en el diseño de los Materiales Educativos Digitales

La presente investigación aborda la contextualización del desarrollo de los materiales educativos digitales en los estudiantes del programa educativo de Ingeniería en Control y Computación de la Universidad Autónoma de Nayarit, la cual toma como fundamento a las teorías de Piaget(1069), Ausbel(1976) y Vigotsky(2006). El método de investigación es cuantitativo y presenta resultados basados concernientes a un grupo de estudiantes universitarios del área de ingenierías

Análisis del uso de las TIC´S en la práctica docente en el Área de Ciencias Básicas e Ingenierías de la Universidad Autónoma de Nayarit

En la actualidad se busca la calidad en la educación, los Programas Educativos del Área de Ciencias Básicas de  Ingenierías (ACBI), dependiente de  la Universidad Autónoma de  Nayarit (UAN), se preparan para ser evaluados, por los Organismos Acreditadores para ofrecer una educación de calidad para los estudiantes que  ingresan a esta Área. La presente investigación tiene como objetivo identificar en qué frecuencia son aplicadas las Tecnologías de  Información y Comunicación (TIC´S) y cuáles de estás son integradas en la práctica Docente

Percepción y significación de la violencia a partir del impacto de las noticias locales relativas al lugar de residencia en jóvenes de educación secundaria

El tema de violencia escolar ha sido considerado de alto interés por lo cual es necesaria una reflexión más profunda de lo que ocurre en sus entornos sociales. El presente artículo plantea resultados de investigación de un proyecto de impacto estatal sobre las formas de percibir la violencia, especialmente en jóvenes. En éste documento se presenta la percepción y el significado que los jóvenes de educación secundaria le imprimen a las noticias locales, así como el impacto que les genera. Es cualitativo de enfoque fenomenológico, se empleó un instrumento cualitativo proyectivo y de preguntas abiertas, así como el análisis de las noticias locales en los años 2017 – 2018. Se aplicó a 246 estudiantes de secundaria de Xalisco Nayarit

Circulating microRNAs in sera correlate with soluble biomarkers of immune activation but do not predict mortality in ART treated individuals with HIV-1 infection: A case control study

Introduction: The use of anti-retroviral therapy (ART) has dramatically reduced HIV-1 associated morbidity and mortality. However, HIV-1 infected individuals have increased rates of morbidity and mortality compared to the non-HIV-1 infected population and this appears to be related to end-organ diseases collectively referred to as Serious Non-AIDS Events (SNAEs). Circulating miRNAs are reported as promising biomarkers for a number of human disease conditions including those that constitute SNAEs. Our study sought to investigate the potential of selected miRNAs in predicting mortality in HIV-1 infected ART treated individuals. Materials and Methods: A set of miRNAs was chosen based on published associations with human disease conditions that constitute SNAEs. This case: control study compared 126 cases (individuals who died whilst on therapy), and 247 matched controls (individuals who remained alive). Cases and controls were ART treated participants of two pivotal HIV-1 trials. The relative abundance of each miRNA in serum was measured, by RTqPCR. Associations with mortality (all-cause, cardiovascular and malignancy) were assessed by logistic regression analysis. Correlations between miRNAs and CD4+ T cell count, hs-CRP, IL-6 and D-dimer were also assessed. Results: None of the selected miRNAs was associated with all-cause, cardiovascular or malignancy mortality. The levels of three miRNAs (miRs -21, -122 and -200a) correlated with IL-6 while miR-21 also correlated with D-dimer. Additionally, the abundance of miRs -31, -150 and -223, correlated with baseline CD4+ T cell count while the same three miRNAs plus miR- 145 correlated with nadir CD4+ T cell count. Discussion: No associations with mortality were found with any circulating miRNA studied. These results cast doubt onto the effectiveness of circulating miRNA as early predictors of mortality or the major underlying diseases that contribute to mortality in participants treated for HIV-1 infection

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe

Importancia de la contextualización en el diseño de los Materiales Educativos Digitales

This research addresses the contextualization of the development of digital educational materials for students of the educational program in Ingeniería en Control y Computación at the Universidad Autónoma de Nayarit, which takes as its basis the theories of Piaget (1069), Ausubel (1976) and Vygotsky (2006). The research method is quantitative and presents data concerning a group of college students in the area of engineering results.La presente investigación aborda la contextualización del desarrollo de los materiales educativos digitales en los estudiantes del programa educativo de Ingeniería en Control y Computación de la Universidad Autónoma de Nayarit, la cual toma como fundamento a las teorías de Piaget(1069), Ausbel(1976) y Vigotsky(2006). El método de investigación es cuantitativo y presenta resultados basados concernientes a un grupo de estudiantes universitarios del área de ingenierías

Search for a nonminimal Higgs boson produced in the reaction e+ e- ---> h Z*

A data sample corresponding to 1.23 million hadronic Z decays collected by the ALEPH detector at LEP has been searched for signals of the production of a non-minimal CP-even Higgs boson h in the reaction e+e- --> hZ*. The h decay modes considered were: those of the minimal standard model Higgs boson, with modified branching ratios; decays into a pair of CP-odd Higgs bosons A; and decays into invisible final states. Only one event was found, a very acoplanar e+e- pair which could originate from the standard model background process e+e- --> e+e- nu (nu) over bar. Upper limits for the cross-section of the reaction e+e- --> hZ* have been derived as a function of m(h), the mass of the Higgs boson h. In the case of invisible decays, the 95% CL lower limit on m(h) is 65 GeV/c(2) for a production cross-section equal to that of a minimal standard model Higgs boson. When combined with previous ALEPH results on the reaction e+e- --> hA, these cross-section upper limits exclude a domain in the (m(h), M(A)) plane of the MSSM such that, if invisible h and A decays can be neglected, 95% CL lower limits of 44 and 21 GeV/c(2) result for m(h) and m(A), respectively, independent of the other parameters of the model

Measurement of the b ---> tau- anti-tau-neutrino X branching ratio

Using a missing energy tag, evidence is presented for the decay b ---> tau- anti-tau-neutrino X, and its branching ratio is measured to be (4.08 ± 0.76 ± 0.62)%

Measurement of the ratio Gamma (b anti-b) / Gamma (hadron) using event shape variables

The branching fraction of relative to all hadronic decays of the Z has been measured using event shape variables to preferentially select events. The method chosen applies a combination of shape discriminators and the selection of high transverse momentum leptons to event hemispheres. From a sample of 440 000 hadronic Z decays collected with the ALEPH detector at LEP, the ration is measured

Observation of the time dependence of B(d)0 - anti-B(d)0 mixing

The time dependence of oscillations has been observed using events with a d∗, decaying into a D0π+, and a lepton in opposite hemispheres. The time dependence of the oscillations is derived from the displacement of the D0 vertex and the D∗-lepton charge correlation. From a fit for the oscillation frequency the mass difference of the B0d states is measured: Δm = [3.44+0.65−0.70(stat.)+0.26−0.20(syst.)] × 10−4 eV/c2