An Analysis of Seed Colour During Ripening of Cabernet Sauvignon Grapes

This case study examines seed colour during ripening using an exhaustive colorimetric analysis. The aim was to associate the chemical ripening with the seed colour in order to estimate the ripening stages of Cabernet Sauvignon grapes. Cluster samples, obtained from a vertical shoot-positioned vineyard in central Chile, were monitored for their technological and phenolic maturity, as well as for the colorimetric and chemical characteristics of the seeds. The colours of the scanned seed images were determined by human as well as by computer vision. In the first case, an expert assigned a colour to each seed part. In the second case, a computer program estimated the colours of the scanned seed images. An exhaustive analysis of seed colour was proposed, instead of a general observation of seed browning. The seed colour presented a wide range of colours, from moss green to dark brown, depending on the maturity and the face observed. The ripening stages identified, along with the chemical and colorimetric information gathered, were under ripe seed (brown with green traces), ripe seed (dark brown with green traces) and overripe seed (dark brown without any green traces). A new way to quantify seed colour is shown in this paper

Why Are Outcomes Different for Registry Patients Enrolled Prospectively and Retrospectively? Insights from the Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF).

Background: Retrospective and prospective observational studies are designed to reflect real-world evidence on clinical practice, but can yield conflicting results. The GARFIELD-AF Registry includes both methods of enrolment and allows analysis of differences in patient characteristics and outcomes that may result. Methods and Results: Patients with atrial fibrillation (AF) and ≥1 risk factor for stroke at diagnosis of AF were recruited either retrospectively (n = 5069) or prospectively (n = 5501) from 19 countries and then followed prospectively. The retrospectively enrolled cohort comprised patients with established AF (for a least 6, and up to 24 months before enrolment), who were identified retrospectively (and baseline and partial follow-up data were collected from the emedical records) and then followed prospectively between 0-18 months (such that the total time of follow-up was 24 months; data collection Dec-2009 and Oct-2010). In the prospectively enrolled cohort, patients with newly diagnosed AF (≤6 weeks after diagnosis) were recruited between Mar-2010 and Oct-2011 and were followed for 24 months after enrolment. Differences between the cohorts were observed in clinical characteristics, including type of AF, stroke prevention strategies, and event rates. More patients in the retrospectively identified cohort received vitamin K antagonists (62.1% vs. 53.2%) and fewer received non-vitamin K oral anticoagulants (1.8% vs . 4.2%). All-cause mortality rates per 100 person-years during the prospective follow-up (starting the first study visit up to 1 year) were significantly lower in the retrospective than prospectively identified cohort (3.04 [95% CI 2.51 to 3.67] vs . 4.05 [95% CI 3.53 to 4.63]; p = 0.016). Conclusions: Interpretations of data from registries that aim to evaluate the characteristics and outcomes of patients with AF must take account of differences in registry design and the impact of recall bias and survivorship bias that is incurred with retrospective enrolment. Clinical Trial Registration: - URL: http://www.clinicaltrials.gov . Unique identifier for GARFIELD-AF (NCT01090362)

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Outcomes from elective colorectal cancer surgery during the SARS-CoV-2 pandemic

This study aimed to describe the change in surgical practice and the impact of SARS-CoV-2 on mortality after surgical resection of colorectal cancer during the initial phases of the SARS-CoV-2 pandemic

Risk profiles and one-year outcomes of patients with newly diagnosed atrial fibrillation in India: Insights from the GARFIELD-AF Registry.

BACKGROUND: The Global Anticoagulant Registry in the FIELD-Atrial Fibrillation (GARFIELD-AF) is an ongoing prospective noninterventional registry, which is providing important information on the baseline characteristics, treatment patterns, and 1-year outcomes in patients with newly diagnosed non-valvular atrial fibrillation (NVAF). This report describes data from Indian patients recruited in this registry. METHODS AND RESULTS: A total of 52,014 patients with newly diagnosed AF were enrolled globally; of these, 1388 patients were recruited from 26 sites within India (2012-2016). In India, the mean age was 65.8 years at diagnosis of NVAF. Hypertension was the most prevalent risk factor for AF, present in 68.5% of patients from India and in 76.3% of patients globally (P < 0.001). Diabetes and coronary artery disease (CAD) were prevalent in 36.2% and 28.1% of patients as compared with global prevalence of 22.2% and 21.6%, respectively (P < 0.001 for both). Antiplatelet therapy was the most common antithrombotic treatment in India. With increasing stroke risk, however, patients were more likely to receive oral anticoagulant therapy [mainly vitamin K antagonist (VKA)], but average international normalized ratio (INR) was lower among Indian patients [median INR value 1.6 (interquartile range {IQR}: 1.3-2.3) versus 2.3 (IQR 1.8-2.8) (P < 0.001)]. Compared with other countries, patients from India had markedly higher rates of all-cause mortality [7.68 per 100 person-years (95% confidence interval 6.32-9.35) vs 4.34 (4.16-4.53), P < 0.0001], while rates of stroke/systemic embolism and major bleeding were lower after 1 year of follow-up. CONCLUSION: Compared to previously published registries from India, the GARFIELD-AF registry describes clinical profiles and outcomes in Indian patients with AF of a different etiology. The registry data show that compared to the rest of the world, Indian AF patients are younger in age and have more diabetes and CAD. Patients with a higher stroke risk are more likely to receive anticoagulation therapy with VKA but are underdosed compared with the global average in the GARFIELD-AF. CLINICAL TRIAL REGISTRATION-URL: http://www.clinicaltrials.gov. Unique identifier: NCT01090362

Un enfoque actual sobre la calidad del software

The quality of software is a set of qualities that characterize it and that determine their utility and existence. The quality is synonymous of efficiency, flexibility, correction, trustworthiness, portability, usability, security and integrity. The quality of software is measurable and varies from a system to another one or from a program to another one. A software elaborated for the control of spaceships must be reliable at the "zero errors level"; a software made to execute a single time does not require the same quality level; whereas a product of software to be exploded during a long period (10 years or more), needs to be reliable and flexible to diminish the costs of maintenance and improvement during the time of operation. The quality of software can be moderate after elaborated the product. But this can be very expensive if problems are detected derives two from imperfections in the design, reason why is essential to consider the obtaining of the quality and its control during all the stages of the service life of software

Effects of decreasing levels of n amendments on organic "granny smith" apple trees

Artículo de publicación ISIThe effect of decreasing levels of organic N-fertilization on fruit production, mineral composition and fruit quality was evaluated in organically cultivated "Granny Smith" apples trees. Treatments included the application of decreasing levels of N fertilization (100 kg N ha(-1), 75 kg N ha(-1), 50 kg N ha(-1) and 0 kg N ha(-1)) applied as fossilized red guano (50% of the total amount of N) and blood meal (50% of the total amount of N) to twelve years old Granny Smith apple trees. Yield was not affected by the treatments (yield ranged from 0.28 to 0.4 kg cm(-2) SCSA). Fruit mineral concentration and ratios were not affected by treatments. Fruits showed low Ca concentrations (2.8 to 3.3 mg Ca 100 g(-1) FW), high levels of K (118.6 to 130.1 mg K 100 g(-1) FW) and high values for K+Mg/Ca (> 12) and K/Ca (> 30) ratios. Mineral concentration on leaves was not affected by treatments (normal concentrations for macro and microelements). Bitter pit was only detected after 60 days of storage (100 kg N ha(-1) tree, 1.1 in a scale 1-4). Besides orchard nitrogen management, fruit mineral ratios and Ca foliar applications should be considered for managing fruit production and quality in organic apples

Performance Assessment of Thermal Infrared Cameras of Different Resolutions to Estimate Tree Water Status from Two Cherry Cultivars: An Alternative to Midday Stem Water Potential and Stomatal Conductance

The midday stem water potential (Ψs) and stomatal conductance (gs) have been traditionally used to monitor the water status of cherry trees (Prunus avium L.). Due to the complexity of direct measurement, the use of infrared thermography has been proposed as an alternative. This study compares Ψs and gs against crop water stress indexes (CWSI) calculated from thermal infrared (TIR) data from high-resolution (HR) and low-resolution (LR) cameras for two cherry tree cultivars: 'Regina' and 'Sweetheart'. For this purpose, a water stress-recovery cycle experiment was carried out at the post-harvest period in a commercial drip-irrigated cherry tree orchard under three irrigation treatments based on Ψs levels. The water status of trees was measured weekly using Ψs, gs, and compared to CWSIs, computed from both thermal cameras. Results showed that the accuracy in the estimation of CWSIs was not statistically significant when comparing both cameras for the representation of Ψs and gs in both cultivars. The performance of all evaluated physiological indicators presented similar trends for both cultivars, and the averaged differences between CWSI's from both cameras were 11 ± 0.27%. However, these CWSI's were not able to detect differences among irrigation treatments as compared to Ψs and gs

The tempo of the Iberian megalithic rituals in the European context: The cemetery of Panoría

Our ability to build precise narratives regarding megalithic societies largely depends on the chronology of the multi-ritual events that usually shaped these complex sites. The cemetery of Panoría offers an excellent opportunity for exploring ritual complexity in Iberia through radiocarbon chronology, as four of the nine recently excavated dolmens are remarkably well preserved. For this purpose, seventy-three radiocarbon dates were obtained and analysed within a Bayesian framework. The resulting refined chronology has led us to three main conclusions: i) in all tombs, the second half of the 4th millennium cal BC was an intensive but brief period of funerary depositions, probably over three to six generations; ii) after a long hiatus, most of the dolmens were reused in the 25th and 21st centuries cal BC during even shorter periods, spanning just a few decades and approximately one to four generations; and (iii) long after the funerary rituals had ended in the 21st century, the memory of the cemetery was revived in Late Antiquity. These short, punctuated periods of use are highly consistent with those seen in a growing number of European megalithic monuments. From Britain to Iberia, a pattern of short spans of use is dramatically changing our perception of the social and political roles of these complex monuments. © 2022 The Author