A Pre-Merger Stage Galaxy Cluster: Abell 3733

The galaxy cluster Abell 3733 (A3733) is a very suitable candidate in addressing dynamical processes throughout galaxy cluster mergers. This study shows structural analysis results of A3733 (z = 0.038) based on X-ray and optical data. According to X-ray luminosity map, A3733 hosts two sub-structures separated in the sky by $\sim$ 0.25 Mpc, and the two distinct clumps are located in the East (A3733E) and the West (A3733W) directions. Both sub-structures are centred on two different brightest cluster galaxies (BCGs), and the X-ray and optical centroids of both BCGs substantially coincide with each other. The intracluster medium (ICM) temperatures of the sub-structures are estimated to be 2.79 keV for A3733E and 3.28 keV for A3733W. Both sub-structures are found to be hosting cool central gas (kT $\sim$ 1.5-2.5 keV) surrounded by hotter gas (kT $\sim$ 3.0-3.5 keV). Besides, the X-ray concentration parameters are found to be c $\sim$ 0.3 for each sub-structure. These results indicate the existence of cool centres for both sub-structures. The optical density map reveals a crowded galaxy population within the vicinity of A3733W. The high probable (% 88.2) dynamical binding model of A3733 suggests that the cores of sub-structures have a 3D separation of 0.27 Mpc and will collide in 0.14 Gyr with the relative in-falling velocity of 1936 km s$^{-1}$. As a conclusion, this study demonstrates some evidence suggesting that the A3733 system is in the pre-merger state.Comment: 9 pages, 7 Figures, published by MNRA

MULTIPLE 450 nm DIODE LASER PROCESSING OF TI64 POWDER

Diode Area Melting (DAM) presents an alternative approach to traditional Laser Powder Bed Fusion (PBF-LB/M) approaches, integrating multiple individually addressable low-power fibre-coupled diode lasers into a laser head; these traverse across a powder bed to melt powdered feedstock. DAM research to date has focused on using low-power 808 nm lasers to process Ti6Al-4V (Ti64) powder. This work focuses on using multiple short wavelengths 450 nm 4W lasers to process Ti64 feedstock. Previous studies found that when processing Ti64, absorption was 11% higher using 450 nm lasers when compared to using 808 nm lasers and 14% higher than 1064nm laser. This work demonstrated the potential to use shorter wavelength lasers in DAM/LPBF for improved melting efficiency. Also, it aimed to examine the impact of 450 nm diode lasers on Ti64 and generate a parameter map for this material. It was found that low power (4W) multiple 450 nm diode lasers can successfully melt the Ti64 for AM applications with above 95% density.Mechanical Engineerin

Probiotic Lactobacillus paracasei effect on cariogenic bacterial flora

Lactobacillus paracasei has been demonstrated to inhibit the growth of many pathogenic microbes such as Streptococcus mutans, in vitro. However, its clinical application remains unclear. Here, we examined whether a novel probiotic L. paracasei GMNL-33 may reduce the caries-associated salivary microbial counts in healthy adults. Seventy-eight subjects (aged 20 to 26) had completed this double-blinded, randomized, placebo-controlled study. A probiotic/test (n = 42) and a control group (n = 36) took a L. paracasei GMNL-33 and a placebo oral tablet three times per day for 2 weeks, respectively. Bacterial counts of salivary S. mutans, lactobacilli, and salivary buffer capacity were measured with chair-side kits at the beginning (T1), the completion (T2) of medication, and 2 weeks after medication (T3). The results did not show differences in the counts of S. mutans and lactobacilli between probiotic and control groups at T1, T2, and T3. Nevertheless, within the probiotic group, an interesting probiotic effect was noticed. Between T1 and T2, no inhibitory effect against S. mutans was observed. However, a significant count reduction in the salivary S. mutans was detected between T2 and T3 (p = 0.016). Thus, a 2-week period of medication via oral administration route may be needed for L. paracasei GMNL-33 to be effective in the probiotic action

Golden Horn Estuary: Description of the ecosystem and an attempt to assess its ecological quality status using various classification metrics

In this paper, we describe the pelagic and benthic ecosystem of the Golden Horn  estuary opening into the Marmara Sea. To improve the water quality of the estuary, which had long been subject to severe anthropogenic pollution (industrial, chemical, shipping),  industrial facilities were moved from the estuary in the 1980s, followed by a rehabilitation plan in the 1990s. Our results, based on chemical parameters and phytoplankton showed some signs of improvement of water conditions in the upper layer. However, macrozoobenthic findings of this study did not reflect such a recovery in bottom life.An approach to the Ecological Quality Status (EQS) assessment was performed by applying the biotic indices BENTIX, AMBI, BOPA, BO2A. Our final assessment was based on 'expert-judgements' and revealed a very disturbed overall ecosystem with 'bad' EQS for the station at the head of the estuary,  'poor' in the rest of the estuary and 'moderate' EQS only in the middle station

LOFAR discovery of a double radio halo system in Abell 1758 and radio/X-ray study of the cluster pair

Radio halos and radio relics are diffuse synchrotron sources that extend over Mpc-scales and are found in a number of merger galaxy clusters. They are believed to form as a consequence of the energy that is dissipated by turbulence and shocks in the intra-cluster medium (ICM). However, the precise physical processes that generate these steep synchrotron spectrum sources are still poorly constrained. We present a new LOFAR observation of the double galaxy cluster Abell 1758. This system is composed of A1758N, a massive cluster hosting a known giant radio halo, and A1758S, which is a less massive cluster whose diffuse radio emission is confirmed here for the first time. Our observations have revealed a radio halo and a candidate radio relic in A1758S, and a suggestion of emission along the bridge connecting the two systems which deserves confirmation. We combined the LOFAR data with archival VLA and GMRT observations to constrain the spectral properties of the diffuse emission. We also analyzed a deep archival Chandra observation and used this to provide evidence that A1758N and A1758S are in a pre-merger phase. The ICM temperature across the bridge that connects the two systems shows a jump which might indicate the presence of a transversal shock generated in the initial stage of the merger

Mechanism of action of probiotics

The modern diet doesn't provide the required amount of beneficial bacteria. Maintenance of a proper microbial ecology in the host is the main criteria to be met for a healthy growth. Probiotics are one such alternative that are supplemented to the host where by and large species of Lactobacillus, Bifidobacterium and Saccharomyces are considered as main probiotics. The field of probiotics has made stupendous strides though there is no major break through in the identification of their mechanism of action. They exert their activity primarily by strengthening the intestinal barrier and immunomodulation. The main objective of the study was to provide a deep insight into the effect of probiotics against the diseases, their applications and proposed mechanism of action

Growth inhibition of oral mutans streptococci and candida by commercial probiotic lactobacilli - an in vitro study

<p>Abstract</p> <p>Background</p> <p>Probiotic bacteria are suggested to play a role in the maintenance of oral health. Such health promoting bacteria are added to different commercial probiotic products. The aim of the study was to investigate the ability of a selection of lactobacilli strains, used in commercially available probiotic products, to inhibit growth of oral mutans streptococci and <it>C. albicans in vitro</it>.</p> <p>Methods</p> <p>Eight probiotic lactobacilli strains were tested for growth inhibition on three reference strains and two clinical isolates of mutans streptococci as well as two reference strains and three clinical isolates of <it>Candida albicans </it>with an agar overlay method.</p> <p>Results</p> <p>At concentrations ranging from 10⁹to 10⁵CFU/ml, all lactobacilli strains inhibited the growth of the mutans streptococci completely with the exception of <it>L. acidophilus </it>La5 that executed only a slight inhibition of some strains at concentrations corresponding to 10⁷and 10⁵CFU/ml. At the lowest cell concentration (10³CFU/ml), only <it>L. plantarum </it>299v and <it>L. plantarum </it>931 displayed a total growth inhibition while a slight inhibition was seen for all five mutans streptococci strains by <it>L. rhamnosus </it>LB21, <it>L. paracasei </it>F19, <it>L. reuteri </it>PTA 5289 and <it>L. reuteri </it>ATCC 55730. All the tested lactobacilli strains reduced candida growth but the effect was generally weaker than for mutans streptococci. The two <it>L. plantarum </it>strains and <it>L. reuteri </it>ATCC 55730 displayed the strongest inhibition on <it>Candida albicans</it>. No significant differences were observed between the reference strains and the clinical isolates.</p> <p>Conclusion</p> <p>The selected probiotic strains showed a significant but somewhat varying ability to inhibit growth of oral mutans streptococci and <it>Candida albicans in vitro</it>.</p

Fibre optic absorbance meter with low limit of detection for waterborne cations

We report an evanescent wave based fibre optic absorbance meter that enables the colorimetric detection of waterborne cations with water insoluble chromoionophoric sensitisers. This establishes an alternative to the PVC membrane based transducers that are conventionally used for this purpose. Here, a water insoluble sensitiser is coated as a thin film on an unclad section of a multimode optical fibre to overlap with the evanescent field of a light beam propagating along the fibre core. The colorimetric response of the sensitiser when in contact with waterborne cation leads to increased absorption of virtual photons associated with the evanescent field. The resulting intensity loss of the propagating beam is detected by a bespoke newly designed self- referenced evanescent wave absorbance meter with beam intensity modulation and Lock-in amplification. We validate our transducer with the well characterised water insoluble sensitizer, 1-(2-pyridylazo)-2-naphthol (PAN), for the detection of aqueous Zn2+ cations. We find a limit of detection (LoD) of 54 nM Zn2+, 28 times lower compared to a PVC membrane based sensor using same sensitiser for same cation (Albero et al., Journal of Pharmaceutical and Biomedical Analysis 29 (2002), 779). Our evanescent wave absorbance meter can easily be adapted to other colorimetric sensitisers, including chromoionophoric complex forming macrocycles

Effect of the probiotic Lactobacilli reuteri (Prodentis) in the management of periodontal disease: a preliminary randomized clinical trial

Objectives: The aim of this study was to evaluate the effects of Lactobacilli reuteri (Prodentis) alone and in combination with scaling and root planing (SRP) in a double blind, randomized, placebo-controlled clinical trial of volunteers with chronic periodontitis. Methods: Thirty, otherwise systemically healthy, chronic periodontitis patients (19 males and 11 females, aged between 34 and 50 years) were included. The study period was 42 days. &#x2018;Split-mouth&#x2019; design was used for the SRP, which was performed on day 0; two quadrants (either right or left) were treated with SRP whereas the remaining two quadrants were left untreated. The participants received a toothbrush, toothpaste, and brushing instructions. L. reuteri Prodentis lozenges (1&#x00D7;108 CFU DSM17938&#x200A;+&#x200A;1&#x00D7;108 CFU ATCC PTA 5289) or the corresponding placebo lozenges were taken twice daily from day 21 to day 42. Statistical analysis was done for comparisons of clinical parameters (Plaque Index (PI), Gingival Index (GI), Gingival Bleeding Index (GBI), probing pocket depth (PPD), clinical attachment level (CAL)) and microbiological levels of the pathogens Aggregibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), and Prevotella intermedia (Pi). All p-values less than 0.05 were considered significant. Assessments were made on day 0 before SRP treatment, on day 21 before administration of the lozenges, and on day 42. Results: At day 42, the PI, GI, and GBI were significantly reduced by all treatment modalities. When ranked, the amount of PI, GI and GBI reduction by the different treatments was SRP&#x200A;+&#x200A;Prodentis&#x200A;&#x003E;&#x200A;Prodentis&#x200A;&#x003E;&#x200A;SRP&#x200A;+&#x200A;placebo&#x200A;&#x003E;&#x200A;placebo; all differences were statistically significant. For PPD and CAL, the best result was obtained with the SRP&#x200A;+&#x200A;Prodentis treatment. PPD was reduced from 5.08&#x00B1;0.75 to 3.78&#x00B1;0.61&#x2009;mm (p&#60;0.001) and CAL from 3.93&#x00B1;0.93 to 2.85&#x00B1;0.74&#x2009;mm (p&#60;0.001). Prodentis, either alone or following SRP, reduced Aa, Pi, and Pg by 1 log10 unit (p&#60;0.01). The SRP&#x200A;+&#x200A;placebo combination did not significantly affect the levels of the pathogens. Conclusion: The present randomized controlled trial confirms the plaque inhibition, anti-inflammatory, and antimicrobial effects of L. reuteri Prodentis. L. reuteri Prodentis probiotic can be recommended during non-surgical therapy and the maintenance phase of periodontal treatment. Considering the beneficial effects of probiotics, this therapy could serve as a useful adjunct or alternative to periodontal treatment when SRP might be contraindicated. Further studies are required in this direction