Aplicación del estudio de trabajo para mejorar la productividad del área de envasado de la empresa INVESTMENTS BERESHIT S.A.C., Chimbote-2021

La presente investigación tuvo como objetivo general aplicar la ingeniería de métodos para incrementar la productividad en el área de envasado, el estudio fue de tipo aplicada con un diseño de investigación pre-experimental. La población estuvo representada por la productividad de los procesos productivos para la elaboración de conserva de filete de caballa, mientras que la muestra por la productividad del área de envasado en la producción de conserva de filete de caballa. Los instrumentos empleados fueron el cursograma analítico del operario, diagrama bimanual y el diagrama de recorrido. Por último, se utilizó un cronómetro y una hoja de análisis de tiempos para determinar el tiempo estándar del proceso. Se obtuvo como resultado que, mediante el muestreo del trabajo se corroboró que el proceso crítico era el área de envasado. Además, se logró aumentar el porcentaje de actividades productivas de 65.00% con el método actual a 75.00% con el método mejorado, evidenciando una variación de 15.78%. Así mismo, se redujo el tiempo estándar de 11.74 min/panera a 10.08 min/panera, denotando una variación de - 14.40%. Finalmente, la productividad de mano de obra y la eficiencia física de materia prima se incrementó en 7.57% y 7.49% respectivamente

Desarrollo de un biosensor para el análisis de la inhibición enzimática causada por fisostigmina

La inhibición enzimática se considera el punto clave en aplicaciones clínicas y farmacoterapia, es por ello que el uso de biosensores enzimáticos es una buena alternativa en la evaluación de los fármacos. En este trabajo se presenta el desarrollo de un biosensor enzimático, basado en la inmovilización de nanopartículas de oro-Acetilcolinesterasa vía crosslinking. La actividad enzimática se evaluó por amperometría, parámetros como concentración de la enzima y del sustrato, pH y potencial de trabajo aplicado (Ea) fueron optimizados. Los resultados mostraron que la respuesta del biosensor es lineal con r² = 0.999, con sensibilidad de 27.621 µA/mM. LOD = 0.022 mM y LOQ = 2.29 mM, el coeficiente de variación fue de 1. 72%, el tiempo de respuesta fue inferior a 0.1 s, además se encontró que no hay diferencias significativas intra e inter biosensores. El biosensor fue viable para la evaluación del efecto farmacológico de fisostigmina a través de la inhibición enzimática, causada por el fármaco.Enzyme inhibition is considered the key point in clinical applications and the pharmacotherapy, so, use of enzymatic biosensors is a good alternative for drug evaluation. This paper presents development of enzymatic biosensor, based on the immobilization of gold nanoparticles¬Acetylcholinesterase via crosslinking. The enzymatic activity was evaluated by amperometry, parameters such as enzyme, and substrate concentration, pH and applied work potential (Ea), were optimized. Results show a linear response of the biosensor with r² = 0.999, and sensitivity of 27.621 µA/mM. LOD = 0.022 mM and LOQ = 2.29 mM, the coefficient of variation was 1. 72 %, while the response time was less than 0.1 s. lt was found that there are no significant differences intra and inter biosensors. The biosensor was suitable for the evaluation of the pharmacological effect of physostigmine through enzymatic inhibition, caused by the drug by cross-linking with glutaraldehyde in a multi-layer deposition

Diseño de la planeación del talento humano en la empresa Abyfragancias de la ciudad de Pereira Risaralda

El presente proyecto de grado tiene como finalidad diseñar la planificación del talento humano en la empresa de fragancias Abyfragancias de Pereira para el año 2022, a partir de un análisis aplicando en dicha compañía donde se identificaron las condiciones del talento humano actualmente en la empresa, teniendo en cuenta la importancia y papel protagónico que el ser humano tiene en las compañías para lograr las metas proyectadas. De esta manera, lo que se busca al planificar el área del talento humano, es identificar la insuficiencia real de la compañía frente al hecho de efectuar y/o reformar el área de gestión de la planificación del talento humano, a fin de identificar los requerimientos laborales, puesto que este factor conlleva claramente a la producción, a la mejora continua y al rendimiento de la organización. La descripción de la compañía producto de estudio, igualmente que el marco teórico hacen preferencia a algunos conceptos asociados a la tara y a la planificación del talento humano, la selección, evaluación, capacitaciones, compensaciones e incentivos al trabajador, encaminados siempre a que la compañía nos brinde un resultado positivo; donde sobresale la importancia no solo de contar con área de gestión de talento humano sino también de su planificación de tal manera que las personas estén de acuerdo con las exigencias con cada departamento de la compañía. Así mismo, se entregan conceptos generales para la planificación del talento humano en la empresa Abyfragancias, donde se atienden las necesidades tanto de la empresa de los colaboradores, poniendo en práctica modelo de gestión y desarrollo de los recursos humanos para así mismo obtener lograr alcanzar las metas proyectadas además que los colaboradores se sientan cómodos y una buena satisfacción laboral.The purpose of this degree project is to design the planning of human talent in the fragrance company Abyfragancias de Pereira for the year 2022, based on an analysis applied in the company where the conditions of human talent currently in the company were identified, taking into account the importance and leading role that the human being has in the companies to achieve the projected goals. In this way, what is sought when planning the area of human talent, is to identify the real insufficiency of the company in the fact of carrying out and/or reforming the management area of human talent planning, in order to identify the labor requirements, since this factor clearly leads to production, continuous improvement and performance of the organization. The description of the company product of study, as well as the theoretical framework give preference to some concepts associated with the tare and the planning of human talent, selection, evaluation, training, compensation and incentives to the worker, always aimed at the company to provide a positive result, which highlights the importance of not only having an area of human talent management but also its planning so that people are in accordance with the requirements with each department of the company. Likewise, general concepts for the planning of human talent in the company Abyfragancias are delivered, where the needs of both the company and the collaborators are attended, putting into practice the model of management and development of human resources in order to achieve the projected goals as well as that the collaborators feel comfortable and a good job satisfaction

The Caldera. No. 15

“No existe gran talento sin gran voluntad”. Honoré de Balzac. Desde la inteligencia emocional se distinguen una serie de cualidades, de aptitudes y de características que diferencian a un ser humano de otro y que nos permiten hablar de los determinados talentos que cada uno de nosotros posee. En nuestra institución, precisamente, existe un nutrido número de niños y de jóvenes talentosos en diferentes campos, a saber: La música, el teatro, la danza, el canto, los deportes, la escritura, la pintura, el diseño y, por supuesto, a nivel académico; personas sensibles al arte y a sus diferentes manifestaciones porque poseen un talento intrínseco que les permite destacarse en el medio en donde interactúan. En esta edición de “La Caldera” se pretende continuar con la labor de seguir destacando, mostrando, promoviendo algunos de los talentosos estudiantes que hacen parte de nuestra Institución. La edición también tiene como meta hacer la invitación a aquellos talentos aprendidos o innatos, pero ocultos, para que compartan con nuestra familia caldista sus dones. Es así como la institución privilegia diferentes espacios institucionales que, años tras año, han ido consolidándose como la muestra de talentos caldistas, en donde conocemos, valoramos, apreciamos y disfrutamos, precisamente, de las destrezas, de las habilidades que tienen nuestros educandos. Hagamos parte activa de estos espacios porque en la medida en la que nos involucremos, en esa medida, nuestra Institución seguirá creciendo y destacándose como una de las mejores a nivel regional y nacional.Entrevista a: William Ospina; Por: Lina maría Beltrán…04 El infinito Océano de la paz; Por: María Camila Escobar y Nicolás Espinel Martínez…05 Homenaje a Gabriel García Márquez; Por: Gisela Afanador…10 Dibujando sueños; Por: Lina maría Beltrán…14 A través de los ojos de Camila; Por: Valentina Vega…16 Expresiones Artísticas…17"There is no great talent without great will." Honoré de Balzac. From emotional intelligence, a series of qualities, aptitudes and characteristics are distinguished that differentiate one human being from another and that allow us to talk about the specific talents that each of us possesses. In our institution, precisely, there is a large number of talented children and young people in different fields, namely: music, theater, dance, singing, sports, writing, painting, design and, of course , at the academic level; people who are sensitive to art and its different manifestations because they have an intrinsic talent that allows them to stand out in the environment where they interact. In this edition of "La Caldera" it is intended to continue with the work of continuing to stand out, showing, promoting some of the talented students that are part of our Institution. The edition also aims to invite those talents learned or innate, but hidden, to share their gifts with our Caldista family. This is how the institution privileges different institutional spaces that, year after year, have been consolidated as the sample of Caldista talents, where we know, value, appreciate and enjoy, precisely, the skills, the abilities that our students have. Let's take an active part in these spaces because to the extent that we get involved, to that extent, our Institution will continue to grow and stand out as one of the best at the regional and national level

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

COVID-19 symptoms at hospital admission vary with age and sex: results from the ISARIC prospective multinational observational study

Background: The ISARIC prospective multinational observational study is the largest cohort of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality to presenting symptoms. Methods: International, prospective observational study of 60 109 hospitalized symptomatic patients with laboratory-confirmed COVID-19 recruited from 43 countries between 30 January and 3 August 2020. Logistic regression was performed to evaluate relationships of age and sex to published COVID-19 case definitions and the most commonly reported symptoms. Results: ‘Typical’ symptoms of fever (69%), cough (68%) and shortness of breath (66%) were the most commonly reported. 92% of patients experienced at least one of these. Prevalence of typical symptoms was greatest in 30- to 60-year-olds (respectively 80, 79, 69%; at least one 95%). They were reported less frequently in children (≤ 18 years: 69, 48, 23; 85%), older adults (≥ 70 years: 61, 62, 65; 90%), and women (66, 66, 64; 90%; vs. men 71, 70, 67; 93%, each P < 0.001). The most common atypical presentations under 60 years of age were nausea and vomiting and abdominal pain, and over 60 years was confusion. Regression models showed significant differences in symptoms with sex, age and country. Interpretation: This international collaboration has allowed us to report reliable symptom data from the largest cohort of patients admitted to hospital with COVID-19. Adults over 60 and children admitted to hospital with COVID-19 are less likely to present with typical symptoms. Nausea and vomiting are common atypical presentations under 30 years. Confusion is a frequent atypical presentation of COVID-19 in adults over 60 years. Women are less likely to experience typical symptoms than men