Difference in prevalence of common mental disorder as measured using four questionnaire delivery methods among young people in rural Zimbabwe.

BACKGROUND: Previous studies have suggested that interviewer-administered questionnaires can under-estimate the prevalence of depression and suicidal ideation when compared with self-administered ones. We report here on differences in prevalence of reporting mental health between four questionnaire delivery modes (QDM). METHODS: Mental health was assessed using the Shona Symptom Questionnaire (SSQ), a locally validated 14-item indigenous measure for common mental affective disorders. A representative sample of 1495 rural Zimbabwean adolescents (median age 18) was randomly allocated to one of four questionnaire delivery modes: self-administered questionnaire (SAQ), SAQ with audio (AASI), interviewer-administered questionnaire (IAQ), and audio computer-assisted survey instrument (ACASI). RESULTS: Prevalence of common affective disorders varied between QDM (52.3%, 48.6%, 41.5%, and 63.6% for SAQ, AASI, IAQ, and ACASI respectively (P<0.001)). Fewer participants failed to complete SSQ using IAQ and ACASI than other methods (1.6% vs. 12.3%; P<0.001). Qualitative data suggested that respondents found it difficult answering questions honestly in front of an interviewer. LIMITATIONS: Direction of accuracy cannot be ascertained due to lack of objective or clinical assessments of affective disorders. CONCLUSIONS: Estimates of prevalence of psychosomatic symptoms and suicidal ideation varied according to mode of interview. As each mode's direction of accuracy remains unresolved evaluations of interventions continue to be hampered

Ionized Nitrogen Mono-hydride Bands are Identified in the Pre-solar and Carbonado Diamond Spectra

None of the well established Nitrogen related IR absorption bands, common in synthetic and terrestrial diamonds, have been identified in the pre-solar diamond spectra. In the carbonado diamond spectra only the single nitrogen impurity (C centre) is identified and the assignments of the rest of the nitrogen-related bands are still debated. It is speculated that the unidentified bands in the Nitrogen absorption region are not induced by Nitrogen but rather by Nitrogen-hydrides because in the interstellar environment Nitrogen reacts with Hydrogen and forms NH+; NH; NH2; NH3. Among these Hydrides the electronic configuration of NH+ is the closest to Carbon. Thus this ionized Nitrogen-mono-hydride is the best candidate to substitute Carbon in the diamond structure. The bands of the substitutional NH+ defect are deduced by red shifting the irradiation induced N+ bands due to the mass of the additional Hydrogen. The six bands of the NH+ defects are identified in both the pre-solar and the carbonado diamond spectra. The new assignments identify all of the nitrogen-related bands in the spectra, indicating that pre-solar and carbonado diamonds contain only single nitrogen impurities

Endotracheal Intubation: The Role of Sterility

Background: There is a paucity of data regarding whether sterile handling of endotracheal tubes (ETTs) impacts the incidence and prevalence of pneumonia in the emergency, urgent, or elective clinical scenarios. Intensive care units employ infection control and reduction schemes to reduce pneumonia rates. Methods: A MEDLINE search of the English-language literature for the last 30 years was performed using the keywords “endotracheal intubation,” “intubation,” “pneumonia,” “sinusitis,” “tracheobronchitis,” “nosocomial infection,” and “infection.” Data were limited to those papers addressing the role of sterile handling or passage of ETTs, infection with antibiotic-resistant micro-organisms, antibiotic prophylaxis, and the role of virulence determinants in supporting invasive infection. Also, a convenience sample of a single author's patients requiring tracheal intubation was undertaken. Data were acquired on tube handling, success of insertion, and subsequent occurrence of pneumonia. Results: Virtually no data exist on the impact of sterile ETT handling, but unsterile manipulation of the ETT prior to insertion is common (112 of 154 intubation events). Within the limited patient sample, no conclusions may be drawn regarding the impact of unsterile handling on pneumonia rates, although sinusitis after nasotracheal intubation clearly increases the incidence of pneumonia. Biofilm generation as a facilitator of bacterial colonization of artificial airway surfaces is a ubiquitous virulence determinant that is not ameliorated by antibiotic administration. Conclusions: Unsterile ETT handling and insertion techniques are not clearly associated with pneumonia induction, but physiologically sound approaches that retard biofilm production may decrease pneumonia rates.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/63193/1/sur.2006.054.pd

The interplay of CMB temperature lensing power reconstruction with primordial non-Gaussianity of local type

In the current era of high-precision CMB experiments, the imprint of gravitational lensing on the CMB temperature is exploited as a source of valuable information. Especially the reconstruction of the lensing potential power spectrum is of great interest. The reconstruction from the optimal quadratic estimator of the lensing potential, though, is biased. As long as the intrinsic CMB fluctuations are Gaussian this bias is well understood and controlled. In the presence of non-Gaussian primordial curvature perturbations, however, the CMB also acquires a non-Gaussian structure mimicking the lensing signal. Concentrating on primordial non-Gaussianity of local type, we address the resulting bias by extracting the lensing potential power spectrum from large samples of simulated lensed CMB temperature maps comprising different values of f_NL. We find that the bias is considerably larger than previous analytical calculations suggested. For current values of f_NL and a sensitivity like that of the Planck mission, however, the bias is completely negligible on all but the largest angular scales.Comment: 8 pages, 4 figures, submitted to MNRA

Anopheles stephensi p38 MAPK signaling regulates innate immunity and bioenergetics during Plasmodium falciparum infection.

BackgroundFruit flies and mammals protect themselves against infection by mounting immune and metabolic responses that must be balanced against the metabolic needs of the pathogens. In this context, p38 mitogen-activated protein kinase (MAPK)-dependent signaling is critical to regulating both innate immunity and metabolism during infection. Accordingly, we asked to what extent the Asian malaria mosquito Anopheles stephensi utilizes p38 MAPK signaling during infection with the human malaria parasite Plasmodium falciparum.MethodsA. stephensi p38 MAPK (AsP38 MAPK) was identified and patterns of signaling in vitro and in vivo (midgut) were analyzed using phospho-specific antibodies and small molecule inhibitors. Functional effects of AsP38 MAPK inhibition were assessed using P. falciparum infection, quantitative real-time PCR, assays for reactive oxygen species and survivorship under oxidative stress, proteomics, and biochemical analyses.ResultsThe genome of A. stephensi encodes a single p38 MAPK that is activated in the midgut in response to parasite infection. Inhibition of AsP38 MAPK signaling significantly reduced P. falciparum sporogonic development. This phenotype was associated with AsP38 MAPK regulation of mitochondrial physiology and stress responses in the midgut epithelium, a tissue critical for parasite development. Specifically, inhibition of AsP38 MAPK resulted in reduction in mosquito protein synthesis machinery, a shift in glucose metabolism, reduced mitochondrial metabolism, enhanced production of mitochondrial reactive oxygen species, induction of an array of anti-parasite effector genes, and decreased resistance to oxidative stress-mediated damage. Hence, P. falciparum-induced activation of AsP38 MAPK in the midgut facilitates parasite infection through a combination of reduced anti-parasite immune defenses and enhanced host protein synthesis and bioenergetics to minimize the impact of infection on the host and to maximize parasite survival, and ultimately, transmission.ConclusionsThese observations suggest that, as in mammals, innate immunity and mitochondrial responses are integrated in mosquitoes and that AsP38 MAPK-dependent signaling facilitates mosquito survival during parasite infection, a fact that may attest to the relatively longer evolutionary relationship of these parasites with their invertebrate compared to their vertebrate hosts. On a practical level, improved understanding of the balances and trade-offs between resistance and metabolism could be leveraged to generate fit, resistant mosquitoes for malaria control

Unparticle Induced Baryon Number Violating Nucleon Decays

We study baryon number violating nucleon decays induced by unparticle interactions with the standard model particles. We find that the lowest dimension operators which cause nucleon decays can arise at dimension 6 + (d_s-3/2) with the unparticles being a spinor of dimension d_s=d_\U +1/2. For scalar and vector unparticles of dimension d_\U, the lowest order operatoers arise at 6+d_\U and 7+d_\U dimensions,respectively. Comparing the spinor unparticle induced n \to O^s_\U and experimental bound on invisible decay of a neutron from KamLAND, we find that the scale for unparticle physics is required to be larger than 10^{10} GeV for d_\U < 2 if the couplings are set to be of order one. For scalar and vector unparticles, the dominant baryon number violating decay modes are n\to \bar \nu + O_\U (O^\mu_\U) and p \to e^+ + O_\U (O^\mu_\U). The same experimental bound puts the scales for scalar and vector unparticle to be larger than 10^{7} and 10^{5} GeV for d_\U <2 with couplings set to be of order one. Data on, p \to e^+ invisible, puts similar constraints on unparticle interactions.Comment: Latex 10 pages with two figure

Socio-economic conditions and small business vulnerability to climate change impacts in Hong Kong

Small and micro businesses bear the brunt of climate change impacts in the climate-challenged economy. Vulnerability is embedded into the socio-economic trajectories of their primary decision-makers. Multiple vulnerabilities may arise if the decision-makers’ socio-economic conditions are associated with climate-sensitive business characteristics. Previous research has provided little evidence on such linkages, thus losing insights into how different facets of vulnerability interact and evolve over time. This paper explores the interactions between elements of small business vulnerability and the socio-economic characteristics of their primary decision-makers. It draws on the results of a survey involving 116 owner-managers of small and micro businesses and in-depth interviews with a sub-sample. Study areas are three remote coastal communities in Hong Kong exposed to high floods. Results show that such interactions exist in multiple, non-linear ways. Socio-economic disadvantages (i.e. low education attainment, old age, low income, and female) are related to some aspects of small business vulnerability, while playing a role in mitigating or avoiding other aspects of it. The findings call for building frameworks that account for the multiple spheres in which vulnerabilities are engendered and their interactions, while allowing for complexities and feedback mechanisms

An empirical comparison of convertible bond valuation models

This paper empirically compares three convertible bond valuation models. We use an innovative approach where all model parameters are estimated by the Marquardt algorithm using a subsample of convertible bond prices. The model parameters are then used for out-of-sample forecasts of convertible bond prices. The mean absolute deviation is 1.86% for the Ayache-Forsyth-Vetzal model, 1.94% for the Tsiveriotis-Fernandes model, and 3.73% for the Brennan-Schwartz model. For this and other measures of fit, the Ayache-Forsyth-Vetzal and Tsiveriotis-Fernandes models outperform the Brennan-Schwartz model

A Chandra view of NGC 3621: a bulgeless galaxy hosting an AGN in its early phase?

We report the detection of a weak X-ray point source coincident with the nucleus of the bulgeless disk galaxy NGC 3621, recently discovered by Spitzer to display high ionization mid-infrared lines typically associated with AGN. These Chandra observations provide confirmation for the presence of an AGN in this galaxy, adding to the growing evidence that black holes do form and grow in isolated bulgeless disk galaxies. Although the low signal-to-noise ratio of the X-ray spectrum prevents us from carrying out a detailed spectral analysis of the nuclear source, the X-ray results, combined with the IR and optical spectroscopic results, suggests that NGC 3621 harbors a heavily absorbed AGN, with a supermassive black hole of relatively small mass accreting at a high rate. Chandra also reveals the presence of two bright sources straddling the nucleus located almost symmetrically at 20" from the center. Both sources have X-ray spectra that are well-fitted by an absorbed power-law model. Assuming they are at the distance of NGC 3621, these two sources have luminosities of the order of 1.e39 erg/s, which make them ULXs and suggest that they are black hole systems. Estimates of the black hole mass based on the X-ray spectral analysis and scaling laws of black hole systems suggest that the 2 bright sources might be intermediate mass black holes with M_BH of the order of a few thousand solar masses. However, higher quality X-ray data combined with multi-wavelength observations are necessary to confirm these conclusions.Comment: 12 pages, 9 figures, 1 table, accepted for publication in Ap