13 research outputs found
Atrasentan and renal events in patients with type 2 diabetes and chronic kidney disease (SONAR): a double-blind, randomised, placebo-controlled trial
- Author
- Abaterusso Cataldo
- Abdul Kadir Khalid
- Abrahamovych Orest
- Acharya Shamasunder
- Acosta Idalia
- Adam Noor
- Adams Luthando
- Adawi Faiad
- Adolphe Allen
- Ahmad Ghazali
- Ahmed Azazuddin
- Ahmed Ziauddin
- Ahn Kyu Jeung
- Alcantara-Gonzalez Altagracia Aurora
- Aldrete Jorge
- Ali Norhaliza Mohd
- Almirall Jaume
- Alscher Mark
- Alvarado Odilon
- Alvarez German
- Alvarisqueta Andres
- Amin Mohammad
- Amodeo Celso
- Andress Dennis L
- Annand Andrew
- Antunes Ferreira Manuel Anibal
- Anzai Jiichi
- Apostolou Theofanis
- Arauz-Pacheco Carlos
- Arciszewska Malgorzata
- Argoud Georges
- Arif Ahmed
- Aronson Ronnie
- Arrieta Lezama Javier
- Assefi Ali
- Ato Keita
- Atray Naveen
- Awua-Larbi Stella
- Aziz Nor Azizah
- Azuma Nobuyuki
- Bai Liqun
- Bailey Gordon
- Bajaj Harpreet Singh
- Bakdash Wa'El
- Baker John
- Baker Penelope
- Bako Gabriel
- Bakris George
- Bakris George
- Bansal Shweta
- Bar-Dayan Yosefa
- Bardymova Tatiana
- Barendregt Jnm
- Barengolts Elena
- Bartaskova Dagmar
- Bau Cho-Tsan
- Bayliss George
- Beddhu Srinivasan
- Bedros Fadi
- Belledonne Mario
- Belo Diogo
- Bentsianov Marie
- Bhargava Anuj
- Bhorat Qasim
- Bieler Tasso
- Birne Rita
- Blagoveshchenskaya Olga
- Bloom Scott
- Blumenthal Samuel
- Bochicchio-Ricardelli Tomasso
- Bock Andreas
- Bohm Guillermo
- Boiskin Mark
- Bonet Sol Josep
- Borges Joao Lindolfo
- Bowman-Stroud Cynthia
- Brantley Roman
- Bressler Peter
- Brown Eric
- Brunati Chiara
- Brusco Osvaldo
- Bucek Petr
- Budde Klemens
- Burga Nunez Jose
- Burgos-Calderon Rafael
- Busch Robert
- Butt Salman
- Cabrita Antonio
- Calderon Ortiz Ricardo
- Calderon Ticona Jorge
- Calero Gonzalez Francesca
- Cangiano Jose
- Capasso Giovambattista
- Carranza-Madrigal Jaime
- Castillo Alvaro
- Castro-Alonso Cristina
- Cathcart Harold
- Cercato Cintia
- Cha Dae-Ryong
- Chan Doris
- Chatha Rupi
- Chen Ching-Chu
- Chen Jung-Fu
- Chen Nan
- Cheung Siu Fai
- Chevaile-Ramos Jose
- Chew Wong Alfredo
- Chmelickova Hana
- Cho Ho Chan
- Cho Yong-Wook
- Choi Kyung Mook
- Choi Moon-Gi
- Chow Stephen
- Christofides Elena
- Chu Chih-Hsun
- Chuang Peale
- Chung Choon Hee
- Ciechanowski Kazimierz
- Cigarran Guldris Secundino
- Coetzee Kathleen
- Cohen Josef
- Combe Christian
- Comulada-Rivera Angel
- Conte Giuseppe
- Cooke Duncan
- Correa-Rotter Ricardo
- Costa e Forti Adriana
- Cournoyer Serge
- Cruz Lucita
- Cusumano Ana
- D'Avila Domingos
- Dahl Neera
- Danin Vargas Alfredo
- Daoud Deeb
- Davis Tim
- de Arteaga Javier
- De Cosmo Salvatore
- De la Calle Gilda
- de Lourdes Noronha Irene
- de Zeeuw Dick
- Deboni Luciane
- Delgado-Butron Cesar
- Dellanna Frank
- Desai Sachin
- Dextre Espinoza Augusto
- Ding Guohua
- Ding Xiaoqiang
- Distiller Larry
- Dixon Brad
- Doo-Man Kim
- Doshi Ankur
- Draibe Sergio
- Dudar Iryna
- Dulude Emily
- Duma Livia
- Dussol Bertrand
- Egido Jesus
- Egstrup Kenneth
- El-Shahawy Mohamed
- Elbert Alicia
- Elder John
- Eliaschewitz Freddy
- Ellis Graham
- Endre Zoltan
- Esnault Vincent
- Esposito Ciro
- Essaian Ashot
- Eustace Joseph
- Fang Michael
- Farfan-Aspilcueta Julio
- Farias Eduardo
- Fekete Jozef
- Felicio Joao
- Fellstrom Bengt
- Fernandez Fresnedo Gema
- Fernandez Giraldez Elvira
- Fernando Ronald
- Fitz-Patrick David
- Flores Jose
- Foo Marjorie Wai Yin
- Fraenkel Margaret
- Fraige Filho Fadlo
- Frajewicki Victor
- Frias Juan
- Fried Linda
- Fu Ping
- Fu Shuxia
- Fujii Shinya
- Fujita Akira
- Fulopova Alla
- Fung Samuel
- Fung Yin Khet
- Furuya Ryuichi
- Fushtey Ivan
- Galan Antonio
- Galfre Andrea
- Galindo Ramos Eugenia
- Gallagher Martin
- Galphin Claude
- Galushchak Olga
- Gansevoort Ronald
- Gaona Raul
- Garcia Mendez Isabel
- Gesualdo Loreto
- Gilbert John
- Gillard Pieter
- Gnudi Luigi
- Godoy Gonzalo
- Goh Bak Leong
- Goldfarb David
- Golestaneh Laden
- Goluch Richard
- Gonzalez Gonzalez Jose
- Gonzalez Fernando
- Gonzalez-Galvez Guillermo
- Goto Daisuke
- Gouge Steven
- Goumenos Dimitrios
- Graf Ronald
- Greenwood Gregory
- Greloni Gustavo
- Guadiz Ramon
- Guasch Antonio
- Gundroo Aijaz
- Guo Xiaohui
- Gutierrez Vicente
- Halimi Jean-Michel
- Hall Karen
- Hames Melanie
- Hancu Nicolae
- Hanson Lenita
- Hao Chuanming
- Harada Hiroyuki
- Hashiguchi Yasuhiro
- Hassan Wan Hasnul Halimi Wan
- Hasslacher Christoph
- Heerspink Hiddo J L
- Hellberg Olof
- Herman Lee
- Hernandez-Jaras Julio
- Herrada Orue Benjamin
- Herrero Calvo Jose
- Hershon Kenneth
- Hirano Fuminori
- Honova Vaclava
- Horwitz Edward
- Hou Fan-Fan
- Hou Fanfan
- Hougardy Jean
- Huang Chien-Ning
- Hugo Christian
- Hussein Zanariah
- Iehara Noriyuki
- Iitsuka Tadashi
- Ijaz Adeel
- Ikeda Naoko
- Imura Mitsuo
- Inoue Toshihiko
- Ionutiu Lavinia
- Ishikawa Kazuo
- Ishiko Tamayo
- Israel Ezra
- Itabashi Naoki
- Ivanova Svetlana
- Iwaoka Hideaki
- Jabbour Serge
- Jadoul Michel
- Jamal Aamir
- James Sam
- Jang Hak Chul
- Jardula Michael
- Jere Charles
- Ji Linong
- Jia Weiping
- Jiang Ju-Ying
- John Rekha
- Jolly Shivinder
- Jones Audrey
- Joshi Sucharit
- Joshi Sudhir
- Juncos Luis
- Kalender Betul
- Kalirao Paramjit
- Kalra Phillip
- Kanai Hidetoshi
- Kaneko Shizuka
- Kantola Ilkka
- Kantor Samuel
- Karim Shahana
- Karonova Tatiana
- Karpova Irina
- Kashihara Naoki
- Kashine Susumu
- Kayali Zeid
- Keitel Elizete
- Kenis Irina
- Khandwala Hasnain
- Kim Beom Seok
- Kim Byung-Joon
- Kim In-Joo
- Kim Min Seon
- Kim Sang Yong
- Kim Sin-Gon
- Kishimoto Rui
- Kitzman Dalane W
- Kiyosue Arihiro
- Klimontov Vadim
- Klodawska Katarzyna
- Knobler Hilla
- Kobayashi Kunihisa
- Kohan Donald
- Kolenyk Mykola
- Kolesarova Eva
- Kolmakova Elena
- Kon Sui Phin
- Kopyt Nelson
- Korpachev Vadym
- Kosch Christine
- Kostynenko Tetyana
- Kosuge Keiichiro
- Kovesdy Csaba
- Koziolova Natalya
- Kronfli Saeed
- Kumar Jayant
- Kuskalo Petro
- Kuzin Anatoly
- Lahtela Jorma
- Lalwani Tarik
- Lantseva Olga
- Lauro Davide
- Laverman Gozewijn
- Lavin Peter
- Lawrence Mary
- Lee Hyoung Woo
- Lee Jae Hyuk
- Lee Joseph
- Lee Kang-Wook
- Lee Kwan Woo
- Lee Moon-Kyu
- Lee Sang Ah
- Leguizamo-Dimas Aniceto
- Legun Oleg
- Leite Silmara
- Leon-Forero Carlos
- Levin Ellis
- Levine Andrew
- Li Yuxiu
- Liakopoulos Vasilios
- Liberanskaya Natalia
- Lien Yeong-Hau
- Liew Adrian
- Lin Ching-Ling
- Link Michael
- Liss Kenneth
- Liu Bicheng
- Liu Zhangsuo
- Lui Sing Leung
- Luik Peter
- Lunt Helen
- Luo Qun
- Macisaac Richard
- Maddukuri Geetha
- Madero Rovalo Magdalena
- Madu Ivy-Joan
- Maeda Hajime
- Maeda Yoshitaka
- Maffei Laura
- Makan Hemant
- Makino Hirofumi
- Makino Shinya
- Makita Yuichiro
- Maksudova Adelya
- Malberti Fabio
- Mangoo-Karim Roberto
- Mankovskyy Borys
- Manley John
- Marasaev Vyacheslav
- Marder Bradley
- Marino Francesco
- Mark Patrick
- Markell Mariana
- Marques Vidas Maria
- Martins Munoz Judith
- Martynenko Vladimir
- Martynyuk Liliya
- Matsuda Hirofumi
- Matsuhisa Munehide
- Matsutani Akira
- Matta Fontanet Evelyn
- Mavromatidis Konstantinos
- Maxwell Peter
- Mayer Gert
- Mazur Stanislaw
- Mcfadden Christopher
- Mcmurray John J V
- Medina-Santander Boris
- Melish John
- Melnick Joel Z
- Menefee Judson
- Merican Nor Shaffinaz Yusuf Azmi
- Mersey James
- Milagres Rosangela
- Miller Alan
- Miller Michael G
- Miller Steven
- Minasian Raffi
- Minga Todd
- Minguela Pesquera Jose Ignacio
- Mistodie Cristina
- Mitha Essack
- Miyaoka Hiroaki
- Mohamed Mafauzy
- Mok Ji Oh
- Molas Coten Jose Ramon
- Montero Manuel
- Montero Nuria
- Mordovin Viktor
- Moura Neto Jose Andrade
- Moya Hechevarria Jaynier
- Muehlfeld Anja
- Mukasa Koji
- Mulloy Laura
- Munoz Rodrigo
- Muoneke Rosemary
- Nagai Sou
- Nagayama Koji
- Naiker Puvenesvari
- Naka Motoji
- Nakamura Takehiro
- Nakashima Eitaro
- Nakazawa Jun
- Nakhle Samer
- Nam-Goong Il-Seong
- Nammour Michael
- Nappi Felice
- Navarro Gonzalez Juan
- Nazeer Imran
- Necki Miroslaw
- Nesrallah Gihad
- Newman George
- Ni Zhaohui
- Nica Romanita
- Nik Ahmad Nik Nur Fatnoon
- Nimura Toshinori
- Nino-Cruz Jose
- Nishimura Motonobu
- Nowicki Michal
- O'Shaughnessy Andrew
- O'Shea Donal
- Obetkova Ida
- Oczachowska-Kulik Anna
- Oh Tae Keun
- Okamoto Hideki
- Oksa Adrian
- Onishi Yukiko
- Ono Keiko
- Ono Yasuhiro
- Oplustilova Alexandra
- Oroszova Aniko
- Osama Sayed
- Osonoi Takeshi
- Ostergaard Ove
- Ozaki Risa
- Panichi Vincenzo
- Panina Svitlana
- Park Kyong-Soo
- Park Tae-Sun
- Parving Hans-Henrik
- Paschoalin Raphael
- Pascual Julio
- Passadakis Ploumis
- Patel Dipesh
- Pavlova Maria
- Pecoits Filho Roberto
- Peguero-Rivera Alfredo
- Pei Dee
- Pergola Pablo
- Pergola Pablo E
- Perkovic Vlado
- Perlman Alan
- Petit Catherine
- Petr Martin
- Petrica Ligia
- Petrosyan Olena
- Phillips Lawrence
- Pichette Vincent
- Pikalova Natalia
- Pilmore Helen
- Pintilei Ella
- Pistrosch Frank
- Pollock Carol
- Pontoriero Giuseppe
- Popenda Grazyna
- Povlsen Johan
- Powell Thomas
- Praga Terente Manuel
- Prager Rudolf
- Prieto Velasco Mario
- Prompt Carlos Alberto
- Pugliese Giuseppe
- Punt Zelda
- Quesada-Suarez Luis
- Rabbat Christian
- Rabindranath Kannaiyan
- Ramlachan Padaruth
- Ramos Aura
- Rampino Teresa
- Raslova Katarina
- Rassi Nelson
- Rastogi Anjay
- Ravera Maura
- Rechkova Elena
- Reichel Ronald
- Reisin Efrain
- Rendell Marc
- Renoirte Lopez Karina
- Rico Hernandez Raul
- Riella Miguel Carlos
- Robey Brooks
- Rodriguez-Perez Jose
- Roger Simon
- Rombola Giuseppe
- Ropero-Cartier Armando
- Rosado Carlos
- Rosenberger Jaroslav
- Rossing Peter
- Roy Louise
- Ruggenenti Piero
- Russo Domenico
- Rychlik Ivan
- Saba Fadi
- Sakai Takashi
- Sakhrani Lakhi
- Salles Joao
- Samoylova Yulia
- Santamaria Olmo Rafael
- Santoro Domenico
- Santos Canani Luis
- Santos Juan
- Sari Ramazan
- Sasaki Hiromitsu
- Sasaki Nobuhiro
- Satman Ilhan
- Sato Nobuyuki
- Sato Toshiaki
- Sato Yuichi
- Sauque Reyna Leobardo
- Savin Virginia
- Sayfutdinov Rustam
- Schenkenberger Isabelle
- Schmidt Alice
- Schmidt Rebecca
- Schmidt-Guertler Hans
- Scott David
- Segiet Thomas
- Sekikawa Takashi
- Sensenbrenner John
- Seo Ji A
- Seron Daniel
- Sezer Siren
- Shahid Newman
- Shamkhalova Minara
- Shaw Sylvia
- Sheu Wayne
- Shi Bingyin
- Shi Wei
- Shibagaki Yugo
- Shin Mijung
- Shinoda Junji
- Shon Ho Sang
- Shvarts Yuri
- Siamopoulos Konstantinos
- Sigitova Olga
- Simon Eric
- Skokowska Ewa
- Sligh Teresa
- Sloan Lance
- Slover Judith
- Smak Gregoor Peter
- Smolko Peter
- Smolyarchuk Elena
- Solomon Richard
- Solovev Oleg
- Soto Gonzalez Alfonso
- Sreenan Seamus
- Stack Austin
- Stanislavchuk Mykola
- Stefanidis Ioannis
- Stoica George
- Strand Jorma
- Stranks Stephen
- Stryzhak Vasyl
- Su Benli
- Suh Sung Hwan
- Sukor Norlela
- Sun Shiren
- Suranyi Michael
- Suzuki Katsunori
- Szerlip Harold
- Tadika Takenobu
- Takeda Tetsuro
- Taliercio John
- Tam Paul
- Tan Kathryn
- Tanaka Tsuyoshi
- Tanaka Yukio
- Tang Sydney
- Tarkan Joshua
- Taya Noriyasu
- Tentolouris Nikolaos
- Teo Boon Wee
- Tesar Vladimir
- Thakar Charuhas
- Thomson Stephen
- Tien Kai-Jen
- Tietjen David
- Timar Romulus
- Tindall Hilary
- Tkac Ivan
- Tkach Sergii
- Tobe Sheldon
- Tobe Sheldon
- Tokui Mikiya
- Tomilina Natalia
- Topchii Ivan
- Toussaint Nigel
- Trokis Julien
- Tseng Shih-Ting
- Tsuchida Kenichi
- Tsujimoto Tetsuro
- Tsutsui Masahiro
- Tulloch Brian
- Tuta Liliana
- Tutescu Adriana
- Ueda Shinichiro
- Ujihara Makoto
- Umayahara Yutaka
- Urena Torres Pablo
- Vaithilingam Indralingam
- Valera Cortes Ildefonso
- Vallejos Augusto
- Van Vlem Bruno
- Van Zyl Louis
- Vargas-Gonzales Rolando
- Varghese Freemu
- Vazquez-Tanus Jose
- Vengadasalam V Paranthaman P
- Vercammen Chris
- Vicks Steven
- Vielhauer Volker
- Vijayasingham Shalini
- Villevalde Svetlana
- Vogel Daniel
- Vogt Liffert
- Wainstein Julio
- Wang Song
- Wanner Christoph
- Warling Xavier
- Watanabe Shuichi
- Weinstein Debra
- Weinstein Talia
- Weiss Robert
- Weng Jian
- Whaley-Connell Adam
- Wiecek Andrzej
- Wigderson Melissa
- Wise Jonathan
- Wong Hin Seng
- Woo Jeong-Taek
- Wruk Michal
- Wu Du-An
- Wu Mai-Szu
- Xiao Guanqing
- Xing Changying
- Xu Gang
- Xu Yan
- Yagil Yoram
- Yalcin Murat
- Yamada Daishiro
- Yamaguchi Yukinari
- Yamamoto Masahiro
- Yamauchi Akira
- Yambe Yuko
- Yang Jinkui
- Yavdosyuk Andrey
- Yeoh Lee Ying
- Yeung Vincent
- Yi Joo Hark
- Yi Tingting
- Yildiz Alaattin
- Yoo Soon-Jib
- Yoon Kun Ho
- Yoon Sun Ae
- Youmbissi Joseph
- Yu Shengqiang
- Yu Tae Yang
- Zahumensky Emil
- Zanella Maria
- Zaoui Philippe
- Zapata-Rincon Luis
- Zea-Nunez Carlos Antonio
- Zeig Steven
- Zhao Hongwen
- Zhao Jiajun
- Zhao Minghui
- Zieve Franklin
- Zolotaikina Viktoriia
- Zrazhevskiy Konstantin
- Zucchini Alfredo
- Zuo Li
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Short-term treatment for people with type 2 diabetes using a low dose of the selective endothelin A receptor antagonist atrasentan reduces albuminuria without causing significant sodium retention. We report the long-term effects of treatment with atrasentan on major renal outcomes. Methods: We did this double-blind, randomised, placebo-controlled trial at 689 sites in 41 countries. We enrolled adults aged 18–85 years with type 2 diabetes, estimated glomerular filtration rate (eGFR)25–75 mL/min per 1·73 m 2 of body surface area, and a urine albumin-to-creatinine ratio (UACR)of 300–5000 mg/g who had received maximum labelled or tolerated renin–angiotensin system inhibition for at least 4 weeks. Participants were given atrasentan 0·75 mg orally daily during an enrichment period before random group assignment. Those with a UACR decrease of at least 30% with no substantial fluid retention during the enrichment period (responders)were included in the double-blind treatment period. Responders were randomly assigned to receive either atrasentan 0·75 mg orally daily or placebo. All patients and investigators were masked to treatment assignment. The primary endpoint was a composite of doubling of serum creatinine (sustained for ≥30 days)or end-stage kidney disease (eGFR <15 mL/min per 1·73 m 2 sustained for ≥90 days, chronic dialysis for ≥90 days, kidney transplantation, or death from kidney failure)in the intention-to-treat population of all responders. Safety was assessed in all patients who received at least one dose of their assigned study treatment. The study is registered with ClinicalTrials.gov, number NCT01858532. Findings: Between May 17, 2013, and July 13, 2017, 11 087 patients were screened; 5117 entered the enrichment period, and 4711 completed the enrichment period. Of these, 2648 patients were responders and were randomly assigned to the atrasentan group (n=1325)or placebo group (n=1323). Median follow-up was 2·2 years (IQR 1·4–2·9). 79 (6·0%)of 1325 patients in the atrasentan group and 105 (7·9%)of 1323 in the placebo group had a primary composite renal endpoint event (hazard ratio [HR]0·65 [95% CI 0·49–0·88]; p=0·0047). Fluid retention and anaemia adverse events, which have been previously attributed to endothelin receptor antagonists, were more frequent in the atrasentan group than in the placebo group. Hospital admission for heart failure occurred in 47 (3·5%)of 1325 patients in the atrasentan group and 34 (2·6%)of 1323 patients in the placebo group (HR 1·33 [95% CI 0·85–2·07]; p=0·208). 58 (4·4%)patients in the atrasentan group and 52 (3·9%)in the placebo group died (HR 1·09 [95% CI 0·75–1·59]; p=0·65). Interpretation: Atrasentan reduced the risk of renal events in patients with diabetes and chronic kidney disease who were selected to optimise efficacy and safety. These data support a potential role for selective endothelin receptor antagonists in protecting renal function in patients with type 2 diabetes at high risk of developing end-stage kidney disease. Funding: AbbVie
Design and baseline characteristics of the finerenone in reducing cardiovascular mortality and morbidity in diabetic kidney disease trial
- Author
- Abdel-Rahman Emaad
- Abhayaratna Walter
- Abramof Ness Rosane
- Acosta Idalia
- Adams Atoya
- Adawi Faiad
- Adler Sharon
- Ahmed Fayzal
- Aizenberg Diego
- Ajani Dilawar
- Al-Karadsheh Amer
- Albota Adrian
- Alferi Dino
- Alicic Radica
- Alla Sreedhara
- Allison D
- Almeida Edgar
- Alpizar Salazar Melchor
- Amer Joseph
- Amod Aslam
- Andrawis Nabil
- Antonio Bossi Carlo
- Antsiferov Mikhail
- Antunes Daniela
- Araki Hideo
- Arango Clara
- Arcos Edgar
- Arif Ahmed
- Arif Imrozia
- Arkhipov Mikhail
- Armaly Zaher
- Aroca Gustavo
- Asprusten Emil
- Atar Shaul
- Avila Pardo Sandro
- Awad Ahmed
- Axthelm Christoph
- Azizad Masoud
- Azizah Aziz Nor
- B Brouwer C
- Babikova Jana
- Babkin Andrey
- Badak Ozer
- Bahrami Michael
- Bajcsi Dora
- Baker John
- Bala Cornelia
- Ballesteros Rosa
- Bansal Shweta
- Barag Steven
- Barakzoy Ahmad
- Baranov Vitaliy
- Barbarash Olga
- Barbonta Hortensia
- Barney Mark
- Barre Paul
- Barrera Sandra
- Barreto Carlos
- Barreto Germ\ue1n
- Bartolacci In\ue9s
- Bashir Khalid
- Bashkin Amir
- Bastidas Adrian Miriam
- Bautista Albert
- Bautista Jose
- Bech Jesper
- Beddhu Srinivasan
- Beltr\ue1n L\uf3pez Nelly
- Ben Chetrit Sydney
- Benitez Diego
- Benjamin Sabrina
- Berar Yanay Noa
- Berenji Ramin
- Bertram Pitt
- Bertsch John
- Besada Diego
- Bhana Sindeep
- Bhargava Anuj
- Bilz Stefan
- Birkenfeld Andreas
- Birriel Jose
- Bittar Julio
- Blanco Guillermo
- Bleich David
- Boletis Ioannis
- Bondarets Iryna
- Bonora Enzo
- Bornfreund Jonathan
- Boshnyashka Radostina
- Botelho Roberto
- Botero Rodrigo
- Botsyurko Volodymyr
- Bouarich Hanane
- Brada Michal
- Brandao Ilidio
- Brar Harjeet
- Braun Hermann
- Brezina Jiri
- Brian Susan
- Brietzke Stephen
- Brito Claudia
- Bruchfeld Annette
- Bruno Giorda Carlo
- Brusco Osvaldo
- Bu Ruifang
- Bucek Petr
- Buganova Ingrid
- Burgner Anna
- Busch Klaus
- Busch Robert
- Butrymowicz Patrycja
- C Bakker R
- C\ue1rdenas Tatiana
- Caceaune Elena
- Cai Hanqing
- Calabr\uf2 Paolo
- Calero Francesca
- Canadas Rafael
- Canani Luis
- Caramori Maria
- Cardona Jose
- Cariou Bertrand
- Carlo Maggi Davide
- Carlos Palma Juan
- Carlos Prieto Juan
- Carlson Brian
- Carpio Jose
- Carvalho Rui
- Case Christopher
- Castro Cristina
- Catindig Elizabeth
- Catrinoiu Doina
- Cayli Murat
- Cereto Castro Fernando
- Cerqueira Maria
- Chahin Mariano
- Chang Chiz-Tzung
- Chantrel Fran\ue7ois
- Chen Dejun
- Chen Nan
- Chen Qinkai
- Cheng Jinluo
- Chernikova Viktoriia
- Chernin Gil
- Chernyavskaya Elena
- Chew Wong Alfredo
- Christina Nowack
- Chuang Lee-Ming
- Chung ChoonHee
- Ciechanowski Kazimierz
- Cieslik Grazyna
- Cigarr\ue1n Guldris Secundino
- Cimino Roberto
- Clavel Sylvaine
- Clodi Martin
- Cobos Jorge
- Colman Peter
- Colquhoun David
- Constantin Ciprian
- Contzen Christel
- Conway James
- Coronel Julian
- Cortes-Maisonet Gregorio
- Cortes-Maisonet Gregorio
- Cournoyer Serge
- Crawford Veronica
- Cristina Gregorini Maria
- Cruz Humberto
- Cruzado Garrit Josep
- Cure Carlos
- Curiac Dan
- Cutfield Rick
- Dandillaya Ramprasad
- Dang Cuong
- Danos Peter
- Darawsha Mahmud
- de \uc1lvaro Fernando
- de Paula Rogerio
- Deerochanawong Chaicharn
- Degenhardt Stefan
- Demko Arkadiy
- Derwahl Karl
- Dhanireddy Soni
- Din Zia
- Distiller Larry
- Dixon Bradley
- Dolores Mart\uednez Esteban M\uaa
- Donath Marc
- Donets Oleksandra
- Dong Junwu
- Dong Youping
- Doshi Ankur
- Doubel Peter
- Dreval Alexander
- Drexel Heinz
- Du Yuming
- Dumas Richard
- Dumitrescu Adriana
- Dunn Peter
- Dur\ue1n Carlos
- Duyck Francis
- Dzupina Andrej
- E Costa Fernando Teixeira
- Ebenbichler Christoph
- Ebisui Osamu
- Edelsberger Tomas
- Edin Anton
- Eduardo Figueiredo Carlos
- Eduardo Salles Joao
- Efrati Shai
- Ekinci Elif
- El Shahawy Mahfouz
- El-Shahawy Mohammed
- Elbert Alicia
- Elias Mazen
- Eliaschewitz Freddy
- Eliasson Ken
- Emdin Michele
- Engelen Wendy
- Eren Necmi
- Eriksen Erik
- Ermakova Polina
- Escalada San Mart\uedn Javier
- Escobedo de la Pe\uf1a Jorge
- Esteves Cesar
- Eugenia Canziani Maria
- Eustace Joe
- Evans John
- Faber Jens
- Fadda George
- Fang Sum Chee
- Fang Yi
- Fangh\ue4nel Salm\uf3n Guillermo
- Farah Ghassan
- Farber Evgeny
- Farooq Umar
- Fauvel Jean-Pierre
- Fernando Roland
- Fiaccadori Enrico
- Fikry Sameh
- Fink Raymond
- Finnes Trine
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- First Brian
- Fitz-Patrick David
- Flack John
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- Fluck Patrick
- Fogelfeld Leon
- Fonseca Vivian
- Forti Adriana
- Franek Edward
- Frank Malin
- Frias Juan
- Fujita Naruhiro
- Furuya Ryuichi
- Fushtey Ivan
- G Lieverse A
- Galcer\ue1n Josep
- Gallouj Karim
- Galphin Claude
- Galyavich Albert
- Gansevoort Ron
- Garc\ueda Hern\ue1ndez Pedro
- Garc\ueda Luis
- Garcia-Mayol Luis
- Gaysina Leyla
- Gelersztein Elizabeth
- George L Bakris
- Georgiev Dimitar
- Gerasimos Filippatos
- Giebel Thomas
- Gillard Pieter
- Giorgio Battaglia Giovanni
- Gislason Gunnar
- Glandt Mariela
- Goldstein Gary
- Goluch Richard
- Gonz\ue1lez Albarr\ue1n Olga
- Gonz\ue1lez G\ue1lvez Guillermo
- Gonz\ue1lez Gonz\ue1lez Jos\ue9
- Gonz\ue1lez Fernando
- Gonzalez Edgar
- Gonzalez-Abreu Francisco
- Gordeev Ivan
- Gore Ashwini
- Gouet Didier
- Grachova Mariia
- Grant David
- Grossman Ehud
- Guan Tianjun
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- Guia Jose
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- Gumprecht Janusz
- Guo Weiying
- Guron Gregor
- Gushterova Valentina
- Guti\ue9rrez Ochoa Ramiro
- Guzm\ue1n Gustavo
- H Boonstra A
- H\uf8ivik Hans
- Habwe Violet
- Hagemeier Robert
- Hagenow Andreas
- Halabi Majdi
- Haller Hermann
- Halpern Stephen
- Hamamoto Yoshiyuki
- Hamasaki Akihiro
- Hamet Pavel
- Hamilton Maxine
- Hammoud Jamal
- Handelsman Stuart
- Hangaard J\uf8rgen
- Hanna Fahmy
- Hanusch Ursula
- Hao Chuanming
- Harcsa Eleonora
- Hart Randolph
- Hartman Israel
- Hasalova Zapletalova Jitka
- Hasnul Halimi Bin Wan Hasan Wan
- Hasslacher Christoph
- Hatazaki Masahiro
- Hatunic Mensud
- Hatziagelaki Erifili
- Hayashi Terumasa
- Heigerick Glenn
- Heitor Susana
- Hellberg Olof
- Hellgren Margareta
- Henein Sam
- Hern\ue1ndez Jaras Julio
- Hern\ue1ndez Eric
- Hernandez German
- Hernandez-Cassis Carlos
- Herrera Carlos
- Higashi Takayuki
- Hirohata Yoshihide
- Hissa Miguel
- Hoffmann Michal
- Hola Olga
- Holian John
- Honkasalo Mikko
- Honkasalo Mikko
- Horacek Thomas
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- Hornova Lucie
- Houdova Jana
- Hougardy Jean-Michel
- Hrmova Helena
- Humaloja Kari
- Hung Cheng-Chieh
- Hwang YouCheol
- Ibarra Jaime
- Ibern\uf3n Meritxell
- Imoto Hirofumi
- Inagaki Akemi
- Inagaki Masayuki
- Ioannidis Ioannis
- Ipatko Irina
- Iranmanesh Ali
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- Ishiko Tamayo
- Jackson Timothy
- Jain Mahendra
- Jamerson Kenneth
- Jansen van Rensburg Dirkie
- Jaramillo Carlos
- Jaramillo Nicol\ue1s
- Jaroslaw Pacyk Grzegorz
- Jiang Fangfang
- Jiang Ju-Ying
- Jiang Sheng
- Jinnouchi Hideaki
- Johnson Karen
- Joshi Mukesh
- Joshi Shaifali
- Juhl Claus
- Juli\ue1n Segura de la Morena Jos\ue9
- Jungmair Wolfgang
- Kahal Hassan
- Kalashnikova Marina
- Kalathil Dhanya
- Kalina Akos
- Kanai Hidetoshi
- Kananen Kristiina
- Kanda Daisuke
- Kanehara Hideo
- Kang JunGoo
- Kantola Ilkka
- Karasek David
- Karlsson Thomas
- Kashima Masayuki
- Kato Kiyoe
- Katsuki Takeshi
- Kattah William
- Kawamitsu Katsunori
- Kawasaki Satsuki
- Kayali Zeid
- Kaye William
- Kazup Szilvia
- Kelly Allan
- Keltai Katalin
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- Khan Bobby
- Khan Muhammad
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- Kilvert Anne
- Kim HyeSoon
- Kim InJoo
- Kim JaeHyeon
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- Kirschner Robert
- Kiss Julianna
- Klein Alexandre
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- Kloos Christof
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- Kosmacheva Elena
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- Kr\ufcger Thilo
- Krarup Thure
- Kravchun Nonna
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- Krebs Jeremy
- Kreit Camil
- Krekels Marielle
- Kriauciuniene Dovile
- Krishna Arvind
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- Kurnatowska Ilona
- Kusano Yoshiro
- Kutejova Vlasta
- Kvitkova Lyudmila
- Kyriakidou Christina
- L Penne E
- L\uf3pez M\uf3nica
- L\uf6ndahl Magnus
- La Manna Gaetano
- Lahtela Jorma
- Laimer Markus
- Lakha Deepak
- Lamboy Beata
- Landa Katarzyna
- Larnefeldt Hans
- Lasiene Jurate
- Lazcano Soto Jos\ue9
- LE Meur Yannick
- Lee ByungWan
- Lee Chien-Te
- Lee Keung
- Lee Paul
- Lee WooJe
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- Leite Jr Maurilo
- LeJeune Derek
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- Lerman Sam
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- Li Dongmei
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- Li Ling
- Li Yan
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- Liutkus Joanne
- Long Gang
- Loong Loh Chek
- Lora Henry
- Lu Guoyuan
- Lu Weiping
- Lu Yibing
- Lubanda Hana
- Lucheva Mariya
- Ludvik Bernhard
- Luigi Cavalot Franco
- Luis M Ruilope
- Lurie Alexander
- M Barendregt J N
- M van Leendert Ruud J
- M\ue9ndez Machado Gustavo
- M\ufcller Joachim
- Ma Jianhua
- MacIsaac Richard
- Maddukuri Geetha
- Madero Rovalo Magdalena
- Madore Francois
- Madrzejewski Adam
- Madsbad Sten
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- Magno Alexander
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- Makriniotou Ioanna
- Maletz Louis
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- Malyutina Sofya
- Mandayam Sreedhar
- Mandviwala Mustafa
- Mankovsky Borys
- Mann Mah Peak
- Manova Petya
- Mar\ueda Pascual Izuel Jos\ue9
- Marasaev Vyacheslav
- Mareev Vyacheslav
- Maria Veronelli Anna
- Markell Mariana
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- Martin Earl
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- Mazza Giuseppe
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- McMullen Dierdre
- Mediavilla Juan
- Medina Marcelo
- Meisner Carl
- Melo Pedro
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- Meyer Jill
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- Mileder Margit
- Min Cho Young
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- Minh Nui Nguyen
- Minkova Dotska
- Minton Stephen
- Mirasol Roberto
- Mistodie Cristina
- Mitha Essack
- Miyaoka Hiroaki
- Mkrtumyan Ashot
- Mo Zhaohui
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- Mokrejsova Magdalena
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- Monier Arnaud
- Montero Manuel
- Moranne Olivier
- Morita Takeshi
- Mosenzon Ofri
- Moustafa Moustafa
- Murao Satoshi
- Myshanych Halyna
- Myung Yu Jae
- Nadkarni Salil
- Nagy Laszlo
- Najme Khir Rizmy
- Nakayama Mikihiro
- Nakazawa Jun
- Nakhle Samer
- Napora Piotr
- Navarro Jesus
- Navickas Antanas
- Nechaeva Galina
- Negrisanu Gabriela
- Nelson Craig
- Neudorfer Peter
- Nevarez Ruiz Luis
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- Ngoc Nguyen Boi
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- Nicole Mentenich
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- Nikolaev Konstantin
- Nimer Assy
- Nina Petunina
- Nirmalaraj Kingsley
- Nischik Ruth
- Niu Jianying
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- Nomiyama Takashi
- Nonchev Boyan
- Noori Ebrahim
- Noritake Masayuki
- Noronha Irene
- Norwood Paul
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- Numrungroad Visal
- Nur Fatnoon Nik Ahmad Nik
- Nyirati Gabor
- O Donovan Richard
- O Keefe Dennis
- O Meara Yvonne
- Ochodnicka Zuzana
- Ocicka-Kozakiewicz Anna
- Odugbesan A
- Ogiwara Takayuki
- Oguz Aytekin
- Ohashi Hiroshi
- Okamoto Hideki
- Okenka Libor
- Oliver David
- Onaca Adriana
- Oparil Suzanne
- Osonoi Takeshi
- Ozdogan Oner
- P\ue9rez Manghi Federico
- Packham David
- Palyutin Shamil
- Pamugas Glenda
- Pang Ip Tai
- Pani Antonello
- Paoli-Bruno Jorge
- Paolino Bruno
- Papadopoulou Dorothea
- Papagianni Aikaterini
- Pape Alexia
- Paschoalin Nathalia
- Paschoalin Raphael
- Pascual Santos Julio
- Passadakis Ploumis
- Patel Rajesh
- Patel Rakesh
- Paulweber Bernhard
- Paveliu Silvia
- Pech\ue8re-Bertschi Antoinette
- Pecoits Filho Roberto
- Pedersen-Bjergaard Pedersen-Bjergaard Ulrik
- Peixoto Aldo
- Peng Ai
- Pereira Amalia
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- Perico Norberto
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- Peter Kolkhof
- Peterson Sean
- Petro Gizella
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- Pf\ufctzner Andreas
- Phi Kon Sui
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- Piatti PierMarco
- Pichmanova Mariyana
- Pimenov Leonid
- Pintilei Ella
- Pisani Antonio
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- Prabhakar Sharma
- Prager Rudolf
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- Prazny Martin
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- Prei f Wolfgang
- Prischl Friedrich
- Pumprla Jiri
- R Winkelmann Bernhard
- Radulian Gabriela
- Radzeviciene Lina
- Raina Rupesh
- Rajiv Agarwal
- Ramanathan Kodangudi
- Ramos L\uf3pez Gabriel
- Ramos-Gonez Luis
- Rangelov Rangel
- Ranjith Naresh
- Rashkov Rosen
- Rasmussen Ole
- Rastogi Anjay
- Ratnasingam Jeyakantha
- Rayner Brian
- Rea Rosangela
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- Red\uf3n Josep
- Reddan Donal
- Rein-Hedin Erik
- Reisin Efrain
- Rendell Marc
- Rewerska Barbara
- Reyes Eliana
- Rheeder Paul
- Ricardo Colomar Javier
- Rice Sam
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- Roger Simon
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- Romero Carmen
- Romeu Hugo
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- Rosario Francisco
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- Rose Ludger
- Ross Dennis
- Rossing Peter
- Rothman Jeffrey
- Roussel Ronan
- Roy-Chaudhury Prabir
- Rudofsky Gottfried
- Rudolph Lance
- Ruhullah Yusuf
- Rump Lars
- Ruoff Gary
- Rusicka Teresa
- Ruxer Jan
- Rymar Oksana
- Ryu Jeffrey
- S\ue1nchez Juan Carlos
- S\ue1nchez Gregorio
- Saavedra Victor
- Sadeharju Karita
- Sahani Mandeep
- Sahin Idris
- Salda\uf1a Mendoza Arturo
- Samuels Garfield
- San Tan Ru
- Sanabria Hugo
- Sanchez William
- Santamar\ueda Olmo Rafael
- Santorelli Gennaro
- Santoro Domenico
- Sardinov Ruslan
- Sari Ramazan
- Sarvan Mohamed
- Sasaki Nobuhiro
- Satirapoj Bancha
- Sauque Reyna Leobardo
- Saxena Sanjeev
- Sch\uf6ll Norbert
- Sch\uf6nherr Hans-Robert
- Sch\ufcrholz Thomas
- Scheen Andr\ue9
- Schernthaner Gerit-Holger
- Schettler Volker
- Schiefke Ingolf
- Schlichthaar Heike
- Schneider Karoly
- Schousboe Karoline
- Schr\uf6ppel Bernd
- Schwartz Daniel
- Schwartz Doron
- Scott David
- Scott Russell
- Seco Gilberto
- Seeber Mary
- Sekigami Taiji
- Sels\ue5s Hilde
- Semenova Olga
- Serhiyenko Oleksandr
- Seron Daniel
- Serota Harvey
- Serusclat Pierre
- Shafi Tariq
- Shahid Nauman
- Shanik Michael
- Sharma Santosh
- Shen Feixia
- Shen Jiansong
- Sherenkov Alexander
- Shi Bingyin
- Shibasaki Taro
- Shibata Hirotaka
- Shinoda Junji
- Shu Daniel
- Siebert Heidi
- Sigal Helena
- Silva Ana
- Silva Gil
- Simon Judit
- Sinha Arjun
- Skokowska Ewa
- Smelser James
- Smirnov Ivan
- Smith Mark
- Smolyarchuk Elena
- Smuts Nine
- Sobajima Hiroshi
- Soe Kyaw
- Sokolova Liubov
- Solache Ortiz Gustavo
- Soln\uf8r Leidulv
- Solomon Richard
- Solovev Oleg
- Soroka Eugene
- Sosovec Dalibor
- Soto Alfonso
- Soufer Joseph
- Sourij Harald
- Soveri Inga
- Spaak Jonas
- Speeckaert Marijn
- Spodniakova Denisa
- Sritara Piyamitr
- Stanchev Pavel
- Stankiewicz Andrzej
- Stas Koen
- Steele Andrew
- Stefan D Anker
- Stefanidis Ioannis
- Stemler Lutz
- Stephenson Hugo
- Stompor Tomasz
- Stoyanovska-Elencheva Bilyana
- Strack Georg
- Strand Jorma
- Strey Christopher
- Strongin Leonid
- Stryzhak Vasyl
- Su Qing
- Suarez Rosa
- Subramanian Bala
- Sue Kirkman M
- Sugitatsu Kazuya
- Sugiura Toshiyuki
- Sugiyama Toru
- Sulosaari Sakari
- Sun Zhuxing
- Suranyi Michael
- Suzuki Daisuke
- Suzuki Masaaki
- Swift Pauline
- Szerlip Harold
- Szilagyi Iosif
- Szocs Albert
- T Luik P
- T\ue4schner Heidrun
- Tagarev Zhivko
- Tamirisa Aparna
- Tanaka Asami
- Tanaka Seiichi
- Tang Shuifu
- Tanque Maribel
- Tarng Der-Cherng
- Tavli Talat
- Tayob Mohammed
- Teitelbaum Ivor
- Tellier Guy
- Temelkova-Kurktschieva Theodora
- Temizhan Ahmet
- Tengmark Bengt-Olov
- Tennankore Karthik
- Terront M\uf3nica
- Thomson Stephen
- Thorup Frode
- Tigen Mustafa
- Tirador Louie
- Tiuryn-Petrulewicz Agnieszka
- Tobe Sheldon
- Tomanek Pavel
- Tong Nanwei
- Tonolo Giancarlo
- Topliss Duncan
- Toursarkissian Nicole
- Tran Tuan-Huy
- Treger Richard
- Trevisan Roberto
- Trokis J
- Troya Maribel
- Trujillo Freddy
- Trullenque Gretel
- Tsch\uf6pe Diethelm
- Tsoukas George
- Tsunematsu Izumi
- Tu Shih-Te
- Turcu Liana
- Turk Thomas
- Tytus Richard
- Ujihara Makoto
- Ukhanova Olga
- Ulmer Achim
- Umpierrez Guillermo
- Urbach Daniel
- Urbach Dorothea
- Urbanaviciene Egle
- Urbonas Gediminas
- Urina Miguel
- Ustundag Sedat
- Vacaru Georgeta
- Valdes Martin
- Valdez Ortiz Rafael
- Valika Shujauddin
- Vallejos Augusto
- van Buren M
- van den Born Bert-Jan
- van der Giet Markus
- VAN Gaal Luc
- VAN Hoang Lam
- van Zyl Louis
- Vanbelleghem Hilde
- Vandeleur James
- Varleta Paola
- Vasas Szilard
- Vasconcellos Eduardo
- Vasileva Svetla
- Vega Damaris
- Velaviciene Audrone
- Vencio Sergio
- Verges Bruno
- Verlan Nadezhda
- Vi\uf1es Gloria
- Vijayaraman Arutchelvam
- Vila Lobos Ana
- Villagordoa Mesa Juan
- Villegas Iv\ue1n
- Vitou Louise
- Vlad Adrian
- Vlasenko Maryna
- Vorokhobina Natalya
- Wainstein Julio
- Wainstein Julio
- Walsh Michael
- Wan Ronald Ma Ching
- Wang Hao
- Wang Jianqin
- Wang Li
- Wang Lihua
- Wang Xinjun
- Wanner Christoph
- Wasilewska Katarzyna
- Wassermann Alfredo
- Wei Jiali
- Weisnagel Stanley
- Weissman Peter
- Whaley-Connell Adam
- Wierusz-Wysocka Bogna
- Wilderman Igor
- Winston Jonathan
- Wise Jonathan
- Wittert Gary
- Wnetrzak-Michalska Renata
- Wong Yuk-Ki
- Wu Chaoqing
- Wu Mai-Szu
- Wu Ming-Ju
- Wu Tianfeng
- Wudi Krisztina
- Wuerzner Gregoire
- Wynne Katie-Jane
- Xing Changying
- Xiong Fei
- Xu Ning
- Xu Xudong
- Yagil Yoram
- Yajima Ken
- Yakhontov Davyd
- Yale Jean-Francois
- Yamada Daishiro
- Yamada Masayo
- Yamagata Kazuo
- Yamakawa Fumiko
- Yamakawa Ken
- Yamasaki Yoshimitsu
- Yambe Yuko
- Yanai Hidekatsu
- Yang Jinkui
- Yasuda Tetsuyuki
- Yenicerioglu Yavuz
- Yeung Vincent
- Yilmaz Huseyin
- Yin Aiping
- Yoncheva-Mihaylova Mariana
- Young Park Cheol
- Yuan Lee Li
- Yupanqui Hern\ue1n
- Yuryev Michael
- Zakharova Elena
- Zalevskaya Alsu
- Zanozina Olga
- Zaoui Philippe
- Zeig Steven
- Zeng Longyi
- Zhang Hao
- Zhang Yanlin
- Zhang Ying
- Zhao Zhiquan
- Zhdanova Elena
- Zheng Hongguang
- Zhong Ling
- Zhong Liyong
- Zhu Dalong
- Zhukova Larisa
- Zilahi Zsolt
- Zsom Marianna
- Zukermann Robert
- Zykova Tatyana
- Publication venue
- 'S. Karger AG'
- Publication date
- 01/01/2019
- Field of study
Background: Among people with diabetes, those with kidney disease have exceptionally high rates of cardiovascular (CV) morbidity and mortality and progression of their underlying kidney disease. Finerenone is a novel, nonsteroidal, selective mineralocorticoid receptor antagonist that has shown to reduce albuminuria in type 2 diabetes (T2D) patients with chronic kidney disease (CKD) while revealing only a low risk of hyperkalemia. However, the effect of finerenone on CV and renal outcomes has not yet been investigated in long-term trials.
Patients and Methods: The Finerenone in Reducing CV Mortality and Morbidity in Diabetic Kidney Disease (FIGARO-DKD) trial aims to assess the efficacy and safety of finerenone compared to placebo at reducing clinically important CV and renal outcomes in T2D patients with CKD. FIGARO-DKD is a randomized, double-blind, placebo-controlled, parallel-group, event-driven trial running in 47 countries with an expected duration of approximately 6 years. FIGARO-DKD randomized 7,437 patients with an estimated glomerular filtration rate >= 25 mL/min/1.73 m(2) and albuminuria (urinary albumin-to-creatinine ratio >= 30 to <= 5,000 mg/g). The study has at least 90% power to detect a 20% reduction in the risk of the primary outcome (overall two-sided significance level alpha = 0.05), the composite of time to first occurrence of CV death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for heart failure.
Conclusions: FIGARO-DKD will determine whether an optimally treated cohort of T2D patients with CKD at high risk of CV and renal events will experience cardiorenal benefits with the addition of finerenone to their treatment regimen.
Trial Registration: EudraCT number: 2015-000950-39; ClinicalTrials.gov identifier: NCT02545049
Popular Irish drama in the decade leading up to the opening of the Abbey Theatre
- Publication venue
- Publication date
- 01/01/2004
- Field of study
EThOS - Electronic Theses Online ServiceGBUnited Kingdo
Robust and stable drinking behavior following long-term oral alcohol intake in rhesus macaques
- Author
- Amanda J. Roberts
- Brown
- Budygin
- Cadell
- Christopher C. Lay
- Clingerman
- Cressman
- Crowley
- Crowley
- Crowley
- Erwin
- Fincham
- Fitz-Gerald
- Grant
- Grant
- Grant
- Grant
- Green
- Higley
- Howard S. Fox
- Katner
- Michael A. Taffe
- Rebecca D. Crean
- Schweinsburg
- Shelton
- Simon N. Katner
- Sophia A. Davis
- Stefani N. Von Huben
- Stewart
- Tapert
- Tapert
- Tapert
- Vivian
- Vivian
- Williams
- Williams
- Publication venue
- 'Elsevier BV'
- Publication date
- Field of study
Pathogenic implications of distinct patterns of iron and zinc in chronic MS lesions
- Author
- A Creange
- B Todorich
- B Yao
- BF Popescu
- BF Popescu
- BF Popescu
- BF Popescu
- BF Popescu
- BN Patel
- Bogdan F. Popescu
- C Earl
- C Lopez-Garcia
- CF Lucchinetti
- Christopher A. Robinson
- CI Prodan
- CJ Frederickson
- Claudia F. Lucchinetti
- CM Poser
- D Finazzi
- D Kidd
- D Pitt
- D Tsang
- DL Schonberg
- E Madsen
- E Stephenson
- F Bagnato
- FD Lublin
- G Bartzokis
- G Ristori
- Graham N. George
- Guo Yong
- H Lassmann
- Hans Lassmann
- I Pelizzoni
- IJ Pickering
- Imke Metz
- Ingrid J. Pickering
- JE Holley
- JM Frischer
- JM Frischer
- Josa M. Frischer
- Joseph E. Parisi
- JP Rubio
- JR Connor
- JR Connor
- K Hopp
- K Schulz
- KI Rathore
- KJ Weigel
- L Zecca
- LJ Wu
- M Heidari
- M Heidari
- M Schrag
- MJ Hackett
- MJ O’Connell
- MJ Pushie
- MM Rahaman
- Mylyne Tham
- N Brown
- P Ferenci
- P Kursula
- Patrick D. Fitz-Gibbon
- R Dringen
- R Macco
- R Meguro
- Reginald C. Adiele
- RJ Ward
- RJ Ward
- RM Cornell
- RM Cornell
- S Hametner
- S Recalcati
- Samuel M. Webb
- SC Andrews
- Simon Hametner
- SM LeVine
- Stephen D. Weigand
- Susan Nehzati
- SW Hulet
- T Vogl
- V Mehta
- VJ Bush
- W Chua-anusorn
- W Zheng
- W Zheng
- WI McDonald
- WO Tobin
- Wolfgang Brück
- X Zhang
- X Zhang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Why Consider the Lighthouse a Public Good?
- Author
- A P Usher
- A Stevenson
- Alfred Marshall
- Alwyn A Ruddock
- Andrew Adams
- Anne O Krueger
- Armen A Alchian
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- C Kingston
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- Canada Province Du
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- D Stevenson
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- Eric Dolin
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- I I Barnett
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- Joseph Cotton
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- Kuniyoshi Saito
- Laurent Carnis
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- Lawerence W C Lai
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- Liam Clarke
- Maier-Rigaud
- Marc Valli�res
- Matthew Mckenzie
- Matthew Mckenzie
- Max Satchell
- Nathaniel Bowditch
- Paul A Samuelson
- Paul A Samuelson
- Paul A Samuelson
- Paul A Samuelson
- Peter J Boettke
- Peter T Leeson
- Pierre Camu
- Pierre Camu
- R Miller
- Ralph Davis
- Richard Cornes
- Richard Cornes
- Roger Clancy
- Ronald Eastman
- Ronald H Coase
- Ronald H Coase
- Ronald H Coase
- Rosolino A Candela
- Rosolino A Candela
- Rosolino A Candela
- Rosolino A Candela
- Rosolino Candela
- Sheilagh Ogilvie
- Simon Finger
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- Tyler Cowen
- Vincent Geloso
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- W G East
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- William A Baker
- William Jones
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- William Russell
- Yannis Bakos
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
- Author
- Abbott Benjamin P.
- Abbott Rich
- Abbott Thomas D.
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adams Thomas
- Addesso Paolo
- Adhikari Rana X.
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- Affeldt Christoph
- Afrough Mohammad
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- Willke Benno
- Wimmer Maximilian H.
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- Wipf Christopher C.
- Wittel Holger
- Woan Graham
- Woehler Janis
- Wofford Jared
- Wong K.W.K.
- Worden John
- Wright Jennifer L.
- Wu David S.
- Wysocki Daniel M.
- Xiao Sophia
- Yamamoto Hiro
- Yancey Cregg C.
- Yang Le
- Yap M.J.
- Yazback Maher
- Yu Hang
- Yu Haocun
- Yvert Michel
- Zadrożny Adam
- Zanolin Michele
- Zelenova Tatiana
- Zendri J.-P.
- Zevin Michael
- Zhang Liyuan
- Zhang Mi
- Zhang Teng
- Zhang Y.-H.
- Zhao Chunnong
- Zhou Minchuan
- Zhou Zifan
- Zhu Sylvia J.
- Zhu Xingjiang J.
- Zucker Michael E.
- Zweizig J.
- Publication venue
- 'American Physical Society (APS)'
- Publication date
- 01/01/2017
- Field of study
International audienceSpinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far
Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
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- David E.
- Jo F. J.
- Karl
- Loic
- Marc
- Nathan A.
- Romain
- Shreya
- a R.
- a Pratap K.
- Abbott Rich
- Abbott Thomas D.
- Abraham Sheelu
- Acernese Fausto
- Ackley Kendall
- Adams Carl
- Adhikari Rana X.
- Adya Vaishali B.
- Affeldt Christoph
- Agathos Michalis
- Agatsuma Kazuhiro
- Aggarwal Nancy
- Aguiar Odylio D.
- Aich Amit
- Aiello Lorenzo
- Ain Anirban
- Allen Gabrielle
- Allocca Annalisa
- Altin Paul A.
- am Manasadevi P.
- Amato Alex
- An
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- Anderson Stuart B.
- Anderson Warren G.
- Angelova
- Ankit
- Ansoldi Stefano
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- Ascenzi Stefano
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- Astone Pia
- Aubin Florian
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- y J.
- Yamamoto Hiro
- Yang Le
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- Yang Ziyan
- Yap Min-jet J.
- Yazback Maher
- Yeeles David W.
- Yiqiu Ma
- Yu Hang
- Yu Haocun
- Yuen Shingheirobin
- Zadrozny Adam
- Zadrozny Adam K.
- Zanolin Michele
- Zelenova Tatiana
- Zendri Jean-pierre
- Zevin Michael
- Zhang Jue
- Zhang Liyuan
- Zhang Teng
- Zhao Chunnong
- Zhao Guoying
- Zhou Minchuan
- Zhou Zifan
- Zhu Xingjiang J.
- Zimmerman Aaron B.
- Zucker Michael E.
- Zweizig John
- Publication venue
- 'Elsevier BV'
- Publication date
- 25/12/2019
- Field of study
Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and second observing runs. The main data products are gravitational-wave strain time series sampled at 16384 Hz. The datasets that include this strain measurement can be freely accessed through the Gravitational Wave Open Science Center at http://gw-openscience.org, together with data-quality information essential for the analysis of LIGO and Virgo data, documentation, tutorials, and supporting software
Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- A. Lina Rosengren
- Abram Burgher
- Adam B. Brosz
- Adam Rosen
- Adam Schwartz
- Adriana Sordo Duran
- Adrienna Marquez
- Adrienne E. Shapiro
- Aeiress Duhart
- Afsoon Roberts
- Albert Liu
- Alejandro Hoberman
- Alejandro Quintín Barrat Hernández
- Alex Greninger
- Alexander Clark
- Alfredo Gilberto Guerreros Benavides
- Alice McGarry
- Alicia Arrazcaeta
- Alisha Lutat
- Alison Bondell
- Alison Pellecchia
- Allie Oplinger
- Allison Green
- Allison O'Brien
- Alpa Patel
- Alyssa-Kay Peay
- Amanda Horn
- Amanda Lilienthal
- Amanda Occhino
- Amanda Philyaw
- Amaran Moodley
- Amber Grant
- Amber Stanford
- Amesika Nyaku
- Amie Shannon
- Amina Z. Haggag
- Amit Paliwal
- Amy Caldwell
- Amy Chamberlain
- Amy Dye
- Amy Falk
- Amy Kelley
- Amy Medina
- Amy Potts
- Amy Salzl
- Amy Sherman
- Amy Starr
- Amy Thompson
- Andrea Berry
- Andrea Clement
- Andrea Wendrow
- Andrea Zimmer
- Andres Bran
- Andres Camacho-Gonzalez
- Andrew Lauria
- Andrew McConnell
- Andrew McWilliams
- Anelgine C. Yoon
- Angela Lee
- Angela R. Branche
- Angelica Kottkamp
- Angella Webb
- Ann M. Milliken
- Ann R. Falsey
- Anna S. Lok
- Anna Wald
- Anne Marit de Groot
- Anne-Marie Rick
- Annette R. Bennett
- Annie Ciambruschini
- Annie Luetkemeyer
- Anthony Kim
- Anum Abbas
- Anyela Lara
- April Pixler
- Ariana C. Stanton
- Arthur L. Zemanek
- Asha Inniss
- Ashley Kennedy
- Ashley Perez
- Ashley Warden
- Asif Noor
- Atoya Adams
- Aurelio Cruz-Valdez
- Austin Chan
- Austin Swanson
- Ayanna Walters
- Ayoade Avworo
- Bailey Jordan
- Barbara Corral
- Barbara Rizzardi
- Barbara Rizzardi
- Barbara S. Taylor
- Barry S. Zingman
- Barton G. Williams
- Beatriz Grinsztejn
- Becky Martinez
- Ben Ladner
- Benjamin Eckhardt
- Benjamin J. Luft
- Bernard Grunstra
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- Uriel R. Felsen
- Valentine M. Ebuh
- Valeria D. Cantos
- Valerie K. Arnold
- Vanessa Abad
- Vanessa Raabe
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- Veronica Garcia-Fragoso
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- Victoria R. Anderson
- Vida Veronica Ruiz Herrera
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- Vincent Mirkil
- Vivek Rajasekhar
- Viviana Gonzalez
- Vladimir Berthaud
- Walter Patton
- Wanda Ramon
- Waseem Chughtai
- Wayne L. Harper
- Wayne Woo
- Wendell Lewis
- Wendell Lewis III
- Wendy A. Keitel
- Wesley Campbell
- Wesley Van Ever
- Westly Keating
- Whitney West
- Will Hernandez
- William B. Davis
- William B. Smith
- William H. Jones
- William Jennings
- William Kirby
- William P. Silver
- William R. Hartman
- William S. Davis Jr.
- William Schnitz
- William Seger
- Winniberg Stephany Alvarez León
- Winston Cavert
- Xiaomi Tong
- Yaa D. Oppong
- Yi H. Wu
- Ying Huang
- Yogesh K. Paliwal
- Youyi Fong
- Yunda Huang
- Yunda Huang
- Yvonne Davis
- Zachary Bittner
- Zainab Rizvi
- Zindy Yazmín Zárate Hinojosa
- Zudi-Mwak Takizala
- Publication venue
- Elsevier
- Publication date
- 01/10/2023
- Field of study
Summary: Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health
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Risk of COVID-19 after natural infection or vaccinationResearch in context
- Author
- Abad Vanessa
- Abate Getahun
- Abbas Anum
- Ackerman Jamie
- Ackerman Ronald
- Ackermann Jeremy
- Adams Atoya
- Adams Mark S.
- Adams Michael R.
- Adelglass Jeffrey
- Afework Sarah
- Ahmad Nina
- Akamine Christine
- Ake Julie A.
- Al-Ibrahim Mohamed S.
- Albert Gary
- Alcaide Maria L.
- Alderson Nathan
- Aleman Lily
- Alemán José O.
- Allaw Mohammed
- Alva E. Javier Pretell
- Alvarado Hilario
- Amador Carmen
- Andersen James
- Anderson Corey G.
- Anderson Evan J.
- Anderson Victoria R.
- Andes David R.
- Andrasik Michele P.
- Andree Stephanie
- Andrews Jeb
- Andriesen Jessica G.
- Andriulis Victoria
- Ansel Jessica L.
- Anthony Codi M.
- Antwi Mohammed
- Arduino Roberto C.
- Aristy Florida
- Arnold Valerie K.
- Arrazcaeta Alicia
- Atmar Robert L.
- Avworo Ayoade
- Bacher Christina
- Baden Lindsey R.
- Badillo Diana
- Bainbridge Emma
- Baka Michele
- Baker Sherrie
- Balani Bindu
- Ball Brandy
- Bances Karla Beatriz Tafur
- Baron Mira
- Barranco-Santana Elizabeth
- Bartilucci Darlene
- Bashour Jennifer
- Batteiger Teresa A.
- Baudelaire Clarisse
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- Belhorn Linda R.
- Benavides Alfredo Gilberto Guerreros
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- Bennett Annette R.
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- Beresnev Tatiana
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- Bermudez Maria I.
- Bernard Marcia
- Bernstein David I.
- Berry Andrea
- Berry Jennifer
- Berthaud Vladimir
- Bialobok Kristin
- Billings Joanne L.
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- Blevins Jeanne
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- Áñez Germán
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/10/2023
- Field of study
Background: While vaccines have established utility against COVID-19, phase 3 efficacy studies have generally not comprehensively evaluated protection provided by previous infection or hybrid immunity (previous infection plus vaccination). Individual patient data from US government-supported harmonized vaccine trials provide an unprecedented sample population to address this issue. We characterized the protective efficacy of previous SARS-CoV-2 infection and hybrid immunity against COVID-19 early in the pandemic over three-to six-month follow-up and compared with vaccine-associated protection. Methods: In this post-hoc cross-protocol analysis of the Moderna, AstraZeneca, Janssen, and Novavax COVID-19 vaccine clinical trials, we allocated participants into four groups based on previous-infection status at enrolment and treatment: no previous infection/placebo; previous infection/placebo; no previous infection/vaccine; and previous infection/vaccine. The main outcome was RT-PCR-confirmed COVID-19 >7–15 days (per original protocols) after final study injection. We calculated crude and adjusted efficacy measures. Findings: Previous infection/placebo participants had a 92% decreased risk of future COVID-19 compared to no previous infection/placebo participants (overall hazard ratio [HR] ratio: 0.08; 95% CI: 0.05–0.13). Among single-dose Janssen participants, hybrid immunity conferred greater protection than vaccine alone (HR: 0.03; 95% CI: 0.01–0.10). Too few infections were observed to draw statistical inferences comparing hybrid immunity to vaccine alone for other trials. Vaccination, previous infection, and hybrid immunity all provided near-complete protection against severe disease. Interpretation: Previous infection, any hybrid immunity, and two-dose vaccination all provided substantial protection against symptomatic and severe COVID-19 through the early Delta period. Thus, as a surrogate for natural infection, vaccination remains the safest approach to protection. Funding: National Institutes of Health