26 research outputs found
CAEP 2015 Academic Symposium: Leadership within the emergency medicine academic community and beyond
OBJECTIVES: A panel of emergency medicine (EM) leaders endeavoured to define the key elements of leadership and its models, as well as to formulate consensus recommendations to build and strengthen academic leadership in the Canadian EM community in the areas of mentorship, education, and resources
Sloan Digital Sky Survey IV: mapping the Milky Way, nearby galaxies, and the distant universe
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median ). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July
Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median ). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July
Sloan Digital Sky Survey IV : mapping the Milky Way, nearby galaxies, and the distant universe
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median z ~ 0.03). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between z ~ 0.6 and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July
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Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing
three major spectroscopic programs. The Apache Point Observatory Galactic
Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky
Way stars at high resolution and high signal-to-noise ratio in the
near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA)
survey is obtaining spatially-resolved spectroscopy for thousands of nearby
galaxies (median redshift of z = 0.03). The extended Baryon Oscillation
Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas
distributions between redshifts z = 0.6 and 3.5 to constrain cosmology using
baryon acoustic oscillations, redshift space distortions, and the shape of the
power spectrum. Within eBOSS, we are conducting two major subprograms: the
SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray
AGN and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey
(TDSS), obtaining spectra of variable sources. All programs use the 2.5-meter
Sloan Foundation Telescope at Apache Point Observatory; observations there
began in Summer 2014. APOGEE-2 also operates a second near-infrared
spectrograph at the 2.5-meter du Pont Telescope at Las Campanas Observatory,
with observations beginning in early 2017. Observations at both facilities are
scheduled to continue through 2020. In keeping with previous SDSS policy,
SDSS-IV provides regularly scheduled public data releases; the first one, Data
Release 13, was made available in July 2016
Finishing the euchromatic sequence of the human genome
The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers âŒ99% of the euchromatic genome and is accurate to an error rate of âŒ1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead
Sloan Digital Sky Survey IV: mapping the Milky Way, nearby galaxies, and the distant universe
We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median ). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July
Pesticide use water quality : an assessment of claims
Title from JPEG cover page (University of Missouri Digital Library, viewed May 10, 2010)."June 1997"--Cover."SR505 New 5/97/1M"--Page 4 of cover
Nrf2 Knockout Attenuates the Anti-Inflammatory Effects of Phenethyl Isothiocyanate and Curcumin
The
role of phytochemicals in preventive and therapeutic medicine
is a major area of scientific research. Several studies have illustrated
the mechanistic roles of phytochemicals in Nrf2 transcriptional activation.
The present study aims to examine the importance of the transcription
factor Nrf2 by treating peritoneal macrophages from Nrf2<sup>+/+</sup> and Nrf2<sup>â/â</sup> mice <i>ex vivo</i> with phenethyl isothiocyanate (PEITC) and curcumin (CUR). The peritoneal
macrophages were pretreated with the drugs and challenged with lipopolysaccharides
(LPSs) alone and in combination with PEITC or CUR to assess their
anti-inflammatory and antioxidative effects based on gene and protein
expression in the treated cells. LPS treatment resulted in an increase
in the expression of inflammatory markers such as cycloxygenase-2
(COX-2), inducible nitric oxide synthase (iNOS), interleukin-6 (IL-6),
and tumor necrosis factor-α (TNF-α) in both Nrf2<sup>+/+</sup> and Nrf2<sup>â/â</sup> macrophages, detected by quantitative
polymerase chain reaction (qPCR). Nrf2<sup>+/+</sup> macrophages treated
with PEITC and CUR exhibited a significant decrease in the expression
of these anti-inflammatory genes along with an increase in the expression
of hemeoxygenase-1 (HO-1), which is an antioxidative stress gene downstream
of the Nrf2 transcription factor battery. Although there was no significant
decrease in the expression of the anti-inflammatory genes or an increase
in HO-1 expression in Nrf2<sup>â/â</sup> macrophages
treated with either PEITC or CUR, there was a significant decrease
in the protein expression of COX-2 and an increase in the expression
of HO-1 in Nrf2<sup>+/+</sup> macrophages treated with PEITC compared
to that with CUR treatment. No significant changes were observed in
the macrophages from knockout animals. Additionally, there was a significant
decrease in LPS-induced IL-6 and TNF-α production following
PEITC treatment compared with that following CUR in Nrf2<sup>+/+</sup> macrophages, whereas no change was observed in the macrophages from
knockout animals. The results from qPCR, western blot, and ELISA
analyses in macrophages from Nrf2<sup>+/+</sup> and Nrf2 <sup>â/â</sup> mice indicate that Nrf2 plays an important role in the anti-inflammatory
and antioxidative effects of PEITC and CUR, as observed by their decreased
activities in Nrf2<sup>â/â</sup> macrophages