Mapping temporal dynamics in social interactions with unified structural equation modeling: A description and demonstration revealing time-dependent sex differences in play behavior

Developmental science is rich with observations of social interactions, but few available methodological and statistical approaches take full advantage of the information provided by these data. The authors propose implementation of the unified structural equation model (uSEM), a network analysis technique, for observational data coded repeatedly across time; uSEM captures the temporal dynamics underlying changes in behavior at the individual level by revealing the ways in which a single person influences – concurrently and in the future – other people. To demonstrate the utility of uSEM, the authors applied it to ratings of positive affect and vigor of activity during children’s unstructured laboratory play with unfamiliar, same-sex peers. Results revealed the time-dependent nature of sex differences in play behavior. For girls more than boys, positive affect was dependent upon peers’ prior positive affect. For boys more than girls, vigor of activity was dependent upon peers’ current vigor of activity.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/123050/1/Mapping temporal dynamics in social interactions with unified structural equation modeling_ A description and demonstration revealing time-dependent sex differences in play behavior.pd

The Mass Distribution of Stellar Black Holes

We examine the distribution of masses of black holes in transient low mass X-ray binary systems. A Bayesian analysis suggests that it is probable that six of the seven systems with measured mass functions have black hole masses clustered near seven solar masses. There appears to be a significant gap between the masses of these systems and those of the observed neutron stars. The remaining source, V404 Cyg, has a mass significantly larger than the others, and our analysis suggests that it is probably drawn from a different distribution. Selection effects do not appear to play a role in producing the observed mass distribution, which may be explained by currently unknown details of the supernova explosions and of binary evolution prior to the supernova.Comment: 22 pages including figures, submitted to Ap

A Population of Faint Non-Transient Low Mass Black Hole Binaries

We study the thermal and viscous stability of accretion flows in Low Mass Black Hole Binaries (LMBHBs). We consider a model in which an inner advection-dominated accretion flow (ADAF) is surrounded by a geometrically thin accretion disk, the transition between the two zones occurring at a radius R_tr. In all the known LMBHBs, R_tr appears to be such that the outer disks could suffer from a global thermal-viscous instability. This instability is likely to cause the transient behavior of these systems. However, in most cases, if R_tr were slightly larger than the estimated values, the systems would be globally stable. This suggests that a population of faint persistent LMBHBs with globally stable outer disks could be present in the Galaxy. Such LMBHBs would be hard to detect because they would lack large amplitude outbursts, and because their ADAF zones would have very low radiative efficiencies, making the systems very dim. We present model spectra of such systems covering the optical and X-ray bands.Comment: LateX, 37 pages, 11 figures; Accepted for publication in The Astrophysical Journa

Personalized treatment of adult depression: medication, psychotherapy, or both? A systematic review

Background Personalized medicine aims to identify which characteristics of an individual predict the outcome of a specific treatment, in order to get a better match between the individual and the treatment received. We conducted a systematic review and meta-analysis of randomized trials comparing two treatments directly in a group of patients with a specific characteristic. Methods We searched relevant studies from bibliographical databases and included trials comparing (1) medication with psychotherapy, (2) medication with combined treatment, and (3) psychotherapy with combined treatment, in specific target groups (a) with a predefined sociodemographic characteristic, (b) a specific type of depression, (c) a comorbid mental or somatic disorder, or (d) from a specific setting (outpatients, primary care). Results We included 52 studies with 4,734 depressed patients. In these studies, 20 characteristics of the target groups were examined. The results showed that medication is probably the best treatment for dysthymia, and combined treatments are more effective in depressed outpatients, as well as in depressed older adults. However, in order to examine the 20 characteristics in the three categories of comparisons, 254 studies would be needed for having sufficient statistical power to show an effect size of g = 0.5. Currently, only 20.1% of these studies have been conducted. Conclusions Although a considerable number of studies have compared medication, psychotherapy, and combined treatments, and some preliminary results are useful for deciding which treatment is best for which patient, the development of personalized treatment of depression has only just begun

A peptide-duocarmycin conjugate targeting the Thomsen-Friedenreich antigen has potent and selective antitumour activity

Solid phase synthesis allowed the rapid generation of a peptide-drug conjugate. A peptide targeting the Thomsen-Friedenreich antigen (TFα) was conjugated to the alkylating subunit of the potent cytotoxin duocarmycin SA. The compound, containing a cathepsin B cleavable linker, was shown to be active and selective against TFα expressing tumour cell lines

Long-term optical/infrared variability in the quiescent X-ray transient V404 Cyg

We present the results of optical and infrared photometry of the quiescent X-ray transient V404 Cyg during the period 1992-2003. The ellipsoidal modulations extracted from the most complete databases (years 1992, 1998 and 2001) show unequal maxima and minima with relative strength varying from year to year although their peak to peak amplitudes remain roughly constant at 0.24+-0.01 magnitudes. Fast optical variations superimposed on the secondary star's double-humped ellipsoidal modulation were detected every year with a mean amplitude of ~0.07 mags. We have not found significant changes in the activity during this decade which indicates that this variability is probably not connected to the 1989 outburst. We have found periodicities in the 1998 and 2001 data near the 6 hr quasi-periodicity observed in 1992, although we interpret it as consequence of the appearance of a flare event almost every night. Significant variability is also present in the I and near infrared (J and K_short) bands and this decreases slightly or remains approximately constant at longer wavelengths. A cross correlation analysis shows that both the R and I emission are simultaneous down to 40 s.Comment: 13 pages, 11 figures; accepted for publication in MNRA

BlackCAT: A catalogue of stellar-mass black holes in X-ray transients

During the last ~50 years, the population of black hole candidates in X-ray binaries has increased considerably with 59 Galactic objects detected in transient low-mass X-ray binaries, plus a few in persistent systems (including ~5 extragalactic binaries). We collect near-infrared, optical and X-ray information spread over hundreds of references in order to study the population of black holes in X-ray transients as a whole. We present the most updated catalogue of black hole transients, which contains X-ray, optical and near-infrared observations together with their astrometric and dynamical properties. It provides new useful information in both statistical and observational parameters providing a thorough and complete overview of the black hole population in the Milky Way. Analysing the distances and spatial distribution of the observed systems, we estimate a total population of ~1300 Galactic black hole transients. This means that we have already discovered less than ~5% of the total Galactic distribution. The complete version of this catalogue will be continuously updated online and in the Virtual Observatory, including finding charts and data in other wavelengths.Comment: http://www.astro.puc.cl/BlackCAT - Accepted for publication in Astronomy & Astrophysics. 20 pages, 8 figures, 5 Table

Human monoclonal antibodies against Staphylococcus aureus surface antigens recognize in vitro and in vivo biofilm

Implant-associated Staphylococcus aureus infections are difficult to treat because of biofilm formation. Bacteria in a biofilm are often insensitive to antibiotics and host immunity. Monoclonal antibodies (mAbs) could provide an alternative approach to improve the diagnosis and potential treatment of biofilm-related infections. Here, we show that mAbs targeting common surface components of S. aureus can recognize clinically relevant biofilm types. The mAbs were also shown to bind a collection of clinical isolates derived from different biofilm-associated infections (endocarditis, prosthetic joint, catheter). We identify two groups of antibodies: one group that uniquely binds S. aureus in biofilm state and one that recognizes S. aureus in both biofilm and planktonic state. Furthermore, we show that a mAb recognizing wall teichoic acid (clone 4497) specifically localizes to a subcutaneously implanted pre-colonized catheter in mice. In conclusion, we demonstrate the capacity of several human mAbs to detect S. aureus biofilms in vitro and in vivo