Recent results from the Arctic Radiation and Turbulence Interaction STudy (ARTIST) project

Ground-based measurements were conducted at Ny-˚Alesund in the Svalbard Islands in the framework of the research project ARTIST (Arctic Radiation and Turbulence Interaction STudy) funded by the European Communities. Key objectivesof the campaign were: 1) provide all participantswith ground reference data as input to models describing the development of the atmospheric boundary level, 2) compute the surface roughness length in order to characterise the surface of the site, 3) parameterise the surface energy exchanges, calculating the surface radiation flux, the sensible and latent heat fluxes, and 4) obtain the surface energy balance during both clear and cloudy sky conditions. The cloud radiative forcing has been also estimated. Final results of the analysis of the data set are presented

Aerosol-ozone correlations during dust transport episodes

Its location in the Mediterranean region and its physical characteristics render Mt. Cimone (44&deg;11&prime; N, 10&deg;42&prime; E), the highest peak of the Italian northern Apennines (2165 m asl), particularly suitable to study the transport of air masses from the north African desert area to Europe. During these northward transports 12 dust events were registered in measurements of the aerosol concentration at the station during the period June&ndash;December 2000, allowing the study of the impact of mineral dust transports on free tropospheric ozone concentrations, which were also measured at Mt. Cimone. Three-dimensional backward trajectories were used to determine the air mass origin, while TOMS Aerosol Index data for the Mt. Cimone area were used to confirm the presence of absorbing aerosol over the measurement site. <P style='line-height: 20px;'> A trajectory statistical analysis allowed identifying the main source areas of ozone and aerosols. The analysis of these back trajectories showed that central Europe and north and central Italy are the major pollution source areas for ozone and fine aerosol, whereas the north African desert regions were the most important source areas for coarse aerosol and low ozone concentrations. During dust events, the Mt. Cimone mean volume concentration for coarse particles was 6.18 &micro;m³/cm³ compared to 0.63 &micro;m³/cm³ in dust-free conditions, while the ozone concentrations were 4% to 21% lower than the monthly mean background values. Our observations show that surface ozone concentrations were lower than the background values in air masses coming from north Africa, and when these air masses were also rich in coarse particles, the lowest ozone values were registered. Moreover, preliminary results on the possible impact of the dust events on PM₁₀ and ozone values measured in Italian urban and rural areas showed that during the greater number of the considered dust events, significant PM₁₀ increases and ozone decreases have occurred in the Po valley

Five‐year analysis of background carbon dioxide and ozone variations during summer seasons at the Mario Zucchelli station (Antarctica)

The work focuses on the analysis of CO 2 and O 3 surface variations observed during five summer experimental campaigns carried out at the 'Icaro Camp' clean air facility (74.7°S, 164.1°E, 41 m a.s.l.) of the 'Mario Zucchelli' Italian coastal research station. This experimental activity allowed the definition of summer average background O 3 values that ranged from 18.3 ± 4.7 ppbv (summer 2005–2006) to 21.3 ± 4.0 ppbv (summer 2003–2004). Background CO 2 concentrations showed an average growth rate of 2.10 ppmv yr -1 , with the highest CO 2 increase between the summer campaigns 2002–2003 and 2001–2002 (+2.85 ppmv yr -1 ), probably reflecting the influence of the 2002/2003 ENSO event. A comparison with other Antarctic coastal sites suggested that the summer background CO 2 and O 3 at MZS-IC are well representative of the average conditions of the Ross Sea coastal regions. As shown by the analysis of local wind direction and by 3-D back-trajectory calculations, the highest CO 2 and O 3 values were recorded in correspondence to air masses flowing from the interior of the Antarctic continent. These results suggest that air mass transport from the interior of the continent exerts an important influence on air mass composition in Antarctic coastal areas. DOI: 10.1111/j.1600-0889.2011.00576.

Significant variations of trace gas composition and aerosol properties at Mt. Cimone during air mass transport from North Africa – contributions from wildfire emissions and mineral dust

Abstract. High levels of trace gas (O3 and CO) and aerosol (BC, fine and coarse particle volumes), as well as high scattering coefficient (σp) values, were recorded at the regional GAW-WMO station of Mt. Cimone (CMN, 2165 m a.s.l., Italy) during the period 26–30 August 2007. Analysis of air-mass circulation, aerosol chemical characterization and trace gas and aerosol enhancement ratios (ERs), showed that high O3 and aerosol levels were likely linked to (i) the transport of anthropogenic pollution from northern Italy, and (ii) the advection of air masses rich in mineral dust and biomass burning (BB) products from North Africa. In particular, during the advection of air masses from North Africa, the CO and aerosol levels (CO: 175 ppbv, BC: 1015 ng/m3, fine particle volume: 3.00 μm3 cm−3, σp: 84.5 Mm−1) were even higher than during the pollution event (CO: 138 ppbv, BC: 733 ng/m3, fine particles volume: 1.58 μm3 cm−3, σp: 44.9 M

Transport of Stratospheric Air Masses to the Nepal Climate Observatory–Pyramid (Himalaya; 5079 m MSL): A Synoptic-Scale Investigation

AbstractThis work analyzes and classifies stratospheric airmass transport events (ST) detected at the Nepal Climate Observatory–Pyramid (NCO-P; 27°57′N, 86°48′E, 5079 m MSL) Global Atmospheric Watch–World Meteorological Organization station from March 2006 to February 2008. For this purpose, in situ ozone (O3), meteorological parameters (atmospheric pressure and relative humidity), and black carbon (BC) are analyzed. The paper describes the synoptic-scale meteorological scenarios that are able to favor the development of ST over the southern Himalaya, by analyzing the meteorological fields provided by the ECMWF model (geopotential height, wind speed, and potential vorticity), satellite Ozone Monitoring Instrument data (total column ozone), and three-dimensional back trajectories calculated with the Lagrangian Analysis Tool (LAGRANTO) model. The study, which represents the first "continuous" classification of ST in the southern Himalaya, permitted classification of 94% of ST days within four synoptic-scale scenarios: stratospheric potential vorticity structures (PVS), subtropical jet stream (SJS), quasi-stationary ridges (QSR), and monsoon depressions (MD). SJS and PVS were the most frequent scenarios (48% and 30% of occurrences, respectively), QSR occurred for 12% of the ST days, and MD were detected only during the monsoon season (3%). SJS and PVS scenarios presented a peak frequency during the nonmonsoon seasons, when the jet stream and westerly disturbances influence atmospheric circulation over the southern Himalaya. During the identified ST, significant variations of O3 (+24%) and BC (−56%) were recorded relative to the averaged 2-yr mean values. On average, PVS and SJS were the most effective synoptic-scale scenarios in modifying the O3 and BC levels at NCO-P from postmonsoon to premonsoon seasons, and ST is one of the leading processes in defining the "background" BC variability at NCO-P

Performance of the CMS Cathode Strip Chambers with Cosmic Rays

The Cathode Strip Chambers (CSCs) constitute the primary muon tracking device in the CMS endcaps. Their performance has been evaluated using data taken during a cosmic ray run in fall 2008. Measured noise levels are low, with the number of noisy channels well below 1%. Coordinate resolution was measured for all types of chambers, and fall in the range 47 microns to 243 microns. The efficiencies for local charged track triggers, for hit and for segments reconstruction were measured, and are above 99%. The timing resolution per layer is approximately 5 ns

Up-regulation of cell cycle arrest protein BTG2 correlates with increased overall survival in breast cancer, as detected by immunohistochemistry using tissue microarray

<p>Abstract</p> <p>Background</p> <p>Previous studies have shown that the <it>ADIPOR1</it>, <it>ADORA1</it>, <it>BTG2 </it>and <it>CD46 </it>genes differ significantly between long-term survivors of breast cancer and deceased patients, both in levels of gene expression and DNA copy numbers. The aim of this study was to characterize the expression of the corresponding proteins in breast carcinoma and to determine their correlation with clinical outcome.</p> <p>Methods</p> <p>Protein expression was evaluated using immunohistochemistry in an independent breast cancer cohort of 144 samples represented on tissue microarrays. Fisher's exact test was used to analyze the differences in protein expression between dead and alive patients. We used Cox-regression multivariate analysis to assess whether the new markers predict the survival status of the patients better than the currently used markers.</p> <p>Results</p> <p>BTG2 expression was demonstrated in a significantly lower proportion of samples from dead patients compared to alive patients, both in overall expression (<it>P </it>= 0.026) and cell membrane specific expression (<it>P </it>= 0.013), whereas neither ADIPOR1, ADORA1 nor CD46 showed differential expression in the two survival groups. Furthermore, a multivariate analysis showed that a model containing BTG2 expression in combination with HER2 and Ki67 expression along with patient age performed better than a model containing the currently used prognostic markers (tumour size, nodal status, HER2 expression, hormone receptor status, histological grade, and patient age). Interestingly, BTG2 has previously been described as a tumour suppressor gene involved in cell cycle arrest and p53 signalling.</p> <p>Conclusions</p> <p>We conclude that high-level BTG2 protein expression correlates with prolonged survival in patients with breast carcinoma.</p

Uridine Metabolism in HIV-1-Infected Patients: Effect of Infection, of Antiretroviral Therapy and of HIV-1/ART-Associated Lipodystrophy Syndrome

Background Uridine has been advocated for the treatment of HIV-1/HAART-associated lipodystrophy (HALS), although its metabolism in HIV-1-infected patients is poorly understood. Methods Plasma uridine concentrations were measured in 35 controls and 221 HIV-1-infected patients and fat uridine in 15 controls and 19 patients. The diagnosis of HALS was performed following the criteria of the Lipodystrophy Severity Grading Scale. Uridine was measured by a binary gradient-elution HPLC method. Analysis of genes encoding uridine metabolizing enzymes in fat was performed with TaqMan RT-PCR. Results Median plasma uridine concentrations for HIV-1-infected patients were 3.80 µmol/l (interquartile range: 1.60), and for controls 4.60 µmol/l (IQR: 1.8) (P = 0.0009). In fat, they were of 6.0 (3.67), and 2.8 (4.65) nmol/mg of protein, respectively (P = 0.0118). Patients with a mixed HALS form had a median plasma uridine level of 4.0 (IC95%: 3.40-4.80) whereas in those with isolated lipoatrophy it was 3.25 (2.55-4.15) µmol/l/l (P = 0.0066). The expression of uridine cytidine kinase and uridine phosphorylase genes was significantly decreased in all groups of patients with respect to controls. A higher expression of the mRNAs for concentrative nucleoside transporters was found in HIV-1-infected patients with respect to healthy controls. Conclusions HIV-1 infection is associated with a decrease in plasma uridine and a shift of uridine to the adipose tissue compartment. Antiretroviral therapy was not associated with plasma uridine concentrations, but pure lipoatrophic HALS was associated with significantly lower plasma uridine concentrations

Performance and Operation of the CMS Electromagnetic Calorimeter

The operation and general performance of the CMS electromagnetic calorimeter using cosmic-ray muons are described. These muons were recorded after the closure of the CMS detector in late 2008. The calorimeter is made of lead tungstate crystals and the overall status of the 75848 channels corresponding to the barrel and endcap detectors is reported. The stability of crucial operational parameters, such as high voltage, temperature and electronic noise, is summarised and the performance of the light monitoring system is presented