Preliminary study of La Cañada del Arco’s Roman aqueduct. Municipalities of Calicasas and Albolote (Granada)

La localización de distintos restos arqueológicos junto a la Cañada del Arco, entre el Barranco Quitasueños (Albolote) y el Río Bermejo (Calicasas), correspondientes a un tramo de un acueducto romano de unos 6 km de longitud, ha motivado la realización de un estudio arqueológico preliminar de estos restos hidráulicos con el objeto de contextualizarlos histórica y geográficamente. Aunque algunos de estos restos fueron dados a conocer por Fernández Casado en 1972 su ubicación exacta se desconocía hasta ahora.The location of several archaeological remains next to Cañada del Arco, between Barranco Quitasueños (Albolote) and the Bermejo River (Calicasas), corresponding to approximately 6 km long stretch of a roman aqueduct, has led to a preliminary archaeological study of these water remains in order to provide a historical and geographical context for them. Although some of these remains were discovered in 1972 by Fernández Casado their exact location has been unknown until now

Estudio preliminar de los elementos constructivos hidráulicos de época romana del río Cubillas (tramo Deifontes-Albolote, Granada).

El área de estudio, el Valle del Río Cubillas, en su curso medio, también denominado localmente Río Deifontes o Río Iznalloz al paso por las localidades de Iznalloz, Deifontes y Albolote, se ubica, desde el punto de vista geográfico, en el extremo nororiental de la Depresión de Granada. Dicha Depresión constituye una de las cuencas internas intramontañosas de las Cordilleras Béticas 2 . Los materiales sobre los que se encaja el Valle del Río Cubillas son arcillas, limos rojos y conglomerados de Edad Pliocuaternaria (Plioceno Superior-Pleistoceno). Aparecen, además, otros más recientes que se relacionan con los depósitos subactuales y actuales del propio río junto a la descarga de sedimentos que se produce a través de los cauces tributarios, y que se corresponden con los de relleno del cau­ce y de la llanura de inundación actual, lo que hace que en la mayoría de las ocasiones gran parte de los restos arqueológicos en relación con las construcciones hidráulicas estudiadas se vean afectados, en mayor o menor medida, por estos aportes sedimentarios del río. Se tratan principalmente de arcillas, limos y, en menor medida, arenas con cantos. Todos estos aportes han constituido una base actual de tierras con gran calidad y muy fértiles para el desarrollo de la agricultura

El ager Ilurconensis

In this article we are presented with all the data related to the Roman settlement of the basin of the rivers Velillos and Genil, and brooks Charcón, Brácana and Molinos from an epigraphical, archaeological and toponymycal point of view.En este artículo se dan a conocer los datos relativos a la implantación del poblamiento romano en las cuencas de los ríos Velillos y Genil, y arroyos del Charcón, Brácana y Molinos desde el punto de vista epigráfico, arqueológico y toponímico

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Atlas de las praderas marinas de España

Knowledge of the distribution and extent of seagrass habitats is currently the basis of management and conservation policies of the coastal zones in most European countries. This basic information is being requested through European directives for the establishment of monitoring programmes and the implementation of specific actions to preserve the marine environment. In addition, this information is crucial for the quantification of the ecological importance usually attributed to seagrass habitats due to, for instance, their involvement in biogeochemical cycles, marine biodiversity and quality of coastal waters or global carbon budgets. The seagrass atlas of Spain represents a huge collective effort performed by 84 authors across 30 Spanish institutions largely involved in the scientific research, management and conservation of seagrass habitats during the last three decades. They have contributed to the availability of the most precise and realistic seagrass maps for each region of the Spanish coast which have been integrated in a GIS to obtain the distribution and area of each seagrass species. Most of this information has independently originated at a regional level by regional governments, universities and public research organisations, which explain the elevated heterogeneity in criteria, scales, methods and objectives of the available information. On this basis, seagrass habitats in Spain occupy a total surface of 1,541,63 km2, 89% of which is concentrated in the Mediterranean regions; the rest is present in sheltered estuarine areas of the Atlantic peninsular regions and in the open coastal waters of the Canary Islands, which represents 50% of the Atlantic meadows. Of this surface, 71.5% corresponds to Posidonia oceanica, 19.5% to Cymodocea nodosa, 3.1% to Zostera noltii (=Nanozostera noltii), 0.3% to Zostera marina and 1.2% to Halophila decipiens. Species distribution maps are presented (including Ruppia spp.), together with maps of the main impacts and pressures that has affected or threatened their conservation status, as well as the management tools established for their protection and conservation. Despite this considerable effort, and the fact that Spain has mapped wide shelf areas, the information available is still incomplete and with weak precision in many regions, which will require an investment of major effort in the near future to complete the whole picture and respond to demands of EU directives

Pasados y presente. Estudios para el profesor Ricardo García Cárcel

Ricardo García Cárcel (Requena, 1948) estudió Historia en Valencia bajo el magisterio de Joan Reglà, con quien formó parte del primer profesorado de historia moderna en la Universidad Autónoma de Barcelona. En esta universidad, desde hace prácticamente cincuenta años, ha desarrollado una extraordinaria labor docente y de investigación marcada por un sagaz instinto histórico, que le ha convertido en pionero de casi todo lo que ha estudiado: las Germanías, la historia de la Cataluña moderna, la Inquisición, las culturas del Siglo de Oro, la Leyenda Negra, Felipe II, Felipe V, Austrias y Borbones, la guerra de la Independencia, la historia cultural, los mitos de la historia de España... Muy pocos tienen su capacidad para reflexionar, ordenar, analizar, conceptualizar y proponer una visión amplia y llena de matices sobre el pasado y las interpretaciones historiográficas. A su laboriosidad inimitable se añade una dedicación sin límites en el asesoramiento de alumnos e investigadores e impulsando revistas, dosieres, seminarios o publicaciones colectivas. Una mínima correspondencia a su generosidad lo constituye este volumen a manera de ineludible agradecimiento

Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes

Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues

Computational advances in polynomial optimization: RAPOSa, a freely available global solver

[Abstract]: In this paper we introduce RAPOSa, a global optimization solver specifically designed for (continuous) polynomial programming problems with box-constrained variables. Written entirely in C++, RAPOSa is based on the Reformulation-Linearization (Sherali and Tuncbilek in J Glob Optim 103:225–249, 1992). We present a description of the main characteristics of RAPOSa along with a thorough analysis of the impact on its performance of various enhancements discussed in the literature, such as bound tightening and SDP cuts. We also present a comparative study with three of the main state-of-the-art global optimization solvers: BARON, Couenne and SCIP.Ministerio de Ciencia y Tecnología; PID2021-124030NB-C32Ministerio de Educación; FPU Grant 17/02643Xunta de Galicia; ED431C-2020-14Xunta de Galicia; ED431G2019/0