1,323 research outputs found

    Historia de los reyes godos que vinieron de la Scythia de Europa contra el Imperio romano y a España, con sucession dellos hasta los catolicos reyes Don Fernando y Doña Isabel

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010ColofónSign.: [calderón]\p4\s, 2[calderón]\p8\s, A-Z\p8\s, 2A-2G\p8\s, 2H\p6\s, 2I\p8\s, 2K\p6\s, 2L\p4\sTexto a dos col. y con apostillas marginalesLas [3] h. de grab. calc

    Oracion del divino Hyerotheo : sol español que en la esphera de Grecia, fue iuez del Areopago, y primer Obispo de Atenas ...

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Prelim. fechados en 1662Sign.: []4, A-C4Port. con orla tip.Apostillas marginale

    Triunfos y penas del mas soberano Alcides, muerte del divino Adonis ... oracion panegyrica

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    Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-2010Sign.: A4-C4, D3Apostillas marginalesPort. orlada tip

    Crónica del rey don Enrique el Quarto de este nombre

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    Sign.: A-Z4, 2A-2V4, 2XAl final la Tabla de los capítulos p. 135-145. - Sign.: [], S4, T1Copia digital. Valladolid : Junta de Castilla y León. Consejería de Cultura y Turismo, 2009-201

    Search for new phenomena in final states with an energetic jet and large missing transverse momentum in pp collisions at √ s = 8 TeV with the ATLAS detector

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    Results of a search for new phenomena in final states with an energetic jet and large missing transverse momentum are reported. The search uses 20.3 fb−1 of √ s = 8 TeV data collected in 2012 with the ATLAS detector at the LHC. Events are required to have at least one jet with pT > 120 GeV and no leptons. Nine signal regions are considered with increasing missing transverse momentum requirements between Emiss T > 150 GeV and Emiss T > 700 GeV. Good agreement is observed between the number of events in data and Standard Model expectations. The results are translated into exclusion limits on models with either large extra spatial dimensions, pair production of weakly interacting dark matter candidates, or production of very light gravitinos in a gauge-mediated supersymmetric model. In addition, limits on the production of an invisibly decaying Higgs-like boson leading to similar topologies in the final state are presente

    Systemic treatment with pulsed electromagnetic fields do not affect bone microarchitecture in osteoporotic rats

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    Purpose: Pulsed electromagnetic fields (PEMF) are currently used in the treatment of spinal fusions and non-unions. There are indications that PEMF might also be effective in the treatment of osteoporosis. In this study we examined whether whole-body PEMF treatment affects the bone microarchitecture in an osteoporotic rat model. Methods: Twenty-week-old female rats were ovariectomised (n020). Four different PEMF treatment protocols based on previous experimental studies and based on clinically used PEMF signals were examined (2 h/day, 5 days/week). A control group did not receive PEMF. At zero, three and six weeks cancellous and cortical bone architectural changes at the proximal tibia were evaluated using in vivo microCT scanning. Results: PEMF treatment did not induce any changes in cancellous or cortical bone compared to untreated controls. Conclusions: Although previous studies have shown strong effects of PEMF in osteoporosis we were unable to demonstrate this in any of the treatment protocols. Using in vivo microCT scanning we were able to identify small bone changes in time. Subtle differences in the experimental setup might explain the differences in study outcomes in the literature. Since PEMF treatment is safe, future experimental studies on the effect of PEMF on bone can better be performed directly on humans, eliminating the potential translation issues between animals and humans. In this study we found no support for the use of PEMF in the treatment of osteoporosis

    Immunosenescence and lymphomagenesis

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    One of the most important determinants of aging-related changes is a complex biological process emerged recently and called \u201cimmunosenescence\u201d. Immunosenescence refers to the inability of an aging immune system to produce an appropriate and effective response to challenge. This immune dysregulation may manifest as increased susceptibility to infection, cancer, autoimmune disease, and vaccine failure. At present, the relationship between immunosenescence and lymphoma in elderly patients is not defined in a satisfactory way. This review presents a brief overview of the interplay between aging, cancer and lymphoma, and the key topic of immunosenescence is addressed in the context of two main lymphoma groups, namely Non Hodgkin Lymphoma (NHL) and Hodgkin Lymphoma (HL). Epstein Barr Virus (EBV) plays a central role in the onset of neoplastic lymphoproliferation associated with immunological changes in aging, although the pathophysiology varies vastly among different disease entities. The interaction between immune dysfunction, immunosenescence and Epstein Barr Virus (EBV) infection appears to differ between NHL and HL, as well as between NHL subtypes
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