58 research outputs found
Weight loss and ethnicity: a cohort study of the effects induced by a very low calorie diet.
- Author
- Publication venue
- 'Hikari, Ltd.'
- Publication date
- 31/12/2012
- Field of study
We aimed to determine whether British Asians of Indian or Pakistani descent differed in their baseline characteristics and in response to a twelve-week, very-low-calorie diet (VLCD). We then assessed whether or not a VLCD had a different effect on Asians and Caucasians, in terms of changes in weight and waist circumference. Weight loss was achieved using a nutritionally-complete VLCD with an average daily intake of 550kcal, using greater than or equal to 50g protein, greater than or equal to 50g carbohydrate, mean 15.9g fats, and greater than or equal to 100% of the recommended daily allowances (RDA) for key vitamins and minerals. The VLCD was used alongside a unique behaviour-change programme, called LighterLife (LL). Data were analysed for Asians who were recruited onto LL in 2009/2010, and for whom twelve-week weight change information was available. Waist circumference data were available for a subset of Asians, including age, body mass index and gender. These were matched to a Caucasian population and compared by independent t-test. No differences were observed between the Indian and Pakistani group for baseline measurements or weight change at twelve weeks. Caucasians had a greater percent excess body weight loss (%EBWL) than Asians at twelve weeks (72.4 ± 22.1 vs 48.9 ± 18.0, p < 0.0001). However, Asians had a greater waist circumference reduction per kilogram of weight loss when compared to Caucasians (1.16 ± 0.7 vs 0.95 ± 0.3, p = 0.037). It appears that, despite a greater %EBWL for Caucasians, Asians had a greater waist circumference reduction per kilogram of weight loss using a VLCD approach for a twelve-week period
Decellularised extracellular matrix-derived peptides from neural retina and retinal pigment epithelium enhance the expression of synaptic markers and light responsiveness of human pluripotent stem cell derived retinal organoids
- Author
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/04/2019
- Field of study
Tissue specific extracellular matrices (ECM) provide structural support and enable access to molecular signals and metabolites, which are essential for directing stem cell renewal and differentiation. To mimic this phenomenon in vitro, tissue decellularisation approaches have been developed, resulting in the generation of natural ECM scaffolds that have comparable physical and biochemical properties of the natural tissues and are currently gaining traction in tissue engineering and regenerative therapies due to the ease of standardised production, and constant availability. In this manuscript we report the successful generation of decellularised ECM-derived peptides from neural retina (decel NR) and retinal pigment epithelium (decel RPE), and their impact on differentiation of human pluripotent stem cells (hPSCs) to retinal organoids. We show that culture media supplementation with decel RPE and RPE-conditioned media (CM RPE) significantly increases the generation of rod photoreceptors, whilst addition of decel NR and decel RPE significantly enhances ribbon synapse marker expression and the light responsiveness of retinal organoids. Photoreceptor maturation, formation of correct synapses between retinal cells and recording of robust light responses from hPSC-derived retinal organoids remain unresolved challenges for the field of regenerative medicine. Enhanced rod photoreceptor differentiation, synaptogenesis and light response in response to addition of decellularised matrices from RPE and neural retina as shown herein provide a novel and substantial advance in generation of retinal organoids for drug screening, tissue engineering and regenerative medicine
Assessing the significance of ethnicity on VLCD induced weight loss and outcomes at 1 year follow up.
- Publication venue
- 'S. Karger AG'
- Publication date
- 31/12/2012
- Field of study
Introduction: Few studies have examined the relationship between ethnicity and longer-term outcomes following a very-low-calorie diet (VLCD)
Insights into the structure-function relationships of dimeric C3d fragments
- Author
- Alastair D. G. Lawson
- Alex Macpherson
- Alex Macpherson
- Andrew G. Watts
- Andrew G. Watts
- Ayla A. Wahid
- Bayan Alkhawaja
- Beth G. Gibson
- Catherine Back
- Claire L. Harris
- Ingrid Meschede
- Jean M. H. van den Elsen
- Jean M. H. van den Elsen
- Kevin J. Marchbank
- Kevin Whale
- Liudmila Kulik
- Maisem Laabei
- Rebecca L. Martin
- Rhys W. Dunphy
- Susan J. Crennell
- Thomas M. Hallam
- V. Michael Holers
- Publication venue
- 'Frontiers Media SA'
- Publication date
- 01/08/2021
- Field of study
Cleavage of C3 to C3a and C3b plays a central role in the generation of complement-mediated defences. Although the thioester-mediated surface deposition of C3b has been well-studied, fluid phase dimers of C3 fragments remain largely unexplored. Here we show C3 cleavage results in the spontaneous formation of C3b dimers and present the first X-ray crystal structure of a disulphide-linked human C3d dimer. Binding studies reveal these dimers are capable of crosslinking complement receptor 2 and preliminary cell-based analyses suggest they could modulate B cell activation to influence tolerogenic pathways. Altogether, insights into the physiologically-relevant functions of C3d(g) dimers gained from our findings will pave the way to enhancing our understanding surrounding the importance of complement in the fluid phase and could inform the design of novel therapies for immune system disorders in the future
Exploring the relative lack of impact of research on ‘ability grouping’ in England: a discourse analytic account
- Author
- Ainscow M.
- Balbus I.
- Ball S.
- Ball S.
- Ball S.
- Becky Francis
- Becky Taylor
- Boaler J.
- Burman E.
- Butler J.
- Cassen R.
- Clifton J.
- Croll P.
- Crozier G.
- David Pepper
- DCSF
- DfES
- Dunne M.
- Feyerabend P.
- Foucault M.
- Francis B.
- Francis B.
- Hacker R.
- Hallam S.
- Harding S.
- Harding S.
- Hutchings M.
- Ireson J.
- Jackson B.
- Jackson B.
- Jeremy Hodgen
- Kutnick P.
- Louise Archer
- Lyotard J.
- Mary-Claire Travers
- Reay D.
- Schleicher A.
- Stobart G.
- Sukhnandan L.
- Tomlinson S.
- Vincent C.
- Waldfogel J.
- Whitty G.
- Publication venue
- 'Informa UK Limited'
- Publication date
- 04/01/2016
- Field of study
Grouping students by ‘ability’ is a topic of long-standing contention in English education policy, research and practice. While policy-makers have frequently advocated the practice as reflecting educational ‘standards’, research has consistently failed to find significant benefits of ‘ability’ grouping; and indeed has identified disadvantages for some (low-attaining) pupil groups. However, this research evidence has apparently failed to impact on practice in England. This article, contextualised by the authors’ interests in education and social inequality, seeks to do two things. First, it provides a brief analysis of the existing research evidence on the impact of ‘ability’ grouping, with particular reference to socio-economic inequality, identifying seven different explanations for the poorer progress of pupils in low sets that emerge from the literature. Second, it applies Foucaultian ‘analysis of discourse’ to propose potential explanations for the apparent lack of traction of existing research with policy and practice, arguing that practices of ‘ability grouping’ reflect cultural investments in discourses of ‘natural order’ and hierarchy, with particular resonance for the discursive and political habitus of middle-class parents. The authors postulate that investing in a powerful counter-discourse of enlightenment science, illustrated via their current randomised control trial of different approaches to pupil grouping, may offer a means to challenge hegemonic discourses that underpin current classroom practice
The impact of immediate breast reconstruction on the time to delivery of adjuvant therapy: the iBRA-2 study
- Author
- Abdullah Nassreen
- Accurso Antonello
- Accurso Antonello
- Achuthan Raj
- Adam Rahma
- Adelekan Matthew
- Adwani Asha
- Aertssen Anna
- Agrawal Amit
- Agrawal Avi
- Ain Quratul
- Ainsworth Rachel
- Akerlund Malin
- Akolekar Deepika
- Alder Louise
- Alexander Susanna
- Ali Deedar
- Ali Rozina
- Allan Anna
- Allum William
- Aloraifi Fatima
- Amin Khalid
- Amorosi Vittoria
- Arif Tahera
- Armstrong Alexander
- Asaad Oubida
- Asgeirsson Kristjan
- Athanasiou Irene
- Audisio Riccardo
- Azmy Iman
- Bache Sarah
- Bains Salena
- Bajrusevic Sladana
- Balasubramanian Balapathiran
- Balata Safa Ahmed
- Bali Radhika
- Barnes Nicola
- Barnes Nicola LP
- Barrows Sara
- Barry Peter
- Barua Ellora
- Basu Naren
- Bathla Sonia
- Benyon Sarah L
- Bernaudo Lorenzo
- Bhaskar Pud
- Bibi Saira
- Biddle M
- Bignell Kym
- Biswas Bashishta
- Blazeby Jane
- Bourne Roger
- Brock Lisa
- Brown Victoria
- Bucata Claudiu
- Bucknor Alexandra
- Byrne Miriam
- Cain Henry
- Callaghan Maria
- Canny Rebecca
- Catanuto Giuseppe
- Cawthorn Simon
- Ceccarino Raffaele
- Chagla Leena
- Challoner Tom
- Chana Jagdeep
- Chand Natalie
- Chandrashekar Mysore
- Charalambous Michalis
- Charalampou-Dis Petros
- Chew Ben
- Chicken Dennis Wayne
- Chin Kian
- Chong Kelvin
- Choy Christina
- Christopoulos Petros
- Chrysafi Ada
- Clark Sarah
- Clarke Natalie
- Coco Guido
- Colizzi Livio
- Collab Breast Reconstruction Res
- Collis Nick
- Conroy Elizabeth
- Constantinou Chloe
- Critchley Adam
- Cullinane Carolyn
- Curnier Alain
- Curran Terry-Ann
- Dauria Marta
- Dave Rajiv
- Dave Rajiv V
- Dave Rajiv V
- Davey Simon
- de Sousa Emma
- Debanth Debasish
- Depasquale Ivan
- Devane Liam
- Dhooma Naseem
- Di Micco Rosa
- Dixon JM
- Dordea Matei
- Douek Michael
- Down Sue
- Downey Sarah
- Dragoumis Dimitris
- Dumitru Dorin
- Dunn Julie
- Durbar Michael
- El-Sharief Deena
- Elahi Bilal
- Elfadl Dalia
- Epurescu Daniel
- Evoy Denis
- Exarchos Georgios
- Fabio Santanelli di Pompeo
- Fafemi Oladapo
- Fage Elena
- Farrell Eric
- Ferguson Douglas
- Fiddes Roanne
- Figus Andrea
- Fopp Laura
- Foster Rachel
- Fuller Mairi
- Fustaino Loredana
- Gahir Jasdeep
- Gandamihardja Tasha
- Gandhi Ashu
- Gardiner Matthew
- Gardiner Matthew
- Garg Neeraj
- Garnsey Clare
- Geraghty James
- Geropantas Konstantinos
- Ghali Shadi
- Ghilli Matteo
- Gill Emma
- Goh Steven
- Govindarajulu Sasirekha
- Graja Tomasz
- Granger Emily
- Grassi Veronica
- Grover Kartikae
- Grp iBRA-2 Steering
- Guest Francesca
- Gui Gerald
- Gutteridge Eleanor
- Gvaramadze Anzors
- Hallam Kelly
- Hamad Ahmed
- Hamed Hisham
- Hamilton Stephen
- Hamnett Kathryn
- Hamo Ishrak
- Haq Anwar
- Harcourt Ruth
- Harding-MacKean Claudia
- Harnett Adrian
- Harnett Adrian
- Harnett Adrian
- Harris Chad
- Harris Kevin
- Harris Paul
- Harvey James
- Harvey Kate L
- Haywood Richard M
- Healy Samuel
- Henderson Julia
- Henry Francis P
- Hernan Izaro
- Heys Steven
- Hignett Susan
- Hill Arnold DK
- Hogan Brian
- Holcombe Chris
- Holcombe Chris
- Holcombe Chris
- Hollywood Ciaran
- Holt Simon
- Horgan Kieran
- Howes Rachel
- Hu Jennifer
- Humphreys Laura
- Hunter Judith
- Hussien Maged I
- Ihsan Naila
- Iqbal Azhar
- Irakleidis Foivos
- Irwin Gareth
- Irwin Michael S
- Isherwood Jennifer
- Ives Charlotte
- Jafferbhoy Sadaf
- Jafferbhoy Sadaf
- Jain Yogesh
- Jallali Navid
- James Karen
- James Ruth
- James Stuart
- Jibril Jibril A
- Jiwa Natasha
- Johns Neil
- Johnson Laura
- Johnson Richard
- Jones Ben Mancey
- Jones Robin
- Kalles Vasileios
- Kalra Loraine
- Kaushik Monika
- Kearns Marie
- Kelsall Jennett
- Kennedy Katy
- Kenny Frances
- Khalil Haitham
- Khan Mansoor
- Khan Shazia M
- Khattak Ilyas
- Khawaja Saira
- Khout Hazem
- Kirby Robert
- Kirchhoff Chris
- Kirkpatrick Katharine
- Kiruparan Pasupathy
- Kirwan Cliona C
- Kleidi Eleftheria
- Kneeshaw Peter
- Kokan Jalal
- Koris Jacob
- Kothari Ashutosh
- Kovacs Tibor
- Krupa Jaroslaw
- Krupa Katerine
- Kryjak Zbigniew
- Kulkarni Dhananjay
- Lai Lee Min
- Lambert Kelly
- Lampropoulos Pavlos
- Lane Risha
- Langlands Fiona
- Lansdown Mark
- Laurence Nicola
- Lawlor Catriona
- Laws Siobhan
- Ledwidge Serena
- Lee Jason
- Lewis Rebecca
- Li Alessandro Quattrini
- Liccardo Raffaele
- Limite Gennaro
- Lo Michelle
- Lund Jonathan
- Lymperopoulos N
- Maalo Joseph
- Mackay Iain
- MacLean Gael
- MacLennan Louise
- Macmillan Douglas
- MacNeill Fiona
- Mahapatra Tapan
- Majeed Yousef
- Malata Charles M
- Mallon Peter
- Malyon Andy
- Mansfield Lucy
- Mariniello Maria Donatella
- Marsh Daniel
- Marzia Lo Russo
- Masannat Yazan A
- Masood Mohammad
- Massey Julia
- Matey Pilar
- Mathen Vinod
- Mathew Tom
- Mazari Fayyaz
- McCartan Damian
- McCulley Stephen
- McDermott Enda
- McEvoy Kat
- McGill David
- McGuiness Caroline
- McIntosh Jamie
- McIntosh Stuart A
- Mckenzie Shireen
- McManus Penelope
- Mehmood Iftikhar
- Mehta Disha
- Michalakis Ioannis
- Michieletto Silvia
- Milligan Robert
- Misky Adam
- Mitchell Geraldine
- Monib Sherif
- Morgan Mary
- Morrison Colin
- Mortimer Caroline
- Mosahebi Afshin
- Moss Sarah
- Muhibullah Nazli
- Mullan Michelle
- Munot Kailas
- Murali Kothandaraman
- Murphy Claire
- Murphy Declan C
- Murphy John
- Mustafa Mohammed
- Mylvaganam Senthurun
- Nagachandra Geerthan
- Narayanan Sankaran
- Naseem Salma
- Nasr Rana
- Navin Channegowda
- Nguyen Dai
- Nizamoglu Metin
- O'Brien Ciara
- O'Brien Ciara
- O'Brien James
- O'Connell Rachel
- O'Connell Rachel L
- O'Donoghue Joe
- O'Leary Peter
- Okwemba Sylvia
- Oliver James
- Olsen Sisse
- Oluwajana Michael
- Otieno Charlene
- Pain Simon J
- Park Alan
- Parvanta Laila
- Patel Ashraf
- Patel Krupali
- Peel Anthony
- Pereira Bernadette
- Pereira Jerome
- Pikoulas Panagiotis
- Pilgrim Simon
- Piper Jenny
- Poonawala Shabbir
- Popa Elena
- Pope Vanessa
- Potter Shelley
- Potter Shelley
- Potter Shelley
- Power Kieran
- Prichard Ruth
- Prousskaia Elena
- Pujji Ojas
- Rainsbury Dick
- Ramakrishnan Venkat
- Ramsey Kelvin
- Rasheed Tuabin
- Rattay Tim
- Rattay Tim
- Ravichandran Duraisamy
- Ray Biswajit
- Rayter Zenon
- Refsum Sigi
- Reissis Dimitris
- Remoundos Dionysios Dennis
- Ribas Maria Dalmau
- Rizkalla Maged
- Rizki Hirah
- Rocco Nicola
- Roche Nicola
- Roncella Manuela
- Roshanlall Chandeena
- Rossetti Elena
- Rothwell Jane
- Roy Pankaj
- Rusby Jennifer
- Sahu Ajay
- Saibene Tania
- Saleem Talha
- Sami AS
- Sassoon EM
- Scott John
- Seetharam Seema
- Sethu Claire
- Seward Joanna
- Shanks Lindsay
- Shariaha Yousef
- Sherwin Liz
- Shetty Geeta
- Shokuhi Sheila
- Shrestha Deepak
- Sircar Tapan
- Sirianni Chiara
- Sirianni Chiara
- Sjokvist Olivia
- Skillman Joanna
- Skillman Joanna
- Slade-Sharman Diana
- Sloan Samantha
- Smyth Elizabeth
- Sojitra Nilesh
- Soulsby Rachel
- Soumian Soni
- Sowdi Ravi
- Stebbing Anne
- Sundaramoorthy Souganthy
- Sutton Richard
- Svenning Matilda
- Syed Farah
- Tadros Amir
- Taghizadeh Rieka
- Tansley Anne
- Tasoulis Marios
- Tayeh Salim
- Taylor Amanda
- Taylor Jevan
- Taylor Lauren
- Tebbal Sally
- Tevlin Ruth
- Thekkinkattil Dinesh
- Thomas Rachel Bright
- Thomson Simon
- Thorne Amanda
- Thrush Steven
- Tillett Rachel
- To Natalie
- Tomlins Abigail
- Trapszo Pawel
- Trickey Adam
- Turton Philip
- Udayasankar S
- Valassiadou Kalliope
- Verjee Liaquat S
- Vidya Raghavan
- Vigneswaran Natali
- Vinayagam Raman
- Vollermere Angela J
- Walker Philip
- Weiler-Mithoff Eva
- Weston-Petrides Gina
- Whisker Lisa
- Wilkins Alex
- Williamson Paula
- Wilson Rebecca
- Wilson Sherif
- Windle Rebecca
- Wintrip Dorothy
- Wood Simon
- Wooler Brendan
- Woollard Alex
- Woollard Alexander
- Yoshimura Ryo
- Young Oliver
- Younis Ibby
- Youssef Mina
- Zechmeister Katalin
- Zeidan Bashar
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2019
- Field of study
Background:
Immediate breast reconstruction (IBR) is routinely offered to improve quality-of-life for women requiring mastectomy, but there are concerns that more complex surgery may delay adjuvant oncological treatments and compromise long-term outcomes. High-quality evidence is lacking. The iBRA-2 study aimed to investigate the impact of IBR on time to adjuvant therapy.
Methods:
Consecutive women undergoing mastectomy ± IBR for breast cancer July–December, 2016 were included. Patient demographics, operative, oncological and complication data were collected. Time from last definitive cancer surgery to first adjuvant treatment for patients undergoing mastectomy ± IBR were compared and risk factors associated with delays explored.
Results:
A total of 2540 patients were recruited from 76 centres; 1008 (39.7%) underwent IBR (implant-only [n = 675, 26.6%]; pedicled flaps [n = 105,4.1%] and free-flaps [n = 228, 8.9%]). Complications requiring re-admission or re-operation were significantly more common in patients undergoing IBR than those receiving mastectomy. Adjuvant chemotherapy or radiotherapy was required by 1235 (48.6%) patients. No clinically significant differences were seen in time to adjuvant therapy between patient groups but major complications irrespective of surgery received were significantly associated with treatment delays.
Conclusions:
IBR does not result in clinically significant delays to adjuvant therapy, but post-operative complications are associated with treatment delays. Strategies to minimise complications, including careful patient selection, are required to improve outcomes for patients
Global economic burden of unmet surgical need for appendicitis
- Author
- Aahlin E. K.
- Aamer A.
- Aaniana K.
- Ababneh A.
- Abaliksta T.
- Abantanga F.
- Abbas M.
- Abbasy J.
- Abbo O.
- Abbouch M.
- Abd-Elmawla M.
- Abd-Elrasoul Y.
- Abdallah E.
- Abdel-Aty A.
- Abdel-Hameed N.
- Abdel-Kader S. M.
- Abdel-Wahab N. Y. E.
- Abdelaal A.
- Abdelaty M.
- Abdelazeam A. R.
- Abdelazim G.
- Abdelaziz M. A.
- Abdelbadeai K.
- Abdelfatah A.
- AbdelFattah I.
- Abdelgelil A.
- Abdelghany S.
- Abdelhady S.
- Abdelhamed R.
- Abdelhamid A.
- Abdelhaq A.
- Abdelkader M.
- Abdelkader O.
- Abdelkareem A.
- Abdelkhalek M.
- Abdelmageed E.
- Abdelmotaleb I.
- Abdelraheim M.
- Abdelraouf A. M.
- Abdelrouf D. M.
- Abdelshafy M.
- Abdelshakour M.
- Abdrabou A. K.
- Abdul-Latif S.
- Abdulaziz H.
- Abdulbagi O.
- Abdulgawad M.
- Abdulhakeem E. M.
- Abdullah M. A.
- Abdullah N.
- Abdullah N. A. N.
- Abdullahi L.
- Abdurrazzaaq A.
- Abebe N. S.
- Abebe N. S.
- Abem O. E.
- Abiola O.
- Aboarab A.
- Aboelella M.
- Aboelmagd O.
- Aboelsoud M. R.
- Aboraya M.
- Aboraya M.
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- Abouzahra A.
- Abouzaid A.
- Abozaid M.
- Abozeid K.
- Abozyed M. A. F.
- Abu-Toyour M.
- Abubakr M.
- Abudeeb H.
- Abuowda Y.
- Abuqwaider E.
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- Publication venue
- Oxford University Press
- Publication date
- 01/01/2022
- Field of study
Background: There is a substantial gap in provision of adequate surgical care in many low-and middle-income countries. This study aimed to identify the economic burden of unmet surgical need for the common condition of appendicitis. Methods: Data on the incidence of appendicitis from 170 countries and two different approaches were used to estimate numbers of patients who do not receive surgery: as a fixed proportion of the total unmet surgical need per country (approach 1); and based on country income status (approach 2). Indirect costs with current levels of access and local quality, and those if quality were at the standards of high-income countries, were estimated. A human capital approach was applied, focusing on the economic burden resulting from premature death and absenteeism. Results: Excess mortality was 4185 per 100 000 cases of appendicitis using approach 1 and 3448 per 100 000 using approach 2. The economic burden of continuing current levels of access and local quality was US 92492millionusingapproach1and73 141 million using approach 2. The economic burden of not providing surgical care to the standards of high-income countries was 95004millionusingapproach1and75 666 million using approach 2. The largest share of these costs resulted from premature death (97.7 per cent) and lack of access (97.0 per cent) in contrast to lack of quality. Conclusion: For a comparatively non-complex emergency condition such as appendicitis, increasing access to care should be prioritized. Although improving quality of care should not be neglected, increasing provision of care at current standards could reduce societal costs substantially
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
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- Del Basso C
- del Pilar Paucar A
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- Devadasar GH
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- Dione Parreno-Sacdalan M
- Dissanayake T
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- El Halawany M
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El-badawy HA
- El-Dien KS
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- El-Din RA
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- El-Kashef H
- El-Latif NK
- El-Ma'doul AS
- El-Rabaa S
- El-Sagheer N
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- El-Shahat NS
- El-Sheemy H
- El-Taher E
- Elabdin HZ
- Elashmawy M
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- Elazoul M
- Elbanby E
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- Elbatahgy A
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- Elbisomy KH
- Eldafrawy M
- Eldamaty L
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- Elfiky M
- Elfil M
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- Elfouly Y
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- Elgebaly A
- Elgendy AH
- Elgendy FI
- Elgheriany M
- Elhadad A
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- Elhalawany E
- Elhamouly S
- Elhelbawy MS
- Elhendawy A
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- Elhusseiny AAE
- Elizabeth Lopez C
- Elkadsh I
- Elkady F
- Elkelany A
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- Elkhadrawi M
- Elkhalek EA
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- Elsawahly DME
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- Elsemelawy R
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- Elsherbiny AS
- Elsherif FA
- Elshobary M
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- Elsorogy DEAA
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- Elwy E
- Elzahed N
- Elzayat I
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- Elzowawi F
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- Emara E
- Emile S
- Eng C
- English W
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- Escalante Salas MDC
- Espin-Basany E
- Espinoza F
- Essam A
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- Evajelista CV
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- Eyssartier E
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- Farouk SAM
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy AM
- Fattah AA
- Fatuga A
- Faturoti O
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- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe CO
- Fergany A
- Fergusson SJ
- Fergusson SJ
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- Fernandes C
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- Frisk B
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- Fujii F
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- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
- Manrique Sila G
- Manrique Sila GC
- Manriquez-Reyes M
- Manrrique Sila G
- Mansor EY
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marcelo Delgado J
- Marey A
- Marey AS
- Margaritis M
- Maria Garcia-Perez J
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
- Mas R
- Mason C
- Mat TNT
- Mata LPS
- Matheu A
- Mathew SW
- Matos-Puig R
- Mattar O
- Matter SM
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
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- Melo Cardozo RA
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- Mendoza Arango MC
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- Mendoza Arango MC
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mercado Rodriguez L-A
- Mericliler M
- Merlini D
- Merlini D
- Merlo MS
- Mesbah N
- Meshref A
- Messa Aguilar WL
- Messa Aguilar WL
- Metwally MM
- Migliore M
- Mihaljevic AL
- Mihaljevic AL
- Mihanovic J
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- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
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- Milligan W
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- Minguez Garcia J
- Minguez G
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- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu AS
- Mironescu AS
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
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- Miyarde Leon A
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo MM
- Modolo MM
- Modolo MM
- Moe TT
- Mogan YP
- Moghazy ME
- Mohamed A
- Mohamed A
- Mohamed AM
- Mohamed AR
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed AR
- Mohammed H
- Mohammed MM
- Mohammed MMH
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok YT
- Mokhtar A
- Molina G
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- Monrad-Hansen PW
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montoya Botero JA
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora JJV
- Morales C
- Morandi E
- Moreira G
- Moreno SC
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- Morshedy EM
- Morsi A
- Morsi M
- Morton D
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- Morton R
- Mosad A
- Mosalum O
- Mostafa HA
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe AM
- Mshelbwala P
- Msiska N
- Msosa V
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- Muddebihal U
- Mukin ADF
- Muktar U
- Mukuzunga C
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- Muller J
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- Munipalle PC
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- Murutoglu B
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- Musowoya J
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- Musyoka CK
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- Mutabazi AZ
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- Mutlu V
- Muzio E
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- Mykoniatis I
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- Nadkarni S
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- Nagy GS
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- Nanthakumaran S
- Napolitano L
- Napolitano L
- Naqvi SA
- Naqvi T
- Naranjo Aristizaibal FA
- Narayanan R
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- Narvestad JK
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- Nashat M
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- Nashidengo P
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- Nassif D
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- Nataraja R
- Natili A
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- Nawara C
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- Nazir M
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- Ndegwa W
- Ndlovu SR
- Ndwambi P
- Negida A
- Negoi I
- Nel D
- Nemeth K
- Neo YN
- Neo YT
- Neophytou C
- Nepogodiev D
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- Nestorovic M
- Nevieraite V
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- Ngwa TE
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- Njokanma I
- Nnajiuba H
- Nocito A
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- Nofal E
- Noor F
- Normile C
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- Notarnicola M
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- Nouh T
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- Noukpozounkou B
- Novak A
- Nowers J
- Nsengimana VJP
- Nsengiyumva C
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- Nurqistan HD
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O'neill M
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- Palomino Castillo VD
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- Panteli C
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- Papaskarlatos I-A
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- Pena L
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- Perez Velasquez CI
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- Pertersen Servin GR
- Pesenti G
- Petrikenas S
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- Pezas T
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- Pezelj N
- Phillips N
- Picardo A
- Picciariello A
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- Pinkney T
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- Powell A
- Prabhudesai A
- Pranevicius R
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- Preckailaite E
- Primavesi F
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- Pronin S
- Prudhomme T
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- Punja V
- Purwaningsih NA
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- Qaissieh A
- Qawasmi I
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- Qureshi AU
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- Rajmohan S
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- Rakita I
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- Ramarez Cabrera CC
- Ramazzini P
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- Rashad E
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- Rasoaherinomenjanahary F
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- Razek T
- Razi SAU
- Razmdjou S
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- Razzaque J
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- Salah OM
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- Samaraweera DI
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- Sandoval Barrantes AM
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- Schultz JK
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- Scott M
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- Semeda N
- Semiz A
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- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
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- Sfougaris D
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- Shachykava T
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- Shahbaz AR
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- Snyder E
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- Sobnach S
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- Soeselo DA
- Sokratous A
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- Solar Garcia L
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- Soldevila-Verdeguer C
- Soley R
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- Soltani N
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- Sundstrom SM
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- Tade A
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- Taha EMS
- Tahboub H
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- Taieb C
- Taiwo A
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- Tammam A
- Tan C
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- Tan CY
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- Tanase A
- Tang A
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- Tani SI
- Tansoker I
- Tarek A
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- Tarek D
- Targa S
- Tariq S
- Tata MD
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- Tedeschi U
- Tedjaatmadja C
- Telfah MM
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- Tennakoon A
- Teo SY
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- Thabet W
- Thalgaspitiya SPB
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- Thanusan V
- Tharmalingam S
- Theodosopoulos T
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- Ubiali P
- Ugalde P
- Ukwenya Y
- Ulusahin M
- Upadhyaya V
- Upchurch E
- Urbanavicius L
- Urbina Rojas NM
- Urbonas T
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- Urniezius Z
- Urniezius Z
- Usaityte A
- Uscinas L
- Utter M
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- Valente Laufer LA
- Valioulis I
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- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Diaconescu Ib
- Dias S
- Diaz-Jover P
- Diaz-Zorrilla C
- Dick L
- Dickfos M
- Dickson L
- Dijan E
- Dimech T
- Din F
- Dindyal S
- Dindyal S
- Dissanayake T
- Djivoh F
- Domini E
- Domini E
- Donnelly P
- Donoghue D
- Dorani Rmnr
- Dorismé
- Dos Santos DV
- Dossou F
- Doughan S
- Doughty J
- Dousset B
- Dragatas D
- Drake Tm
- Drake Tm
- Driscoll A
- Drungilas M
- Du Plessis D
- du Plooy F
- Du Toit F
- Duane T
- Dubois A
- Dueñ
- Duffy L
- Duhoranenayo D
- Duinhouwer L
- Dulskas A
- Durand Sya
- Dwydar A
- Ebdewi H
- Ebidy M
- Ebidy Mm
- Ebrahim Os
- Eduard P
- Edwards J
- Edye M
- Eid Mm
- Eisner L
- Ekow M
- El Ashal G
- El Dahab AA
- El Deen KN
- El Galeel AA
- El Gendy NH
- El Gendy A
- El Halawany M
- El Hameed OSA
- El Hamid NA
- El Jamassi A
- El Kashash A
- El Kholy A
- El Magd AA
- El Mesery S
- El Salam YA
- El Sayed GS
- El Sayed IM
- El Shoura Y
- El Slam MA
- El-Badawy Ha
- El-Dien Ks
- El-Dien Ks
- El-Din Ra
- El-Din Sa
- El-Gizawy E
- El-Hamouly As
- El-Kashef H
- El-Latif Nka
- El-Ma&apos
- El-Rabaa S
- El-Sagheer N
- El-Salam Fa
- El-Sawy A
- El-Sehily A
- El-Shahat Ns
- El-Sheemy H
- El-Taher E
- Elabdin Hz
- Elashmawy M
- Elashry R
- Elazab A
- Elazayem Aa
- Elazoul M
- Elbanby E
- Elbanby Es
- Elbatahgy A
- Elbe P
- Elbermawy M
- Elbisomy Kh
- Eldafrawy M
- Eldamaty L
- Eldeeb Az
- Eldeen Ea
- Eldin Mab
- Elebute O
- Elebute O
- Elena G
- Elfarargy A
- Elfeki H
- Elfeki H
- Elfiky M
- Elfil M
- Elfouly N
- Elfouly N
- Elfouly Y
- Elfouly Y
- Elgebaly A
- Elgendy Ah
- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
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- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
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- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
- Hall Nj
- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
- Hammad A
- Hammad Am
- Hampton M
- Hampton Mi
- Hamsho W
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
- Hantour U
- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
- Heath J
- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
- Henderson L
- Henderson L
- Heng He
- Henric N
- Henry F
- Henshall De
- Herebat A
- Herikstad R
- Herrera N
- Herrera-Matta J
- Herrod P
- Hervieux E
- Hervieux E
- Hesham O
- Hettiarachchi Ts
- Hewage K
- Heywood Eg
- Highcock S
- Hilal K
- Hinojosa C
- Hjertberg M
- Hjertberg M
- Hmila S
- Ho A
- Ho Cw
- Ho W
- Ho Wc
- Hodonou F
- Hogea M
- Holte S
- Holton P
- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
- Hosh M
- Hossaini S
- Hossameldin A
- Houlden C
- Howells L
- Howie Ee
- Hrora A
- Huaman E
- Huaraya Rc
- Humm G
- Hunter K
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Husseiny R
- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
- Iftikhar Z
- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
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- Irwin G
- Irwin G
- Irwin G
- Irwin G
- Ishak N
- Iskandar F
- Ismaï
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- Ismail M
- Ismail Mjb
- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
- Iyer D
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- Jabal Ms
- Jabbar A
- Jaber S
- Jackson P
- Jacobe M
- Jaffry Z
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- Jaich R
- Jain P
- Jama Gm
- Jamal L
- Janardha Kc
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- Jankus T
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- Jaramillo Ra
- Jarmin M
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- Javed O
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- Jayathilake Ab
- Jck Ng
- Jean-Francois C
- Jeffery A
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- Jenner E
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- Jennings V
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- Jensen E
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- Jeon H
- Jeremic L
- Jethwani Dl
- Jeyakumar J
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- Jha M
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- Jones C
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- Joosten J
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- Julaihi R
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- Kabariti R
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- Kabba J
- Kabongo K
- Kache S
- Kaci Aa
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
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- Kamarajah Sk
- Kamarulzamil Sna
- Kamil R
- Kamya S
- Kanani A
- Kandil Am
- Kandil H
- Kang Mk
- Kanta Th
- Karabacak U
- Karabelias G
- Karabulut K
- Karahan Sr
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
- Karim R
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- Karismaningtyas H
- Karjiker P
- Karkeet M
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- Karlo R
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- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem Ea
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke Kr
- Kelany M
- Kenibar A
- Kennedy Ed
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- Kennedy R
- Keogh K
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- Kershaw S
- Kesinger M
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- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
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- Khatri C
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- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
- Khoja A
- Khokha D
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- Khosla S
- Khreishi R
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- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim My
- Kim Sb
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- Kinandu K
- King R
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- Kirishnan A
- Kirupagaran A
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- Kjellin A
- Kkk Li
- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
- Koh C
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- Kojo Att
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- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
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- Kong V
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- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Kwizera S
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- Kyriazanos I
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- Kyziridis D
- Ló
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- La Brocca A
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- Labib P
- Ladukas A
- Lafferty K
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- Lakhani Sm
- Lakshmi Hn
- Lam Fy
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- Law Jh
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- Lawani I
- Lawther R
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- Leal A
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- Lee C
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- Lo Conte A
- Loaloa Mr
- Lockey J
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- Mabrouk M
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- Macchitella Y
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- Macdonald A
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- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
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- Magdy A
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- Magdy E
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- Magee C
- Maghrabi A
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- Marinkovic B
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- Marples L
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- Marshall Dc
- Martian Bv
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- Mas R
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- Mijuskovic B
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- Milligan W
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- Miranda C
- Mircea H
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- Mironescu A
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- Mirza A
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- Mistry A
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- Mitroudi M
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- Modolo Mm
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- Moe Tt
- Mogan Yp
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- Mohamed F
- Mohamed I
- Mohamed M
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- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
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- Mohammad A
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- Mohammed H
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- Mohammed S
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- Monrad-Hansen Pw
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- Monteleone M
- Monteleone M
- Montes I
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- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
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- Mora Jjv
- Morais Pab
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- Moreira G
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- Mosalum O
- Mostafa Ha
- Mostafa M
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- Mousa M
- Moussa O
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- Mshelbwala P
- Msiska N
- Msosa V
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- Muktar U
- Mukuzunga C
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- Munipalle Pc
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- Musa Aek
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- Musyoka Ck
- Mutabazi Az
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- Mutlu D
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- Muzio E
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- Nada F
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- Nagy Gs
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- Nair H
- Nanthakumaran S
- Napolitano L
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- Naqvi Sa
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- Naranjo Aristizã
- Narayanan R
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- Narvestad Jk
- Nashaat A
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- Nasher O
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- Nasir A
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- Nassif D
- Nastri G
- Natalie H
- Nataraja R
- Natili A
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- Ndajiwo A
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- Ndegwa W
- Ndlovu Sr
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- Ne&apos
- Negida A
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- Neo Yt
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- Nepogodiev D
- Nepogodiev D
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- Nesaratnam A
- Nessa A
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- Nevieraite V
- Newton T
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- Njokanma I
- Nnajiuba H
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- Novak A
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- Nsengimana Vjp
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- Nurqistan Hd
- Nwabuoku E
- Nwinee V
- Nwokoro C
- Nyberg J
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- O&apos
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- Oshati O
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- Pagano G
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- Palma Af
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- Papaskarlatos Ia
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- Parreno-Sacdalan Md
- Parseliunas A
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- Pastora J
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- Patoulias I
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- Ukwenya Y
- Uluş
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- Urbanavicius L
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- Urniež
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- Yip Sbs
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong Co
- Yong Gl
- Younis A
- Youssef D
- Youssef H
- Youssef M
- Youssif Jh
- Yuksek Ma
- Yusufali T
- Zaa&apos
- Zachariades Dc
- Zadoroznas A
- Zahran D
- Zakaria E
- Zakaria M
- Zakaria Y
- Zaki A
- Zakir M
- Zalabia Mf
- Zamarin K
- Zammit S
- Zampitis N
- Zani A
- Zani A
- Zani A
- Zanini N
- Zanini N
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zerihun Ab
- Zhang Z
- Zheng F
- Zidan H
- Zidan H
- Zidan M
- Zielinski M
- Ziff O
- Zikry M
- Zil-E-Ali A
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskas J
- Zilinskiene R
- Zimmermann Ef
- Zohair A
- Zorrilla Cd
- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbü
- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
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- Author
- Publication venue
- 'Wiley'
- Publication date
- 01/05/2000
- Field of study
- …